The concept of using games and simulations to address the problems of epidemics and pandemics is far from new. In the UK there is an old nursery rhyme called “ring a ring o’ roses” which has been attributed to the great plague of London in the 17th century in which the symptoms included a rose-like rash and sneezing. Since Games and Simulations are used in many application areas to raise awareness and influence behaviours which are important interventions for epidemics and viruses, it is not surprising that they can play an important role in tackling the spread of infectious diseases like MERS. This presentation shows some examples of serious games and simulations to both support the early detection of these diseases and to engage the public in actions and behaviours that limit their impact. The presentation goes on to consider the role of gamification and disruptive technologies in future strategies designed to either prevent pandemics or reduce their spread