1. CHEMOPROPHYLAXIS Dr Sangeetha P

2. CHEMOPROPHYLAXIS Definition The Practice of administering an antimicrobial agent for preventing an infection or for suppressing contacted infection before the clinical manifestations.

3. Influencing factors

4. . Prophylaxis effective when Single pathogen Acute exposure Short duration prophylaxis Suitable drug Lethal disease

6. Resistant organisms

7. Economic waste

9. Types of prophylaxis

10. Classification

12. Endocarditis

13. Malaria

14. Cholera

15. Plague

17. Neutropenia

18. Asplenia

20. Surgical prophylaxis To prevent Surgical Site Infection (SSI); not all infections occuring in the post-op period.. Staphylococcus - Cefazolin

23. Oral Erythromycin for 10 daysInj Benzathine Penicillin 6L IM single dose

25. Sulfadiazine 500mg OD

26. Erythromycin 250mg BDInj.Benzathine Penicillin 1.2L IM 4 weekly

27. Endocarditis High morbidity Dental /Surgical procedures with bleeding from mucosa.. 2007 AHA guidelines Choice of drug depend on the flora..

28. Endocarditis . Upper GIT Alpha hemolytic streptococci Ampicillin/Amox/ clindamycin

29. Endocarditis . Lower GIT ENTEROCOCCI Ampi+Genta Vanco+Genta Ampi/Amox

30. Antibiotic Regimens for Prophylaxis of Endocarditis in Adults with High-Risk Cardiac Lesions A. Standard oral regimen 1. Amoxicillin 2.0 g PO 1 h before procedure B. Inability to take oral medication 1. Ampicillin 2.0 g IV or IM within 1 h before procedure C. Penicillin allergy 1. Clarithromycin or azithromycin 500 mg PO 1 h before procedure 2. Cephalexin 2.0 g PO 1 h before procedure 3. Clindamycin 600 mg PO 1 h before procedure D. Penicillin allergy, inability to take oral medication 1. Cefazolinor ceftriaxone1.0 g IV or IM 30 min before procedure 2. Clindamycin 600 mg IV or IM 1 h before procedure

33. Mefloquine 250mg weekly

37. HIV Prophylaxis against opportunistic infections: primary

38. Secondary or c/c suppressive Rx .

39. OTHERS

40. Surgical prophylaxis Maintain peak concentration of antibiotic at time of wound closure To prevent Surgical Site Infection (SSI)

42. Continue for 24 hours only

45. Drugs used

46. High risk when Surgery >2hours Prosthesis Immunosuppressed patient Extremes of age..

47. … Thank you