1. Carlos Santos Pérez Dr. Eneida Díaz Pérez
University of Puerto Rico Dr. Elena González
Cayey Campus BIOL 3095
RISE PROGRAM
Outline of the Review Paper
I. Title
1. Mitochondrial Dysfunctional Activity and the relationship with Parkinson’s
disease(PD)
II. Abstract
1. This part will include the summary of all the review paper including the
introduction and the conclusions.
III. Introduction
1. This part will include the definitions of concept that are important to know to
understand this paper review. Also this introductory part will include the
definitions of PD, HD, AD.
IV. Body of Text
1. Mitochondrial Apoptosis Activity
2. Mitochondria, Ca2+ and neurodegenerative disease (an introduction)
3. Mitochondrial Dysfunctional Activity in PD patients
a. A
n overview in the relationship between PD cells and mitochondrial activity
b. D
ecrease in the activity of the Mitochondrial Complex I
c. E
lectron Transfer Chain and the effects in PD
d. T
he imbalance of the Redox in patients with PD
e. M
utations of the mitochondrial DNA and the effects in PD patients
f. O
xidative Stress
g. T
he Endoplasmic Reticulum and the production of Ca2+
i.The effects of this in the mitochondria
h. M
itochondrial polymorphisms: are related or not related with PD?
i. G
enetics in the mitochondria and the influence in PD patients
j. R
otenone models rats and the presentation of some studies to avoid the mitochondrial
dysfunctional activity.
V. Conclusions

2. 1. This part will include all of my scientific conclusions. This will be with an
objective observation and research.