1. grubreteP .Y dna trenneR .G 404
. .
1002 enuJ 3 loV JAMI
noitazinagro ecnanetniam htlaeh = OMH .]01,9[ hcraeser lacigoloite rof seulc edivorp dna ,secivres
lacidem fo noitacol dna ezis eht gninnalp ni tsissa ,noitacolla
ecruoser retteb eveihca pleh nac setamitse hcuS .]8±5[ sredivorp
eht rof ,suhT .dedivorp ton erew dedrocer eb ot sesaesid eht
dna srennalp htlaeh rof laicurc erofereht era noitalupop eht ni
fo snoitinifed lacideM .tsil detnirp eht fo dne eht ta yleerf dedda
sesaesid cinorhc fo ecnelaverp eht etamitse yltcerroc ot stroffE
eb dluoc stneitap weN .stneitap cinorhc gnittimo fo ytilibaborp
.]4±1[ dlrow nretsew eht ni htlaeh no serutidnepxe fo ytirojam
eht ecuder dna gnitroper retteb retsof ot redro ni dedivorp
eht rof dna ,secivres lacidem fo slevel lla ta nedrub yvaeh
erew stsil esehT .naicisyhp gnidnopserroc eht fo seerusni eht rof
a rof ,gnireffus namuh tsom rof elbisnopser era sesaesid cinorhC
sesaesid fo gnitroper lacirotsih lla dedulcni osla stsil ehT .)ton
ro stneitap cinorhc rehtehw( 56 fo ega eht revo seerusni rieht lla
fo seman sa llew sa ,setats lacidem cinorhc rof snoitpircserp
804±404:3;1002 JAMI
g n i v ie c e r e b o t m e t s y s e ht ot n w o nk s tn e i t ap r ie ht l l a
fo srebmun .D.I dna seman fo tsil a nevig erew yeht ,noitidda nI .sesaesid eseht fo
.sesaesid eseht rof )eraC yramirP ni smelborP htlaeH fo noitac yrotsih larutan dna ytilibitpecsus ,ygoloite eht no seiduts rehtruf
-ifissalC( sedoc CPPHC htiw dedivorp erew snaicisyhp ehT rof llac spuorgbus cihpargomed neewteb secnereffid etaR
.secivres htlaeh fo yreviled dna ytilauq eht ni secnereffid tcelfer
.]1 elbaT[ nedrub
yam ,scitsiretcarahc noitalupop yb elbanialpxe ton ,snaic
cimonoce dna ytireves ,ecnelaverp rieht no desab erew gnitroper
:snoisulcnoC
-isyhp neewteb deton setar ni secnereffiD
rof nesohc sesaesiD .sesaesid cinorhc fo sesongaid 61 fo
.sesaesid cinorhc detceles eht fo erom ro eno dah
yna dah ohw dna 02 fo ega eht revo erew ohw erac lacidem rieht
noitalupop tluda eht fo %02 tuobA .sweJ naht aimedipilrepyh
rednu stneitap lla no esabatad lartnec a ot troper ot detseuqer
dna noisnetrepyh ,esaesid traeh cimehcsi fo setar rewol
erew )stneilc noillim 5.3 tuoba rof elbisnopser ,secivreS
dna sutillem setebaid fo setar rehgih dah sbarA .amhtsa dna
htlaeH tilalC( learsI ni redivorp htlaeh epyt-OMH tsegral
eruliaf traeh ,esaesid yranomlup evitcurtsbo cinorhc ,esaesid
eht ni snaicisyhp erac yramirp 407,2 lla 8991 fo gninnigeb eht tA
traeh cimehcsi fo setar rewol dna ,seicnangilam dna sesor
