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Stroke Presentation Guide
1. presentation on
STROKE
DR SAHIDUL ISLAM
PGT, DEPT OF RADIODIAGNOSIS,
FAAMCH
Moderator
DR MK THAKUR
PROF & HOD
Dept of Radiodiagnosis, FAAMCH
DR SANGITA MAHELA
Asst Prof
Dept of Radiodiagnosis, FAAMCH
dr.sahidul@gmail.com
7. ISCHEMIC STROKE
In cerebral ischemia, the affected tissue remains viable although blood flow is
inadequate to sustain normal cellular function.
In cerebral infarction, frank cell death occurs with loss of neurons, glia, or
Both.
8. • CEREBRAL BLOOD VOLUME (CBV)
100
• CEREBRAL BLOOD FLOW (CBF)
100
• BLOOD FLOW
0 DEATH OF BRAIN TISSUE
<16-18ML/100G INFARCTION
<20ML/100GM ISCHEMIA WITHOUT INFARCTION
Vasogenic edema
cytotoxicedema
40. MIDDLE CEREBRAL ARTERY
M1 segment –
horizontal-extends laterally from the ica
bifurcation toward the sylvian fissure
M2 segments-insular the postbifurcation
mca trunks turn posterosuperiorly in the
sylvian fissure, following a gentle curve (the
genu or "knee" of the mca)
M3 (cortical) segments. The mca branches
loop at or near the top of the sylvian fissure,
then course laterally under the parts
("opercula") of the frontal, parietal, and
temporal lobes that hang over and enclose
the sylvian fissureand ramify over the lateral
surface of the cerebral hemisphere
47. PCA
P1 (Precommunicating) Segment. The P1 PCA
segment extends laterally from the basilar
artery (BA) bifurcation to the junction with the
PCoA.
P2 (Ambient) Segment. The P2 segment
extends from the P1-PCoA junction, running
in the ambient (perimesencephalic)cistern as
it sweeps posterolaterally around the
midbrain.
P3 (Quadrigeminal) Segment. The P3 PCA is a
short segment that lies entirely within the
quadrigeminal cistern
P4 (Calcarine) Segment. The P4 segment
terminates within the calcarine fissure, where
it divides into two terminal PCA trunks
P1
P3
P2
P4
P4
P4
56. SUPERIOR CEREBELLAR ARTERY
whole superior surface of the
cerebellar hemispheres down to the
great horizontal fissure
superior vermis
dentate nucleus
most of the cerebellar white matter
parts of the midbrain
superior cerebellar peduncle
middle cerebellar peduncle
57. ANTERIOR INFERIOR CEREBELLAR ARTERY
middle cerebellar peduncle
inferolateral portion of the pons
flocculus
anteroinferior surface of the
cerebellum
cranial nerves VII and VIII
58. POSTERIOR IINFERIOR CEREBELLAR ARTERY
It has a variable territory depending
on the size of the AICA (AICA-PICA
dominance). Typically it supplies:
posteroinferior cerebellar
hemispheres (up to the great
horizontal fissure)
• cerebellar tonsils: 85% of the
time
• biventral lobule: 80%
• nucleus gracilis: 85%
• superior semilunar lobule: 50%
inferior portion of the vermis
lower part of the medulla: 50%
inferior cerebellar peduncles
68. VENOUS DRAINAGE OF BRAIN
• The cerebral venous system, somewhat
unlike the majority of the rest of the body,
does not even remotely follow the cerebral
arterial system.
• Cerebral veins have thin walls with no
muscular tissue and possess no valves.
• They emerge from the brain and lie in the
subarachnoid space, coursing over the
surface of the brain, aggregating into larger
channels until they pierce the arachnoid
mater and the meningeal layer of the dura
mater and drain into the dural venous
sinuses.
