1. Sandra Catalina Ramírez Palacio
Medicine student
III semester
Molecular biology

3. sciencedaily, january 14, 2014
Sciencedaily, January 15, 2014

4. INTRODUCTION
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•
for the replication of DNA, There are
different components that handle it a
suitable replication. there are even
enzymes dedicated to the repair of
DNA when there are errors or some
alteration during replication. But
despite all controls that have to
spend the DNA can be mutated or
modified and get small or big
diseases. Showing that the genome is
of great importance for human.
The replication is the process from
which a molecule of mother DNA is
synthesized a new, giving rise two
molecules of daughters DNA, it have
identical sequence to the mother
DNA. The replication occurs so
coordinated with cell division. In the
phase s of the cell cycle. The
replication of DNA is
semiconservative, this is a process
where a thread of progenitor DNA is
conserve in each of the molecules
daughters DNA.
•
The main enzyme In replication is
DNA polymerase, the cell eukaryotic
have three DNA polymerase (α,δ,ε).
these enzyme work in replication of
DNA nuclear , a polymerase γ is
locate in the mitochondria and it
work in the replication DNA
mitochondria and a final polymerase
β working in the bug fixes.

5. CELL DIVISION DISCOVERY COULD OFFER FRESH
INSIGHT INTO CANCER
sciencedaily, january 14, 2014
•
They discovered a set of proteins that
stabilise the sequence of events in
which cells duplicate their DNA and
then separate into two new cells,
each identical to the original. Flaws in
this delicate, complex operation can
lead to cancer.

6. CELL DIVISION DISCOVERY COULD OFFER FRESH INSIGHT INTO CANCER
sciencedaily, january 14, 2014
•
Researchers at the University of
Edinburgh found that a set of
proteins, known as the Ska complex,
help anchor DNA, the form of
chromosomes, by interacting with
strands of cell material.
Chromosomes remain attached to
these strands as they are separated,
in a process that helps distribute DNA
correctly to the newly formed cells

7. CELL DIVISION DISCOVERY COULD OFFER FRESH
INSIGHT INTO CANCER
sciencedaily, january 14, 2014
Scientists determined the structure of the relevant part
of the protein complex by analysing crystals of it with lab
tools and cell-based experiments. This showed how the
Ska complex attaches to the strands, helping to bind the
DNA material.

8. CELL DIVISION DISCOVERY COULD OFFER FRESH
INSIGHT INTO CANCER
sciencedaily, january 14, 2014
"Our findings represent a milestone in resolving the
mystery of how these key proteins enable new cells to
separate properly and equally, in this essential process
for life. The findings of our work have the potential to
create new avenues in drug discovery towards fighting
cancer."

9. PERONAL OPINION
I think that is very important know how
the world is evolving and have found
response to all diseases. Previously could
only be cured by death because the
medicine sometimes seems more
business and see that this is improving is
good. The medicine is to prevent and
cure diseases not is a form to acquire
money depending one diseases. Just
need to wait to be used in a new
therapeutic knowledge.
This shows one more time that all
disease is curable only don't have eyes
open and aware easily reach them.

10. INTERNATIONAL STUDY ALLOWS BETTER PREDICTION OF RISK OF HEREDITARY
CANCER.
•
•
Sciencedaily, January 15, 2014
All cancers are caused by
abnormalities in the genetic
material of cells , that make
them lose their function and
become malignant .
In 90 or 95 % of cases of
people with cancer are born
with genes functioning
properly until, by external
factors, for errors that may
occur during normal DNA
replication or by the passage
of time, the genetic material
, which had always worked
properly, breaks down. When
genes embrace alterations or
mutations, the cells do not
perform its function properly.

11. INTERNATIONAL STUDY ALLOWS BETTER PREDICTION OF RISK OF HEREDITARY
CANCER.
Sciencedaily, January 15, 2014
A small percentage of people are born with an error in
the genetic material that greatly increases the chances
of developing cancer. When this is the main cause for
the occurrence of the disease, we talk about hereditary
cancer or hereditary cancer predisposition. It is
estimated that only between 5 and 10% of all tumors are
hereditary
.

12. INTERNATIONAL STUDY ALLOWS BETTER PREDICTION OF RISK OF HEREDITARY
CANCER.
Sciencedaily, January 15, 2014
•
Lynch syndrome, also called
hereditary nonpolyposis colorectal
cancer polyposis (English HNPCC) is
an inherited disease that increases
the risk of various tumors , especially
colon and endometrial cancer , being
responsible for between 2 and 5 % of
cases .

13. INTERNATIONAL STUDY ALLOWS BETTER PREDICTION OF RISK OF HEREDITARY
CANCER.
Sciencedaily, January 15, 2014
•
The classification of a variant
responsible for Lynch syndrome is
critical for genetic counseling of
families, allowing predictive study of
families at risk and , if they are
carriers , help them take preventive
measures and adequate monitoring

14. PERSONAL OPINION

15. CELL DIVISION DISCOVERY COULD OFFER FRESH INSIGHT INTO
CANCER
The main importance
is that through this
research can be
corrected portions of
mutated DNA
can serve as a basis
for the creation of
different drugs
enabling the
treatment of cancer in
the correction of your
DNA, impeding that
the cells from dividing
with your mutated
DNA

16. can save many lives, because this is a very common pathology worldwide even in
Colombia.

17. INTERNATIONAL STUDY ALLOWS BETTER PREDICTION OF RISK OF
HEREDITARY CANCER.
see abnormalities related to
cancer in their chromosomes,
which come from the inheritance

18. INTERNATIONAL STUDY ALLOWS BETTER PREDICTION OF RISK
OF HEREDITARY CANCER

19. BIBLIOGRAPHY
•
Martínez S. Lina María. Biología molecular. 7ma edición Medellín: UPB. Fac. de
Medicina, 2012. 78-84.p
•
Bryony A Thompson, Amanda B Spurdle, John-Paul Plazzer, Marc S Greenblatt,
Kiwamu Akagi, Fahd Al-Mulla, Bharati Bapat, Inge Bernstein, Gabriel Capellá,
Johan T den Dunnen, Desiree du Sart, Aurelie Fabre, Michael P Farrell, Susan M
Farrington, Ian M Frayling, Thierry Frebourg, David E Goldgar, “International study
allows better prediction of risk of hereditary cancer.” ScienceDaily. (Online
magazine), 15 January 2014. Avaible online:
http://www.sciencedaily.com/releases/2014/01/140115100134.htm.
•
Maria Alba Abad, Bethan Medina, Anna Santamaria, Juan Zou, Carla Plasberg-Hill,
Arumugam Madhumalar, Uma Jayachandran, Patrick Marc Redli, Juri Rappsilber,
Erich A. Nigg, A. Arockia Jeyaprakash “cell division discovery could offer fresh
insight into cancer” ScienceDaily. (Online magazine), 14 January 2014. Availed
online: http://www.sciencedaily.com/releases/2014/01/140114103013.htm.

20. THANKS