1. Skeletal-Muscle Energy Metabolism

2. ATP (Adenosine Triphosphate) performs functions directly related to muscle-fiber contraction and relaxation provides energy for myosin cross-bridge movements allosteric binding of ATP on myosin cross-bridge provide energy for Ca+ transport ATP molecules must be produced rapidly to sustain contractile activity

3. Three ways to form ATP during contractile activity Phosphorylation of ADP by creatine phosphate Oxidative phosphoryation of ADP in the mitochondria Substrate-level phosphorylation of ADP by the glycotic pathway in the cytosol

4. Phosphorylation of ADP by creatine phosphate - provides a very rapid means of forming ATP at the onset of contractile activity - when the bond between creatine and phosphate is broken, energy is released - energy can be transferred to ADP to form ATP in a reversible reaction catalyzed by creatinekinase CP + ADP C + ATP - amount of energy formed is limited by the initial concentration of creatine phosphate in the cell - at the start of contractile activity, provides few seconds necessary for oxidative phosphorylation & glycolysis to increase their rates of ATP formation

5. oxidative phosphorylation of ADP in the mitochondria - produced most of the ATP used for muscle contraction at moderate levels of muscular activity muscle glycogen The major fuel contributing to oxidative phosphorylation during the first 5 – 10 minutes o exercise Blood glucose & fatty acids Become dominant in the next 30 minutes of the exercise fatty acids Become more important beyond 30 minutes of the exercise Glycolysis Contributes to the total ATP when the intensity of the exercise exceeds 70% of the maximal rate of ATP breakdown

6. Glycolytic pathways Can produce large quantities of ATP when enough enzymes and substrates are available in the absence of oxygen two sources of glucose for glycolysis Blood Stores of glycogen within the contracting muscle fibers as intensity of muscle activity increases Greater fraction of total ATP production is formed by anaerobic glycolysis at the end of muscle activity Creatine phosphate & glycogen levels in the muscle decreases

7. creatine phosphate & glycogen (energy-storing compounds) Must be replaced Replacement requires energy elevated consumption of oxygen following an exercise repays oxygen dept – the increased production of ATP by oxidative phosphorylation following exercise that is used to restore the energy reserves in the form of creatine phosphate & glycogen

8. Muscle fatigue the decline in muscle tension as a result of previous contractile activity decreased shortening velocity and a slower rate of relaxation at the onset, its rate of development depend on the type of skeletal-muscle fiber that is active on the intensity duration of contractile activity

9. if a muscle is allowed to rest after the onset of fatigue it can recover its ability to contract upon restimulation the rate of recovery depends upon The duration and the intensity of the previous activity types of fatigue High-frequency fatigue Accompanies high-intensity, short duration exercise (ex. Weight lifting) Low-frequency fatigue Develops more slowly with low-intensity, long duration exercise (ex. Long-distance running requires much longer periods of rest before the muscles achieves complete recovery

10. Muscle fatigue have evolved as a mechanism for preventing the onset of rigor High-frequency fatigue occurs primarily because of a failure of the muscle action potential to be conducted into the fiber along the T tubules and thus a failure to release calcium from the sarcomastic reticulum Recovery is rapid with rest No single process can account for the low-frequency fatigue One major factor is the build up of lactic acid Recovery probably requires protein synthesis

11. Central command fatigue Due to failure of the appropriate regions of the cerebral cortex to send excitatory signals to the motor neurons Causes an individual to stop exercising though the muscle are not fatigue

13. Slow fibersMajor pathway used to form ATP Oxidative fibers glycolytic fibers

14. Fast fibers Fibers containing myosin with high ATPase activity containing myosin with lower ATPase activity slow fibers

15. Three types of skeletal-muscle fibers Slow-oxidative fibers (type I) Combine low myosin-ATPase activity with high oxidative capacity Fast-oxidative fibers (type IIa) Combine high myosin-ATPase activity with high oxidative capacity Fast-glycolytic fibers (type IIb) Combine high myosin-ATPase activity with high glycolytic capacity