70. Cerebral veins
Superficial veins
The superficial venous system is comprised of the
sagittal sinuses and cortical veins. The cortical veins
course along the cortical sulci, drain the cortex and
some of the adjacent white matter. There are
numerous cortical veins, and most of them are
unnamed;
large cortical veins can be identified according to their
locations, the cortical venous system can be
subdivided into
• superficial middle cerebral vein (Sylvian vein)
• superior anastomotic vein (of Trolard)
• inferior anastomotic vein (of Labbé)
71. Cerebral veins
Deep veins
The deep venous system consists of the lateral
sinuses, sigmoid sinuses, straight sinus and
draining deep cerebral veins (subependymal and
medullary veins).
medullary veins: they are numerous and originate
1-2 cm below cortical gray matter and pass
through deep medullary white matter and drain
into subependymal veins. The medullary veins are
arranged in a wedge-shaped manner and
distributed at a right angle to subependymal
veins.
subependymal veins: they receive medullary veins
and aggregate into greater tributaries, mainly into
septal veins, thalamostriate veins, internal cerebral
veins, basal vein of Rosenthal and vein of Galen.
72. DURAL VENOUS SINUSES
venous channels located intracranially
between the two layers of the dura mater
(endosteal layer and meningeal layer).
They can be conceptualised as trapped
epidural veins. Unlike other veins in the
body, they run alone, not parallel to
arteries.
PAIRED
• superior sagittal sinus
• inferior sagittal sinus
• straight sinus
• occipital sinus
• intercavernous sinus
UNPAIRED
• transverse sinus
• sigmoid sinus
• superior petrosal sinus
• inferior petrosal sinus
• cavernous sinus
• sphenoparietal sinus
• basilar venous plexus
73. The superior sagittal sinus
(SSS) is the largest dural
venous sinus. As the name
suggests, it runs in a sagittal
plane from the anterior
aspect of the falx cerebri at
the foramen cecum to its
termination at the confluence
of sinuses at the occipital
protuberance, where it usually
proceeds rightward and into
the right transverse sinus.
DURAL VENOUS SINUSES
SUPERIOR SAGITAL SINUS
74. DURAL VENOUS SINUSES
SUPERIOR SAGITAL SINUS
INFERIOR SAGITAL SINUS
The inferior sagittal sinus is one
of the dural venous sinuses
and runs along the inferior
(free) edge of the falx cerebri.
It runs from anterior to
posterior, the same as the
superior sagittal sinus, and
drains into the straight sinus.
75. DURAL VENOUS SINUSES
SUPERIOR SAGITAL SINUS
INFERIOR SAGITAL SINUS
STRAIGHT SINUS
The straight sinus is one of the
main dural venous sinuses and
is found at the junction
between the falx cerebri and
the tentorium cerebelli and is
triangular in cross-section.
76. Transverse sinus
Sigmoid sinus
Superior petrosal
sinus
Inferior petrosal
sinus
Cavernous sinus
Sphenoparietal
sinus
Basilar venous
plexus
The paired left and right
transverse sinuses are
major dural venous
sinuses and arise from
the confluence of the
superior sagittal,
occipital and straight
sinuses at the torcular
herophili (confluence of
sinuses)
77. Transverse sinus
Sigmoid sinus
Superior petrosal
sinus
Inferior petrosal
sinus
Cavernous sinus
Sphenoparietal
sinus
Basilar venous
plexus
The sigmoid sinus is a
paired structure and one
of the dural venous
sinuses. It is the
continuation of the
transverse sinus (which is
similarly variable in size)
and becomes the
sigmoid sinus as the
tentorium ends. It is here
that the sinus receives
the superior petrosal
sinus
78. Transverse sinus
Sigmoid sinus
Superior petrosal
sinus
Inferior petrosal
sinus
Cavernous sinus
Sphenoparietal
sinus
Basilar venous
plexus
drains the cavernous
sinus. It courses
posterolaterally to drain
into the sigmoid sinus at
the continuation of the
transverse sinus. It runs
along the superior
aspect of the petrous
temporal bone
79. Transverse sinus
Sigmoid sinus
Superior petrosal
sinus
Inferior petrosal
sinus
Cavernous sinus
Sphenoparietal
sinus
Basilar venous
plexus
a plexus of venous channels
rather than a true sinus and
drains blood from the
cavernous sinus to the jugular
bulb through the jugular
foramen
80. Transverse sinus
Sigmoid sinus
Superior petrosal
sinus
Inferior petrosal
sinus
Cavernous sinus
Sphenoparietal
sinus
Basilar venous
plexus
• located on either side of the
pituitary fossa and body of the
sphenoid bone between the
endosteal and meningeal layers
of the dura.
