5. 12/09/54
ลกษณะสาคญของ
ISafE และ EMCI
1.Evidence based medicine
2.Transparent expert judgment
3.Comprehensive quality indicators
4.Multiplication system
5.Explicit scoring system
6.Cost assessment comparison
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advanced Pubmed search, TRIP
database, BMJ clinical evidence,
Cochrane library, Micromedex
Drugdex Drug Evaluation,
Evaluation
Micromedex Drug Interactions,
WHO Defined Daily Dose Website,
Clinical Pharmacology 2004 CD
ROM, M d
ROM Medscape Druginfo,
D i f
Physician Desk Reference (PDR),
Martindale และ BNF
1.Evidence based medicine
ตัวอยาง search strategy
ที่ใชคนใน Pubmed
Atenolol[MeSH] AND
"Migraine"[MeSH] AND
(Randomized Controlled
Trial[ptyp] OR Meta-
Meta-
Analysis[ptyp] OR Review,
Academic[ptyp])
1.Evidence based medicine
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ฐานขอมูล Micromedex
Drugdex Drug
Evaluation
ERYTHROPOIETINS
1.CLINICAL APPLICATIONS
2.THERAPEUTIC USES
3.C. ANEMIA - CHRONIC RENAL FAILURE
FDA Labeled Indication
1.1. OVERVIEW:
FDA APPROVAL: Adult, yes; pediatric, yes
EFFICACY: Adult, effective; pediatric, effective
Documentation: Adult, excellent;
pediatric, good
1.Evidence based medicine
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คะแนน ISafE
(คะแนนคุณลักษณะอันพึงประสงคของยา)
I=I f
Information
ti
S = Safety
a = administration restriction
compliance
f=f
frequency of administration
f d i i t ti
E = Efficacy
3.Comprehensive quality indicators
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คะแนน ISafE
(คะแนนคุณลักษณะอันพึงประสงคของยา)
Ibuprofen
Ib p ofen Celecoxib
Celeco ib
Information 0.90 0.90
Efficacy 1.00 1.00
Safety 0.90 0.90
Compliance 0.81 0.86
ISafE score 0.66 0.70
3.Comprehensive quality indicators
รายละเอียดการคํานวณ
คะแนน ISafE
Generic
Name EV I MM E RK S IES a f af ISafE
Oxybutynin 23GG 0.95 EE 1.00 M17C68 0.85 0.81 0.95 0.95 0.90 0.73
Tolterodine 17EF 0.85 EE 1.00 M13C68 0.90 0.77 1.00 0.95 0.95 0.72
Trospium 18GF 0.88 EP 0.95 Mn/aCn/a 1.00 0.84 0.95 0.95 0.90 0.72
Flavoxate 2GG 0.70
0 70 PP 0.90
0 90 M6C43 1.00
1 00 0.63
0 63 1.00
1 00 0.90
0 90 0.90
0 90 0.57
0 57
คะแนน 50 percentile = 0.72
3.Comprehensive quality indicators
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