1. Number of transplants, by donor type Figure 7.1 transplant counts as known to the USRDS (reconciled from various sources).

2. Counts of transplants from living donors, by donor relation Figure 7.2 transplant counts as known to the USRDS (reconciled from various sources).

3. Incident ESRD & transplant rates Figure 7.3 transplant rates among all ESRD patients in the given year.

4. Wait list patient counts, by age, gender, & race Figure 7.4 patients listed for kidney or kidney-pancreas transplant on December 31 of each year. Multiple listings not counted. Age determined as of December 31 of the given year.

5. Wait list counts & listings Figure 7.5 patients listed for kidney or kidney-pancreas transplant on December 31 of each year.

6. Median wait times, by age, race, blood type, & PRA Figure 7.6 patients receiving deceased donor, kidney-only, first transplants; unadjusted. Year is the year of transplant, not the year the patient was first listed

7. Median wait time (in years), by state, 2004 Figure 7.7 patients receiving deceased donor, kidney-only, first transplants, 2004, unadjusted. State is the state of residence of the transplant recipient.

8. Patients wait-listed or transplanted within one year of ESRD initiation, by age, gender, & race Figure 7.8 patients certified as having ESRD in the given year; includes transplants of all donor types. Percents estimated using Kaplan-Meier methodology.

9. Patients wait-listed or transplanted within one year of ESRD initiation, by state, 2003 Figure 7.9 patients certified as having ESRD in 2003. Percents estimated using a Cox model, & adjusted for age, gender, race, & primary diagnosis. Includes transplants of all donor types

10. Outcomes for first-time wait-listed patients five years after listing, 1999 Figure 7.10 patients first listed for a kidney-only transplant in 1999. Patients transplanted may have subsequent outcomes within the five-year followup period.

11. Transplant rates (per 100 dialysis patient years), by state, 2004 Figure 7.11 per 100 dialysis patient years, 2004, adjusted for age, gender, race, & primary diagnosis.

12. Transplant rates, by age, gender, race, & primary diagnosis Figure 7.12 adjusted for age, gender, race, & primary diagnosis.

13. Transplant rates, by donor type Figure 7.13 unadjusted; transplants from donors of unknown type are omitted.

14. Transplant rates, by donor type Figure 7.14 donors with a known age younger than 70, whose organs are eventually transplanted.

15. Transplant rates, by donor type Figure 7.14 (continued) donors with a known age younger than 70, whose organs are eventually transplanted.

16. Geographic variations in donation rates (per million population), by state, 2004: living donor Figure 7.15 donation rates per million population, 2004, unadjusted. Excludes patients residing in Puerto Rico & the Territories.

17. Geographic variations in donation rates (per million population), by state, 2004: deceased donor Figure 7.15 (continued) donation rates per million population, 2004, unadjusted. Excludes patients residing in Puerto Rico & the Territories.

18. Deceased donations per 100 deaths, by state, 2003–2004 Figure 7.16 donations per 100 deaths, July 1, 2003, to July 1, 2004; unadjusted. Excludes patients residing in Puerto Rico & the Territories.

19. Graft outcomes: deceased donor transplants Figure 7.17 first-time, kidney-only transplants. Cumulative incidences are estimated using the Kaplan-Meier method.

20. Survival: deceased donor transplants Figure 7.17 (continued) first-time, kidney-only transplants.

21. Half-lives: deceased donor transplants Figure 7.17 (continued) first-time, kidney-only transplants. Half-life estimates are adjusted for age, gender, race, & primary diagnosis, using Cox proporational hazards models. Conditional half-life estimates are conditional on first-year graft survival; unconditional half-life estimates are applicable at time of transplant.

22. Graft outcomes: living donor transplants Figure 7.18 first-time, kidney-only transplants. Cumulative incidences are estimated using the Kaplan-Meier method.

