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London Health 2012
Dr Keith Meadows
DHP Research & Consultancy Ltd




                      The Diabetes Health Profile –
                                Developments and
                              Practical Applications
Diabetes in the U.K.
UK Diagnosed


                          2.9 million
                          diagnosed with
                          diabetes by 2011




Diabetes type




                                                                            The impact
    10%      of               90%      of
    people with               people with
   diabetes have             diabetes have
      Type 1                    Type 2                       52%        Deaths due cardiovascular disease


Financial costs                                              21%       Type 1 Deaths due to kidney disease

                   £192 million           a week                        Of people die within 5 years of an
                   spent by the NHS                          70%                   amputation


                                      Copyright DHP Research & Consultancy Ltd
Diabetes in the U.K.




   Copyright DHP Research & Consultancy Ltd
The psychological impact of living with
              diabetes
                                       The facts

10%                                    according to Diabetes UK,      people with
    of the
population in
                                       diabetes are           twice        as likely to

 Britain have                           experience depression…
depression at
any one time

                              …and
                                the risk is higher for
                 women than for man
                                                                                          ANXIETY
        “Yet
           there is little                                                     aggression
     routine psychological                                                         Denial
      support for people                                                Eating problems
        with diabetes.”                                            POOR QUALITY OF LIFE
                Diabetes UK                                  disruption to social life
                               Copyright DHP Research & Consultancy Ltd
The Diabetes Health profile (DHP-18)

         The conceptual model




           Copyright DHP Research & Consultancy Ltd
The Diabetes Health profile
                                                             DHP-1

25 In-depth patient                                Insulin dependent (TYPE 1)
                                                            32-items
     interviews




Literature review/
 Interviews with
  clinicians/HCP
                                                             DHP-18
                                                        Insulin dependent
                                                         Insulin requiring
   Patient /HCP                                                Oral
      review                                                    Diet
                                                            18-items


   Psychometric
    testing and
     validation



                  Copyright DHP Research & Consultancy Ltd
The Diabetes Health Profile (DHP-18)




                                       Ways of administering the DHP-18




           Copyright DHP Research & Consultancy Ltd
For the psychometrician




     Copyright DHP Research & Consultancy Ltd
An international perspective

                              Over

Using the DHP         Type 1 and Type 2
                           patients
                     have completed the
                           DHP-18




                Copyright DHP Research & Consultancy Ltd
Living with diabetes -                                               Interpreting the
          DIABETES HEALTH PROFILE (DHP)
                                                                                         DHP domain scores by treatment
       3173                                                                              modality
                                                                  Mean
                                                                   age                                                              Disinhibeted
                                                                                                                                    eating

                                                                   63.9                                                             Psycholigical

                                55%
                                                                                                                                    distress
91% Type 2 and 9% Type 1                     45%                  years            Insulin
  patients completed the
                                                                                                                                    Barriers to
      questionnaire.                                                                 Oral                                           activity

                                            Patients (mean) scores on the                    40         45    50       55      60
                                              Disinhibited eating domain                            Score 0=No dysfunctioning p<0.05

             77%                                        by BMI
             Of patients experiencing                                                         100%
             three severe hypoglycaemic        BMI           BMI            BMI                   90%        Barriers to activity domain
             episodes reported their days      <25          25-34           >35                   80%                   scores
             are tied to meal times.
                                                                                                  70%
                                                                                                  60%

              59%                                                                                 50%
                                                                                                  40%                  Patients reporting
              Of patients experiencing
              one severe hypoglycaemic                                                            30%                        severe
              episode reported their days     47.8                                                20%                   hypoglycaemic
              are tied to meal times.                                                             10%                       episodes
                                                             49.2
                                                                                                  0%
                                                                            52.4                    35-44      45-54        55-64    65-74        >75


                                                Score 0=No dysfunctioning p<0.05                                Score 0=No dysfunctioning




                                             Copyright DHP Research & Consultancy Ltd
Getting an in-depth look at diabetes with
               the DHP-18
      Psychological                   Barriers to                       Disinhibited
         distress                      activity                            eating                                     Yes
                                                                                                 Food controls life   69%




       MOST AT RISK                       MOST AT RISK                   MOST AT RISK



                                                                                                 Hard saying no to    Yes
  •    Comorbidity                    •    Severe                       • Younger                  food you like      69%
                                           hypoglycaemia                  women
  •    Severe
       hypoglycaemia                  •    Other health                 • Forgetting to
                                           issues                         take insulin
  •    Female
                                      •    Visit to the                 • Unaware of
  •    > Age                               psychiatrist                   HbA1 level
                                                                                                                      Yes
  •    Visit to the                                                     • Visit to the           Eat to cheer
       pyschiatrist
                                                                                                                      53%
                                                                          psychiartrist            self up


                                Represents high scores
         Frequent and or                  Very significant               Substantial and or
 PD      substantial             BA       levels of anxiety        DE    frequent levels of      Depressed            Yes
         emotional stress                 restricting behaviour          eating in response to     due to             50%
         including: dysphoric             and perceived                  food cues and            diabetes
         mood, irritability               limitations in                 emotional arousal.
         and externally                   social/role activities
         directed hostility.


                                                Copyright DHP Research & Consultancy Ltd
Interpreting the Diabetes Health Profile

What does a DHP-18 score mean?

