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April 8­9  2008 
       Hotel Radisson, Bogotá


Latin­American Expert Consensus on 
    Neuropathic Pain Management 

        Preliminary Agenda 
Preliminary Agenda (I) 
Latin­American Expert Consensus on Neuropathic Pain Management, 
Bogota, April 8th­9th of 2008 

  n  April 7th  Arrival of participants 
      n  20:00 “Get together” and welcome dinner at the Hotel Radisson 
  n  April 8th:  First Day consensus meeting (Salón Roble) 
      n  8:30 – 9:00    Welcome and Methodology 
                        Neuropathic Pain Management                 Dr. Eduardo Ibarra 

      n  9:00 –10:00   Neuropathic Pain Treatment in Europe      Dr. J.J. Hernandez 
           n  European Guidelines for Neuropathic Pain Treatment 
           n  Experience with Versatis (lidocaine patch) 

      n  10:00 – 10:15 Break 

      n  10:15 – 11:00  Neuropathic Pain Treatment in US    Dr. Leon­Casasola 
           n  Clinical experience in US 
           n  Experience with lidocaine patch 

      n  11:00 Moderated group work in different expert panels 
           n  Pain Assessment, Treatment recommendations, Monitoring 

      n  13:00 – 14:00  Lunch
Preliminary Agenda (II) 
Latin­American Expert Consensus on Neuropathic Pain Management, 
Bogota, April 8th­9th of 2008 


  n  Cont. April 8th: 
      n  14:00 ­ 16:00              Continuation of group work 
      n  16:00 ­ 18:00 (app.)    Presentations and discussion of first results of the 6 
                                    working groups in the working rooms using the pin walls 
      n  20:00                      Dinner (Restaurant Ochenta Sillas) 

  n  April 9th:   Second day consensus meeting 
       n  09:00 – 12:00             Continuation of group work and finalization of the 
                                    results into checklists 
       n  12:00 – 13.00             Bringing the results in a presentable format, suitable 
                                    for understanding and consensus finding 

       n  13:00 – 14:00              Lunch 
       n  14:00 ­  17:30             Report in plenum: results and discussion 
                                     Consensus findings in plenum 
       n  17:30 – 18:00              Closing remarks and farewell 
       n  20:00                      Dinner (Restaurant Harry & Sassón) 

  n  April 10th:   Departure or staying for the Colombian Pain Congress
Preliminary Agenda (III) 
Latin­American Expert Consensus on Neuropathic Pain Management, 
Bogota, April 8th­9th of 2008 


  n  Location of the Consensus Meeting: 
        Hotel Radisson Royal 
        Address: Calle 113 N° 7­65 
                  Bogotá, Colombia 
        Phone:    +57­16295009, +57­16578720
More detailed information 
on the working Group works
Target of the Meeting 


 n  Develop a set of recommendations for assessment and 
    treatment of neuropathic pain 
     n  For the routine situation at the GP practice 
     n  With checklists on the most important facts 
     n  Develop first draft of recommendations (algorithm) for 
        Latin America 
 n  Basis 
     n  Given NP diagnosis 
     n  Recently published clinical guidelines and studies 
 n  What we shall not do in the workshop 
    n  Revise clinical guidelines (this is a “homework” previous to the 
       meeting) 
    n  Assess differences in the different health care systems
Principal structure of the decision process 

         History 

       Examination 

      Investigation 

                       yes 
       Red Flags?             Exit point 
             no

        Therapy 
        decisions 




        Follow up 
Organisation of the Meeting 


 n  Overall sequence 
     n  Introduction 
     n  Work group Group works (in parallel) 
         n Topic 1: Pain Assessment 
         n Topic 2: Therapy recommendations 
         n Topic 3: Checklist for monitoring 
     n  Consensus
Principal structure and topics 

         History 

       Examination 

       Investigation               Topic 1: Pain assessment 
                        yes 
       Red Flags?               Exit point 
              no

         Therapy 
         decisions      Topic 2: Therapy recommendations 


        Follow up 
                           Topic 3: Checklist for monitoring 
Topics and Working groups 

