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5/2/2012
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Clinico-Radiological Approach
For Diagnosis Of Neck Swellings
5/2/2012
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Prof. Hossam Thabet, M.D.
Otolaryngology-Head & Neck Surgery
Department
Alexandria University
 Very common & A challenge for physicians
 H & PE commonly lead to the correct diagnosis
 An understanding of cervical embryology is
crucial in treatment of congenital &
developmental masses
 Diagnosis and management of neck masses
need unique diagnostic skills and knowledge
of H & N anatomy, pathology, & radiology
Neck Mass
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Epidemiology
 Adult neck masses are 90% malignant
 Pediatric neck masses are rarely malignant.
 Most common neck mass in children is an
enlarged reactive lymph node 2ry to
bacterial/viral infections
 Almost 50% of all 2 Y/O children have
palpable normal cervical lymph nodes
Neck Mass
Physical Examination
 Anatomical Considerations
 Local Examination Of The Mass
 Complete H & N Examination
 Cranial Nerves Examination
 General Examination
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Anatomical Considerations
 Prominent Landmarks
 Triangles of the Neck
 Regional Anatomy
 Lymph Node Levels
 Carotid Bulb
 Transverse Process of C1
Modified from Head and Neck Imaging, Mosby 2003
Level I
Level II
Level III
Level IV
Level V
Level VI
Level VII
IIB
IV
VB
VA
VI
VII
IA
IB
IIA
III
AAO-HNS (1988)
LYMPH NODE LEVELS
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Diagnostic Work Up
 Imaging Studies
1. Ultrasonography
2. CT & CTA
3. MRI & MRA
4. Radiology; Chest, Neck, Sialography, barium swallow, Angiography
5. Radionucleotide scanning
6. PET & PET/CT
 Endoscopy
 Laboratory Work Up; (PPD,Gram stain,Culture)
 Fine Needle Aspiration Biopsy (FNAB)
 Surgical Biopsy
Gold Standard
Identification of Neck Masses
On Basis of their location
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Identification of Neck Masses On
Basis Of Their Location
Anterior Neck Swellings
Lateral Neck Swellings
Posterior Neck Swellings
Diffuse Neck Swellings
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Midline
(Submental)
Midline
(PrelaryngeaL)
(Laryngeal)
Midline
(Suprasternal)
(Pretracheal(
Midline
(Thyrohyoid)
Paramedian
(Paralaryngeal)
Paramedian
(Paratracheal)
Anterior Neck Mass
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Supraclavicular
Sub-
mandibular
Ant. to SCM
(Carotid Triangle)
Retro-
Mandibular
Along/ Deep
to SCM
Post. To SCM
Lateral Neck Mass
Midline
(Submental)
Anterior Neck Mass
 Lymph Node
 Abscess
 Ludwig’s Angina
 Dermoid
 TGDC
 Soft Tissue Neoplasm
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Lymph Node
Submental lymphoid tissue hyperplasia
Submental lymphadenitis
Submental Region
Lymph Node
Submental Region
Squamous Cell Carcinoma of the Lip: CECT; multiple Level I
submental metastatic lymph nodes with rim enhancement.
I A
I B
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Dermoid Cyst
Submental Region
 Mesoderm & Ectoderm (Skin appendages)
 Sublingual, submental or midline cervical mass
 Painless & do not elevate with tongue protrusion.
 Misdiagnosed as TGDC
 D.D. by MRI & Intraoperative aspiration
 Fat & fluid density
 Treatment is simple excision
CECT, sublingual cyst with fat & fluid
attenuation. Faint peripheral
enhancement (arrows).
*
*
Between genohyoid & myelohyoid
Subligual
(Supramyelohyoid)
Dermoid
Clinical signs & surgical approach are determined by the
relationship of the cyst to the musculature of the FOM.
Submental
(Inframyelohyoid)
Dermoid
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A B C
*
*
Dermoid Cysts:
 Thin-walled, unilocular, homogeneous,
hypoattenuating (0–18 HU) fluid on CT
 “Marbles" appearance (Coalescence of fat into small nodules)
 Hyperintense or isointense on T1-MRI.
 Hyperintense on T2-MRI. Heterogeneous internal
appearance.
Epidermoid cysts: Fluid attenuation on CT.
Hypointense on T1- MRI & hyperintense on T2- MRI
Submental Region
Ludwig’s Angina
 Cellulitis - Not an abscess
 Sublingual & submandibular
spaces
 90% 2ry to dental infection
in the lower jaw
 Foul, serosanguinous fluid,
no frank pus
 Fascia, muscles & C.T.
involvement
CECT, multiple low attenuation (fluid) collections in sublingual (SL)& submandibular
(SM) spaces. No peripheral rim enhancement. An abscess on CT is an area of low
attenuation with rim enhancement
SL
SM
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Submental Region
Submental Abscess
CECT; a submental low attenuation with rim enhancement (arrow).
Inflammatory changes in the left submandibular region.
May be related to a dental or skin infection.
Submental Region
FOM Tumor
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Submental Region
Lipoma
Midline
(Thyrohyoid)
Anterior Neck Mass
 Thyroglossal DC
 Dermoid
 Supraglottic Ca (PES)
 Thyroid (Ectopic/accessory)
 TGDC Ca
 Hyoid bone tumors
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Midline Thyrohyoid Region
Thyroglossal Duct Cyst
 TGD extends from F. cecum through the hyoid bone to
pyramidal lobe of the thyroid.
 Incomplete involution results in a TGDC
 80% infrahyoid
Rim enhancement if infected
Midline Thyrohyoid Region
Thyroglossal Duct Cyst
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Midline Thyrohyoid Region
Dermoid Cyst
1. Do not elevate with tongue protrusion (Not attached to
the hyoid bone)
2. MRI, variable T1 signal (Lipid) & No superior tract on
sagittal T2 MRI
3. Aspiration
“Usually misdiagnosed
as TGDC”
Midline Thyrohyoid Region
Supraglottic Carcinoma
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Midline Thyrohyoid Region
Supraglottic Carcinoma
Midline Thyrohyoid Region
Supraglottic Carcinoma
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Midline Thyrohyoid Region
Metastatic PTC
Midline Thyrohyoid Region
Hyoid Bone Tumor
 Hirunpata S, et al.
Chondrosarcoma of the
Hyoid Bone: Imaging,
Surgical, and
Histopathologic Correlation.
American Journal of
Neuroradiology 27:123-125,
January 2006
Chondrosarcoma of the Hyoid Bone
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Midline
(PrelaryngeaL/Laryngeal)
Anterior Neck Mass
 Thyroglossal DC
 Dermoid
 Laryngeal tumor
 Hypopharyngeal tumor.
 Retroph. Lesion
 Thyroid (pyramidal lobe)
 Thyroid (Accessory/ Ectopic)
 TGDC Ca
 Prelaryngeal L.N.
 Teratoma
Midline (Prelaryngeal/Laryngeal)
Thyroglossal Duct Cyst
 Most common congenital midline
neck mass (70%)
 2nd most common neck mass in
children after L.N.
