3. 3
Focused Ultrasound
New, revolutionary, noninvasive therapeutic technology
Alternative or adjunct
Surgery
Radiation therapy
Drug delivery
Early stage, MR 25 years ago, additional R&D
As important to therapy as MR is to diagnoses
Transform treatment of a variety of serious medical disorders
Benign and malignant tumors
Metastatic cancer
Parkinson’s disease & epilepsy
Back pain, hypertension
Real today, infancy
11. Uterine Fibroid Treatment Comparison
Hysterectomy Focused Ultrasound
Major surgery Noninvasive, no incision
General anesthesia Conscious sedation
Painful Minimal discomfort
Hospitalization Outpatient
6 weeks recovery 1 day recovery
Side effects No side effects
No more children Preserved fertility
12. Uterine Fibroid Treatment
Pre-treatment 9 months post-treatment
Nine months after treatment, the fibroid has been absorbed
15. Marriage of Two Breakthrough Technologies
Focused Ultrasound: therapy
Treat tissue deep in body
• Noninvasively
• Accurately and precisely
Magnetic Resonance (MR) or Ultrasound (US) Imaging
Identify and target tissue to be treated
Guide and control treatment in real time
Immediate confirmation of effectiveness
17. Focused Ultrasound
Multiple intersecting
beams of ultrasound
Focused with extreme
accuracy
Point: 1 mm diameter
Deep in body
Individual beams pass harmlessly
through tissue
Point of convergence: profound effect
Adjacent tissue unaffected
18. Effects at Focal Point
Destroy tissue: thermal ablation, cavitation
Deliver drugs
Dissolve clots: sonothrombolysis
Radiation sensitization
Drug activity enhancement
Coagulate blood vessels
Amplification of cancer biomarkers
Immunomodulation
Neuromodulation
Vasodilation
Variety of effects, variety of disorders
Abundant research opportunities
19. Destroy Tissue: Thermal Ablation
Heating any tissue to 130 F (56 C) for one second
Destroys any tissue, normal or abnormal.
20. Focal Drug Delivery
Deliver drugs in high concentrations
Precisely where needed
Minimizing systemic toxicity
Drugs
Chermotherapeutic agents
Antibotics
Genes
Growth factors
21. Drugs contained in microbubbles released by ultrasound
only at the target 1/5
22. Drugs contained in microbubbles released by ultrasound
only at the target 2/5
23. Drugs contained in microbubbles released by ultrasound
only at the target 3/5
24. Drugs contained in microbubbles released by ultrasound
only at the target 4/5
25. Drugs contained in microbubbles released by ultrasound
only at the target 5/5
30. FUS Advantages vs Radiation
Single treatment
Immediate and verifiable effect
Greater precision and accuracy
Real time localization
No cumulative dose
No limitations on lesion size
No limitations on number of treatments
No secondary tumors
100% cell death
Sharp margins
34. Limitations: Cannot be used for all conditions
Scoliosis Leukemia
Traumatic Injuries
Lung Tumors
35. Potential Impact, Urgent Need
Technology widely available
Delay = unnecessary death, disability, suffering
Countless individuals: friends, family, you!
Focused Ultrasound Foundation
Shorten time to wide-spread use
Saving time, saving lives