La Dra. Silvia Valbuena López repasa las conclusiones más relevantes del registro presentado en ESC Congress 2019.

1. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
Eur Heart J. doi:10.1093/eurheartj/ehz660
CLARIFY - IN STABLE CORONARY DISEASE,
PATIENTS WITH ANGINA AND PRIOR
MYOCARDIAL INFARCTION HAVE A POOR
PROGNOSIS DESPITE ADHERENCE TO GUIDELINE
RECOMMENDED THERAPIES. FINAL 5-YEAR
RESULTS FROM THE CLARIFY STUDY

2. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS

3. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
AIMS
1.- To describe demographics, clinical characteristics, and
management of patients with chronic coronary syndromes
2.- To assess the rates and determinants of outcomes in patients
with chronic coronary syndromes

4. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
• Prospective longitudinal observational registry of patients with stable coronary disease
• N 32703 patients from 45 countries.
• Nov 2009-June 2010. Database lock 2016
• Yearly visit. Median follow-up 5 years
• Inclusion criteria
- Prior MI > 3 months
- Prior revascularization > 3 months
- Proven symptomatic myocardial ischaemia
- Angiographic coronary artery stenosis >50%
METHODS

5. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
BASELINE CHARACTERISTICS

6. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
BASELINE CHARACTERISTICS

7. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
PRIMARY AND SECONDARY OUTCOMES

8. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
PREDICTORS OF PRIMARY OUTCOME

9. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
5-YEAR INCIDENCE OF CV DEATH AND MI

10. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
LIMITACIONES
• 45 countries, but no USA. In Africa only South Africa
• Majority of patients with prior MI (≈ 60%)  post MI patients rather than chronic
coronary síndromes
• Only 22,% has angina (disease previously known as stable angina)
• Anginal symptoms only reported at baseline but 5-year follow-up

11. Silvia Valbuena LópezCLARIFY: FINAL 5-YEAR RESULTS
CONCLUSIONES
La incidencia de muerte CV e IAM fue de 1.7 por 100 paciente-año, menor que la
descrita en otros registros
La angina fue un parámetro pronóstico solamente entre los pacientes con IAM previo
Los pacientes con angina e IAM previo constituyen un grupo de riesgo aumentado que
requieren optimización máxima del tratamiento médico