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Sigma-Aldrich Corporation
 Q1 2009 Earnings Review




            Creating Differentiation
             Through Innovation

                                       ®
Cautionary Statements
    Our presentation today will include forward looking statements relating to the Company’s future performance, goals, strategic
    actions and initiatives and similar intentions and beliefs, including expectations, goals, beliefs, intentions and the like regarding
    future sales, earnings, cash flow, share repurchases and other matters. These statements involve assumptions regarding
    Company operations, investments and acquisitions and conditions in the markets the Company serves. While we believe that
    these expectations are based on reasonable assumptions, such statements are subject to risks and uncertainties including, among
    others, certain economic, political and technological factors. Actual results could differ materially from those stated or implied
    during this review or contained in other Company communications due to, but not limited to, such factors as (1) declining global
    economic conditions, (2) changes in pricing and the competitive environment and the global demand for our products,
    (3) fluctuations in foreign currency exchange rates, (4) changes in research funding and the success of research and development
    activities, (5) dependence on uninterrupted manufacturing operations, (6) changes in the regulatory environment in which the
    Company operates, (7) changes in worldwide tax rates or tax benefits from domestic and international operations, including the
    matter described in Note 9 – Income Taxes – to the Consolidated Financial Statements in the Company’s Form 10-K report for the
    year ended December 31, 2008, (8) exposure to litigation, including product liability claims, (9) the ability to maintain adequate
    quality standards, (10) reliance on third party package delivery services, (11) the impact of acquisitions and success in integrating
    and obtaining projected results from the acquisitions, (12) other changes in the business environment in which the Company
    operates, and (13) the outcome of the matters described in Note 10-Contingent Liabilities and Commitments-in the Company’s
    Form 10-K report for the year ended December 31, 2008. A further discussion of risk factors can be found in Item 1A of the
    Company’s Form 10-K report for the year ended December 31, 2008. The Company does not undertake any obligation to publicly
    update the matters covered in this presentation.

    With over 60% of sales denominated in currencies other than the U.S. dollar, management uses currency-adjusted growth, and
    believes it is useful to investors, to judge the Company’s controllable, local currency performance. Organic sales growth data
    presented in this review is proforma data and excludes currency. While able to report historical currency impacts after the fact, we
    are unable to estimate changes that may occur later in 2009 to applicable rates of exchange and thus are unable to reconcile the
    projected non-GAAP currency adjusted internal growth rates to reported GAAP growth rates for 2009. Any significant changes in
    currency exchange rates would likely have a significant impact on our reported growth rates due to the volume of our sales
    denominated in foreign currencies.

    Management also reports both GAAP and adjusted sales and income comparisons to reflect what it believes are ongoing and/or
    comparable operating results excluding currency impacts. Management excludes this item in judging its historical performance
    and in assessing its expected future performance. Management also uses free cash flow, a non-GAAP measure, to judge its
    performance and ability to pursue opportunities that enhance shareholder value. Management believes this non-GAAP
    information is useful to investors as well.

2



                                                                                                                                            ®
First Quarter 2009 Financial Results


                                                           YEAR-OVER-YEAR

                                                                        Excluding
                           Q1 2009
                                                 As Reported         Currency Impact
                     (in millions, except EPS)


                           $519M                                            1%
                                                      9%
            Sales

                            $84M                                            19%
                                                      -
       Net Income

                            $0.68                                           27%
                                                      6%
      Diluted EPS

                            $86M                     22%                    22%
    Free Cash Flow




                        Strong performance despite
                     global recessionary environment.
3



                                                                                       ®
Q1 2009 Sales Growth
    (Adjusted for Currency)

      Sales Mix
                                      Year Over Year   Vs. Previous Quarter


                          Research         3.4%                6.8%
                26%
               SAFC


                            SAFC
    RESEARCH                              (5.3%)              (5.2%)
       74%


                            Total
                                           1.0%                3.4%
                         Company



                  Demand for research products and services
                         continued to show growth.
4



                                                                              ®
First Quarter Income Statement
    (in millions, except per share amounts)




                                              THREE MONTHS ENDED MARCH 31

                                                                        VS. PREVIOUS
                                                       YEAR OVER
                                      2009                               QUARTER
                                                         YEAR
                                    $ 519                                    $9
                                                         $ (50)
                     Net Sales
                                     (250)                                    (5)
                                                           27
         Cost of Products Sold
                                      269
                  Gross Profit                                                 4
                                                           (23)
                                     (127)
                       S,G&A                                                   7
                                                            21
                                      (16)
                         R&D                                                   -
                                                            -
                                      126
             Operating Income                                                  11
                                                            (2)