23. Survival: living donor transplants Figure 7.18 (continued) first-time, kidney-only transplants.

24. Half-lives: living donor transplants Figure 7.18 (continued) first-time, kidney-only transplants. Half-life estimates are adjusted for age, gender, race, & primary diagnosis, using Cox proporational hazards models. Conditional half-life estimates are conditional on first-year graft survival; unconditional half-life estimates are applicable at time of transplant.

25. Counts of graft failures: overall Figure 7.19 preemptive retransplantations are counted here as a return to dialysis. For total patients starting or restarting dialysis, refer to Figure p.2 in the Précis.

26. Counts of graft failures, by donor type & by subsequent treatment Figure 7.19 (continued) preemptive retransplantations are counted here as a return to dialysis.

27. Patients retransplanted within one year of failure Figure 7.20 includes preemptive retransplants, & excludes failures due to death.

28. Graft survival preceding return to dialysis or preemptive retransplant Figure 7.21

29. Graft survival preceding return to dialysis or preemptive retransplant: grafts surviving 7+ days Figure 7.22 patients whose grafts fail within seven days of transplant are removed from this measure in an effort to eliminate primary failures.

30. Outcomes after transplant Figure 7.23 adjusted for age, gender, & race. Preemptive retransplantations are counted as a return to dialysis.

31. Rates of return to dialysis or preemptive retransplant, by age, gender, & race Figure 7.24 adjusted for age, gender, & race. Preemptive retransplantations are counted as a return to dialysis.

32. Baseline calcineurin inhibitor use Figure 7.25 first-time, kidney-only transplants. Immunosuppression as identified to OPTN.

33. Center-specific calcineurin inhibitor use, 2003–2004 Figure 7.26 first-time, kidney-only transplants, 2003–2004. Immunosuppression as identified to OPTN. Centers are classified as using exclusively cyclosporine A/cyclosporine microemulsion, exclusively tacrolimus, both, or neither.

34. Baseline antimetabolite use Figure 7.27 first-time, kidney-only transplants. Immunosuppression as identified to OPTN.

35. Rapamycin use Figure 7.28 first-time, kidney-only transplants. Immunosuppression as identified to OPTN.

36. Steroid use Figure 7.29 first-time, kidney-only transplants. Immunosuppression as identified to OPTN.

37. Antibody induction Figure 7.30 first-time, kidney-only transplants. Immunosuppression as identified to OPTN.

38. Most common immunosuppression regimens at time of transplant: 2002–2004 Figure 7.31 first-time, kidney-only transplants, 2002–2004. Maintenance immunosuppression as identified to OPTN.

39. Transplants with delayed graft function Figure 7.32 patients with functioning grafts upon discharge. Odds ratios determined using logistic regression; adjusted for age, gender, race, ethnicity, transplant year, primary diagnosis, & several clinical & donor characteristics.

40. Factors associated with delayed graft function: by donor status, 2000–2004 Figure 7.33 patients with functioning grafts upon discharge. Odds ratios determined using logistic regression; adjusted for age, gender, race, ethnicity, transplant year, primary diagnosis, & several clinical & donor characteristics.

41. Acute rejections as reported to the OPTN Figure 7.34 ar cumulative incidence of acute rejection for transplants in the given year, as identified from OPTN followup data. Does not include acute rejection episodes at the time of tranpslant or acute rejections listed as the cause of graft failure. Kaplan-Meier methodology.

42. Complications* identified through Medicare claims Figure 7.35 first-time, kidney-only transplants, 1999–2003, with Medicare as primary payor. *three-year cumulative incidence of complications (ICD-9-CM code 996.81: complications of transplanted organ/kidney) as identified from Medicare claims. Kaplan-Meier methodology.

43. Risk factors for post- transplant complications* Figure 7.36 first-time, kidney-only transplants, 1999–2003, with Medicare as primary payor. relative risk determined using Cox regression; adjusted for age, gender, race, ethnicity, transplant year, primary diagnosis, & several clinical & donor characteristics. *Complications (ICD-9-CM code 996.81: complications of transplanted organ/kidney) as identified from Medicare claims.

