emka TECHNOLOGIES provides a complete suite of integrated solutions for pulmonary studies: - conscious, unrestrained, freely moving animal in whole body plethysmograph - conscious, restrained animal in head-out or double chamber plethysmograph - anesthetized animal in standard plethysmograph, with spontaneous or ventilated breathing - full pulmonary mechanics systems - exposure systems :aerosol, gas, cigarette smoke

1. pulmonary solutions
for small & large animals
emka TECHNOLOGIES
pulmonary.emka.fr

2. pulmonary solutions from emka TECHNOLOGIES
software suite for all your needs
iox2, data acquisition and real time analysis
»» iox2 acquires, analyzes, displays, controls and stores data
generated during an experiment
»» one file per subject
(can append data to same file during successive sessions)
»» subject file contains all information
(configuration, calibration, protocol, event and signal data)
»» real-time monitoring, on line or off line review
»» synchronized video signal stored in same file or in separate file
(user option)
»» protocols as experimental guideline or automation
»» remote control of nebulization
Specific analyzers for real time processing of:
»» respiratory flow, penh, cough and apnea detection
»» lung resistance/compliance
ecgAUTO, advanced post-processing analysis
»» analysis module for respiration from conductive belts
»» synchronized video review
»» pioneering shape-recognition techniques for in-depth analysis of ECG for all species, normal and pathological morphologies
datanalyst, data post-processing software
datanalyst processes calculated parameters from files
generated by iox2. Fast and versatile data from an unlimited
number of experiments are extracted automatically.
Extraction of key data
»» edits event markers, finds min, max, area, kinetics...
»» automated extraction using protocols
»» results as graphs & tables
Data reduction
»» pools subjects into single study
»» full experiment review, identifies protocol events
»» exclusion of artefacts
Reporting
»» distributes subjects in groups
»» performs simple statistics, computes EC50, kinetics...
»» versatile text format export
studyDESIGNER, data base tool for your studies
studyDESIGNER is a high level tool to organize
data recording, analysis, review and archiving on large toxicology or
safety pharmacology studies.
During recording sessions, studyDESIGNER automatically drives iox2,
ecgAUTO and datanalyst software to record and analyze data and
send calculated parameters to its data base.
GLP modules
Available for all software:
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electronic signature
audit trail
user access management
study management
emka TECHNOLOGIES
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defines subject and study structure
defines recording protocols and analysis configurations
reviews and edits analysis results
stores and archives results in database
generates on-demand/custom reports for any combination
of group, phase, subject and all parameters
service & support
emka TECHNOLOGIES provides a full range of
support services:
»» pre-installation audits to design optimal system setup,
SOP
»» installation and training
»» hardware and software validation service
»» warranty extension and maintenance