• It spans from the apex of the
orbit to the apex of the petrous
temporal bone.
It receives venous blood from
• inferior and superior ophthalmic
veins
• intercavernous sinus
• sphenoparietal sinus
• superficial middle cerebral vein
92. VARIANTS
hypoplasia of one or both
PCOM ~30% (range 25-34%)
hypoplastic/absent A1 segment
of ACA ~15% (range 10-15%)
absent or fenestrated ACOM
~12.5% (range 10-15%)
origin of PCA from the ICA
with absent/hypoplastic P1
segment (fetal PCA) ~20%
(range 17-25%)
infundibular dilatation of the
PCOM origin ~10% (range 5-
15%)
Gme.I m going to present a seminar on STROKE. I have divided the topic into two parts. I am beginning with part 1 today.
evolving STROKE:A stroke in which focal
neurological deficits worsen with time. COMPLETED STROKE:A stroke in which the focal
neurological deficits persists & donot worsen with time. TIA-A clinical syndrome of
rapid onset of focal deficits of brain function, which
resolves with in 24 hours,regardless of whether there’s
imaging evidence of new permanent brain injury.
Depending on the factor of how blood supply is compromised causing stroke, we have Ischemic or hemorrhagic stroke. Ischemic -85% hemorrhagic -5% --among ischemic embolic events are commoner.
In ischemic – narrowing of a blood vessel or a clot blocking a vessel compromises blood supply to an area in the brain resulting into tussue damage. In hemorrhagic stroke – rapture or leakage of blood into the brain tissue cause the damage.
The distinction between cerebral ischemia and cerebral
infarction is subtle but important
2 more phenomena involving with stroke pathophysiology is Vasogenic edema & cytotoxic edema. Vasogenic- Vasogenic cerebral edema refers to a type of cerebral edema in which the blood brain barrier (BBB) is disrupted--commonly seen in brain tumors,abcess & hemorrhage. Cytotoxic edema on the other hand most commonly seen in cerebral ischemia, in which extracellular water passes into cells, resulting in their swelling. I will elaborate both while discussiong stroke imaging.
Since time is a cruicial factor in stroke so, clinically classification is done based on CHRONOLOGY which is very much important in diagnosis too.
Restrictions in blood flow may occur from vessel narrowing (stenosis), clot formation (thrombosis), blockage (embolism) or blood vessel rupture (hemorrhage). Lack of sufficient blood flow (ischemia) affects brain tissue and may cause a stroke in the particular area depending on the vessel involved. So , through understanding of the of the arterial system is essential before going deeper into stroke.
An understanding of brain arterial vascular territories is important in understanding stroke and complications
Although one could be excused for thinking that within the brain, such a carefully organized organ, blood supply would be constant, the truth is that a great deal of variety exists. Two main factors contributing to this fact is-
circle of Willis anatomy and normal variants
intrinsic variability in the extent of tissue each main branch supplies
As a result, different sources will have surprisingly different diagrams and descriptions. What is presented here is a general ball-park scheme, with a brief description of the main branches and anatomy.
The intracranial circulation can be conveniently divided into anterior and posterior circulation, on the basis of internal carotid artery and vertebral artery supply
The Circle of Willis is an arterial polygon (heptagon) formed as the internal carotid and vertebral systems anastomose around the optic chiasm and infundibulum of the pituitary stalk in the suprasellar cistern. This communicating pathway allows equalization of blood-flow between the two sides of the brain, and permits anastomotic circulation, should a part of the circulation be occluded.
Both the vertebral arteries ascends upward through foramen in the transverse process of cervical vertebra & enters the cranial cavity through foramen magnum. Then RT & LT vertebral artery fuses to form basilar artery.
Lateral view showing both vertebral artery joing together at pontomedullary junction & going up as basilar artery.
Schematic diagram showing different branches of the vertebra-basilar artery. We can see that both vertebral arteries before fusion as basilar artery supplies the spinal cord also. While going up it is supllying various parts of the hindbrain ; we will get the individual branches in awhile.
In this view we can see few branches of vertebrobasilar system--- 1ST BR -
SO from posterior circulation we get these major arterial branches.
The aortic arch gives rise to the brachiocephalic artery, from which subsequently stems the right common carotid artery; the left common carotid artery branches off the aortic arch just downstream the brachiocephalic trunk.
