9. CORTISOL
Main Actions of Cortisol
Regulates the changes that occur
in the body in response to stress
• Blood sugar levels
• Energy metabolism
• Immune function
• Blood pressure
• Central nervous system action
10. Cortisol Excess
Cortisol Deficiency
High blood pressure
High blood sugar and diabetes
Water retention
Difficulty losing weight
Decreased sex drive
Digestive problems
Anxiety
Difficulty sleeping
Deceased ability to cope
Chronic fatigue
Muscle weakness
Decreased sex drive
Low blood sugar
Salt/sugar cravings
Lightheadedness
Depression
17. ESTRONE ESTRADIOL ESTRIOL
Potent estrogen
Strong
association with
breast cancer
Produced by fat
cells even after
menopause
Strongest and
most abundant
estrogen
Builds bone
density
Association with
breast cancer if
elevated
Most commonly
prescribed
estrogen
Weakest estrogen
Protective against
breast cancer
Produced mainly
by the placenta
during pregnancy
Supports vaginal
health
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18. ESTROGEN
MAIN ACTIONS of Estrogen
Breast development
Endometrial development
Female reproduction
Libido
Body fat distribution
Vaginal health and lubrication
Bone formation
Skin and blood vessel health
Cholesterol balance
Cardiovascular health
19. ESTROGEN
Breast development
Endometrial development
Female reproduction
Libido
Body fat distribution
Vaginal health and lubrication
Bone formation
Skin and blood vessel health
Cholesterol balance
Cardiovascular health
ESTROGEN DEFICIENCY
A state of imbalance
between estrogen and
progesterone
Typically associated
with MENOPAUSE
20. ESTROGENESTROGEN DEFICIENCY
Hot flashes
Night sweats
Heart palpitations
Insomnia
Low libido
Thinning hair
Decreased skin tone
Urinary incontinence
Foggy thinking
Yeast infections
Dry skin
Brittle bones
Depression and anxiety
21. ESTROGEN DOMINANCE
A state of imbalance
between estrogen and
progesterone
May reflect high estrogen
or low progesterone
22. ESTROGEN DOMINANCE
Breast tenderness
Fibrocystic (lumpy) breasts
Fatigue
Irritability
Bloating
Sugar cravings
Heavy or irregular periods
Spotting between periods
Significant PMS
Hair loss on the scalp
Headaches
Weight gain
24. PROGESTERONE
MAIN ACTIONS
Regulates menstrual cycles
Sustains pregnancy
Precursor for many other hormones
Promotes energy production
Burns fat
Builds bone
Anti-anxiety
Balances effects of estrogen
26. Progesterone Deficiency
Anxiety
Bloating
Menstrual cramps
Bleeding between
periods
Low libido
Difficulty achieving
orgasm
Fatigue
Endometriosis
Heavy, frequent, or
irregular periods
Hair loss
Hot flashes
Inflammation and pain
Insomnia
Mood swings
Urinary incontinence
PCOS
Weight gain
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30. TESTOSTERON
ELOW TESTOSTERONE HIGH TESTOSTERONE
Hot flashes, night sweats
Arthritis/ painful joints
Depression and anxiety
High cholesterol
Low energy
Loss of muscle mass
Low libido
Memory loss
Thinning skin
Dry hair and skin
Weight gain
Vaginal dryness
Weight gain (muffin top)
Acne, oily skin
Depression and anxiety
Difficulty falling asleep
Excessive energy
Hair growth on chip/ upper lip
Male pattern hair loss
Salt and sugar cravings
PCOS
31. HONOURABLE MENTIONS
LEPTIN: appetite-suppressing, satiety hormone
GHRELIN: hunger hormone, produced by the
stomach
INSULIN: blood sugar stabilizing hormone, gets sugar
into cells where it is needed
GROWTH HORMONE: tissue repair, muscle growth,
bone density. Highest production before 25 years
DHEA: most abundant hormone in the body.
