CHAMP Monthly Teleconference Training - PrEP's the Word: Everyone's Talking About It... But What Do We Need To Know, And Do, About Pre-Exposure Prophylaxis

1. Drug Therapy For Prevention? J. Jeff McConnell, Sociologist GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY UNIVERSITY OF CALIFORNIA, SAN FRANCISCO September 30, 2008

2. An excellent resource available at http://www.avac.org/prep08.pdf

4. Adults and Children Estimated to be Living with HIV, 2007

5. HSV-2 Suppressive therapy Management of genital infections (STIs) Cervical Barriers Male circumcision Chemoprophylaxis MTCTP PEP PrEP Vaccines Condoms HIV PREVENTION Microbicides Behavioral Counseling and Testing

7. Male circumcision (Not known to be helpful for men who have sex with men) Chemoprophylaxis MTCTP (PEP PrEP have unknown efficacy) Condoms HIV PREVENTION Behavioral Counseling and Testing (Intensive not better than standard)

18. Pre vs. Post-exposure prophylaxis 0h 36h 72h HIV 28 d 3 m 6 m

19. Pre vs. Post-exposure prophylaxis 0h 36h 72h HIV 28 d 3 m 6 m HIV infection

20. Pre vs. Post-exposure prophylaxis 0h 36h 72h HIV Post-exposure prophylaxis 28 d 3 m 6 m HIV infection

21. Pre vs. Post-exposure prophylaxis 0h 36h 72h HIV Pre -exposure prophylaxis 28 d 3 m 6 m HIV infection

23. Pre vs. Post-exposure prophylaxis 0h 36h 72h HIV 28 d 3 m 6 m HIV HIV Pre -exposure prophylaxis

29. The iPrEx Study: Safety, Efficacy, Behavior, and Biology Sponsored by NIH/NIAID/DAIDS with co-funding by the Bill and Melinda Gates Foundation and drug donated by Gilead Sciences

31. The iPrEx Study: Safety, Efficacy, Behavior, and Biology Gladstone Institute of Virology and Immunology

33. “ Let’s Communicate” From February 2004, the iPrEx study communicated with participants, activists, government, sponsors, physicians…

35. The PrEP Research Portfolio http://www.avac.org/prep08.pdf

36. Current PrEP Portfolio