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Genomic Medicine and
Bioinformatics
Prof. Vajira H. W. Dissanayake
Director, Human Genetics Unit
Faculty of Medicine
University of Colombo
Where We Are Now
Income Group Lower-Middle-Income
Total Population 20.3 Million
Total Area 65,610 sqkm
Population Density 324 per sqkm
Life Expectancy At Birth 75 (71M, 78F)
Maternal Mortality Ratio 37.7 per 100,000 live births
Infant Mortality Rate 9 per 100,000 live births
Total Expenditure of Health as a % of GDP 3.8
Per Capita GDP (USD) 2,923
Sri Lanka’s Health Care provides – Good outcomes with low investment.
But this is because of investment in the past, to keep our health outcomes good in the
future, we need introduce technologies that will deal with problems of the future
Current Challenges
• Aging population
• Increase of Obesity, Non Communicable
Diseases [Diabetes, Hypertension, Ischaemic
Heart Disease, Stroke, Cancer]
• cKDU
Global Trends
Genome/Exome Sequencing
Bioinformatics and Electronic Health Records
Genetic Information linked with Clinical Information
Personalised Medicine
• Develop Genome Sequencing Facilities
- First facility already set up at the Human Genetic Unit [need to upscale
facilities]
• Develop a Database of Genetic Variants in the Sri Lankan
population to enable proper interpretation of
- Sri Lankan Genetic Variation Database already initiated by Human
Genetics Unit [need to expand the database]
• Train Scientists on Genome Sequencing
- A core team has been developed in the Human Genetics Unit
• Train Bioinformaticians on Genome Analysis
- A core team has been developed in the Human Genetics Unit
• Train Doctors to Use These Technologies in Clinical Practice
- Already initiated by the Human Genetics Unit – MSc Clinical Genetics
and CPD Programmes
What do we have to do to
prepare for this?
These efforts have to be scaled up with appropriate funding.

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Genomic medicine and Bioinformatics Prof Vajira Dissanayake

  • 1. Genomic Medicine and Bioinformatics Prof. Vajira H. W. Dissanayake Director, Human Genetics Unit Faculty of Medicine University of Colombo
  • 2. Where We Are Now Income Group Lower-Middle-Income Total Population 20.3 Million Total Area 65,610 sqkm Population Density 324 per sqkm Life Expectancy At Birth 75 (71M, 78F) Maternal Mortality Ratio 37.7 per 100,000 live births Infant Mortality Rate 9 per 100,000 live births Total Expenditure of Health as a % of GDP 3.8 Per Capita GDP (USD) 2,923 Sri Lanka’s Health Care provides – Good outcomes with low investment. But this is because of investment in the past, to keep our health outcomes good in the future, we need introduce technologies that will deal with problems of the future
  • 3. Current Challenges • Aging population • Increase of Obesity, Non Communicable Diseases [Diabetes, Hypertension, Ischaemic Heart Disease, Stroke, Cancer] • cKDU
  • 4. Global Trends Genome/Exome Sequencing Bioinformatics and Electronic Health Records Genetic Information linked with Clinical Information Personalised Medicine
  • 5. • Develop Genome Sequencing Facilities - First facility already set up at the Human Genetic Unit [need to upscale facilities] • Develop a Database of Genetic Variants in the Sri Lankan population to enable proper interpretation of - Sri Lankan Genetic Variation Database already initiated by Human Genetics Unit [need to expand the database] • Train Scientists on Genome Sequencing - A core team has been developed in the Human Genetics Unit • Train Bioinformaticians on Genome Analysis - A core team has been developed in the Human Genetics Unit • Train Doctors to Use These Technologies in Clinical Practice - Already initiated by the Human Genetics Unit – MSc Clinical Genetics and CPD Programmes What do we have to do to prepare for this? These efforts have to be scaled up with appropriate funding.