       Process improvement and cost containment initiatives offset currency headwinds
      versus a year ago. Financial performance improved further versus previous quarter.
5



                                                                                           ®
First Quarter Margin Analysis

                                            PERCENTAGE
                                             OF SALES
                                               21.8%
           Q1 2008: Pre-tax Profit Margin

                                               (2.2%)
                     Impact of Currency

                                               0.8%
                       Price/Volume/Mix

                                               0.9%
                 Supply Chain Initiatives

                                               2.1%
                        S,G&A Expenses

                                               0.2%
                        Interest Expense

                                              23.6%
           Q1 2009: Pre-tax Profit Margin



                 Pre-tax profit margins improved by
                 180 basis points versus a year ago.
6



                                                         ®
Free Cash Flow
     (in millions)


                                                                    THREE MONTHS ENDED MARCH 31

                                                                       2009            2008
                                                                       $ 84
                                                   Net Income                           $ 84
                                                                        23               25
                       Depreciation & Amortization
                                                                        (39)            (72)
    Changes in Performance Working Capital*
                                                                        46               52
                                                            Other
                                                                       114               89
                           Net Cash from Operations
                                                                        (28)             (19)
                           Less Capital Expenditures
                                                                       $ 86             $ 70
                                            Free Cash Flow


      *Accounts Receivable + Inventory – Accounts Payable



                                      Free cash flow remains strong.
7



                                                                                                  ®
2009 Guidance




       Organic Revenue Growth    Low single digits


       Reported EPS             Slightly above $2.65


       Free Cash Flow                 > $300M




8



                                                       ®
First Quarter – Key Business
    Highlights
     Increased e-commerce sales to 44% of worldwide research-
     based sales


     Strong growth in CAPLA countries


     Increase of 16% in SAFC booked orders for future delivery


     Added new products and services


     Continued to invest to expand unique manufacturing
     capabilities


9



                                                                 ®
Growth & Profitability Drivers - 2009




     Continue focus on Life Science & High Technology markets
     Invest and grow in emerging markets
     Extend e-commerce capability
     Streamline global supply chain
     Develop/acquire new technologies



       Initiatives expected to mitigate uncertain market conditions.
10



                                                                       ®
Sigma-Aldrich Corporation
     Q1 2009 Earnings Review

                      QUESTIONS?

                       2009 GUIDANCE

            Organic Revenue Growth Low single digits

                                   Slightly above $2.65
                 Reported EPS

                                        > $300M
                Free Cash Flow




11



                                                          ®

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Q1 2009 Earning Report of Sigma Aldrich Corp.