 Twice as common as BCC
 50% present before age 20y
 75% Midline or 25% paramedian
 65% infrahyoid (Midline or off-midline)
 20% suprahyoid (Tend to be midline)
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Midline (Prelaryngeal/Laryngeal)
Laryngeal Tumors
Transglottic Carcinoma with Extralaryngeal Spread
Midline (Prelaryngeal/Laryngeal)
Laryngeal Tumors
*
 95% of laryngeal carcinomas
are squamous cell carcinoma
 Extralaryngeal spread into the
soft tissues in advanced cases
Laryngeal Carcinoma with Extralaryngeal Spread
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Midline (Prelaryngeal/Laryngeal)
Laryngeal Tumors
Chondrosarcoma Of The Larynx
Midline (Prelaryngeal/Laryngeal)
Hypopharyngeal Tumors
Posterior Hypopharyngeal Wall
Carcinoma
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Midline (Prelaryngeal/Laryngeal)
Hypopharyngeal Tumors
Posterior Hypopharyngeal
Wall Carcinoma
Midline (Prelaryngeal/Laryngeal)
Retropharyngeal Lesions
18 year male with post
traumatic Retropharyngeal
Abscess
Child with Retropharyngeal
Abscess
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A
B
Midline (Prelaryngeal/Laryngeal)
Thyroid (Pyramidal Lobe)
An enlarged pyramidal lobe
in a multinodular goiter
A
B
Midline (Prelaryngeal/Laryngeal)
Thyroid (Accessory Thyroid)
Thyroid gland variations,
TGDC, accessory thyroid
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Midline (Prelaryngeal/Laryngeal)
Thyroid (Pyramidal Lobe PTC)
PTC in a pyramidal lobe
CECT; a homogeneous mass with rim
enhancement in the anterior neck
(arrow).
Midline (Prelaryngeal/Laryngeal)
Lymph Node
 Non Hodgkin's Lymphoma,
 Delphian nodes (Anterior
Jugular Nodes).
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Midline (Prelaryngeal/Laryngeal)
Abscess
*
 Occur anywhere in the neck
 Low attenuation mass with rim
enhancement
 Tender mass with overlying skin
erythremia
 Fever & elevated WBC count
 Necrotic lymph nodes should be
excluded in any adult with a lesion
that has this appearance.
CECT; a low attenuation mass (*) with peripheral rim enhancement in the anterior neck. The
overlying skin & platysma muscle (arrow) are thickened with subcut. inflammatory changes.
Anterior Neck Mass
 Thyroid mass
 Dermoid cyst
 Branchial cyst (infant)
 Pretracheal L.N
 Thymic mass or cyst
 Mediastinal mass
 Anomalous CA/innomiate.
 AJ phleboectasia
 Cong. Midline cervical cleft
 Lipoma
 Teratoma
Midline
(Suprasternal&Pretracheal(
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Thyroid Masses
Midline (Supraternal & Pretracheal)
Follicular Adenoma,
hemithyroidectomy
Hashimoto’s
Thyroiditis
Midline (Supraternal & Pretracheal)
Mass was mobile with degluitition but not with tongue protrusion
Thyroglossal Duct Cyst
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Midline (Supraternal & Pretracheal)
Midline Suprasternal Dermoid
Midline (Supraternal & Pretracheal)
Branchial Cyst
2 Y/O child with midline 3rd Arch BCC & sinus
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Midline (Supraternal & Pretracheal)
Congenital Midline Cervical Cleft
 Rare anormaly
 Not a true cleft, no skin gap
 Between mandible & manubrium.
 Asymptomatic
 Overlooked at birth
 Clinical Diagnosis
 Upper skin protuberance & lower blind
mucosal tract
 Subcut. fibrous cord from the skin tag
to chin
AJ phleboectasia
a dilated Lt. AJV CTA , aneurysm of the Lt. AJV
Normal DSA of Arch
of Aorta & neck vs,
Midline (Supraternal & Pretracheal)
Jugular Vein Phlebectasia
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Suprasternal Cyst
Midline (Supraternal & Pretracheal)
PTC metastasis in a Paratracheal L.N.
Midline (Supraternal & Pretracheal)
Anomalous Inomminate A.
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Midline (Supraternal & Pretracheal)
Thymus gland anomalies
Cervical thymoma
 Firm, mobile masses in the lower neck
 Decrease with inspiration (Characteristic)
 1st decade of life.
 Chest Xray & CT.
 Surgical excision is the treatment of choice.
Paramedian
(Paralaryngeal).
Paramedian
(Paratracheal)
Anterior Neck Mass
TGDC
Laryngeal Tumor
Hypopharyngeal Tumor
Laryngocele
Saccular Cyst
Pharyngeal Pouch
Branchial Cyst
 Thyroid mass
 Parathyroid mass
 Metastatic L.N
 Peristomal rec.
 Branchial cyst
 Esoph. & tracheal
Diverticulum
 Pneumocele
 Thymic mass/cyst
 Anomalous Carotid
 AJ phleboectasia
 Bronchogenic Cyst
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Anterior Paramedian Region
Thyroglossal Duct Cyst
Laterally located infrahyoid TGDC with rim enhancement
Laryngeal Tumors
Transglottic Carcinoma with Extralaryngeal Spread
Anterior Paramedian Region
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Anterior Paramedian Region
Papillary Thyroid Carcinoma
Anterior Paramedian Region
Congenital Cervical Lung Herniation
 The least common location
of lung herniation.
 Patients <3 years of age
 Unilateral or bilateral,
 Congenital; parietal pleura
is intact
 Traumatic; parietal pleura is
disrupted
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Anomalous Carotid Artery
Anterior Paramedian Region
Cervical Bronchogenic cyst
 Rare anomalies due to abnormal
tracheobronchial development
 Extrathoracic suprasternal or
presternal.
 Intrathoracic in the mediastinum,
diaphragm, pericardium, or lung
 The definitive treatment is
surgical excision
Anterior Paramedian Region
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Peristomal Recurrence
Peristomal Recurrence
Anterior Paramedian Region
Commonest Midline Neck Mass
Cystic Solid
 Thyroglossal duct cyst
 Cystic thyroid nodule
 Lymph Node
 Solid thyroid nodule
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Supraclavicular
Sub-
mandibular
Ant. to SCM
(Carotid Triangle)
Retro-
Mandibular
Along/ Deep
to SCM
Post. To SCM
Lateral Neck Mass
Submandibular
 SMG Swellings
 Lymph Node
 Lymphadenitis
 Atypical mycobacteria
 Cat scratch disease
 Metastatic
 Abscess
 Plunging Ranula
 PPS tumor
 Soft tissue Tumors
e.g. lipoma..etc
Lateral Neck Mass
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SMG enlargement may
be 2ry to:
1. Tumor in the gland
2. Stone obstruction
3. FOM carcinoma
compressing the duct
Submandibular Region
s
Submandibular Chronic Sialadenitis with Stone
Submandibular Region
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Submandibular Space Abscess
 May be 2ry to dental infection
 D.D. a necrotic L.N. with extracapsular extension of
 Clinical history is key
a multiloculated low- attenuation mass with peripheral rim enhancement in the Lt SM
space.
A B
Submandibular Region
Submandibular Region
Submandibular Sialadenitis
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Floor Of Mouth Carcinoma
• 90% occur in the anterior FOM
• Cause obstruction of the S.M.duct
• Present with a hard submandibular L.N. or an enlarged S.M.G.
CECT (A) shows a mass (*) in the anterior FOM causing obstruction of the left
SM.duct (arrow). (B) shows enlargement of the left SMG (arrow).
A B
*
Submandibular Region
Submandibular Lymph Node Hyperplasia
Submandibular Region
Level IB L.N.
“Homogenous lymph nodes are often
encountered in patients with Lymphoma,
Sarcoidosis or Reactive lymphoid hyperplasia”
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Submandibular Region
Submandibular Atypical
Mycobactrial Lymphadenitis Level IB L.N.
S S
Submandibular Region
Cervical Lymphadenitis
Enhanced CT shows multiple masses with rim enhancement in the right submandibular
region.
Level IB & IIA L.N.
Cat Scratch Disease
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Submandibular Region
Granulomatous Lymphadenitis(Sarcoidosis)
S S
Level IB L.N.
Submandibular Region
Lymphoma
Diffusly homogenously enlarged level IB
submandibular lymph nodes
Level IB L.N.