M   Minimally
                 the minimally
I   Important    important difference
                 (MID) is the smallest
                 score difference on
D   Difference   the Diabetes Health
                 Profile that represents
                 the minimal clinically
                 significant difference.



                                                         The required MID change in score
                                                              for the DHP-18 domains

                                                     Psychological distress     7 - 11

                                                     Barriers to activity     6.5 - 9.9

                                                     Disinhibited eating      7.5 - 11.4

                                Copyright DHP Research & Consultancy Ltd
Interpreting the Diabetes Health Profile




             Copyright DHP Research & Consultancy Ltd
Thank you
 For more information
info@dhpresearch.com




 Copyright DHP Research & Consultancy Ltd

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The Diabetes Health Profile - Development and applications

  • 1. London Health 2012 Dr Keith Meadows DHP Research & Consultancy Ltd The Diabetes Health Profile – Developments and Practical Applications
  • 2. Diabetes in the U.K. UK Diagnosed 2.9 million diagnosed with diabetes by 2011 Diabetes type The impact 10% of 90% of people with people with diabetes have diabetes have Type 1 Type 2 52% Deaths due cardiovascular disease Financial costs 21% Type 1 Deaths due to kidney disease £192 million a week Of people die within 5 years of an spent by the NHS 70% amputation Copyright DHP Research & Consultancy Ltd
  • 3. Diabetes in the U.K. Copyright DHP Research & Consultancy Ltd
  • 4. The psychological impact of living with diabetes The facts 10% according to Diabetes UK, people with of the population in diabetes are twice as likely to Britain have experience depression… depression at any one time …and the risk is higher for women than for man ANXIETY “Yet there is little aggression routine psychological Denial support for people Eating problems with diabetes.” POOR QUALITY OF LIFE Diabetes UK disruption to social life Copyright DHP Research & Consultancy Ltd
  • 5. The Diabetes Health profile (DHP-18) The conceptual model Copyright DHP Research & Consultancy Ltd
  • 6. The Diabetes Health profile DHP-1 25 In-depth patient Insulin dependent (TYPE 1) 32-items interviews Literature review/ Interviews with clinicians/HCP DHP-18 Insulin dependent Insulin requiring Patient /HCP Oral review Diet 18-items Psychometric testing and validation Copyright DHP Research & Consultancy Ltd
  • 7. The Diabetes Health Profile (DHP-18) Ways of administering the DHP-18 Copyright DHP Research & Consultancy Ltd
  • 8. For the psychometrician Copyright DHP Research & Consultancy Ltd
  • 9. An international perspective Over Using the DHP Type 1 and Type 2 patients have completed the DHP-18 Copyright DHP Research & Consultancy Ltd
  • 10.
  • 11. Living with diabetes - Interpreting the DIABETES HEALTH PROFILE (DHP) DHP domain scores by treatment 3173 modality Mean age Disinhibeted eating 63.9 Psycholigical 55% distress 91% Type 2 and 9% Type 1 45% years Insulin patients completed the Barriers to questionnaire. Oral activity Patients (mean) scores on the 40 45 50 55 60 Disinhibited eating domain Score 0=No dysfunctioning p<0.05 77% by BMI Of patients experiencing 100% three severe hypoglycaemic BMI BMI BMI 90% Barriers to activity domain episodes reported their days <25 25-34 >35 80% scores are tied to meal times. 70% 60% 59% 50% 40% Patients reporting Of patients experiencing one severe hypoglycaemic 30% severe episode reported their days 47.8 20% hypoglycaemic are tied to meal times. 10% episodes 49.2 0% 52.4 35-44 45-54 55-64 65-74 >75 Score 0=No dysfunctioning p<0.05 Score 0=No dysfunctioning Copyright DHP Research & Consultancy Ltd
  • 12. Getting an in-depth look at diabetes with the DHP-18 Psychological Barriers to Disinhibited distress activity eating Yes Food controls life 69% MOST AT RISK MOST AT RISK MOST AT RISK Hard saying no to Yes • Comorbidity • Severe • Younger food you like 69% hypoglycaemia women • Severe hypoglycaemia • Other health • Forgetting to issues take insulin • Female • Visit to the • Unaware of • > Age psychiatrist HbA1 level Yes • Visit to the • Visit to the Eat to cheer pyschiatrist 53% psychiartrist self up Represents high scores Frequent and or Very significant Substantial and or PD substantial BA levels of anxiety DE frequent levels of Depressed Yes emotional stress restricting behaviour eating in response to due to 50% including: dysphoric and perceived food cues and diabetes mood, irritability limitations in emotional arousal. and externally social/role activities directed hostility. Copyright DHP Research & Consultancy Ltd
  • 13. Interpreting the Diabetes Health Profile What does a DHP-18 score mean? M Minimally the minimally I Important important difference (MID) is the smallest score difference on D Difference the Diabetes Health Profile that represents the minimal clinically significant difference. The required MID change in score for the DHP-18 domains Psychological distress 7 - 11 Barriers to activity 6.5 - 9.9 Disinhibited eating 7.5 - 11.4 Copyright DHP Research & Consultancy Ltd
  • 14. Interpreting the Diabetes Health Profile Copyright DHP Research & Consultancy Ltd
  • 15. Thank you For more information info@dhpresearch.com Copyright DHP Research & Consultancy Ltd