The left and right common carotid arteries run along parallel to each other and divide near the angle of the mandible to the external and internal carotid arteries. The external carotid supplies the face and neck branching off immediately, while the internal carotid arteries do not branch until the origin of the ophthalmic artery bilaterally. Subsequently, the internal carotid arteries bifurcate onto the anterior and middle cerebral arteries, on each internal carotid artery.
The anterior choroidal artery arises from the distal part of the internal carotid artery, distally from the origin of the posterior communicating artery. supplies the crus cerebri of the midbrain, lateral geniculate body, choroid plexus of the lateral ventricles and third ventricle, globus pallidus, caudate nucleus, amygdala, hypothalamus, red nucleus, substantia nigra, posterior limb of the internal capsule, optic tract, hippocampus
The anterior choroidal artery arises from the distal part of the internal carotid artery, distally from the origin of the posterior communicating artery. supplies the crus cerebri of the midbrain, lateral geniculate body, choroid plexus of the lateral ventricles and third ventricle, globus pallidus, caudate nucleus, amygdala, hypothalamus, red nucleus, substantia nigra, posterior limb of the internal capsule, optic tract, hippocampus
terminal branch of the internal carotid artery. Supplies the medial aspect of the brain. It may be divided into 2 or 3 segments, A1 A2 A3
A1-horizontal, A2-vertical, A3-callosal
A1- inferior parts of the head of the caudate and the anterior limb of the internal capsule A2- genu of corpus callosum A3-medial portions of frontal lobes, superior medial part of parietal lobes, anterior part of the corpus callosum
A1- inferior parts of the head of the caudate and the anterior limb of the internal capsule A2- genu of corpus callosum A3-medial portions of frontal lobes, superior medial part of parietal lobes, anterior part of the corpus callosum
Summerise the ant cerebral artery supply– it supplies major portion of the medical aspect of frontal lobe and outer cortex of later frontal lobe……xxxxACA vascular
territory (green) includes
the anterior two-thirds of
the medial surface of the
hemisphere ſt, a thin
strip of cortex over the
top of the hemisphere
vertex , and a small
wedge along the
inferomedial frontal lobe
Graphic reltnship of ACA to underlying brain. A2
segment ascends in
front of 3rd ventricle. A3
curves around corpus
callosum genu.
Pericallosal ,
callosomarginal arteries
ſt are major terminal
ACA branches. (8-13)
Sagittal MIP of CTA shows
A2 segments of both ACAs
ſt ascending in
interhemispheric fissure in
front of 3rd ventricle, A3
segments curving
around corpus callosum
genu.
The middle cerebral artery (MCA) is one of the three major paired arteries that supply blood to the brain. The MCA arises from the internal carotid artery as the larger of the two main terminal branches (the other being the anterior cerebral artery), coursing laterally into the lateral sulcus where it branches to perfuse the cerebral cortex.
Submentovertex graphic depicts the MCA and its relationship to adjacent structures. Note the horizontal (M1) segment and the genu with bifurcation into M2 branches. (8-17) Coronal graphic shows the lateral lenticulostriate arteries , M2 segments over the insula , M3 segments running laterally in the sylvian fissure, and (cortical) branches ſt coursing over the lateral surface of the hemisphere. The lateral lenticulostriate arteries arise from the proximal middle cerebral artery (MCA), usually from M1 segment, more rarely from the postbifurcation or M2 segment. They supply the lateral portion of the putamen and external capsule as well as the upper internal capsule.
Note that medial lenticulostriate arteries, which arise more proximally, originating from A1 ACA segment.
M1 segment extends from the ending of the internal carotid artery, perforating the brain up to its division. The M2 segment bifurcates or occasionally trifurcates. It travels laterally to the Sylvian fissure, and its branches end in the cerebral cortex. The M3 segment travels externally through the insula into the cortex.
Its
penetrating branches supply most of the lateral basal brain
The middle cerebral artery territory is the most commonly affected territory in a cerebral infarction, due to the size of the territory and the direct flow from internal carotid artery into the middle cerebral artery, providing the easiest path for thromboembolism.
ACA territory infarcts are less common because if the A1 segment is occluded there is generally enough collateral flow via the contralateral A1 segment to supply the distal ACA territory 2.
