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Therapies For Severe Asthma

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Dang Thanh Tuan
Dang Thanh Tuan

This document summarizes established and emerging therapies for severe asthma exacerbations in children. It discusses the prevalence and severity of asthma, as well as standard therapies like oxygen, steroids, and beta agonists. It also reviews newer approaches like continuous albuterol, IV terbutaline, heliox, magnesium sulfate, and mechanical ventilation strategies. Highlights various clinical patterns of asthma and approaches to managing mild-moderate vs. severe exacerbations.

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Therapies for Severe Asthma Joan Roberts, M.D. Assistant Professor Pediatric Critical Care Medicine University of Washington
Asthma is More Prevalent ,[object Object],[object Object],[object Object],[object Object],[object Object]
Is Asthma More Severe? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Asthma Death ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Established Therapies for Asthma Exacerbation ,[object Object],[object Object],[object Object],[object Object]
Steroids for an “Inflammatory” Disease ,[object Object],[object Object],[object Object],[object Object]
Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Steroid Therapy ,[object Object],[object Object],[object Object],[object Object]
Beta agonists ,[object Object],[object Object],[object Object],[object Object]
Inhaled β agonists ,[object Object],[object Object],[object Object],[object Object]
Delivery of Inhaled Medication ,[object Object],[object Object],[object Object],[object Object]
MDI vs Nebs ,[object Object],[object Object],[object Object]
Continuous Albuterol ,[object Object],[object Object],[object Object]
IV Terbutaline ,[object Object],[object Object],[object Object],[object Object],[object Object]
Terbutaline Toxicity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Toxicity ,[object Object],[object Object],[object Object],[object Object],[object Object]
Terbutaline Dosing ,[object Object],[object Object],[object Object],[object Object]
Anticholinergics ,[object Object],[object Object],[object Object],[object Object]
Other Non-Established Therapies ,[object Object],[object Object],[object Object],[object Object],[object Object]
Theophylline ,[object Object],[object Object],[object Object],[object Object]
Theophylline for Status Asthmaticus ,[object Object],[object Object],[object Object],[object Object]
Magnesium Sulfate ,[object Object],[object Object],[object Object],[object Object],[object Object]
Magnesium Sulfate ,[object Object],[object Object],[object Object],[object Object]
Helium + Oxygen = Heliox ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Heliox ,[object Object],[object Object],[object Object],[object Object],[object Object]
Heliox ,[object Object],[object Object],[object Object]
Heliox ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Heliox and Ventilation ,[object Object],[object Object],[object Object]
Volatile Agents ,[object Object],[object Object],[object Object],[object Object]
Extracorporeal Life Support ,[object Object],[object Object],[object Object]
Mechanical Ventilation ,[object Object],[object Object],[object Object]
Mechanical Ventilation ,[object Object],[object Object],[object Object]
Mechanical Ventilation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Controlled Ventilation ,[object Object],[object Object],[object Object]
Controlled Ventilation ,[object Object],[object Object]
Support Mode Ventilation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Support Ventilation ,[object Object],[object Object],[object Object]
Clinical PICU Practice ,[object Object],[object Object],[object Object],[object Object]
PICU Clinical Practice ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NonVentilation among “High” & “Low” Use Centers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ventilation among “High” & “Low” Use Centers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
High vs Low Ventilation Centers ,[object Object],[object Object]
Severity of Asthma Exacerbation
Management Mild-Moderate Asthma Exacerbation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management Moderate Asthma Exacerbation ,[object Object],[object Object],[object Object],[object Object]
Management of Severe Asthma Exacerbation ,[object Object],[object Object],[object Object],[object Object]
Near or Impending Respiratory Failure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
My Treatment for Severe Asthma ,[object Object],[object Object],[object Object],[object Object],[object Object]
My Treatment for Severe Asthma ,[object Object],[object Object],[object Object],[object Object],[object Object]
My Treatment for Severe Asthma ,[object Object],[object Object],[object Object],[object Object],[object Object]
My Treatment for Severe Asthma ,[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Asthma Patterns ,[object Object],[object Object],[object Object]

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Therapies For Severe Asthma

  • 1. Therapies for Severe Asthma Joan Roberts, M.D. Assistant Professor Pediatric Critical Care Medicine University of Washington
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