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Submandibular Region
Granulomatous Sialadenitis
Sarcoidosis Xanthogranuloma
Submandibular Gland Tumor
• 50% malignant (Adenoid cystic & mucoepidermoid
carcinoma)
a heterogenous mass enlarging the gland & almost replacing the entire glandular tissue.
A B
Submandibular Region
Benign Mixed Tumor.
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Submandibular Region
Submandibular Gland Tumor
Lymphoepithelial Lesion
Pleomorphic. Adenoma
**
**
Submandibular Tumor
Submandibular Region
Submandibular Lipoma
S S
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CECT (A) shows a low density lesion in the sublingual space (arrow) that extends
posterior medial to the SMG(B). This lesion can be differentiated from a branchial cleft
cyst when a portion of the lesion is identified in the sublingual space (tail sign).
B
SM
A
SM
SL
M
SM
Submandibular Region
Plunging Ranula
Plunging Ranula
SM
The pathognomonic radiological sign for plunging ranula is
the presence medial to the SMG, & presence of the tail sign
Submandibular Region
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Parapharyngeal Tumor
Submandibular Region
Vagal Paraganglioma
Parapharyngeal Tumor
Submandibular Region
Deep Lobe Parotid Pl. Adenoma
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Phlepoectasia (Common facial V)
Submandibular Region
Retromandibular
 Transverse Process of
Atlas / Styloid Process
 Lymph Node (2ry to naso
or oropharyngeal lesion)
 Tail of parotid Tumor
 Deep lobe Parotid
 Branchial cleft I/II
 Paraph. tumor
Lateral Neck Mass
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Lymphoid Tissue Hyperplasia
Retromandibular Region
Metastatic Nasopharyngeal Carcinoma
Retromandibular Region
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Parotid Lymphoepithelial Lesion
Retromandibular Region
Intraparotid Lipoma
Retromandibular Region
Parotid Fibrolipoma
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Parotid Fibromatosis
Retromandibular Region
Parotid Adenocarcinoma
Retromandibular Region
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T.B. Parotitis & Lympadenitis
Retromandibular Region
Parapharyngreal Lymphoma
Retromandibular Region
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Deep Lobe Parotid Pl.Adenoma
Retromandibular Region
Elongated Styloid Process
Retromandibular Region
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Ant. To SCM
(Carotid Triangle)
 Normal; hyoid, thyroid c., & carotid bulb
 Lymph Node (Jugulodigastric)
 Branchial Cyst II, III,IV
 CBT/ G. Vagale
 Schwannoma
 Laryngocele
 Lat.Saccular Cyst
 Pharyngeal Pouch
 Carotid anurysm
 Phleboectasia (I.J.V
 Hemangioma
 Lymphangioma
Lateral Neck Mass
Carotid Triangle
Cervical Lymphadenitis
Atypical Mycobacterial Cervical Lymphadenitis
Level II A & B L.N.
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Carotid Triangle
Branchial Cyst
2nd Arch Branchial Cleft Cysts
SMG
SCM
Carotid Triangle
Branchial Cyst
SCM
*
C
Diagram (A) a BCC with reference to SCM. Axial CECT (B) and sagittal image (C) show a low
attenuation, well-circumscribed mass anterior to SCM with anterior displacement of the
submandibular gland (SM) and posterior medial displacement of the carotid sheath structures. Axial
T2WMR (D) shows the anterior aspect of the SCM being flattened by this high-signal intensity cyst
A
*
SM
*
B
D
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Carotid Triangle
Metastatic Lymph Node
Bilateral low attenuation JD nodes
(Level II) with rim enhancement in
a patient with a tonsillar
carcinoma.
Level II A L.N.
Carotid Triangle
Metastatic PTC
Metastatic PTC. Level IIa & III
Level II A & III L.N.
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Carotid Triangle
B-Cell Lymphoma Level II A & III L.N.
Carotid Triangle
Schwannoma
A B
(A) an enhancing mass in the left carotid space causing splaying of carotid sheath
structures. MRA shows splaying of the carotid bifurcation with no neovascularity (B)
 Occur in the same locations as paragangliomas.
 May enhance on CT similar to paragangliomas.
 MR, MRA, or CTA can exclude paraganglioma (no
neovascularity or salt & pepper pattern)
IJV
M
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Carotid Triangle
Sympathetic Schwannoma
Carotid Triangle
Neurofibroma
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Carotid Triangle
A
Carotid Body Tumor
B
Axial CECT (A) & CTA (B) show an enhancing mass splaying the carotid arteries.
The ICA (arrow) is displaced posteriorly & ECA anteriorly (arrow).
IJV
M
 Signal voids on MRI & evidence of neovascularity is
noted on MRA & CTA.
Carotid Triangle
Carotid Body Tumor
CBA
Axial T1WI (A( an intermediate signal intensity mass with typical “salt and pepper”
appearance caused by flow voids (vessels = pepper) & areas of subacute hemorrhage
(salt). There is anterior displacement of ECA (arrows). & posterior displacement of ICA
(arrows). The lesion enhances on post contrast FST1WI (B). The splaying of the carotid
bifurcation and enhancement of the lesion are seen on MRA (C).
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Carotid Triangle
Carotid Body Tumor
Carotid Triangle
Extra Parotid Warthin’s Tumor
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Carotid Triangle
Laryngomucocele
Carotid Triangle
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Carotid Triangle
Lateral Saccular Cyst (Laryngoscleroma)
Bilateral saccular cyst , Rhino-laryngo-tracheoscleroma
Huge lateral saccular cyst herniating through the thyrohyoid membrane into the soft
tissues of the neck
 Saccular cyst is a mucous filled dilatation of the saccule that
does not communicate with the laryngeal lumen.
 “Early obstruction of the saccule opening results in the
accumulation of fluid in the saccule with no presence of air”
 Can be distinguished from laryngoceles in that there is no
communication with the laryngeal lumen, they do not contain
air (No air fluid level) & located submucosally
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Carotid Triangle
Carotid Artery Aneurysm
Rt. ICA Aneurysm
 Mostly 2ry to atherosclerosis
 May be due to degeneration,
infection (mycotic forms),
congenital, trauma,
fibromuscular dysplasia,
irradiation arteritis, dissecting
aneurysm or non-specific
causes
 Present commonly with
pulsatile neck swelling.
 Other Sx include pain, TIA,
stroke and dysphagia.
Post. To SCM
(Posreior Triangle)
 Lymph Nodes
 Lymphadenitis
 T.B
 Metastatic
 Soft tissue tumors;
(Lipoma, sarcoma)
 Lymphangiomas
 Neural tumors
 Lesions of the vertebral axis
Lateral Neck Mass
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Posterior Triangle
Lymph Node
Cervical Lymphadenitis, Kawasaki Disease
Level II B & VA L.N.
Posterior Triangle
TB Lymphadenitis
BA
Bilateral heterogenous enhancing L.N.
Level III & V L.N.
Posterior triangle L.N. enlargement may be due to;
1. TB
2. Lymphoma ( especially Hodgkin’s Lymphoma(
3. Head and neck cancer
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Posterior Triangle
Lymphangioma
*
*
*
s
A
B
C
*
 Uni or multiloculated, non-enhancing
 Capillary, cavernous, & cystic
 Large, soft, compressible masses
 Posterior vs. anterior triangle location
 Do not transilluminate.
 CT scan
 Spontaneous regression is rare
 Surgical excision is the treatment of choice.
 Sclerotherapy with OK-432
CECT (A) a low attenuation mass (*) medial & ant.to SCM (S). Axial TIMRI (B) a hypointense
mass that increases in signal intensity on T2MRI (C). Septations are seen in the lesion on
T2WI.
