6. Pathogenesis
The virus replicates in the mucosa of the upper
respiratory and intestinal tracts.
Virus spreads via blood to spleen and bone marrow
(viremia) causing infection of other organs: lung
,intestines & C.N.S.
7. Clinical Signs and Symptoms
Respiratory symptoms.
Nervous signs.
Digestive symptoms.
Drop in egg production with thin, rough-shelled eggs.
Swelling of tissues around eyes and in the neck.
Sudden death.
In human;(Mild conjunctivitis, influenza-like symptoms and
laryngitis).
28. the haemorrhages
and congestion in
the mucosa of
The cecal tonsils as
indicated by the
arrows, C-1 and C-
2, necrosis and
sloughing off of
the lymphoid
tissues (D)
35. A is control while B and C: amalgamation of collapsed cell and inflammatory
exudates created the homogeneous and pink-staining appearance in the white
pulps of spleens (black arrow)
38. S is control while T and U: venous congestion in the
cerebrum (black arrow)
39. References
Anandan Paldurai et al. Journal of Virology. 2014;88:8579-8596
A thesis on LESIONS AND PREVALENCE OF NEWCASTLE DISEASE IN CHICKEN
PRESENTED FOR NECROPSY AT FACULTY OF VETERINARY MEDICINE,
MAKERERE UNIVERSITY by Afayoa Mathias.
Avian Disease Manual by AAAP 7th Edition
Diseases of Poultry by David E. Swayne 13th Edition
A presentation by Dennis A. Senne from U.S. Department of Agriculture, Animal and Plant
Health Inspection Service, Veterinary Services, National Veterinary Services Laboratories, Ames,
IA 50010
http://partnersah.vet.cornell.edu/avian-atlas/#/disease/Newcastle_Disease