             History                                  Working group A 
           Examination 
1                                                     Working group B 
           Investigation 

                            yes 
           Red Flags?                   Exit point    Working group C 
                  no 
                                   Drug treatment     Working group D 
             Therapy 
2            decisions 
                               Non­pharmacological    Working group E 
                                    treatment

            Follow up                                 Working group F 
3 
Meeting: Work group participants 


  WG            Theme               Participants 

  A     NP definition and 
        Clinical history 
  B     Examinations and 
        investigations 
  C     Red flags 

  D     Drug treatment 

  E     Non­pharmacological 
        treatment 
   F    Monitoring 
Flow of the group work (example history) 

    Literature, Guidelines 



   Knowledge and skills of 
          the WG 
     (3­4 participants) 



  Description (text) of history 
   What should be asked? 


         Appropriate?              Plenary audit   Consensus 


           Check list 
Meeting: Work group topics 


 n  Topic 1: Pain Assessment 
     n  Working groups A, B, C 
        n A= History 
        n B= Examinations and investigations 
        n C= Red flags 
 n  Topic 2 : Therapy recommendations 
     n  Working groups D, E 
        n D: Drug treatment 
        n E: Non­pharmacological treatment 
 n  Topic 3: Monitoring 
     n  Working group F
Topic 1: Pain Assessment 

 Working groups A, B, C 

       n Group A: History 
       n Group B: Examinations and investigations 
       n Group C: Red Flags
Group work 1: 
Pain Assessment 

 Objectives (for each group): 
   describe the information needed to objectify 
   neuropathic pain and red flags 
 n  History 
    n  What information is needed to know that there is probably 
       neuropathic pain 
 n  Examinations an investigations 
    n  Which examinations/investigations will confirm for neuropathic 
       pain? 
 n  Red flag procedures 
    n  Which red flags should the GP know? How to recognize a red flag? 
        n History 
        n Examinations 
        n Investigations
Elements of the assessment phase 
                                           C

                                           Red 
     Decision step      Information 
                                          flags 




A       History       What to ask for? 




     Examination      What to examine 

B 
     Investigation    What to invest? 
Topic 1:   Pain Assessment 

 n  Read the literature 
 n  List all the relevant information you can think of 
 n  Check the list on completeness 
 n  Check the list on appropriateness for the goal of the assessment 
    (reduction to the essential information) 
 n  Method: Brainstorming on the pin wall 
      n  the group members name elements of the list 
      n  one person is writing on the pin wall 
      n  one person in the group is checking in parallel 
         whether all nominations are written down 
 n  Do not !!! 
      n  criticize any nomination 
      n  discuss any item 
      n  look for any topic 
 n  After completion of the brainstorming 
      n  check your results on appropriateness 
      n  Make changes step by step 
      n  Finalize in a presentable check list format
Topic 2: Therapy recommendations 


    Working groups D, E 
       n Group D:  Drug treatment of neuropathic pain 
           Ø Peripheral focal and multi­focal 
           Ø Peripheral generalized 
           Ø CNS induced 
           Ø Mixed Pain Syndrome 

       n Group E:  Non pharmacological treatment of neuropathic pain 
           Ø Peripheral focal and multi­focal 
           Ø Peripheral generalized 
           Ø CNS induced 
           Ø Mixed Pain Syndrome (neuropathic + nociceptive)
Topic 2: Therapy recommendations 


 Objectives: 
   give your therapy recommendations for each type of 
   neuropathy in a priority list, with literature references 
 n  Therapy 
     n Drug 
     n Non pharmacological 
 n  Literature reference 
     n  Please name the supportive literature
Group work 2: 
Therapy recommendations  


          Type             Treatment recommendation    Literature 

                              n  Gabapentin 
   Peripheral focalized       n  Topical Lidocaine     Finnerup… 
   NP                         n  Pregabalin            Dworkin…. 
                              n  … 
Topic 2: Therapy recommendations 

 n    Fill the left column: 4 neuropathic pain types 
 n    Read the literature 
 n    Assign possible therapies to the NP type 
 n    Assign the literature 
 n    Brainstorm on recommendation/prioritizing 
       n  How effective? 
       n  How safe? 
       n  Nature and frequency of adverse events? 