stroper naicisyhp erac yramirP
-uen ,sesohcysp ,msidioryhtopyh fo setar rehgih yltnacifingis
dah selameF .tnelaverp tsom eht erew )001/3.4( esaesid traeh
.sdrocer cinilc tneitap
cimehcsi dna )001/7.4( reclu citpep ,)001/7.5( aimedipilrepyh
-tuo dna sdrocer noitazilatipsoh ,selif esu-noitacidem ,stroper
:stluseR
,)001/1.6( setebaid ,)001/2.01( noisnetrepyH
naicisyhp erac yramirp :secruos fo yteirav a morf detcelloc noit
.)stluda 527,904,1 fo latot
-amrofni sedulcni esabatad yrtsigeR secivreS htlaeH tilalC ehT
a rof elbisnopser snaicisyhp 356,1( ylno secitcarp gnitroper
sdohteM dna slairetaM eht no desab detaluclac erew setar ecnelaverP .esabatad eht
ot dedda erew stneve noitazilatipsoh tnaveler lla dna sesaesid
detagitsevni eht ot tnaveler snoitacidem rof snoitpircserp dellif
.sesaesid
eht lla ,noitidda nI .sesaesid cinorhc detceles htiw stneitap
cinorhc fo retsiger evisneherpmoc a poleved ot )secivreS htlaeH
lla no troper ot detseuqer erew redivorp htlaeh tsegral s'learsI
tilalC( learsI ni noitazinagro ecnanetniam htlaeh tsegral eht
:sdohteM
ni snaicisyhp erac yramirp 407,2 lla ,8991 nI
yb troffe detartnecnoc a fo stluser eht stneserp elcitra sihT
.sesaesid cinorhc fo
.ytilauq hgih htiw eveihca ot redrah era yeht ,dilav erom
retsiger evisneherpmoc a poleved ot redro ni )secivreS htlaeH
eb ot detcepxe era snoitalupop elohw ro egral morf devired setar
tilalC( learsI ni noitazinagro ecnanetniam htlaeh tsegral eht yb
desab-noitalupop elihW .]31±11[ sesaesid deiduts eht fo erom ro
:sevitcejbO
troffe detartnecnoc a fo stluser eht tneserp oT
eno fo ecnelaverp laer eht tcelfer ton erofereht thgim dna desaib
.sredivorp
eb yam ,seitilauq lacigolodohtem rieht ot eud ,seiduts rellams
dna srennalp htlaeh rof laitnesse si noitalupop eht ni esaesid
esehT .sutats htlaeh detroper-fles no yler netfo hcihw ,syevrus
:dnuorgkcaB
cinorhc fo ecnelaverp eht fo egdelwonK
dna seiduts desab-elpmas fo stluser eht morf detamitse yllausu
tcartsbA
era sesaesid cinorhc suoirav fo ecnelaverp eht no ataD
ecnelaverp ,esaesid traeh cimehcsi ,noisnetrepyh ,ygoloimedipe ,setebaid ,sesaesid cinorhc :sdrow yeK
learsI ,avehS reeB ,vegeN eht fo ytisrevinU noiruG
-neB ,secneicS htlaeH fo ytlucaF dna ,afiaH ,ygolonhceT fo etutitsnI learsI-noinhceT ,enicideM fo ytlucaF troppaR dna retneC
3
lacideM lemraC ,ygoloimedipE dna enicideM ytinummoC fo tnemtrapeD ,vivA leT ,sretrauqdaeH secivreS htlaeH tilalC
2 1
grubreteP kahztiY dna trenneR daG
3,1 2,1
learsI ni sesaesiD cinorhC detceleS fo ecnelaverP
selcitrA lanigirO

2. learsI ni sesaesiD cinorhC
504 . .
