Canary Foundation Luncheon Presentation

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emilycarrsmith

Gesundheit & Medizin

Welcome
Canary Foundation Luncheon
Progress to Patients:
Canary’s 10 year journey from
tests to clinical trial
March 26, 2015

# 1 Most cancers take decades to develop

1p
IT
F01
IN
d
dt
q1p = (IN + IT)-q1p x F01
IN + IT
(1-e-F01t)q1p =
F01
ln(2)
t1/2marker
qsts=
[IN(mass/time) + IT(mass/time)]
Steady state can be calculated as:
# 2 Cancer generates measurable items in blood

# 3 But old technology can’t find it until too large

# 4 New nano-technology can find it 1000 times
smaller and 1000 times cheaper!

# 5 Models show we will save lots of lives

# 6 Tests will be cost-effective for high-risk patients

# 7 Finding new blood tests has been elusive

# 8 Molecular imaging is progressing at a rapid pace

# 10 An unprecedented partnership with Stanford

# 11 And we have inspired global investment
CRUK

# 12 New tests and companies are coming to market

Cyrcadia health – Detected Movie Trailer

Scientific Panel
Sanjiv Sam Gambhir, MD, PhD – Chair, Department of Radiology,
Stanford University
Jim Brooks, MD - Chief, Urologic Oncology, Stanford University
Utkan Demirci, PhD - Associate Professor, Stanford University
Heidi Auman, PhD – Scientific Program Manager,
Canary Foundation

New
Ideas
Clinical
Research
$10M
Team
10 years
$50K
Individual
1 year

New
Ideas
Clinical
Research
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Science

New
Ideas
Clinical
Research
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Facilities
Faculty
Associates
Science
Technology
$50M
Center
10 years
Science

New
Ideas
Clinical
Research
Clinical
Trials
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COE
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Team
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Individual
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Facilities
Faculty
Associates
Science
Technology
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Center
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Science
Spin-outs
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New
Ideas
Clinical
Research
Clinical
Trials
$20M
COE
7 years
$10M
Team
10 years
$50K
Individual
1 year
Facilities
Faculty
Associates
Diagnostic
Companies
Science
Technology
$50M
Center
10 years
Science
Spin-outs
Medical device
Imaging tech
Diagnostic test

Lung Cancer Breast Cancer
Molecular Imaging

Measuring densities of cells in real-time down to a single-cell level

Development of a Clinical Test Clinical Trials for CT + Biomarkers
CT + Biomarker Trial
initiated by MD Anderson
10,000 in US &
International
participation in China,
Germany, Brazil
Multiple techniques to analyze a
common set of samples
Integrate data and discover biomarkers
Smokers vs. Never Smokers
Cell Lines Tumors Blood
Pro-Surfactant Protein B (pro-SFTPB)
Validation
Lung cancer research & clinical trial

PASS Clinical Trial
1,000+ Men
5 Year
Follow-upNo Progression
Suspected
Central
Bio-Repository
Progression Suspected
Option for Treatment
Tissue Resources for Validation
Tissue of 1,000+
men who have
had radical
treatment
500+ Non-recurrent cancer
500+ Recurrent cancer
1,000s of prostate cancer
tissues arrayed to maximize
rapid and efficient analysis
Prostate cancer clinical trial

Motivation for TRUSPA Imaging of Prostate
TRUS guided prostate biopsy Sagittal Ultrasound Transverse Ultrasound

45
Pilot Clinical Trial: TRUSPA Imaging of Prostate
Prostate Capsule

Clinical Trials
Prostate Ovary Pancreas
$1,500 to sponsor 1 person
$3,000 to sponsor 2 people
$4,500 to sponsor 3 people

Thank You
Canary Luncheon Committee
Dear Pixels
Lobird
Laure Woods
Avaya
Union Bank
Village Doctors
William K Bowes Jr. Foundation
Franklin and Cathryn Johnson Family Foundation
Debbi Spungen in memory of Florence Spungen

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Dr. Faiza delivers an insightful lecture on the distinguishing characteristics of skeletal, smooth, and cardiac muscles, offering a comprehensive understanding of their histology, physiological anatomy, electrophysiological properties, and contractile mechanisms. Through meticulous tabulation and comparison, she aims to equip learners with a detailed comprehension of the unique features and functionalities of each muscle type. Beginning with a detailed exploration of histological differences, Dr. Faiza outlines key distinctions such as multinucleation in skeletal muscle, mononucleation in smooth and cardiac muscles, and the presence of striations in skeletal and cardiac muscles. She meticulously elucidates the structural arrangement of each muscle type, highlighting their cellular morphology and organization within tissues. Transitioning to physiological anatomy, Dr. Faiza navigates through various aspects including innervation, level of control, initiation of contraction, and modification by hormones. By delineating the role of the somatic nervous system in skeletal muscle control, and contrasting it with the autonomic nervous system's influence on smooth and cardiac muscles, she offers a nuanced understanding of neural regulation in muscle physiology. Furthermore, Dr. Faiza delves into electrophysiological properties, elucidating the mechanisms underlying action potential generation, duration, and ionic basis in each muscle type. Through insightful analysis, she reveals how differences in action potential characteristics contribute to variations in muscle contraction speed, duration, and resistance to fatigue. Finally, Dr. Faiza meticulously examines the contractile mechanisms of skeletal, smooth, and cardiac muscles, shedding light on the sliding filament theory, mechanisms of calcium action, and speed of contraction. By comprehensively comparing these mechanisms, she provides learners with a deep understanding of the intricate processes governing muscle contraction and function. Through engaging presentation and meticulous analysis, Dr. Faiza's lecture serves as a valuable resource for students seeking a thorough understanding of the fundamental differences between skeletal, smooth, and cardiac muscles.

Difference Between Skeletal Smooth and Cardiac Muscles

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