  • 1. Sigma-Aldrich Corporation Q1 2009 Earnings Review Creating Differentiation Through Innovation ®
  • 2. Cautionary Statements Our presentation today will include forward looking statements relating to the Company’s future performance, goals, strategic actions and initiatives and similar intentions and beliefs, including expectations, goals, beliefs, intentions and the like regarding future sales, earnings, cash flow, share repurchases and other matters. These statements involve assumptions regarding Company operations, investments and acquisitions and conditions in the markets the Company serves. While we believe that these expectations are based on reasonable assumptions, such statements are subject to risks and uncertainties including, among others, certain economic, political and technological factors. Actual results could differ materially from those stated or implied during this review or contained in other Company communications due to, but not limited to, such factors as (1) declining global economic conditions, (2) changes in pricing and the competitive environment and the global demand for our products, (3) fluctuations in foreign currency exchange rates, (4) changes in research funding and the success of research and development activities, (5) dependence on uninterrupted manufacturing operations, (6) changes in the regulatory environment in which the Company operates, (7) changes in worldwide tax rates or tax benefits from domestic and international operations, including the matter described in Note 9 – Income Taxes – to the Consolidated Financial Statements in the Company’s Form 10-K report for the year ended December 31, 2008, (8) exposure to litigation, including product liability claims, (9) the ability to maintain adequate quality standards, (10) reliance on third party package delivery services, (11) the impact of acquisitions and success in integrating and obtaining projected results from the acquisitions, (12) other changes in the business environment in which the Company operates, and (13) the outcome of the matters described in Note 10-Contingent Liabilities and Commitments-in the Company’s Form 10-K report for the year ended December 31, 2008. A further discussion of risk factors can be found in Item 1A of the Company’s Form 10-K report for the year ended December 31, 2008. The Company does not undertake any obligation to publicly update the matters covered in this presentation. With over 60% of sales denominated in currencies other than the U.S. dollar, management uses currency-adjusted growth, and believes it is useful to investors, to judge the Company’s controllable, local currency performance. Organic sales growth data presented in this review is proforma data and excludes currency. While able to report historical currency impacts after the fact, we are unable to estimate changes that may occur later in 2009 to applicable rates of exchange and thus are unable to reconcile the projected non-GAAP currency adjusted internal growth rates to reported GAAP growth rates for 2009. Any significant changes in currency exchange rates would likely have a significant impact on our reported growth rates due to the volume of our sales denominated in foreign currencies. Management also reports both GAAP and adjusted sales and income comparisons to reflect what it believes are ongoing and/or comparable operating results excluding currency impacts. Management excludes this item in judging its historical performance and in assessing its expected future performance. Management also uses free cash flow, a non-GAAP measure, to judge its performance and ability to pursue opportunities that enhance shareholder value. Management believes this non-GAAP information is useful to investors as well. 2 ®
  • 3. First Quarter 2009 Financial Results YEAR-OVER-YEAR Excluding Q1 2009 As Reported Currency Impact (in millions, except EPS) $519M 1% 9% Sales $84M 19% - Net Income $0.68 27% 6% Diluted EPS $86M 22% 22% Free Cash Flow Strong performance despite global recessionary environment. 3 ®
  • 4. Q1 2009 Sales Growth (Adjusted for Currency) Sales Mix Year Over Year Vs. Previous Quarter Research 3.4% 6.8% 26% SAFC SAFC RESEARCH (5.3%) (5.2%) 74% Total 1.0% 3.4% Company Demand for research products and services continued to show growth. 4 ®
  • 5. First Quarter Income Statement (in millions, except per share amounts) THREE MONTHS ENDED MARCH 31 VS. PREVIOUS YEAR OVER 2009 QUARTER YEAR $ 519 $9 $ (50) Net Sales (250) (5) 27 Cost of Products Sold 269 Gross Profit 4 (23) (127) S,G&A 7 21 (16) R&D - - 126 Operating Income 11 (2) Process improvement and cost containment initiatives offset currency headwinds versus a year ago. Financial performance improved further versus previous quarter. 5 ®
  • 6. First Quarter Margin Analysis PERCENTAGE OF SALES 21.8% Q1 2008: Pre-tax Profit Margin (2.2%) Impact of Currency 0.8% Price/Volume/Mix 0.9% Supply Chain Initiatives 2.1% S,G&A Expenses 0.2% Interest Expense 23.6% Q1 2009: Pre-tax Profit Margin Pre-tax profit margins improved by 180 basis points versus a year ago. 6 ®
  • 7. Free Cash Flow (in millions) THREE MONTHS ENDED MARCH 31 2009 2008 $ 84 Net Income $ 84 23 25 Depreciation & Amortization (39) (72) Changes in Performance Working Capital* 46 52 Other 114 89 Net Cash from Operations (28) (19) Less Capital Expenditures $ 86 $ 70 Free Cash Flow *Accounts Receivable + Inventory – Accounts Payable Free cash flow remains strong. 7 ®
  • 8. 2009 Guidance Organic Revenue Growth Low single digits Reported EPS Slightly above $2.65 Free Cash Flow > $300M 8 ®
  • 9. First Quarter – Key Business Highlights Increased e-commerce sales to 44% of worldwide research- based sales Strong growth in CAPLA countries Increase of 16% in SAFC booked orders for future delivery Added new products and services Continued to invest to expand unique manufacturing capabilities 9 ®
  • 10. Growth & Profitability Drivers - 2009 Continue focus on Life Science & High Technology markets Invest and grow in emerging markets Extend e-commerce capability Streamline global supply chain Develop/acquire new technologies Initiatives expected to mitigate uncertain market conditions. 10 ®
  • 11. Sigma-Aldrich Corporation Q1 2009 Earnings Review QUESTIONS? 2009 GUIDANCE Organic Revenue Growth Low single digits Slightly above $2.65 Reported EPS > $300M Free Cash Flow 11 ®