1002 enuJ 3 loV JAMI
hcihw ,scitsitatS fo uaeruB lartneC learsI eht yb dehsilbup
6.0 5.0±3.0 4.0 eruliaf traeh evitsegnoC
esoht ot derapmoc rehtruf erew setaR .tnemtsujda rof ecnerefer
0.1 8.0±7.0 7.0 tneve ralucsavorbereC
1.1 2.1±4.0 8.0 DPOC eht sa srebmem tilalC fo noitalupop latot eht fo erutcurts ega
9.0 1.1±6.0 9.0 esaesid s'nosnikraP eht gnisu tuo deirrac saw tnemtsujda egA .OMH eht fo stcirtsid
4.1 7.1±1.1 1.1 sesohcysP thgie eht rof yletarapes dna noitalupop latot eht rof detaluclac
2.1 3.1±2.1 2.1 yspelipE e r ew , de ts u j da e g a d n a e d u r c h t o b ,s e ta r e c ne l av e r P
7.1 8.1±9.0 3.1 aimhtyhrrA
.)sesaesid tnangilam dna snoitidnoc traeh cimehcsi ot
4.1 2.2±7.0 4.1 msidioryhtopyH
gnitaler yltsom( noitasnepmoc laiceps sedivorp metsys lacidem
1.2 0.2±5.1 8.1 seicnangilaM
ilearsI eht hcihw rof serudecorp niatrec gniogrednu stneitap
5.3 3.4±0.3 3.3 amhtsA
6.3 0.4±6.2 3.3 )sesoruen( cirtaihcysP eht fo %001 fo atad eht dna ,elbaliava erew sedoc DCI hcihw
1.5 7.4±1.4 3.4 esaesid traeh cimehcsI rof snoitazilatipsoh lareneg eht fo %03 tuoba fo atad gnisu tuo
0.5 3.5±8.3 7.4 reclu citpeP deirrac saw troffe sihT .yrtsiger esaesid cinorhc eht ni sesaesid
1.6 6.6±8.3 7.5 aimedipilrepyH tnaveler eht htiw deknil erew demrofrep serudecorp fo ro
6.6 6.6±4.5 1.6 sutillem setebaiD
srettel egrahcsid no gniraeppa sedoc DCI eht dna ,deiduts erew
2.11 2.11±8.8 2.01 noisnetrepyH
noitalupop tegrat eht fo selif noitazilatipsoh deziretupmoc llA
001/etar stcirtsid 001/etar
sdrocer latipsoH
ecnelaverp neewteb ecnelaverp
edurC noitairaV detsujda-egA sisongaiD
.srebmem OMH yb dellif
02 fo ega eht revo srebmem rof retsigeR
snoitpircserp lautca eht fo %08 naht erom revoc ot detamitse
secivreS htlaeH tilalC eht ni detroper sesaesid cinorhc detceles
si elif ycamrahp ehT .deretsiger gurd fo epyt eht nopu ylelos
.3 elbaT
fo )edurc dna detsujda ega( setar ecnelaverp 8991
desab denifed eb tonnac esaesid tcaxe eht hcihw rof ,esaesid
traeh cimehcsi ro noisnetrepyh htiw esoht fo ton tub ,amhtsa
esaesid yranomlup evitcurtsbo cinorhc = DPOC
dna esaesid citpep ,sredrosid cirtaihcysp ,esaesid s'nosnikraP
tneve ralucsavorberec ,yspelipe ,msidioryhtopyh ,sesaesid tnangilam ,setebaid ,aim
,eruliaf traeh evitsegnoc ,saimhtyhrra ,sesorueN %58 rednU -edipilrepyh htiw stneitap fo noitartsiger eht ot detubirtnoc elif
sesohcysp
noitacidem ehT .sesaesid cinorhc tnaveler htiw stneitap fo elif
,DPOC ,seicnangilam ,esaesid traeh cimehcsi ,noisnetrepyH %98±58
lanoitidda na decudorp esabatad eht ,tsil siht tsniaga nur nehW
esaesid s'nosnikraP ,yspelipe ,msidioryhtopyh
.deraperp saw sesaesid cificeps ot detaler yltcerid snoitacidem
,amhtsa ,esaesid citpep ,aimedipilrepyh ,setebaiD %001±09
tnaveler fo tsil A .yrotisoper lartnec a ot troper dna dezi
sesaesiD ycaruccA
-retupmoc era OMH eht yb esu ni seicamrahp ytinummoc llA
.2 elbaT
retsigeR esaesiD cinorhC eht ni ycarucca fo eergeD elif esu-noitacideM
setar ecnelaverp stneserp 3 elbaT .ylno secitcarp gnitroper eht
.sisylana atad eht morf dedulcxe erew ylbailernu dellif neeb evah
