This document summarizes a study that analyzed genetic variations in African and European cattle genomes using workflows built in the Taverna workflow system. Researchers sequenced the genome of an African Boran cow and identified 11.9 million genetic variants. The variants were mapped between assemblies, filtered to find those in protein-coding genes, and analyzed with PolyPhen to identify variants likely to affect proteins. The full analysis workflow was packaged in a virtual machine image for easy sharing. The workflow demonstrated new features of Taverna 2.2 for reproducible analysis of large genomic datasets.