3. pulmonary solutions from emka TECHNOLOGIES
provides a complete suite of integrated
solutions for pulmonary studies:
emka TECHNOLOGIES
»» conscious, unrestrained, freely moving animal
in whole body plethysmograph
»» conscious, restrained animal
in head-out or double chamber plethysmograph
double chamber & head-out plethysmograph
Conscious restrained animals can be used for long-term measurements
and chronic studies.
A large number of subjects can be screened, with no surgery,
nor anesthetic.
»» anesthetized animal in standard plethysmograph,
with spontaneous or ventilated breathing
»» full pulmonary mechanics systems
»» exposure systems : aerosol, gas, cigarette smoke
whole body plethysmograph
The non-invasive whole body
plethysmography is a proven way to
study pulmonary function and evaluate
bronchoconstriction on unrestrained
conscious animals.
»» moving freely, animals are neither
stressed, nor influenced by
anesthesia
»» same subjects can be their own
control and be studied several times
»» start experiment on multiple animals
only in a few minutes
Key features
»» for mouse, rat, guinea-pig, rabbit, primate
»» regulated ventilation for noise-free air renewal
»» drinking bottle for long experiments (24 hrs or more)
Measured parameters
»» respiratory rates and durations
»» indication on breathing depth, volume and flow
»» quantifies the degree of bronchoconstriction (penH)
The double chamber plethysmograph measures nasal flow from
the head chamber and thoracic flow from the body chamber.
»» computes specific airway resistance using the time shift between
nasal and thoracic flows
»» measures ventilatory parameters on mouse, rat, guinea-pig
»» conical restrainer for less stressed animal and easier manipulation
»» aerosol can be delivered in head chamber
»» the head-out configuration (head part is removed) can be
combined with inhalation tower to expose several animals
simultaneously, keeping them under measurement (all ventilatory
parameters are measured except specific airway resistance)
double-chamber plethysmography
& implantable telemetry
New
Combining the lung pressure signal coming from a telemetry implant
with flow signal from a double chamber plethysmograph in the
head-out configuration allows direct resistance/compliance
measurements in non-sedated animals.
easyMATRIX
Options
»» tower for swivel/tether system, for IV injection or blood pressure
»» temperature and humidity monitoring and compensation
»» behavioral and EEG studies in rats. Height design ensures that the
rat can stand on its hind legs into the plethysmograph
combined measurement of respiration & ECG
»» measures respiratory
parameters (like in whole
body plethysmograph model)
»» gets complete
6-lead ECG signal
ecgTUNNEL
emka TECHNOLOGIES
»» designed for conscious
restrained mouse and rat
Take advantage of the emka TECHNOLOGIES
software suite with the easyMATRIX16, which synchronizes respiratory
signal & pressure signal from DSITM implant.
cough detection
»» usually performed within whole body plethysmograph,
sometimes in double chamber plethysmograh
»» audio and respiration signals are correlated to reject random
sound noise : only true cough bursts are processed
»» optional video recording helps performing quick control

4. complete pulmonary mechanics on rodents
plethysmograph for anesthetized rodents
On anesthetized animals, pulmonary pressure and flow are measured.
This allows to access lung resistance and compliance and, as well, full list of ventilation parameters.
Mainly used on ventilated animals, this models is also used with spontaneously breathing subjects.
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for mouse, rat and guinea-pig
tracheotomized or intubated animals
thoracic flow is computed from pressure changes in the plethysmograph
pressure is measured from a cannula inserted in the pleural, oesophagus or trachea
can be combined with vital signs monitoring
aerosol can be delivered during ventilation
large animals with Fleish tubes
For large animals, plethysmographs can not be used and are replaced by heated Fleisch tube measuring flow.
On anesthetized animals, pressure is measured from pleura or oesophagus.
advanced respiratory mechanics with flexiVentTM
flexiVentTM
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broadest range of measurements in a single platform
volume or pressure-controlled mechanical ventilation
customized or standard pressure or volume manoeuvers
dynamic R&C measurements
low frequency forced oscillations
unique distinction between central & peripheral lung mechanics
animals from 10 g to 40 kg
pressure-volume loop with static compliance
automatic Control of Peep
advanced µCT & µMRI lung gating
enhanced drug delivery system
dose/response curves
files exported under Excel® or text
Options
»» FEV extension for FEVx, FVC and PEF measurements:
flexiVent can uniquely perform both forced expiratory and forced oscillation measurements.
»» Multi-Subject extention, for measurement in parallel subjects (1 to 4 subjects)
FEV extension
MSX Multi-Subject extension

