2. It is an auto immune disease
Usually triggered by an acute infections
process
It is a rare disorder that causes immune
system to attack peripheral nervous system
It is an acute inflammatory demyelinating
polyneuropathy
2
4. The exact causes of Guillain-Barre syndrome are still not known.
The main cause may be destruction of myelin sheath
But the reason for this destruction is not known
But there are chances where in occurrence of an infection before
the onset of condition mainly episodes of gastroenteritis or a
respiratory tract infection.
4
5. It is a rapidly evolving areflexic motor
paralysis with or without sensory
disturbances.
The usual pattern is an ascending paralysis
that may be first noticed as rubbery legs.
Usually begin in both legs, then progress
upward to the arms .
Occasionally symptoms begin in the arms
or head and progress downward
Weakness typically evolves over hours to a
few days and is frequently accompanied by
tingling parasthesia in the extremities.
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6. Blurred vision
Clumsiness
Muscle contraction
Palpitatons
Paralysis
Drooling
Loss of bladder
control
Fast heart rate
Difficulty in walking
steadily
Difficulty in
breathing
fainting
Back pain
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7. PNS is involved in electric
transmission of sensory and motor
impulses to and from the CNS.
Term Peripheral neuropathy is used
for disorders of the peripheral nerves
of any cause.
The manifestation of such a disorder
may be so bewildering and complex
It may be poly neuropathy,
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8. It is a common and important type of
peripheral neuropathy
The prototypical picture of poly neuropathy
occur with acquired toxic or metabolic
neuropathic states.
The first symptoms tends to be sensory and
consist of tingling, pricking, burning or
numbness in general distribution over soles.
It is characteristically symmetrical with
noticeable sensory features such as tingling,
pricking, burning sensation in feet and toes.
Motor features in the form of muscle
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9. Risk increases with age
But occasionally parasthesia appear in
one foot shortly before the other or more
pronounced in one foot.
If the poly neuropathy remains mild, no
objective motor or sensory signs may be
detectable.
It is a rapidly evolving illness that
commonly presents as symmetrical
weakness, sensory loss and areflexia.
Inflammatory peripheral neuropathy in
which lymphocytes and macrophages strip
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10. A demyelinating disease is any
disease of the nervous system in
which the myelin sheath of neurons is
damaged
This impairs the conduction of signals
in the affected nerves , causing
impairment in sensation , movement,
cognition, or other functions
depending on which nerves are
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11. The prevalence of guillain-barre
syndrome is estimated to be 6 to 40
cases per 1 million people
In 90% of people who have GB
syndrome, weakness is most severe
within 3 weeks.
In 5 to 10%, the muscles that control
breathing become so weak that a
ventilator is needed. 2/28/2023
11
12. The condition often develops a few days or weeks
after a digestive tract or respiratory infection,
however, suggesting that they may be related.
Rarely, Guillain-Barre can arrive following surgery or
immunization.
Some scientists believe that, somehow, the virus that
precedes the onset of Guillain-Barre syndrome
changes the cells of the nerves in some way, making
them unrecognizable to the immune system and lining
them up for attack
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13. Poly neuropathy may be the result of
axonal degeneration (axonopathy) or
segmental demyelination
(Demyelinating poly neuropathy)
In each type - acute , subacute, and
chronic forms are distinguished
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14. The legs are usually more affected than the
arms and facial diparesis is present in 50 % of
affected individuals.
Symptoms include weakness and a pins- and –
needles sensation or loss of sensation
Muscle tenderness or pain ,weakness alone or
in combination
This is followed by weakness of legs and arms
that is symmetrical and worsening in
time,abnormal heart rate.Paralysis,reduced
power and reduced or absent tendon reflexes
Syndrome can worsen rapidly and impair the
muscles involved in breathing.
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15. In general, the disease worsens quickly for
a couple of weeks
The average recovery time for Guillain-
Barre syndrome is 6-12 months.
Recovery from Guillain-Barre syndrome can
be very slow, needing a lot of support,
physiotherapy, counseling and occupational
therapy.
A few patients, sadly, are left with long term
disability.