Nerves In The Neck
Cervical sympathetic
chain
Vagus nerve
Recurrent LN
Phrenic nerve
Cervical nerve
root
You must be familiar with the location of the
nerves in the neck when evaluating for a possible
neural tumor.
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Posterior Triangle
Neural Tumors
A B
The location of the lesion may be the key to diagnosis.
CECT (A) multiple bilateral low attenuation, vagal and cervical nerve root lesions in a
patient with neurofibromatosis. A heterogeneously-enhancing mass is seen in the left
prevertebral region (B). This sympathetic chain schwannoma is causing anterior
displacement of the carotid sheath structures (circle).
Posterior Triangle
Neural Tumors: Neurofibromatosis
Axial T1WI (A & B( a “dumbbell ” shaped homogeneous, isointense mass in the left
posterior cervical space that extends from the spinal canal and enlarges the neural
foramen (arrows). The intraspinal component (arrow) is seen on the coronal T2 MRI (C).
“ When you have a mass in the posterior triangle, look
for evidence of communication with the spinal canal or
adjacent nerves”
A B C
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Posterior Triangle
Neural Tumors
(A) a heterogenous mass with a low attenuation center in the Rt. posterior cervical
space (arrow). Sequential image (B) shows an enlarged cervical nerve root passing
between the anterior (A) & middle (M) scalene muscles leading to the mass. This finding
suggests the diagnosis of a neurogenic lesion.
A
B
M
A
A
M
Schwannomas
Posterior Triangle
Metastatic disease
“Commonly presents as an asymmetric mass that
involves cervical lymph nodes or vertebra”
A B
Metastatic breast Ca: (A) an expansile lytic lesion involving the vertebral body &
posterior elements. Metastatic melanoma: (B) a large, centrally-necrotic mass in the
right paraspinal muscles.
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Posterior Triangle
Rhabdomyosarcoma
1. Ill defined
2. Enhancing soft tissue density
3. Areas of necrosis
Malik et al, 2002
 Most common solid H & N
tumor in children
 Symptoms related to tumor site
 Rapidly growing, <1 month
before diagnosis
 Complete resection if possible
 Chemotherapy with radiation
and/or surgical salvage has
cure rates of 50-65%
Posterior Triangle
Embryonal Rhabdomyosarcoma
 10-15% of all solid tumors.
 Median age = 5y
 Aggressive tumor
 Occur in multiple sites
 35-50% originate in H & N
 Metastases in lungs, L.Ns,
mediastinum, brain, liver, &
skeleton.
 Surgical excision, with
adjunctive chemotherapy &
radiation therapy
5/2/2012
65
Posterior Triangle
External Jugular V. Phleboectasia
 Rare anomaly - An isolated fusiform
or saccular dilatation of a vein
 Affect IJV, EJV, AJV, sequentially.
 An intermittent neck swelling during
straining & Valsalva manoeuvre .
 Diagnosis is confirmed by Doppler
US, CE. CT,CTA, MRA & MR
venography.
 Surgical excision for symptomatic
patients or for cosmetic reasons.
Along /Deep to SCM
 Lymph nodes
 Lymphadenitis
 T.B
 Metastatic
 SCM tumor of infancy
 SCM pseudotumor
 Lipoma
 Lymphangiomas
 Neural tumors
 IJ Phleboectasia
Lateral Neck Mass
5/2/2012
66
Along/Deep To SCM
SCM Tumor of Infancy (Fibromatosis Colli)
Along/Deep To SCM
Jugular Vein Phlebectasia
 Only 5 Pediatric neck swelling enlarge on Valsalva
manoeuvre :
1. Phlebectasia (Venous Aneurysm )
2. Laryngocele or lateral saccular cyst
3. Superior Mediastinal tumor
4. Tracheocele or Tracheal diverticulum
5. Cervical apical Lung herniation
IJ Phleboectasia
5/2/2012
67
Along/Deep To SCM
Vascular Malformation
Along/Deep To SCM
Vascular Malformation
5/2/2012
68
Supraclavicular
 Fat pad
 Lymph nodes
 Granulomatous
 Metastatic
 Lymphoma
 Lipoma
 Cystic hygroma
 Pneumatocele
 Cervical rib
 Chyloma
 Hypertrophy of sternoclavicular joint/ clavicle
Lateral Neck Mass
Supraclavicular Region
Supraclavicular Lymphadenopathy
 Left supraclavicular lymph nodes (The Virchow node)
may represent:
1.Metastasis from distant malignancy (abdominal or
thoracic), particularly lung (bronchogenic ca.), breast & GIT
(stomach, esophagus)
2.Non-Hodgkin lymphoma, Hodgkin disease.
3.Mediastinal disease (lymphoma, TB, atypical mycobacterial
infection, or sarcoid)
4.Chronic fungal & mycobacterial infections (eg,
scrofula)
5/2/2012
69
Supraclavicular Region
Lymph Nodes
 35% of patients with H&N lymphoma present with a
supraclavicular mass
 35% of pts with suprclavicular masses had lymphoma
Torsiglieri et al., 1988
Lymphoma
Supraclavicular Region
Lymph Nodes
SCM
Nontuberculous Mycobacterial Lymphadenitis
5/2/2012
70
Supraclavicular Region
Lymph Nodes
Metastatic Lt.
Supraclaviular L.N. from
gastric carcinoma
Rt. Supraclavicular T.B
Lymphadenitis
Supraclavicular Region
Phleboectasia Lymphangioma
5/2/2012
71
Supraclavicular Region
Chyloma
A well defined negative density collection is seen in the
retro-esophageal space in the right supraclavicular region
Chyloma
Supraclavicular Region
Cervical Rib
5/2/2012
72
Supraclavicular Region
Cervical Rib
Supraclavicular Region
Supraclavicular
Diffuse Lipoma
 Soft, ill-defined mass
 Usually >35 years of age
 Asymptomatic
 Clinical diagnosis – confirmed by
excision
Supraclavicular
Abscess
5/2/2012
73
Posterior Neck
(Occipital/Median/Paramedian)
 Lymph node
 Lymphadenitis
 Metastatic
 Lymphoma
 Abscess
 Lipoma
 Meningocele
 Encephalocele
 Neural tumors
 Vertebral lesions
Lateral Neck Mass
Posterior Neck
Lymph Node
Enlarged occipital & spinal accessory lymph
nodes may present as posterior neck masses.
A B
Lymphoma: CECT (A and B) show enlarged homogenous occipital lymph
nodes (arrows).
5/2/2012
74
Posterior Neck
Carbuncle / Furuncle
 A furuncle is an acute, round, firm, tender,
circumscribed, perifollicular staphylococcal pyoderma
that usually ends in central suppuration.
 A carbuncle is two or more confluent furuncles with
separate heads
Posterior Neck
Hemangioma Lipoma
5/2/2012
75
Posterior Neck
Myelomeningocele Neurofibromatosis
Diffuse Neck Swellings
 Madelung’s Disease
 Lymphoma/Leukemia
 Massive Cervical
Lymphadenitis
 Cystic Hygroma
 Huge Teratoma
 Lymphatic Obstruction
 Huge goiter
Lateral Neck Mass
5/2/2012
76
Madelung’s Disease
Diffuse Neck Swellings
 Middle-aged (50 y) alcoholic males
 Non-encapsulated fatty masses
 At least 10 years of heavy drinking
 Typical lipomas are encapsulated
Lymphoma / Leukemia
Diffuse homogeneous cervical lymphadenopathy in
adults is often encountered in patients with
lymphoma & leukemia.
Diffuse homogeneously-enlarged cervical lymph nodes.The lingual tonsils are also
enlarged (circle).