 n  Method: Brainstorming on the pin wall 
     n  the group members name elements in the list 
     n  one person is writing on the pin wall 
     n  one person in the group is checking in parallel 
         whether all nominations are written down 
 n  Do not !!! 
     n  criticize any nomination 
     n  discuss any item 
     n  look for any topic 
 n  After completion of the brainstorming 
     n  check your results 
     n  Make changes step by step 
     n  Finalize in a presentable format
Group work 3: Monitoring 


 Objectives: 
   what information should be collected for monitoring the 
   patient? 
        n History 
        n Examinations 
        n Investigations 


    n  Report as check lists 
    n  Add literature references
Topic 3: Monitoring 

 n  Read the literature 
 n  Write down all the information you will use for monitoring 
      n  History 
      n  Examinations 
      n  Investigations 
 n  Brainstorm on appropriateness 
      n  What is really relevant to know? 
      n  Which validated patient questionnaire could be used? 
      n  Assign the supportive literature 


 n  Method: Brainstorming on the pin wall 
     n  the group members name elements in the list 
     n  one person is writing on the pin wall 
     n  one person in the group is checking in parallel 
         whether all nominations are written down 
 n  Do not !!! 
     n  criticize any nomination 
     n  discuss any item 
     n  look for any topic 
 n  After completion of the brainstorming 
     n  check your results 
     n  Make changes step by step 
     n  Finalize in a presentable format
General rules for working in a working group 

 n    Read the literature 
 n    First write down all the items relevant for your topic 
 n    Then brainstorm on appropriateness (what could be missed) 
 n    Check constantly on the goal of your task, to stay on track 
 n    “ Small is beautiful”  
 n    Decide on who should present the result 

 n  Method: Brainstorming on the pin wall 
     n  the group members name the topics for the list 
     n  one person is writing on the pin wall 
     n  one person in the group is checking in parallel 
        whether all nominations are written down 
 n  Do not !!! 
     n  criticize any nomination 
     n  discuss any item 
     n  look for any topic 
 n  After completion of the brainstorming 
     n  check your results again on completeness 
     n  Make changes item by item 
     n  Finalize your result in a computer­presentable format
Consensus 

 n  Present the result of the 6 working groups 
 n  Discuss the result for last comments 
 n  Ask for agreement: 
    n If agreement is >= 80% : consensus 
    n If agreement is < 80% : ask who disagrees, ask for 
      arguments, adapt if wanted the result and vote again; 
      proceed when consensus has been achieved 
 n  Follow  the procedure for the next work group 
    results