5. respiratory parameters from large animals
RIP respiration from belts
Lung volume measurement via respiratory inductive plethysmography (RIP) is a proven method
for quantitative and qualitative non-invasive respiratory measurements on large animals:
»» for freely moving primate, dog, pig etc.
»» thoracic and/or abdominal belts are fully adjustable and directly connected to emkaPACK4G transmitter
»» emkaPACK4G transmitter is housed into a jacket, worn by the animal
»» data is wirelessly transmitted by telemetry
»» respiration flow is derived from lung volume
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all standard pulmonary parameters
phase shift computation for bronchoconstriction assessment
easy subject specific absolute calibration
ECG, blood pressure, acceleration & temperature can be optionally acquired,
simultaneously with respiration
emkaPACK4G transmitter with RIP belts
Ask for specific brochure and see all our telemetry solutions on telemetry.emka.fr
exposure systems
aerosol generation and delivery
Precise and automated aerosol delivery with Aerogen Aeroneb® nebulizer,
emka TECHNOLOGIES’ nebulizationCONTROLLER and iox2 software:
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generation rate adjusted from 5% to 100% of maximum delivery
continuous nebulization or only during inspiration
nebulization started manually or by iox2 software
large variety of nebulization protocols automatically executed
drives up to 4 Aerogen Aeroneb® nebulizers
»» multiple controllers can be linked to drive more than 4 Aeroneb® nebulizers
nebulizationCONTROLLER
®
and plethysmograph with Aerogen Aeroneb nebulizer
mass flow controller
»» option for plethysmography
»» deliver a specific gas mixture
»» ideal to evaluate the effects of hypoxia, hyperoxia, hypercapnia etc.
»» aquisition is performed in iox2 software which also controls the mass flow controllers
»» modify the composition of the gas mixture in real time, directly from iox2 software
exposure to cigarette smoke and toxins
inExposeTM for exposing laboratory subjects to cigarette smoke,
aerosolized liquids, solutions, suspensions, inhaled toxins, compounds,
vapours, gases... :
»» controlled delivery of multiple gas/toxin mixtures
»» nose-only and whole-body exposure
»» cigarette smoke exposure for mice and rats:
. computer-controlled & programmable rotary cigarette smoker
. up to 24 cigarettes smoked in any possible parallel/sequential
combination, with programmable puffing profiles and automatic
lighting & ejection
inExposeTM
cigarette smoking robot
pulmonary.emka.fr

6. 4 compelling reasons
to choose emka TECHNOLOGIES pulmonary systems!
1 complete solution for pulmonary studies
Our systems include all needed hardware and software components.
A one stop shop solution to be sure to obtain a reliable, field proven setup.
2 wide array of options, solutions & add-ons
Cough detection, temperature and humidity correction, combined
telemetry measurement, automated aerosol generation, synchronized
video, connection to LIMS and many more solutions to answer your
specific study requirements.
Do not compromise; challenge us with tough questions!
CONTACT US!
for simple to very demanding projects, please call on us
europe
emka TECHNOLOGIES SA
3 20 years of experience
emka TECHNOLGIES has been providing in depth pulmonary study
systems from its start in 1991.
4 21 cfr part 11 compliance
Our list of references includes more than 300 users worldwide.
We produce single files per subject which not only contain the raw
data and the calculated data points, but also the complete copy of all
settings, calibration values etc.
This is a major advantage when having to comply with 21 cfr part.
59, bd. Général Martial Valin - 75015 Paris - France
tel: +33 (0)1 40 60 76 00 - fax: +33 (0)1 40 60 65 55
emka@emka.fr
north america
emka TECHNOLOGIES Inc.
307 Annandale Road, suite 203 - Falls Church,VA 22042 - USA
tel: +1 (703)237-9001 - fax: +1 (703)237-9006
emkatech@emkatech.com
china
Beijing GYD Labtech Co Ltd
Rm 935 Laho Studio, No.15-A1 East Jianguo Road
Chaoyang District, Beijing 100024
tel: +86-(0)10-85376382 or +86-(0)13-031151180
or +86-(0)13-01151181
fax:+86-(0)10-58208944
info@bjgyd.com
emka TECHNOLOGIES
All contents Copyright © November 2013 emka TECHNOLOGIES SA. All rights reserved.
Because emka TECHNOLOGIES has a policy of continuous product improvement, we reserve the right to change design and specifications without notice.
pulmonary solutions from emka TECHNOLOGIES