A B
Diffuse Neck Swellings
5/2/2012
77
Lymphoma Level II A & B, III, IV, V
Diffuse Neck Swellings
Cystic Hygroma
Diffuse Neck Swellings
5/2/2012
78
Teratoma
Diffuse Neck Swellings
Newborn with Massive Cervical Teratoma

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Clinico radiological approach for diagnosis of neck swellings

  • 2. 5/2/2012 2 Prof. Hossam Thabet, M.D. Otolaryngology-Head & Neck Surgery Department Alexandria University  Very common & A challenge for physicians  H & PE commonly lead to the correct diagnosis  An understanding of cervical embryology is crucial in treatment of congenital & developmental masses  Diagnosis and management of neck masses need unique diagnostic skills and knowledge of H & N anatomy, pathology, & radiology Neck Mass
  • 3. 5/2/2012 3 Epidemiology  Adult neck masses are 90% malignant  Pediatric neck masses are rarely malignant.  Most common neck mass in children is an enlarged reactive lymph node 2ry to bacterial/viral infections  Almost 50% of all 2 Y/O children have palpable normal cervical lymph nodes Neck Mass Physical Examination  Anatomical Considerations  Local Examination Of The Mass  Complete H & N Examination  Cranial Nerves Examination  General Examination
  • 4. 5/2/2012 4 Anatomical Considerations  Prominent Landmarks  Triangles of the Neck  Regional Anatomy  Lymph Node Levels  Carotid Bulb  Transverse Process of C1 Modified from Head and Neck Imaging, Mosby 2003 Level I Level II Level III Level IV Level V Level VI Level VII IIB IV VB VA VI VII IA IB IIA III AAO-HNS (1988) LYMPH NODE LEVELS
  • 5. 5/2/2012 5 Diagnostic Work Up  Imaging Studies 1. Ultrasonography 2. CT & CTA 3. MRI & MRA 4. Radiology; Chest, Neck, Sialography, barium swallow, Angiography 5. Radionucleotide scanning 6. PET & PET/CT  Endoscopy  Laboratory Work Up; (PPD,Gram stain,Culture)  Fine Needle Aspiration Biopsy (FNAB)  Surgical Biopsy Gold Standard Identification of Neck Masses On Basis of their location
  • 6. 5/2/2012 6 Identification of Neck Masses On Basis Of Their Location Anterior Neck Swellings Lateral Neck Swellings Posterior Neck Swellings Diffuse Neck Swellings
  • 8. 5/2/2012 8 Supraclavicular Sub- mandibular Ant. to SCM (Carotid Triangle) Retro- Mandibular Along/ Deep to SCM Post. To SCM Lateral Neck Mass Midline (Submental) Anterior Neck Mass  Lymph Node  Abscess  Ludwig’s Angina  Dermoid  TGDC  Soft Tissue Neoplasm
  • 9. 5/2/2012 9 Lymph Node Submental lymphoid tissue hyperplasia Submental lymphadenitis Submental Region Lymph Node Submental Region Squamous Cell Carcinoma of the Lip: CECT; multiple Level I submental metastatic lymph nodes with rim enhancement. I A I B
  • 10. 5/2/2012 10 Dermoid Cyst Submental Region  Mesoderm & Ectoderm (Skin appendages)  Sublingual, submental or midline cervical mass  Painless & do not elevate with tongue protrusion.  Misdiagnosed as TGDC  D.D. by MRI & Intraoperative aspiration  Fat & fluid density  Treatment is simple excision CECT, sublingual cyst with fat & fluid attenuation. Faint peripheral enhancement (arrows). * * Between genohyoid & myelohyoid Subligual (Supramyelohyoid) Dermoid Clinical signs & surgical approach are determined by the relationship of the cyst to the musculature of the FOM. Submental (Inframyelohyoid) Dermoid
  • 11. 5/2/2012 11 A B C * * Dermoid Cysts:  Thin-walled, unilocular, homogeneous, hypoattenuating (0–18 HU) fluid on CT  “Marbles" appearance (Coalescence of fat into small nodules)  Hyperintense or isointense on T1-MRI.  Hyperintense on T2-MRI. Heterogeneous internal appearance. Epidermoid cysts: Fluid attenuation on CT. Hypointense on T1- MRI & hyperintense on T2- MRI Submental Region Ludwig’s Angina  Cellulitis - Not an abscess  Sublingual & submandibular spaces  90% 2ry to dental infection in the lower jaw  Foul, serosanguinous fluid, no frank pus  Fascia, muscles & C.T. involvement CECT, multiple low attenuation (fluid) collections in sublingual (SL)& submandibular (SM) spaces. No peripheral rim enhancement. An abscess on CT is an area of low attenuation with rim enhancement SL SM
  • 12. 5/2/2012 12 Submental Region Submental Abscess CECT; a submental low attenuation with rim enhancement (arrow). Inflammatory changes in the left submandibular region. May be related to a dental or skin infection. Submental Region FOM Tumor
  • 13. 5/2/2012 13 Submental Region Lipoma Midline (Thyrohyoid) Anterior Neck Mass  Thyroglossal DC  Dermoid  Supraglottic Ca (PES)  Thyroid (Ectopic/accessory)  TGDC Ca  Hyoid bone tumors
  • 14. 5/2/2012 14 Midline Thyrohyoid Region Thyroglossal Duct Cyst  TGD extends from F. cecum through the hyoid bone to pyramidal lobe of the thyroid.  Incomplete involution results in a TGDC  80% infrahyoid Rim enhancement if infected Midline Thyrohyoid Region Thyroglossal Duct Cyst
  • 15. 5/2/2012 15 Midline Thyrohyoid Region Dermoid Cyst 1. Do not elevate with tongue protrusion (Not attached to the hyoid bone) 2. MRI, variable T1 signal (Lipid) & No superior tract on sagittal T2 MRI 3. Aspiration “Usually misdiagnosed as TGDC” Midline Thyrohyoid Region Supraglottic Carcinoma
  • 16. 5/2/2012 16 Midline Thyrohyoid Region Supraglottic Carcinoma Midline Thyrohyoid Region Supraglottic Carcinoma
  • 17. 5/2/2012 17 Midline Thyrohyoid Region Metastatic PTC Midline Thyrohyoid Region Hyoid Bone Tumor  Hirunpata S, et al. Chondrosarcoma of the Hyoid Bone: Imaging, Surgical, and Histopathologic Correlation. American Journal of Neuroradiology 27:123-125, January 2006 Chondrosarcoma of the Hyoid Bone
  • 18. 5/2/2012 18 Midline (PrelaryngeaL/Laryngeal) Anterior Neck Mass  Thyroglossal DC  Dermoid  Laryngeal tumor  Hypopharyngeal tumor.  Retroph. Lesion  Thyroid (pyramidal lobe)  Thyroid (Accessory/ Ectopic)  TGDC Ca  Prelaryngeal L.N.  Teratoma Midline (Prelaryngeal/Laryngeal) Thyroglossal Duct Cyst  Most common congenital midline neck mass (70%)  2nd most common neck mass in children after L.N.  Twice as common as BCC  50% present before age 20y  75% Midline or 25% paramedian  65% infrahyoid (Midline or off-midline)  20% suprahyoid (Tend to be midline)
  • 19. 5/2/2012 19 Midline (Prelaryngeal/Laryngeal) Laryngeal Tumors Transglottic Carcinoma with Extralaryngeal Spread Midline (Prelaryngeal/Laryngeal) Laryngeal Tumors *  95% of laryngeal carcinomas are squamous cell carcinoma  Extralaryngeal spread into the soft tissues in advanced cases Laryngeal Carcinoma with Extralaryngeal Spread
  • 20. 5/2/2012 20 Midline (Prelaryngeal/Laryngeal) Laryngeal Tumors Chondrosarcoma Of The Larynx Midline (Prelaryngeal/Laryngeal) Hypopharyngeal Tumors Posterior Hypopharyngeal Wall Carcinoma
  • 21. 5/2/2012 21 Midline (Prelaryngeal/Laryngeal) Hypopharyngeal Tumors Posterior Hypopharyngeal Wall Carcinoma Midline (Prelaryngeal/Laryngeal) Retropharyngeal Lesions 18 year male with post traumatic Retropharyngeal Abscess Child with Retropharyngeal Abscess
  • 22. 5/2/2012 22 A B Midline (Prelaryngeal/Laryngeal) Thyroid (Pyramidal Lobe) An enlarged pyramidal lobe in a multinodular goiter A B Midline (Prelaryngeal/Laryngeal) Thyroid (Accessory Thyroid) Thyroid gland variations, TGDC, accessory thyroid
  • 23. 5/2/2012 23 Midline (Prelaryngeal/Laryngeal) Thyroid (Pyramidal Lobe PTC) PTC in a pyramidal lobe CECT; a homogeneous mass with rim enhancement in the anterior neck (arrow). Midline (Prelaryngeal/Laryngeal) Lymph Node  Non Hodgkin's Lymphoma,  Delphian nodes (Anterior Jugular Nodes).