The two posterior cerebral arteries (PCAs) are the major
terminal branches of the distal basilar artery .it courses from basilar towards the occiput. PCA curls around the cerebral peduncle & passes above the tentorium to supply the posteromedial surface of the temporal lobe & the occipital lobe. The visual cortex responsible for contralateral field of vision lies in its territories.
1.P1 segment lies above the oculomotor nerve (CN III) and has
perforating branches (the posterior thalamoperforating
arteries) that course posterosuperiorly in the interpeduncular fossa to enter the undersurface of the midbrain.
2. The
P2 segment lies above the tentorium and the cisternal
segment of the trochlear nerve (CN IV). Two major cortical
branches—the anterior and posterior temporal
arteries—arise from the P2 PCA segment and pass laterally
toward the inferior surface of the temporal lobe
3. It begins
behind the midbrain and ends where the PCA enters the
calcarine fissure of the occipital lobe
4. The medial trunk gives off the medial occipital
artery, parietooccipital artery, calcarine artery, and
posterior splenial arteries, whereas the lateral trunk gives
rise to the lateral occipital artery
Lateral
graphic depicts the PCA
ſt above and the superior
cerebellar artery
below the oculomotor
nerve . Perforating ,
choroidal , and cortical
st PCA branches are also
shown.
The PCA supplies most of the inferior surface of the cerebral
hemisphere, with the exception of the temporal tip and
frontal lobe. It also supplies the occipital lobe, posterior onethird
of the medial hemisphere and corpus callosum, and
most of the choroid plexus (8-23). Penetrating PCA branches
are the major vascular supply to the midbrain and posterior
thalami
One important issue with PCA is its variation. A common normal variant is the "fetal" origin of the PCA.
Here the proximal PCA arises from the ICA instead of from the
basilar bifurcation. "Fetal" PCA origin is seen in 10-30% of
cases. This variant is easily recognized on CTA, MRA, and DSA
this can produce substantial left-right
asymmetry on perfusion imaging. Knowledge of this common
normal variant is essential, as such asymmetry can mimic
cerebrovascular pathology.
Actually We can discuss these three arteries together due to their origin from vertebrobasilar system & common posterior fossa supply. We already discussed that The vertebrobasilar system consists of the two vertebral
arteries (VAs), the basilar artery (BA), and their branches. Each VA arises from the
ipsilateral subclavian artery and courses posterosuperiorly to
enter the C6 transverse foramen. they enters cranial cavity through foramen magnum courses superomedially behind the clivus and in front of the
Medulla. The two VAs unite at or near the
pontomedullary junction to form the BA. The BA courses
superiorly in the prepontine cistern, lying between the clivus
in front and the pons behind. It terminates in the
interpeduncular fossa by dividing into the two posterior
cerebral arteries
Now if we draw a schematic diagram to show the origin of SCA. AICA & PICA
superior cerebellar
arteries (SCAs) originate from each side of the distal BA,
course laterally below CN III, then curve posterolaterally
around the midbrain just below the tentorium (8-25). SCA
branches ramify over the surface of the superior cerebellum
and upper vermis, curving into the great horizontal fissure…gap
SCA is rarely absent, it is frequently duplicated:
unilateral duplication: 28%
bilateral duplication: 8%
The AICA arises from the
proximal BA and courses ventromedially to CNs VII and VIII,
frequently looping into the internal auditory meatus. Gap.
99% of AICAs arise from the basilar artery, but where along the vessel is variable:
75% lower third
16% middle third
9% vertebrobasilar junction
The posterior
inferior cerebellar artery (PICA) arises from the distal VA,
curves around/over the tonsil, and gives off the perforating
medullary, choroid, tonsillar, and inferior cerebellar branches. It is the most variable and tortuous cerebellar artery. Its origin is highly variable:
~20% arise extracranially, inferior to the foramen magnum
10% arise from the basilar rather than vertebral artery
2% bilaterally absent
occasionally loops around the cerebellar tonsil. Gap--AICA-PICA dominance refers to the principle that the cerebellar vascular territory supplied by the anterior inferior cerebellar artery and posterior inferior cerebellar artery have a reciprocal arrangement. That is the size of the AICA and the subsequent territory it supplies is inversely proportional to that of the PICA, and vice versa.
