Estuaries, long recognized for their local importance, form collectively an important global ecosystem, sensitive to both climate change and local pressures. This has been recognized by a 2013 U.S. workshop, which issued a set of recommendations directed at building worldwide capacity and collaborations to address estuaries as a global ecosystem. The workshop recognized that modern observation and modeling technology is poised to play a key role in advancing the scientific understanding of estuaries, and identified the need to map the resulting understanding of individual estuaries into a common global framework. An international partnership has since emerged, driven by the increasingly recognized need to advance estuarine observation, modeling, science and science translation worldwide. Anchoring the partnership is a belief that there are important commonalities across estuaries that, if explored, will prove synergistic and transformation towards understanding and sustainable management of all estuaries. On behalf of this emerging international partnership, we describe here steps that are being taken to develop Our Global Estuary. Integral to these efforts are: (a) the organization of regular international workshops, to build a common vision and global capacity and collaborative networks—the first of these workshops planned for Chennai, India; (b) the creation of a pilot project, Our Virtual Global Estuary, where a common modeling and analysis framework, supported by and supporting local observations, will be progressively put in place for estuaries across the world—with an initial set identified in Brazil, China, Portugal, Spain, and United States, and additional estuaries under consideration; and (b) exploration of synergies with global organizations (such as the Partnership for Ocean Global Observations) and global-scale programs and initiatives (such as Blue Planet), to further contextualize the role of estuaries in the earth’s sustainability.