fo noitalupop eht no desab detaluclac erew setar ecnelaverP
ot degduj stropeR .)?troper eht ot dedda stneitap wen ereW
.]2 elbaT[ sesaesid detceles rof detaluclac erew ?detroper sesaesid fo seirogetac lla ereW ?stneitap fo ytirojam
ycarucca fo setamitse gniwollof eht ,stroper naicisyhp eht dna eht rof dedoc sesaesid ereW :elpmaxe rof( meht gnitelpmoc ni
selif deziretupmoc eseht fo snosirapmoc no desaB .stcirtsid lla ni detsevni troffe fo eerged
egarevoc dna ytilauq hgih emas eht fo erew selif noitazilatipsoh eht rof detaulave ylevit esaesid s'nosnikraP
d n a e s u - n o i t a c i d e m e h T . t s e h g i h eh t ni % 8 8 o t t c i r t s i d -cejbus erew yeht erehw yspelipE
gnitroper tsewol eht ni %03 morf gnignar ,stcirtsid evitartsi msidioryhtopyH
sretrauqdaeh OMH
-nimda eht neewteb deirav snaicisyhp gnitroper fo noitroporp aimhtyhrrA
eht ot deliam erew
ehT .sisylana siht morf dedulcxe erew dna detroper-rednu eruliaf traeh evitsegnoC
stroper esaesid llA
)sesoruen dna sesohcysp( redrosid cirtaihcysP
eb ot degduj erew eruliaf traeh evitsegnoc dna saimhtyhrrA
.tneitap eht yb noitazilitu
tneve ralucsavorbereC
.setebaid dna noisnetrepyh rof tsehgih eb ot detamitse
secivres htlaeh fo level esaesid gnul evitcurtsbo cinorhC
saw dna ,sesongaid lla rof lauqenu eb ot dnuof saw troffe
eht senifed taht ,suoen amhtsA
sihT .meht gnitelpmoc ni detsevni troffe tnedive eht no desab
-orre ro tcerroc rehtehw reclu citpeP
,yrotcafsitas sa dedarg erew stroper 02 tub llA .)seerusni eht
recnaC
,sisongaid s'naicisyhp eht
fo %2.26( OMH eht fo seerusni tluda 527,904,1 fo latot a rof aimedipilrepyH
si ti esuaceb nesohc saw
elbisnopser era ohw ,snaicisyhp 356,1 yb denruter erew stropeR sutillem setebaiD
noitinifed gnikrow sihT
esaesid traeh cimehcsI
.naicisyhp erac yramirp
stluseR noisnetrepyH
s'tneitap eht yb detroper
os fi esaesid a gnivah retsigeR secivreS
.srebmem dlohesuoh yb stroper-fles no desab sesaesid cinorhc sa desongaid saw tneitap htlaeH tilalC eht ni detroper
.1 elbaT
fo ecnelaverp eht no syevrus dlohesuoh cidoirep stcudnoc a ,retsiger siht fo ekas sesaesid cinorhC
selcitrA lanigirO

3. grubreteP .Y dna trenneR .G 604
. .
1002 enuJ 3 loV JAMI
.elbaliava saw troper 3.708,1 8.016,3 8.402,3 7.757,1 3.383 7.74 0.31 sbarA
naicisyhp a mohw rof 4.152,01 9.530,51 7.111,9 2.765,3 7.018 7.841 9.72 sweJ
aimedipilrepyH
seerusni rof ylno detaluc
2.290,8 1.634,6 7.451,3 4.559 8.981 1.82 4.01 sbarA
-lac erew setar dna ,esab
8.443,91 0.930,11 1.398,3 1.759 5.651 0.91 8.21 sweJ
-atad siht rof secruos eht
esaesid traeh cimehcsI
fo eno ylno erew strop
4.680,1 4.690,2 5.886,1 2.767 4.453 5.711 0.47 sbarA
- e r n a i c i s y h p , r e v ew o H 7.464,1 1.600,2 4.864,1 2.246 1.083 2.992 9.861 sweJ
.snaicisyhp eht fo setar setebaiD
ecnailpmoc tnereffid eht 1.649,81 2.878,41 9.346,7 7.649,2 7.155 2.97 6.31 sbarA
4.862,33 2.617,42 5.710,11 6.366,3 5.597 8.931 8.81 sweJ
yb decudortni neeb evah
noisnetrepyH
dluoc saib emoS .]02,91[
+57 ry 47±56 ry 46±55 ry 45±54 ry 44±53 ry 43±52 ry 42±51 nigiro yb esaesiD
