Angelosanto final-b

Bordetella pertussis http://www.hhmi.princeton.edu/sw/2002/psidelsk/Microlinks.htm Jill Angelosanto Bio 360

Outline ,[object Object],[object Object],[object Object],[object Object]

Bordetella pertussis Basics ,[object Object],[object Object],[object Object],[object Object],[object Object],http://microvet.arizona.edu/Courses/MIC420/lecture_notes/bordetella_pertussis/ gram_pertussis.html

Transmission ,[object Object],[object Object],http://www.ratbags.com/rsoles/history/2000/12december.htm http://www.universityscience.ie/imgs/scientists/whoopingcough.gif

Virulence Steele, R.W. Pertussis: Is Eradication Achievable. Pediatric Annals. Aug 2004. 33(8):525-534

Adhesions ,[object Object],[object Object],[object Object],http://www.rivm.nl/infectieziektenbulletin/bul1306/kinkhoest.jpg http://www.my-pharm.ac.jp/~yishibas/research/Pertussis1.jpg

Toxins ,[object Object],[object Object],[object Object],[object Object],[object Object],www.ibl.fr/u447/u447.htm

Pertussis Toxin ,[object Object],[object Object],gsbs.utmb.edu / microbook/ch031.htm www.med.sc.edu:85/ ghaffar/pertussis.jpg

Adenylate Cyclase Toxin ,[object Object],[object Object],[object Object],Babu et al., 2001

The bvg locus ,[object Object],[object Object],[object Object],Babu et al., 2001

Whooping Cough ,[object Object],[object Object],[object Object],paaap.org /immunize/ course/slide27.html

Clinical Features ,[object Object],[object Object],[object Object],[object Object],[object Object],http://www.cdc.gov/nip/publications/pertussis/chapter1.pdf

Pertussis Infection gsbs.utmb.edu / microbook/ch031.htm

Diagnosis ,[object Object],[object Object],[object Object],[object Object],http://medinfo.ufl.edu/year2/mmid/bms5300/images/d7053.jpg

Treatment ,[object Object],[object Object],[object Object],http://www.aboutthatbug.com/AboutThatBug/files/CCLIBRARYFILES/ FILENAME/0000000032/033_lg.jpg http://www.vet.purdue.edu/bms/courses/lcme510/chmrx/macrohd.htm

Pertussis Vaccine ,[object Object],[object Object],[object Object],http://www.nfid.org/publications/clinicalupdates/pediatric/pertussis.html http://www.tdh.state.tx.us/immunize/providers.htm

Increase in Pertussis cases ,[object Object],[object Object],[object Object],[object Object],[object Object],http://www.cdc.gov/nip/publications/pertussis/chapter1.pdf

Cases in 2003 http://www.pertussis.com/digest/index.html

Massachusetts Yih et al., 2000 Substantial increase in the number of cases in adolescents and adults since 1980’s

Netherlands ,[object Object],Mooi et al., 2001

Strain Variation ,[object Object],[object Object],[object Object],Mooi et al., 2001

Vaccine problems ,[object Object],[object Object],[object Object],[object Object],http://www.healthcareforhoosiers.com/Member/vaccineschedule.html

Conclusions ,[object Object],[object Object],[object Object]

References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Reference cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Angelosanto final-b

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