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Drdegiorgis

  • 1. April 8­9  2008  Hotel Radisson, Bogotá Latin­American Expert Consensus on  Neuropathic Pain Management  Preliminary Agenda 
  • 2. Preliminary Agenda (I)  Latin­American Expert Consensus on Neuropathic Pain Management,  Bogota, April 8th­9th of 2008  n  April 7th  Arrival of participants  n  20:00 “Get together” and welcome dinner at the Hotel Radisson  n  April 8th:  First Day consensus meeting (Salón Roble)  n  8:30 – 9:00    Welcome and Methodology  Neuropathic Pain Management  Dr. Eduardo Ibarra  n  9:00 –10:00   Neuropathic Pain Treatment in Europe      Dr. J.J. Hernandez  n  European Guidelines for Neuropathic Pain Treatment  n  Experience with Versatis (lidocaine patch)  n  10:00 – 10:15 Break  n  10:15 – 11:00  Neuropathic Pain Treatment in US    Dr. Leon­Casasola  n  Clinical experience in US  n  Experience with lidocaine patch  n  11:00 Moderated group work in different expert panels  n  Pain Assessment, Treatment recommendations, Monitoring  n  13:00 – 14:00  Lunch
  • 3. Preliminary Agenda (II)  Latin­American Expert Consensus on Neuropathic Pain Management,  Bogota, April 8th­9th of 2008  n  Cont. April 8th:  n  14:00 ­ 16:00              Continuation of group work  n  16:00 ­ 18:00 (app.)    Presentations and discussion of first results of the 6  working groups in the working rooms using the pin walls  n  20:00  Dinner (Restaurant Ochenta Sillas)  n  April 9th:   Second day consensus meeting  n  09:00 – 12:00             Continuation of group work and finalization of the  results into checklists  n  12:00 – 13.00             Bringing the results in a presentable format, suitable  for understanding and consensus finding  n  13:00 – 14:00  Lunch  n  14:00 ­  17:30             Report in plenum: results and discussion  Consensus findings in plenum  n  17:30 – 18:00  Closing remarks and farewell  n  20:00  Dinner (Restaurant Harry & Sassón)  n  April 10th:   Departure or staying for the Colombian Pain Congress
  • 4. Preliminary Agenda (III)  Latin­American Expert Consensus on Neuropathic Pain Management,  Bogota, April 8th­9th of 2008  n  Location of the Consensus Meeting:  Hotel Radisson Royal  Address: Calle 113 N° 7­65  Bogotá, Colombia  Phone:    +57­16295009, +57­16578720
  • 6. Target of the Meeting  n  Develop a set of recommendations for assessment and  treatment of neuropathic pain  n  For the routine situation at the GP practice  n  With checklists on the most important facts  n  Develop first draft of recommendations (algorithm) for  Latin America  n  Basis  n  Given NP diagnosis  n  Recently published clinical guidelines and studies  n  What we shall not do in the workshop  n  Revise clinical guidelines (this is a “homework” previous to the  meeting)  n  Assess differences in the different health care systems
  • 7. Principal structure of the decision process  History  Examination  Investigation  yes  Red Flags?  Exit point  no Therapy  decisions  Follow up 
  • 8. Organisation of the Meeting  n  Overall sequence  n  Introduction  n  Work group Group works (in parallel)  n Topic 1: Pain Assessment  n Topic 2: Therapy recommendations  n Topic 3: Checklist for monitoring  n  Consensus
  • 9. Principal structure and topics  History  Examination  Investigation  Topic 1: Pain assessment  yes  Red Flags?  Exit point  no Therapy  decisions  Topic 2: Therapy recommendations  Follow up  Topic 3: Checklist for monitoring 
  • 10. Topics and Working groups  History  Working group A  Examination  1  Working group B  Investigation  yes  Red Flags?  Exit point  Working group C  no  Drug treatment  Working group D  Therapy  2  decisions  Non­pharmacological  Working group E  treatment Follow up  Working group F  3 
  • 11. Meeting: Work group participants  WG Theme  Participants  A  NP definition and  Clinical history  B  Examinations and  investigations  C  Red flags  D  Drug treatment  E  Non­pharmacological  treatment  F  Monitoring 
  • 12. Flow of the group work (example history)  Literature, Guidelines  Knowledge and skills of  the WG  (3­4 participants)  Description (text) of history  What should be asked?  Appropriate?  Plenary audit Consensus  Check list 
  • 13. Meeting: Work group topics  n  Topic 1: Pain Assessment  n  Working groups A, B, C  n A= History  n B= Examinations and investigations  n C= Red flags  n  Topic 2 : Therapy recommendations  n  Working groups D, E  n D: Drug treatment  n E: Non­pharmacological treatment  n  Topic 3: Monitoring  n  Working group F
  • 14. Topic 1: Pain Assessment  Working groups A, B, C  n Group A: History  n Group B: Examinations and investigations  n Group C: Red Flags
  • 15. Group work 1:  Pain Assessment  Objectives (for each group):  describe the information needed to objectify  neuropathic pain and red flags  n  History  n  What information is needed to know that there is probably  neuropathic pain  n  Examinations an investigations  n  Which examinations/investigations will confirm for neuropathic  pain?  n  Red flag procedures  n  Which red flags should the GP know? How to recognize a red flag?  n History  n Examinations  n Investigations