rehto eht no seiteicos
.4 elbaT
tneulffa erom ot nom sbarA dna sweJ ni 000,001/setar ecnelaverp cificeps-ega esaesid cinorhc detceleS
-moc sesaesid eht fo emos
noitaluclac eht sedulcerp noitamrofni fo kcal ecnis ,revewoh
fo ecnelaverp rewol yrrac osla thgim tub ,dnah eno eht no sutats
d e h g i e w e b t o n n a c s u t a t s l a i c o s n i s e cn e r e f f iD . s e e r u s n i
htlaeh esrow ni stluser yllausu siht ;noitalupop ilearsI latot
rieht fo noitubirtsid ega dna rebmun eht htob ni sredivorp
eht naht tneulffa ssel si OMH tsegral eht fo noitalupop ehT
htlaeh eht neewteb ytilibairav eht tnuocca otni ekat hcihw ,setar
.noitalupop ilearsI elohw eht rof etamitse tniop eht no saib siht
detsujda-ega dna cificeps-ega sa detroper era sisylana siht ni
fo noitcerid eht etamitse ot tluciffid si tI .setar cificeps-ssalc fo
atad ehT .seerusni fo sutats cimonoceoicos dna noitubirtsid ega
,rebmun eht ot tcepser htiw sredivorp htlaeh gnoma secnereffid
5991 setihw .S.U dna 8991 secivreS htlaeH
.2 erugiF era erehT . learsI ni redivorp htlaeh )tsegral eht tiebla(
tilalC .setebaid fo setar cificeps-ega fo nosirapmoC
eno tsuj gnidrager atad no desab era serugif tnerruc ehT
.serugif ecnerefer sa detpecca
eb nac setar eseht erofeb desserdda eb ot deen ytidilav dna
ytilibailer fo seussI .learsI ni noitalupop tluda eht fo %06 naht
erom setutitsnoc taht noitalupop a ni ecnelaverp esaesid cinorhc
erusaem ot troffe evisneherpmoc a sezirammus troper sihT
noissucsiD
.]4 elbaT[
sweJ naht sbarA gnoma tnelaverp erom saw sutillem setebaid
elihw ,sweJ naht aimedipilrepyh dna noisnetrepyh ,esaesid traeh
cimehcsi fo setar ecnelaverp rewol evah ot dnuof erew sbarA
.amhtsa dna ,eruliaf traeh ,esaesid s'nos
-nikraP ,tneve ralucsavorberec ,esaesid evitcurtsbo yranomlup
cinorhc ,esaesid traeh cimehcsi rof deton erew setar rewoL
.selam ni naht selamef ni rehgih yltnacifingis erew seicnangilam
5991 setihw .S.U dna 8991 secivreS htlaeH
dna sesoruen ,sesohcysp ,msidioryhtopyh fo setar ecnelav
.1 erugiF
tilalC .noisnetrepyh fo setar cificeps-ega fo nosirapmoC
-erp ehT .]3 erugiF[ selamef dna selam neewteb ecnelaverp
esaesid ni secnereffid dekram dewohs retsiger tilalC ehT
.]81[ atad yevrus dlohesuoh scitsitatS
fo uaeruB lartneC learsI eht ot derapmoc era atad OMH
ilearsI eht nehw nees si nonemonehp emas ehT .noitalupop
dezilanoitutitsni ylredle eht dehcaer evah ton thgim erofereht
dna desab dlohesuoh si hcihw ,yevrus .S.U eht fo ygolodohtem
eht ni secnereffid ot eud ylbaborp si rettal ehT .learsI ni 57 revo
dega esoht gnoma setar rehgih dna learsI ni 46±54 dega esoht
gnoma setar rewol tub ,sraey 47±56 dega esoht gnoma setar fo
sedutingam cificeps-ega ralimis slaever ]71±41[ syevrus .S.U ni
detroper esoht htiw learsI ni ]2 erugiF[ sutillem setebaid dna ]1
erugiF[ noisnetrepyh fo setar ecnelaverp eht fo nosirapmoc A
.4 elbaT ni detneserp era sesongaid nommoc tsom eht fo eerht
fo setar ecnelaverp cificeps-ega ehT .sesaesid deiduts eht rof
selcitrA lanigirO

4. learsI ni sesaesiD cinorhC
704 . .
