This document provides recommendations for the prevention and treatment of HIV and other sexually transmitted infections among sex workers in low- and middle-income countries. It was published by the World Health Organization in December 2012 after reviewing evidence using the GRADE approach. The document includes good practice recommendations and specific technical recommendations regarding community empowerment, condom promotion, screening and treatment for sexually transmitted infections, voluntary counseling and testing for HIV, antiretroviral therapy, needle and syringe programs, and vaccination for hepatitis B. It also discusses operational considerations and identifies gaps in research that need to be addressed.