This document provides an overview of Ian Quinn and John Mugan's presentation on partnerships from idea to reality at the TCD/UCD Innovation Alliance Lecture Series. It introduces Ian Quinn and John Mugan and their backgrounds. It then discusses Creganna-Tactx Medical, a world leader in minimally invasive medical devices, which was formed from the combination of Creganna and Tactx Medical in 2009 and has over 800 staff and $110M in revenue. It provides examples of their delivery and access devices for various medical applications and discusses their global operational reach and customers. It then describes Creganna-Tactx's design services group and two case studies of devices they developed. It closes by stating they develop

1. Partners from Idea to Reality The role of Innovation. Ian Quinn & John Mugan TCD/UCD Innovation Alliance Lecture Series Science Gallery, Dublin January 27 2010

2. Ian Quinn John Mugan John Mugan BSc. Polymer Engineer MSc. Mechanical Engineer QUB 1992 Project Manager Creganna Design Services john.mugan@creganna.com Ian Quinn Mechanical Engineer. UCD 1972. Post Graduate Diploma in Statistics. TCD. Founded Creganna. Was CEO until 2005. Now Chairman. (Non –Exec.) ian.quinn@creganna.com

4. Ranked in the Top 10 global providers of medical device outsourcing solutions

5. Creganna combined with Tactx Medical Inc. in 2009

6. 800+ staff. 2009 Revenue $110M

7. Global Manufacturing & Service Facilities

9. Global Operational Reach

10. Confidential – not for distribution Global Customers Serving large multinational companies to early stage development companies

11. 8 years ago. We were a contract manufacturer of components. We were becoming dominant in the supply of the shafts of angioplasty catheters.  75%+ of world demand. What next? We decided to become a Medical device Technology Company.

12. We decided that, if we were to design devices we would get: A knowledge of the leading edge. Sales and profit from design fees. Possible subsequent manufacturing contracts. We recruited one experienced Device Design Manager. 7 years ago.

13. Creganna – Tactx Design Services Group Sites : Galway (70) Marlborough Boston (20) Campbell CA (15) Skill sets include : ID, Design Eng, Manufacturing, Process, Quality, Regulatory, Validation & Production Engineers. Customers : Start ups Large companies (BSC, Medtronic, J&J, Cordis) Projects : Cardiology, Vascular, Neurology, Orthopedics, Endoscopy, Oncology, Urology, Pulmonary, Laparoscopy DFM, Device Commercialisation, Contract Manufacturing.

14. Case Study #1 Vertebroplasty Stenting device Stent implant filled with Bone cement Spinal Compression of the vertebra

15. to CAD Model From Concepts to Prototypes to Clinical Trials

16. Case Study #2 First In Man NOTES deviceNaturalOrificeTranluminalEndoscopicSurgery

18. Through the Scope puncture device

19. Over the Scope access device

20. Endoscope Flex Joint Stability Threads Decompression Zone

21. Product design and Innovation at Creganna-Tactx Medical We develop platform technologies. Our own IP. Incorporated into devices.

22. Innovations