1002 enuJ 3 loV JAMI
noisnetrepyH .Y iL ,W gnaW ,D naF ,J oaH ,W gnaF ,X nauD ,X uW ,S oaT .22 yb denialpxe eb tonnac taht snaicisyhp neewteb deton setar
.7±1221:043;9991 ni secnereffiD .]03[ ecnelaverp esaesid gninimreted ni elor rojam
deM J lgnE N .9891 ot 0591 morf yhportrepyh ralucirtnev tfel dna ,ypareht a yalp smsinahcem htoB .]92,82,52,42[ yrotsih larutan tnereffid
evisnetrepyh ,noisnetrepyh fo ecnelaverp eht ni sdnerT .D yveL ,ED eebborG
a ro ecnedicni ni secnereffid lautca rehtie tcelfer yam secnereffid
,BW lennaK ,AP ikswoktyS ,H ztahsrebliS ,BR onitsogA'D ,A dretsoM .12
esehT .sbarA ot derapmoc sweJ dna ,selam ot derapmoc
.68±775:01;5991 deM nretnI neG J .seitilauqeni htlaeh no hcraeser
hsitirB dna naciremA :sutats htlaeh no ssalc laicos fo ecneulfni ehT .O nieF .02 selamef rof deton era snrettap ecnelaverp esaesid euqinU
.64±311:73;1991 reS ruE lbuP geR OHW
.ega htiw noitalerroc gnorts a
.esaesid dna sutats cimonoceoicoS .AM notslE ,M sanivegoK ,GM tomraM .91
htiw detroper saw esaesid cinorhc fo epyt emos noitalupop tluda
.learsI fo etatS ,scitsitatS fo uaeruB lartneC ,7991 ,93 .oN
eht fo %02 naht erom roF .seirtnuoc nretsew ]82±62[ lla ton
.6991 rebmetpeS-lirpA doireP eht rof ataD ecnavdA .79/6991 yevruS htlaeH .81
.13±3:6991 ,sserP ytisrevinU drofxO :kroY weN .noitcrafnI laidracoyM tub ]52±32,51,41[ tsom ni sa llew sa learsI ni noitalupop tluda
fo noitneverP .sde ,HC snekenneH ,MJ onaizaG ,MP rekdiR ,EJ nosnaM .71 eht ni hcae %6±5 ta tnelaverp ,sesaesid nommoc tsom txen eht
.48±74;5991 ,8641-59 HIN .noitide dn2 .aciremA ni setebaiD .DKDDIN .61 era esaesid traeh cimehcsi dna aimedipilrepyh ,sutillem setebaiD
.77±751:61;3991 eraC setebaiD .stluda ni
.]22,12,41[ noitalupop tluda eht fo %01 naht erom gnitceffa
ecnarelot esoculg deriapmi dna sutillem setebaid fo ecnelaverp rof setamitse
± esaesid cinorhc nommoc tsom eht sa segreme noisnetrepyh
labolG .puorG gnitropeR setebaiD coh da OHW .M sreweR ,H gniK .51
.8991 rebotcO ,991 .oN ,01 seireS scitsitatS htlaeH dna latiV ,anihC sa llew sa .S.U eht morf srehto ni sa ,troper siht nI
,5991 ,yevruS weivretnI htlaeH lanoitaN eht morf setamitsE tnerruC .SHCN .41 .sisongaid-revo ro -rednu lacidem fo tluser eht si ecnaived hcus
.04±53:72;8991 gnigA egA .nem ylredle gnoma htlaeh
rehtehw etagitsevni ot redro ni setar detpecca ylnommoc eht ot
detar-fles dna sutats lanoitcnuf ,sesaesid ralucsavoidrac fo yduts a ni saib
sreiltuo era taht secitcarp eht yfitnedi ot sredael lanoisseforp
esnopser-noN .D tuohmorK ,AG soB neD naV ,JE snekseF ,N snamyeoH .31
' s r e d i v o r p e h t f o e l o r e ht s i t I . s e i d u ts e l i r e t s e r om n i
.2001±599:62;7991 loimedipE J tnI