At the level of extrem vertex,--- Yellow- ACA supplying medial part of the frontal and the parietal lobe. Red-The cortical branches of the MCA supply the lateral surface of the hemisphere, except for the inferior part of the temporal lobe (posterior cerebral artery - Blue).
Level of centrumsemiovale---Blue- Cortical branches of the PCA supply the inferomedial part of the temporal lobe, occipital pole,
Superior basal ganglia ---Pink- AchA supplying part of the hippocampus, the posterior limb of the internal capsule & choroid plexuses. Purple- lateral LSA' s are deep penetrating arteries of the (MCA) supplying most of the basal ganglia. Blue- PCA branching off as Posterior thalamoperforating arteries from P1 seg & supplying the thalamus
Superior Part of Lateral ventricle– showing only ACA, MCA PCA territories
The brainstem--- Just aboveOrange- medial LSA' s arising from the ACA usually from A1 segment . Heubner's artery is the largest of the medial lenticulostriate arteries and supplies the anteromedial part of the head of the caudate and anteroinferior internal capsule
AT the level of brain stem.. SCA appearing in the superior part of cerebellum.
At the level of inferior temporal lobe--- Green- basilar artery supplying medulla & part of the pons below..
At the level of cerebellopontine angle--- SCA supplying the entire superior part of cerebellum, Green- Basilar supllying pons at this level. Light Green- We can see AICA coming out covering the anterior aspect of cerebellum. On the behind PICA is supplying inferior occipital surface of the cerebellum .
One very interesting point is AICA & PICA are in equilibrium in respect of territories.---The larger the PICA territory, the smaller the AICA and viceversa.
I would like to mention blood supply of the basal ganglia which is little confusing. Basal ganglia are a group of grey matter nuclei in the deep aspects of the brain that is interconnected with the cerebral cortex, thalami and brainstem.
superficial (cortical) deep (subependymal)
Furthermore, they are valveless, allowing for bidirectional blood flow in intracranial veins. It is also important to note that the draining territories of intracranial veins are different from those of major cerebral arteries. Together the dural venous sinuses form the major drainage pathways from the brain, predominantly to the internal jugular veins
It receives venous blood from the cortical veins through the cerebral hemispheres. Anatomical variation is very frequent like duplication hypoplasia etc.
It receives tributaries from the falx itself as well as some small veins from the medial surface of the cerebral hemispheres.
The straight sinus is one of the main dural venous sinuses and is found at the junction between the falx cerebri and the tentorium cerebelli and is triangular in cross-section. It receives the inferior sagittal sinus and the vein of Galen at its anterior end and some superior cerebellar veins along its course, and runs posteroinferiorly towards the confluence of sinuses.
On each side, the transverse sinus then runs in the lateral border of the tentorium cerebelli and grooves the occipital and squamous temporal bones. They terminate in the sigmoid sinus just as it receives the superior petrosal sinus from the cavernous sinus. In turn, the sigmoid sinuses continue as the jugular bulbs in the skull base.
On each side, the transverse sinus then runs in the lateral border of the tentorium cerebelli and grooves the occipital and squamous temporal bones. They terminate in the sigmoid sinus just as it receives the superior petrosal sinus from the cavernous sinus. In turn, the sigmoid sinuses continue as the jugular bulbs in the skull base.
On each side, the transverse sinus then runs in the lateral border of the tentorium cerebelli and grooves the occipital and squamous temporal bones. They terminate in the sigmoid sinus just as it receives the superior petrosal sinus from the cavernous sinus. In turn, the sigmoid sinuses continue as the jugular bulbs in the skull base.
On each side, the transverse sinus then runs in the lateral border of the tentorium cerebelli and grooves the occipital and squamous temporal bones. They terminate in the sigmoid sinus just as it receives the superior petrosal sinus from the cavernous sinus. In turn, the sigmoid sinuses continue as the jugular bulbs in the skull base.
Unlike other dural venous sinuses, it is divided by numerous fibrous septa into a series of small caves, which is where its name is derived from. The normal lateral wall should be either straight or concave.----- CAVERNOUS SINUS is related to a lot of impo structures- MCA, OPTIC CHIASMA, orbital apex,pituitary fossa & gland etc