  • 24. 5/2/2012 24 Midline (Prelaryngeal/Laryngeal) Abscess *  Occur anywhere in the neck  Low attenuation mass with rim enhancement  Tender mass with overlying skin erythremia  Fever & elevated WBC count  Necrotic lymph nodes should be excluded in any adult with a lesion that has this appearance. CECT; a low attenuation mass (*) with peripheral rim enhancement in the anterior neck. The overlying skin & platysma muscle (arrow) are thickened with subcut. inflammatory changes. Anterior Neck Mass  Thyroid mass  Dermoid cyst  Branchial cyst (infant)  Pretracheal L.N  Thymic mass or cyst  Mediastinal mass  Anomalous CA/innomiate.  AJ phleboectasia  Cong. Midline cervical cleft  Lipoma  Teratoma Midline (Suprasternal&Pretracheal(
  • 25. 5/2/2012 25 Thyroid Masses Midline (Supraternal & Pretracheal) Follicular Adenoma, hemithyroidectomy Hashimoto’s Thyroiditis Midline (Supraternal & Pretracheal) Mass was mobile with degluitition but not with tongue protrusion Thyroglossal Duct Cyst
  • 26. 5/2/2012 26 Midline (Supraternal & Pretracheal) Midline Suprasternal Dermoid Midline (Supraternal & Pretracheal) Branchial Cyst 2 Y/O child with midline 3rd Arch BCC & sinus
  • 27. 5/2/2012 27 Midline (Supraternal & Pretracheal) Congenital Midline Cervical Cleft  Rare anormaly  Not a true cleft, no skin gap  Between mandible & manubrium.  Asymptomatic  Overlooked at birth  Clinical Diagnosis  Upper skin protuberance & lower blind mucosal tract  Subcut. fibrous cord from the skin tag to chin AJ phleboectasia a dilated Lt. AJV CTA , aneurysm of the Lt. AJV Normal DSA of Arch of Aorta & neck vs, Midline (Supraternal & Pretracheal) Jugular Vein Phlebectasia
  • 28. 5/2/2012 28 Suprasternal Cyst Midline (Supraternal & Pretracheal) PTC metastasis in a Paratracheal L.N. Midline (Supraternal & Pretracheal) Anomalous Inomminate A.
  • 29. 5/2/2012 29 Midline (Supraternal & Pretracheal) Thymus gland anomalies Cervical thymoma  Firm, mobile masses in the lower neck  Decrease with inspiration (Characteristic)  1st decade of life.  Chest Xray & CT.  Surgical excision is the treatment of choice. Paramedian (Paralaryngeal). Paramedian (Paratracheal) Anterior Neck Mass TGDC Laryngeal Tumor Hypopharyngeal Tumor Laryngocele Saccular Cyst Pharyngeal Pouch Branchial Cyst  Thyroid mass  Parathyroid mass  Metastatic L.N  Peristomal rec.  Branchial cyst  Esoph. & tracheal Diverticulum  Pneumocele  Thymic mass/cyst  Anomalous Carotid  AJ phleboectasia  Bronchogenic Cyst
  • 30. 5/2/2012 30 Anterior Paramedian Region Thyroglossal Duct Cyst Laterally located infrahyoid TGDC with rim enhancement Laryngeal Tumors Transglottic Carcinoma with Extralaryngeal Spread Anterior Paramedian Region
  • 31. 5/2/2012 31 Anterior Paramedian Region Papillary Thyroid Carcinoma Anterior Paramedian Region Congenital Cervical Lung Herniation  The least common location of lung herniation.  Patients <3 years of age  Unilateral or bilateral,  Congenital; parietal pleura is intact  Traumatic; parietal pleura is disrupted
  • 32. 5/2/2012 32 Anomalous Carotid Artery Anterior Paramedian Region Cervical Bronchogenic cyst  Rare anomalies due to abnormal tracheobronchial development  Extrathoracic suprasternal or presternal.  Intrathoracic in the mediastinum, diaphragm, pericardium, or lung  The definitive treatment is surgical excision Anterior Paramedian Region
  • 33. 5/2/2012 33 Peristomal Recurrence Peristomal Recurrence Anterior Paramedian Region Commonest Midline Neck Mass Cystic Solid  Thyroglossal duct cyst  Cystic thyroid nodule  Lymph Node  Solid thyroid nodule
  • 34. 5/2/2012 34 Supraclavicular Sub- mandibular Ant. to SCM (Carotid Triangle) Retro- Mandibular Along/ Deep to SCM Post. To SCM Lateral Neck Mass Submandibular  SMG Swellings  Lymph Node  Lymphadenitis  Atypical mycobacteria  Cat scratch disease  Metastatic  Abscess  Plunging Ranula  PPS tumor  Soft tissue Tumors e.g. lipoma..etc Lateral Neck Mass
  • 35. 5/2/2012 35 SMG enlargement may be 2ry to: 1. Tumor in the gland 2. Stone obstruction 3. FOM carcinoma compressing the duct Submandibular Region s Submandibular Chronic Sialadenitis with Stone Submandibular Region
  • 36. 5/2/2012 36 Submandibular Space Abscess  May be 2ry to dental infection  D.D. a necrotic L.N. with extracapsular extension of  Clinical history is key a multiloculated low- attenuation mass with peripheral rim enhancement in the Lt SM space. A B Submandibular Region Submandibular Region Submandibular Sialadenitis
  • 37. 5/2/2012 37 Floor Of Mouth Carcinoma • 90% occur in the anterior FOM • Cause obstruction of the S.M.duct • Present with a hard submandibular L.N. or an enlarged S.M.G. CECT (A) shows a mass (*) in the anterior FOM causing obstruction of the left SM.duct (arrow). (B) shows enlargement of the left SMG (arrow). A B * Submandibular Region Submandibular Lymph Node Hyperplasia Submandibular Region Level IB L.N. “Homogenous lymph nodes are often encountered in patients with Lymphoma, Sarcoidosis or Reactive lymphoid hyperplasia”
  • 38. 5/2/2012 38 Submandibular Region Submandibular Atypical Mycobactrial Lymphadenitis Level IB L.N. S S Submandibular Region Cervical Lymphadenitis Enhanced CT shows multiple masses with rim enhancement in the right submandibular region. Level IB & IIA L.N. Cat Scratch Disease
  • 39. 5/2/2012 39 Submandibular Region Granulomatous Lymphadenitis(Sarcoidosis) S S Level IB L.N. Submandibular Region Lymphoma Diffusly homogenously enlarged level IB submandibular lymph nodes Level IB L.N.
