This document discusses the need for interoperability between research infrastructures like NEON and LTAR to better understand the impacts of climate change on agro-ecosystems. It proposes a requirements-driven interoperability framework to integrate data from these organizations. This framework is based on defining science requirements and measurements, establishing common algorithms and protocols, ensuring traceability of measurements, and developing supporting informatics. The goal is to seamlessly integrate data to help address challenges around food security and sustainability under a changing climate.