.puorG gnikroW gnigA no ydutS lanidutignoL nailatI ehT .sesongaid lacinilc detroper esoht morf tnereffid era serugif eht fi neve snaicisyhp
dna detroper-fles gnirapmoc :snailatI redlo ni sesaesid cinorhc fo ecnelaverP .21 gnitaert eht fo snoitinifed eht yb detcelfer sa noitalupop sti fo
.8±661:81;7991 muroF htlaeH dlroW
eliforp htlaeh tnerruc eht wonk redivorp htlaeh a taht laitnesse
.sesaesid cinorhc rof srotcaf ksir gnissessA .D airoL ,M yksneliV ,E sotaM .11
si ti ,suhT .metsys htlaeh eht no sdnamed evitartsinimda dna
.7±682:64;7991 RWMM
.4991 ,lortnoc dna noitneverp esaesid cinorhc rof seitiroirp dna secruoseR .01 cimonoce etaerc taht seitivitca pu-wollof dna pu-krow lacidem
.01±508:78;7991 htlaeH rehto dna ecitcarp noitpircserp ,roivaheb lacinilc eht fo hcum
cilbuP J mA .sesaesid cinorhc htiw detaicossa sutats lanoitcnuf ni secnereffid enimreted ± gnorw ro thgir rehtehw ± sesongaid eseht ,naicisyhp
cinhte dna laicar dna sutats cimonoceoicoS .PJ htimS ,SR notgniK .9
reh ro sih yb nevig sesongaid no desab si tneitap cificeps a fo
.72±1:74;8991 mmuS llievruS CDC RWMM .5991-0691
tnemtaert eht ecnis ,sselehtenoN .erutan desab-ecivres sti ot eud
,setatS detinU ± amhtsa rof ecnallievruS .SD gnaK ,E kcaJ ,BL llaB ,AC
nosnhoJ ,LL noxiN ,A awazihsA ,AC ikswotreP ,MD amoH ,MD oninnaM .8 yduts siht ni desserdda eb ton dluoc sesongaid fo ytidilav ehT
.29±78:41;8991 deM verP J mA .smetsys erac deganam dna .sisongaid lacidem eht fo ytilauq eht ni ro stroper fo
htlaeh cilbup rof segnellahc quot;niwtquot; :amhtsa dna sutillem setebaiD .F rociniV .7
ssenevisneherpmoc eht ni secnereffid yb ro ,noitanalpxe cihparg
.35±343:15;8991 loimedipE nilC J .stluda redlo rof efil yhtlaeh fo sraey
-omed ro lacigoloite na evah taht secnereffid laer yb rehtie
erutuf gnitciderP .DJ nosmailliW ,LG ekruB ,ED dliB ,LD kcirtaP ,P rheiD .6
denialpxe eb nac snoiger cificeps ni setar gnoma secnereffid
.07±46:2;8991 tcarP sruN ganaM emoctuO .semoctuo dna ytilauq eganam
ot pihsrentrap detargetni na :erac evitaroballoc eruliaf traeH .DL nedrU .5 ehT .ytilibailer rieht gnitroppus suht ,llams saw sesaesid
.14±531:92;7991 deM nommoc eht fo setar ni ytilibairav stcirtsid-neewteb ehT
nnA .yduts seirtnuoc neves eht ± ksir ytilatrom esuac-lla ot sesaesid cinorhc
fo noitaler ehT .H amihsoT ,S civokjledeN ,I kecahoM ,S iloapmaiG ,C
sinavarA ,A nenissiN ,D tuohmorK ,F aicceracceS ,H nrubkcalB ,A ittoneM .4
esaesid traeh cimehcsi
.95±343:22;7991 htlaeH ytinummoC J .sesaesid cinorhc rof sksir
gnicuder rof pihsrentrap ediwetats a gnitaulavE .S neoC ,J notsnhoJ ,TV = DHI ,tnedicca ralucsavorberec = AVC .sesaesid cinorhc
ocsicnarF ,KR siweL ,PK rethciR ,BS ttecwaF ,JK sirraH ,A swerdnA eniaP .3 .3 erugiF