Around 80% of patients can walk within 6
months. 2/28/2023
15
16. Nerve conduction exam: electrodes are
taped to the skin and the nerves are tested
by passing small shocks through the skin.
In Guillain-Barre syndrome, the signals
travel along the nerves more slowly
Electromyography: thin needle-like
electrodes are used to test the functioning
of muscle fibers
Spinal tap (lumbar puncture): a sample of
cerebrospinal fluid (CSF) is removed from
the spinal canal and tested in a laboratory
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17. Acute myelopathy- back pain, spincter
disturbances
Botulism- early loss of pupillary activity,
descending paralysis
Diphtheria- early oropharyngeal
involvement
Lyme disease polyradiculitis
Porphyria- abdominal pain , seizure,
psychosis
Vasculitis neuropathy
Poliomyelitis with fever , meningeal signs
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18. Guillain-Barre syndrome can be difficult to
diagnose, especially in its earliest phases
. The symptoms vary from person to person
and are similar to those of other neurological
conditions.
Initially, the doctor might ask whether the
weakness is on both sides of the body - a
feature of Guillain-Barre syndrome.
The speed of onset is another clue; the
progression of many neurological conditions
is much slower than Guillain-Barre
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19. Although there are no known cures for Guillain-
Barre syndrome, there are two types of
treatment the can reduce the severity of its
symptoms and improve the rate of recovery:
Immunoglobulin therapy: immunoglobulins
(also known as antibodies) from donors are
given intravenously. This treatment seems to
block the harmful antibodies involved in the
autoimmune response
Plasma exchange (plasmapheresis): blood is
taken from the body, the plasma is removed and
separated from the blood cells. The blood cells
are then returned and the plasma is regenerated
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20. Both methods are roughly as effective
as each other, but using them
together does not improve outcomes.
Researchers do not yet know why
either method works.
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22. SYMPTOMS ACC.TO AYURVEDA DOSHA
Loss of tendon reflexes Karma kshaya Vata
Numbness Suptata Vata
Muscle tenderness Toda Vata
Difficulty in breathing Swasakrichatha Vatakapha
Paralysis Pakshaghata Vata
Fainting Tamapravesha Kapha
incordinated movement Kampa Vata
Blurred vision Timiradarshana Vata. Pitta
Muscle contractions Peedana Vata
Drooling Lalasrava Vata, kapha
Loss of bladder control Abhikshana mutrasrava Vata, kapha
Back pain Katishoola Vata
Pain and stiffness in head and
neck
Sira and greeva shoola Vata, kapha
Weakness of facial muscles Vaaksthambha Vata
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23. 1. Majjaasthigata vata- main Lakshana are :
Sandhi sula, mamsa bala kshaya
2. Pakshaghata:
Vayu after getting prakopa destructs vama and
dakshinadeha and does nivruthi of sareera
cheshta.Leading to cheshtanivruthi, ruja ,
vaksthambha.
3. Manyasthambha
Lakshanas are shirograha ie pain and
stiffnesss in head and neck
4. Ardita
Lakshanas are vakram vrajati aasye
ie,difficulty in moving face muscles
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25. For paralysis pakshaghata line of treatment
can be given.
Intake of nourishing aahara to manage with
teekshnaagni.
For muscle pain, tingling sensation
majjasthigatavatachikitsa such as snehana,
swedana etc can be given.
Urdwajatrugatachikitsa for
urdhwajatrughatalakshanas.
Navananasya, moordhnitaila ,tarpanaetc can
be given in the case of ardita. 2/28/2023
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26. The mortality of the disease is higher
when respiratory failure and pulmonary
infection is associated
The treatment is only symptomatic
In GBS where there is no cure as per
modern science can be treated according
to the symptoms in Ayurveda
GB syndrome is the classical example of
acute demyleinating polyneuropathy
which has probably an autoimmune
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Hinweis der Redaktion
Unclear, but an autoimmune response is strongly suspected
But even then it is told that the link between other infection and GBS are less certain.
That it is difficult for the physician to know where to begin and how to proceed.