  • 16. Elements of the assessment phase  C Red  Decision step  Information  flags  A  History  What to ask for?  Examination  What to examine  B  Investigation  What to invest? 
  • 17. Topic 1:   Pain Assessment  n  Read the literature  n  List all the relevant information you can think of  n  Check the list on completeness  n  Check the list on appropriateness for the goal of the assessment  (reduction to the essential information)  n  Method: Brainstorming on the pin wall  n  the group members name elements of the list  n  one person is writing on the pin wall  n  one person in the group is checking in parallel  whether all nominations are written down  n  Do not !!!  n  criticize any nomination  n  discuss any item  n  look for any topic  n  After completion of the brainstorming  n  check your results on appropriateness  n  Make changes step by step  n  Finalize in a presentable check list format
  • 18. Topic 2: Therapy recommendations  Working groups D, E  n Group D:  Drug treatment of neuropathic pain  Ø Peripheral focal and multi­focal  Ø Peripheral generalized  Ø CNS induced  Ø Mixed Pain Syndrome  n Group E:  Non pharmacological treatment of neuropathic pain  Ø Peripheral focal and multi­focal  Ø Peripheral generalized  Ø CNS induced  Ø Mixed Pain Syndrome (neuropathic + nociceptive)
  • 19. Topic 2: Therapy recommendations  Objectives:  give your therapy recommendations for each type of  neuropathy in a priority list, with literature references  n  Therapy  n Drug  n Non pharmacological  n  Literature reference  n  Please name the supportive literature
  • 20. Group work 2:  Therapy recommendations   Type Treatment recommendation  Literature  n  Gabapentin  Peripheral focalized  n  Topical Lidocaine  Finnerup…  NP  n  Pregabalin  Dworkin….  n  … 
  • 21. Topic 2: Therapy recommendations  n  Fill the left column: 4 neuropathic pain types  n  Read the literature  n  Assign possible therapies to the NP type  n  Assign the literature  n  Brainstorm on recommendation/prioritizing  n  How effective?  n  How safe?  n  Nature and frequency of adverse events?  n  Method: Brainstorming on the pin wall  n  the group members name elements in the list  n  one person is writing on the pin wall  n  one person in the group is checking in parallel  whether all nominations are written down  n  Do not !!!  n  criticize any nomination  n  discuss any item  n  look for any topic  n  After completion of the brainstorming  n  check your results  n  Make changes step by step  n  Finalize in a presentable format
  • 22. Group work 3: Monitoring  Objectives:  what information should be collected for monitoring the  patient?  n History  n Examinations  n Investigations  n  Report as check lists  n  Add literature references
  • 23. Topic 3: Monitoring  n  Read the literature  n  Write down all the information you will use for monitoring  n  History  n  Examinations  n  Investigations  n  Brainstorm on appropriateness  n  What is really relevant to know?  n  Which validated patient questionnaire could be used?  n  Assign the supportive literature  n  Method: Brainstorming on the pin wall  n  the group members name elements in the list  n  one person is writing on the pin wall  n  one person in the group is checking in parallel  whether all nominations are written down  n  Do not !!!  n  criticize any nomination  n  discuss any item  n  look for any topic  n  After completion of the brainstorming  n  check your results  n  Make changes step by step  n  Finalize in a presentable format
  • 24. General rules for working in a working group  n  Read the literature  n  First write down all the items relevant for your topic  n  Then brainstorm on appropriateness (what could be missed)  n  Check constantly on the goal of your task, to stay on track  n  “ Small is beautiful”   n  Decide on who should present the result  n  Method: Brainstorming on the pin wall  n  the group members name the topics for the list  n  one person is writing on the pin wall  n  one person in the group is checking in parallel  whether all nominations are written down  n  Do not !!!  n  criticize any nomination  n  discuss any item  n  look for any topic  n  After completion of the brainstorming  n  check your results again on completeness  n  Make changes item by item  n  Finalize your result in a computer­presentable format
  • 25. Consensus  n  Present the result of the 6 working groups  n  Discuss the result for last comments  n  Ask for agreement:  n If agreement is >= 80% : consensus  n If agreement is < 80% : ask who disagrees, ask for  arguments, adapt if wanted the result and vote again;  proceed when consensus has been achieved  n  Follow  the procedure for the next work group  results