fo setar detsujda-ega fo noitroporp elam ot elameF
.06±842:81;7991 muroF htlaeH dlroW
.ytinamuh gnihcirne ,gnireffus gnireuqnoC .7991 tropeR htlaeH dlroW ehT .2
.92±91:32;8991 veR eganaM eraC htlaeH .ymonoce SU eht morf snossel
:rotces erac htlaeh SU eht ni noitulover laireganam ehT .ER regnilzreH .1
secnerefeR
.ffats laireganam
eht dna OMH eht fo sesrun dna snaicisyhp erac yramirp fo sdnasuoht
eht fo troffe dna troppus eht tuohtiw nur dna dehsilbatse neeb
evah ton dluoc retsigeR secivreS htlaeH tilalC ehT .stnemegdelwonkcA
.smaet tnemevorpmi ecitcarp lacinilc dna srennalp
secivres htlaeh ,sredivorp htlaeh rof loot lufrewop a sa evres
nac sretsiger esaesiD .secivres htlaeh fo yreviled dna ytilauq
eht ni secnereffid tcelfer ylbissop scitsiretcarahc noitalupop
selcitrA lanigirO

5. li.ca.noinhcet.xt@trenner :liame .8±645:12;8991 eraC setebaiD .yrtsigeR setebaiD
grobarakS eht morf troper A .stnatibahni 114,082 fo noitalupop hsidewS a ni
,8534-438 )4-279( :xaF ,4740-528 )4-279(
setebaid fo ecnelaverp ehT .G tsivkdnuS ,FY gnahC ,G mortsnetS ,B regreB .72
:enohP .learsI ,26343 afiaH ,retneC lacideM lemraC ,ygoloimedipE
.13±4141:12;8991
dna enicideM ytinummoC fo .tpeD ,trenneR .G .rD :ecnednopserroC eraC setebaiD .snoitcejorp dna ,setamitse laciremun ,ecnelaverp
:5202-5991 ,setebaid fo nedrub labolG .HW namreH ,ER trebuA ,H gniK .62
.7±32:8991 .6±366:6991 eraC setebaiD .orienaJ eD oiR ni
,sserP ytisrevinU drofxO :kroY weN .sdohteM dna stpecnoC ,htlaeH ecnelaverP setebaiD fo ydutS eht rof puorG evitarepooC ehT .lizarB ,orienaJ
noitalupoP :nI .snoitalupop ni esaesid dna htlaeh gnirusaeM .KT gnuoY .03 ed oiR ni setebaid fo ecnelaverp ehT .JL ocnarF ,A hceliM ,EJ arievilO .52
.48±771:14;8991
.27±5611:99;9991 noitalucriC .dnalniF ni nemow dna nem dega-elddim 687,41
fo yduts pu-wollof ecnelaverp a :esaesid traeh yranoroc dna ,srotcaf ksir tcarP nilC seR setebaiD .noitalupop nailartsuA redlo na ni setebaiD
ralucsavoidrac ,ega ,xeS .P aksuP ,J othelimoU ,E neniaitraV ,P ithalisuoJ .92 .L ttenruB ,RS redeeL ,GR gnimmuC ,JJ gnaW ,W htimS ,P llehctiM .42
.53±922:31;5991 eraC htlaeH .04±33:34;9991 tcarP nilC seR setebaiD .yduts noitalupop
desab-tset ecnarelot esoculg laro na :)niapS( ainolataC ni setebaid fo
mirP J dnacS .ydutS setebaiD galednorT-droN ehT .ecnelaverp setebaid
gnisaercni na fo snoitacidnI .noitalupop naigewroN tluda na ni ecnarelot ecnelaverP .L sarellaS ,G sarevolL ,A yadoG ,J arreS ,R sarresserT ,C lletsaC .32
esoculg deriapmi dna sutillem setebaid nwonknu ylsuoiverp dna nwonk .9±384:801;5991 lgnE J deM
fo ecnelaverP .K tievtrajB ,O regurK ,J nemloH ,A ladnrojB ,K llejhtdiM .82 nihC .anihC ni lortnoc dna tnemtaert ,ssenerawa fo sutats dna ecnelaverp
selcitrA lanigirO