  • 40. 5/2/2012 40 Submandibular Region Granulomatous Sialadenitis Sarcoidosis Xanthogranuloma Submandibular Gland Tumor • 50% malignant (Adenoid cystic & mucoepidermoid carcinoma) a heterogenous mass enlarging the gland & almost replacing the entire glandular tissue. A B Submandibular Region Benign Mixed Tumor.
  • 41. 5/2/2012 41 Submandibular Region Submandibular Gland Tumor Lymphoepithelial Lesion Pleomorphic. Adenoma ** ** Submandibular Tumor Submandibular Region Submandibular Lipoma S S
  • 42. 5/2/2012 42 CECT (A) shows a low density lesion in the sublingual space (arrow) that extends posterior medial to the SMG(B). This lesion can be differentiated from a branchial cleft cyst when a portion of the lesion is identified in the sublingual space (tail sign). B SM A SM SL M SM Submandibular Region Plunging Ranula Plunging Ranula SM The pathognomonic radiological sign for plunging ranula is the presence medial to the SMG, & presence of the tail sign Submandibular Region
  • 43. 5/2/2012 43 Parapharyngeal Tumor Submandibular Region Vagal Paraganglioma Parapharyngeal Tumor Submandibular Region Deep Lobe Parotid Pl. Adenoma
  • 44. 5/2/2012 44 Phlepoectasia (Common facial V) Submandibular Region Retromandibular  Transverse Process of Atlas / Styloid Process  Lymph Node (2ry to naso or oropharyngeal lesion)  Tail of parotid Tumor  Deep lobe Parotid  Branchial cleft I/II  Paraph. tumor Lateral Neck Mass
  • 45. 5/2/2012 45 Lymphoid Tissue Hyperplasia Retromandibular Region Metastatic Nasopharyngeal Carcinoma Retromandibular Region
  • 46. 5/2/2012 46 Parotid Lymphoepithelial Lesion Retromandibular Region Intraparotid Lipoma Retromandibular Region Parotid Fibrolipoma
  • 48. 5/2/2012 48 T.B. Parotitis & Lympadenitis Retromandibular Region Parapharyngreal Lymphoma Retromandibular Region
  • 49. 5/2/2012 49 Deep Lobe Parotid Pl.Adenoma Retromandibular Region Elongated Styloid Process Retromandibular Region
  • 50. 5/2/2012 50 Ant. To SCM (Carotid Triangle)  Normal; hyoid, thyroid c., & carotid bulb  Lymph Node (Jugulodigastric)  Branchial Cyst II, III,IV  CBT/ G. Vagale  Schwannoma  Laryngocele  Lat.Saccular Cyst  Pharyngeal Pouch  Carotid anurysm  Phleboectasia (I.J.V  Hemangioma  Lymphangioma Lateral Neck Mass Carotid Triangle Cervical Lymphadenitis Atypical Mycobacterial Cervical Lymphadenitis Level II A & B L.N.
  • 51. 5/2/2012 51 Carotid Triangle Branchial Cyst 2nd Arch Branchial Cleft Cysts SMG SCM Carotid Triangle Branchial Cyst SCM * C Diagram (A) a BCC with reference to SCM. Axial CECT (B) and sagittal image (C) show a low attenuation, well-circumscribed mass anterior to SCM with anterior displacement of the submandibular gland (SM) and posterior medial displacement of the carotid sheath structures. Axial T2WMR (D) shows the anterior aspect of the SCM being flattened by this high-signal intensity cyst A * SM * B D
  • 52. 5/2/2012 52 Carotid Triangle Metastatic Lymph Node Bilateral low attenuation JD nodes (Level II) with rim enhancement in a patient with a tonsillar carcinoma. Level II A L.N. Carotid Triangle Metastatic PTC Metastatic PTC. Level IIa & III Level II A & III L.N.
  • 53. 5/2/2012 53 Carotid Triangle B-Cell Lymphoma Level II A & III L.N. Carotid Triangle Schwannoma A B (A) an enhancing mass in the left carotid space causing splaying of carotid sheath structures. MRA shows splaying of the carotid bifurcation with no neovascularity (B)  Occur in the same locations as paragangliomas.  May enhance on CT similar to paragangliomas.  MR, MRA, or CTA can exclude paraganglioma (no neovascularity or salt & pepper pattern) IJV M
  • 55. 5/2/2012 55 Carotid Triangle A Carotid Body Tumor B Axial CECT (A) & CTA (B) show an enhancing mass splaying the carotid arteries. The ICA (arrow) is displaced posteriorly & ECA anteriorly (arrow). IJV M  Signal voids on MRI & evidence of neovascularity is noted on MRA & CTA. Carotid Triangle Carotid Body Tumor CBA Axial T1WI (A( an intermediate signal intensity mass with typical “salt and pepper” appearance caused by flow voids (vessels = pepper) & areas of subacute hemorrhage (salt). There is anterior displacement of ECA (arrows). & posterior displacement of ICA (arrows). The lesion enhances on post contrast FST1WI (B). The splaying of the carotid bifurcation and enhancement of the lesion are seen on MRA (C).
  • 56. 5/2/2012 56 Carotid Triangle Carotid Body Tumor Carotid Triangle Extra Parotid Warthin’s Tumor
  • 58. 5/2/2012 58 Carotid Triangle Lateral Saccular Cyst (Laryngoscleroma) Bilateral saccular cyst , Rhino-laryngo-tracheoscleroma Huge lateral saccular cyst herniating through the thyrohyoid membrane into the soft tissues of the neck  Saccular cyst is a mucous filled dilatation of the saccule that does not communicate with the laryngeal lumen.  “Early obstruction of the saccule opening results in the accumulation of fluid in the saccule with no presence of air”  Can be distinguished from laryngoceles in that there is no communication with the laryngeal lumen, they do not contain air (No air fluid level) & located submucosally
  • 59. 5/2/2012 59 Carotid Triangle Carotid Artery Aneurysm Rt. ICA Aneurysm  Mostly 2ry to atherosclerosis  May be due to degeneration, infection (mycotic forms), congenital, trauma, fibromuscular dysplasia, irradiation arteritis, dissecting aneurysm or non-specific causes  Present commonly with pulsatile neck swelling.  Other Sx include pain, TIA, stroke and dysphagia. Post. To SCM (Posreior Triangle)  Lymph Nodes  Lymphadenitis  T.B  Metastatic  Soft tissue tumors; (Lipoma, sarcoma)  Lymphangiomas  Neural tumors  Lesions of the vertebral axis Lateral Neck Mass
  • 60. 5/2/2012 60 Posterior Triangle Lymph Node Cervical Lymphadenitis, Kawasaki Disease Level II B & VA L.N. Posterior Triangle TB Lymphadenitis BA Bilateral heterogenous enhancing L.N. Level III & V L.N. Posterior triangle L.N. enlargement may be due to; 1. TB 2. Lymphoma ( especially Hodgkin’s Lymphoma( 3. Head and neck cancer
  • 61. 5/2/2012 61 Posterior Triangle Lymphangioma * * * s A B C *  Uni or multiloculated, non-enhancing  Capillary, cavernous, & cystic  Large, soft, compressible masses  Posterior vs. anterior triangle location  Do not transilluminate.  CT scan  Spontaneous regression is rare  Surgical excision is the treatment of choice.  Sclerotherapy with OK-432 CECT (A) a low attenuation mass (*) medial & ant.to SCM (S). Axial TIMRI (B) a hypointense mass that increases in signal intensity on T2MRI (C). Septations are seen in the lesion on T2WI. Nerves In The Neck Cervical sympathetic chain Vagus nerve Recurrent LN Phrenic nerve Cervical nerve root You must be familiar with the location of the nerves in the neck when evaluating for a possible neural tumor.