Precursor for other hormones
51. HORMONE TESTING
Blood (Serum)
Best for thyroid hormones, FSH, LH,
insulin, glucose, hCG, prolactin, vitamin D
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Does not accurately measure free
hormone levels
52. HORMONE TESTING
Saliva
Best for steroid hormones – estrogen,
testosterone, DHEA, DHT, cortisol,
progesterone
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Does not measure metabolites
Less established reference ranges
53. HORMONE TESTING
Urine
Best for hormone and metabolite testing.
Provides information on detoxification and
metabolism of hormones.
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24 hour urine does not show
circadian changes in levels
74. BHRT
The use of bioidentical
hormones, synthesized from
plants, to restore balance to the
body and manage symptoms of
hormone imbalance
75. BHRT
“Synthetic hormones are not
necessarily made, sold, and
prescribed because they work better
than natural hormones, but because
natural hormones can’t be
patented.”
~ Dr. John Lee & Virginia Hopkins
77. BHRT
Women’s Health Initiative
Hormone replacement therapy of synthetic
estrogen and progestin resulted in:
o Increased risk of heart attack
o Increased risk of stroke
o Increased risk of blood clots
o Increased risk of breast cancer
81. 1. Use hormones only if you
need them
2. Use bioidentical hormones
and not synthetic
3. Use hormones only in doses
that create hormone balance
82. Conditions that Benefit from BHRT
PCOS
ENDOMETRIOSIS
Infertility
Premenstrual
Syndrome
Breast tenderness
Perimenopause
Amenorrhea
Irregular
periods
Hot flashes
WEIGHT
GAIN
Anxiety
Recurrent
miscarriage
Hormonal
Acne
HAIR
LOS
S
Fatigue
Menstrual spotting
INSOMNIA
Dysmenorrh
ea
MENOPAUSE
Food, nutrition, environment, lifestyle, body weight and more all influence our hormone balance
Each hormone also influences every other hormone in the body – directing, altering and optimizing their actions
Most commonly associated with adolescence and perimenopause
Estrogen prevents breakdown of bone, but progesterone encourages building bone
Women with PCOS are most likely to have elevated testosterone
Common cause of acne, hair loss, and irregular periods
One of our weight-loss helpers, leptin is our appetite-suppressing, full-sensation hormone. It is released by fat cells and communicates with our brain that we have had enough to eat.
We can improve our leptin levels through our lifestyle. Sleep, regular exercise, sufficient calories from our food and weight loss all help to balance leptin and improve our body composition.
We can also sabotage our leptin balance through our lifestyle choices. A regular intake of excess saturated fat and sugar leads to “leptin resistance”. When this occurs the brain no longer respond to high circulating levels of leptin and allows you to keep eating despite not being hungry.
When insulin levels are too high our cells can become less sensitive to it’s effects – leading to ‘insulin resistance’. This then leads to cravings for more sugar to meet the needs of our cells. And more insulin is released, and a vicious cycle ensues.
High levels of circulating insulin are associated with weight gain (especially around the belly). When you have excess insulin you can not burn fat as energy – your body will just demand more sugar to bring the insulin levels down. This makes losing abdominal fat almost impossible.
DHEA: cardiovascular, metabolic and anti-stress qualities
made in adrenals, skin and brain
helps reverse effects of stress on the immune system
Enhances longevity
Progesterone production peaks at 25 years of age and continues to decline until menopause
Vegetarians eliminate more estrogen
Protein is especially important for testosterone production and for thyroid health
Healthy fat helps to balance hormones by aromatizing testosterone into estrogen
Too little fat – too little estrogen
Too much fat – excess estrogen
Cortisol levels normalize with exercise
Encourages insulin sensitivity
OTHERS??
Top exposures:
- Household cleaning products, plastics, pesticides, herbicides
Other SERMS: Soy, flaxseed, red clover, dong quai
ER-beta – impacts on heart, bone, blood vessels, bladder – but not the breasts or uterus