16. Group 1 Group 2 step-up therapy triple therapy Ticora 2 Protocol
17.
18. was designed by a Dutch rheumatologist to look at multiple strategies for treating RA
19.
20.
21.
22. Comparison of Health Assessment Questionnaire (HAQ) data at 1 year showed that patients receiving initial combination therapy (groups 3 and 4) responded better than those receiving initial monotherapy (groups 1 and 2). However, after 2 years no difference could be seen in functional scores between groups.
28. Approximately 30% of patients in the Swefot trial responded to initial methotrexate and were not randomly assigned to add-on therapy.
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30.
31.
32.
33. 65 patients assessed by 1 year. patient's DAS was assessed Adalimumab was added for those patients in the monotherapy group who did not respond adequately 3 months started on either methotrexate alone or methotrexate and adalimumab At 3 months, more patients in the initial combination therapy group than in the initial monotherapy group had low disease activity. However, the difference disappeared at 1 year, at which time about two thirds of the patients in both groups had low disease activity.