  • 62. 5/2/2012 62 Posterior Triangle Neural Tumors A B The location of the lesion may be the key to diagnosis. CECT (A) multiple bilateral low attenuation, vagal and cervical nerve root lesions in a patient with neurofibromatosis. A heterogeneously-enhancing mass is seen in the left prevertebral region (B). This sympathetic chain schwannoma is causing anterior displacement of the carotid sheath structures (circle). Posterior Triangle Neural Tumors: Neurofibromatosis Axial T1WI (A & B( a “dumbbell ” shaped homogeneous, isointense mass in the left posterior cervical space that extends from the spinal canal and enlarges the neural foramen (arrows). The intraspinal component (arrow) is seen on the coronal T2 MRI (C). “ When you have a mass in the posterior triangle, look for evidence of communication with the spinal canal or adjacent nerves” A B C
  • 63. 5/2/2012 63 Posterior Triangle Neural Tumors (A) a heterogenous mass with a low attenuation center in the Rt. posterior cervical space (arrow). Sequential image (B) shows an enlarged cervical nerve root passing between the anterior (A) & middle (M) scalene muscles leading to the mass. This finding suggests the diagnosis of a neurogenic lesion. A B M A A M Schwannomas Posterior Triangle Metastatic disease “Commonly presents as an asymmetric mass that involves cervical lymph nodes or vertebra” A B Metastatic breast Ca: (A) an expansile lytic lesion involving the vertebral body & posterior elements. Metastatic melanoma: (B) a large, centrally-necrotic mass in the right paraspinal muscles.
  • 64. 5/2/2012 64 Posterior Triangle Rhabdomyosarcoma 1. Ill defined 2. Enhancing soft tissue density 3. Areas of necrosis Malik et al, 2002  Most common solid H & N tumor in children  Symptoms related to tumor site  Rapidly growing, <1 month before diagnosis  Complete resection if possible  Chemotherapy with radiation and/or surgical salvage has cure rates of 50-65% Posterior Triangle Embryonal Rhabdomyosarcoma  10-15% of all solid tumors.  Median age = 5y  Aggressive tumor  Occur in multiple sites  35-50% originate in H & N  Metastases in lungs, L.Ns, mediastinum, brain, liver, & skeleton.  Surgical excision, with adjunctive chemotherapy & radiation therapy
  • 65. 5/2/2012 65 Posterior Triangle External Jugular V. Phleboectasia  Rare anomaly - An isolated fusiform or saccular dilatation of a vein  Affect IJV, EJV, AJV, sequentially.  An intermittent neck swelling during straining & Valsalva manoeuvre .  Diagnosis is confirmed by Doppler US, CE. CT,CTA, MRA & MR venography.  Surgical excision for symptomatic patients or for cosmetic reasons. Along /Deep to SCM  Lymph nodes  Lymphadenitis  T.B  Metastatic  SCM tumor of infancy  SCM pseudotumor  Lipoma  Lymphangiomas  Neural tumors  IJ Phleboectasia Lateral Neck Mass
  • 66. 5/2/2012 66 Along/Deep To SCM SCM Tumor of Infancy (Fibromatosis Colli) Along/Deep To SCM Jugular Vein Phlebectasia  Only 5 Pediatric neck swelling enlarge on Valsalva manoeuvre : 1. Phlebectasia (Venous Aneurysm ) 2. Laryngocele or lateral saccular cyst 3. Superior Mediastinal tumor 4. Tracheocele or Tracheal diverticulum 5. Cervical apical Lung herniation IJ Phleboectasia
  • 67. 5/2/2012 67 Along/Deep To SCM Vascular Malformation Along/Deep To SCM Vascular Malformation
  • 68. 5/2/2012 68 Supraclavicular  Fat pad  Lymph nodes  Granulomatous  Metastatic  Lymphoma  Lipoma  Cystic hygroma  Pneumatocele  Cervical rib  Chyloma  Hypertrophy of sternoclavicular joint/ clavicle Lateral Neck Mass Supraclavicular Region Supraclavicular Lymphadenopathy  Left supraclavicular lymph nodes (The Virchow node) may represent: 1.Metastasis from distant malignancy (abdominal or thoracic), particularly lung (bronchogenic ca.), breast & GIT (stomach, esophagus) 2.Non-Hodgkin lymphoma, Hodgkin disease. 3.Mediastinal disease (lymphoma, TB, atypical mycobacterial infection, or sarcoid) 4.Chronic fungal & mycobacterial infections (eg, scrofula)
  • 69. 5/2/2012 69 Supraclavicular Region Lymph Nodes  35% of patients with H&N lymphoma present with a supraclavicular mass  35% of pts with suprclavicular masses had lymphoma Torsiglieri et al., 1988 Lymphoma Supraclavicular Region Lymph Nodes SCM Nontuberculous Mycobacterial Lymphadenitis
  • 70. 5/2/2012 70 Supraclavicular Region Lymph Nodes Metastatic Lt. Supraclaviular L.N. from gastric carcinoma Rt. Supraclavicular T.B Lymphadenitis Supraclavicular Region Phleboectasia Lymphangioma
  • 71. 5/2/2012 71 Supraclavicular Region Chyloma A well defined negative density collection is seen in the retro-esophageal space in the right supraclavicular region Chyloma Supraclavicular Region Cervical Rib
  • 72. 5/2/2012 72 Supraclavicular Region Cervical Rib Supraclavicular Region Supraclavicular Diffuse Lipoma  Soft, ill-defined mass  Usually >35 years of age  Asymptomatic  Clinical diagnosis – confirmed by excision Supraclavicular Abscess
  • 73. 5/2/2012 73 Posterior Neck (Occipital/Median/Paramedian)  Lymph node  Lymphadenitis  Metastatic  Lymphoma  Abscess  Lipoma  Meningocele  Encephalocele  Neural tumors  Vertebral lesions Lateral Neck Mass Posterior Neck Lymph Node Enlarged occipital & spinal accessory lymph nodes may present as posterior neck masses. A B Lymphoma: CECT (A and B) show enlarged homogenous occipital lymph nodes (arrows).
  • 74. 5/2/2012 74 Posterior Neck Carbuncle / Furuncle  A furuncle is an acute, round, firm, tender, circumscribed, perifollicular staphylococcal pyoderma that usually ends in central suppuration.  A carbuncle is two or more confluent furuncles with separate heads Posterior Neck Hemangioma Lipoma
  • 75. 5/2/2012 75 Posterior Neck Myelomeningocele Neurofibromatosis Diffuse Neck Swellings  Madelung’s Disease  Lymphoma/Leukemia  Massive Cervical Lymphadenitis  Cystic Hygroma  Huge Teratoma  Lymphatic Obstruction  Huge goiter Lateral Neck Mass
  • 76. 5/2/2012 76 Madelung’s Disease Diffuse Neck Swellings  Middle-aged (50 y) alcoholic males  Non-encapsulated fatty masses  At least 10 years of heavy drinking  Typical lipomas are encapsulated Lymphoma / Leukemia Diffuse homogeneous cervical lymphadenopathy in adults is often encountered in patients with lymphoma & leukemia. Diffuse homogeneously-enlarged cervical lymph nodes.The lingual tonsils are also enlarged (circle). A B Diffuse Neck Swellings
  • 77. 5/2/2012 77 Lymphoma Level II A & B, III, IV, V Diffuse Neck Swellings Cystic Hygroma Diffuse Neck Swellings
  • 78. 5/2/2012 78 Teratoma Diffuse Neck Swellings Newborn with Massive Cervical Teratoma