44. Time to first post-transplant biopsy Figure 7.37 first-time, kidney-only transplants, 1999–2003, with Medicare as primary payor. three-year cumulative incidence of biopsy as identified from Medicare claims. Kaplan-Meier methodology.

45. Clinical correlates to post-transplant biopsy Figure 7.38 first-time, kidney-only transplants, 1999–2003, with Medicare as primary payor. relative risk determined using Cox regression; adjusted for age, gender, race, ethnicity, transplant year, primary diagnosis, & several clinical & donor characteristics.

46. Listings willing to accept an extended criteria donor (ECD) kidney Figure 7.39 new listings: patients first wait-listed for a kidney-only transplant between January 1 & December 31 of the given year. Prevalent listings: patients on the wait list for a kidney-only transplant any time during the given year, regardless of date first listed. Multiple listings are not counted.

47. Listings willing to accept an ECD kidney, by age, gender, & race, 2003–2004 Figure 7.40 new listings: patients first wait-listed for a kidney-only transplant between January 1, 2003, & December 31, 2004. Prevalent listings: patients on the wait list for a kidney-only transplant any time between January 1, 2003, & December 31, 2004, regardless of date first listed. Multiple listings are not counted.

48. Deceased donor transplants from an ECD Figure 7.41 first-time, deceased-donor, kidney-only transplants, 1995–2004. Expanded Criteria Donors (ECDs) are age 60 or older, or age 50–59 with two or more of the following: death attributed to CVA, history of hypertension, or creatinine > 1.5 mg/dl.

49. New listings willing to accept an ECD kidney (percent), by state, 2003–2004 Figure 7.42 multiple listings within a state or region are not counted, but a patient may be listed in more than one state or region.

50. Prevalent listings willing to accept an ECD kidney (percent), by state, 2003–2004 Figure 7.42 (continued) multiple listings within a state or region are not counted, but a patient may be listed in more than one state or region.

51. Listings willing to accept an ECD kidney, by OPTN region, 2003–2004 Figure 7.43 multiple listings within a state or region are not counted, but a patient may be listed in more than one state or region.

52. Characteristics of patients willing & not willing to accept an ECD kidney, 2003–2004 Table 7.a incident wait-listed patients. Odds ratios adjusted for age, gender, ethnicity, region, primary diagnosis, PRA, & blood type. P ≤0.0001 compared to the reference group, except for non-Hispanic (p=0.37), region 8 (p=0.26), & region 11 (p=0.018).

53. Observed & projected median waiting times, overall & by race Figure 7.44 first-time, kidney-only transplants. Observed data plotted when Kaplan-Meier median is observed; otherwise, median projected using linear regression, & 95 percent confidence bands are given. Medians suppressed when cell counts <15.

54. Observed & projected median waiting times, by blood type & PRA Figure 7.44 (continued) first-time, kidney-only transplants. Observed data plotted when Kaplan-Meier median is observed; otherwise, median projected using linear regression, & 95 percent confidence bands are given. Medians suppressed when cell counts <15.

55. Projected median waiting times, by OPTN region Figure 7.45 first-time, kidney-only transplants. Observed data plotted when Kaplan-Meier median is observed; otherwise, median projected using linear regression, & 95 percent confidence bands are given. Medians suppressed when cell counts <15.

56. Projected median waiting times, by OPTN region Figure 7.45 (continued) first-time, kidney-only transplants. Observed data plotted when Kaplan-Meier median is observed; otherwise, median projected using linear regression, & 95 percent confidence bands are given. Medians suppressed when cell counts <15.

57. Projected median waiting times, by OPTN region Figure 7.45 (continued) first-time, kidney-only transplants. Observed data plotted when Kaplan-Meier median is observed; otherwise, median projected using linear regression, & 95 percent confidence bands are given. Medians suppressed when cell counts <15.