Novel drug delivery system

Novel Drug Delivery System
Dr. Basavaraj Nanjwade M. Pharm., PhD
Asst. Vice President and Plant Head
KJD Pharmaceuticals Pvt Ltd
BIDAR-585402, Karnataka, India.
1Karnatak Registered Pharmacist Association (KRPA), Mysuru.31/07/2020

By Mode of NDDS
• Targeted Drug Delivery Systems
• Controlled Drug Delivery Systems
• Modulated Drug Delivery Systems

By Route of Administration
• Oral Drug Delivery Systems
• Pulmonary Drug Delivery
• Injectable Drug Delivery Systems
• Infusion Drug Delivery
• Ocular Drug Delivery
• Nasal Drug Delivery
• Topical Drug Deliver
• Implantable Drug Delivery
• Transmucosal Drug Delivery
• Transdermal Drug Delivery Systems
• Vaccines
• Biosimilars
• others

On the basis of carrier type, NDDS market is
segmented into
• Nanoparticles
• Liposomes
• Microspheres
• Monoclonal antibodies
• others
Karnatak Registered Pharmacist Association (KRPA), Mysuru. 431/07/2020

Scope of the NDDS
• The novel drug delivery system (NDDS) is
intended to increase the efficacy of drugs.
• NDDSs are adopted to increase the
bioavailability of the drug, to reduce adverse
effects and side effects, and increase drug
stability.

Targeted Drug Delivery Systems
• Targeted drug delivery, sometimes called
smart drug delivery, is a method of delivering
medication to a patient in a manner that
increases the concentration of the medication
in some parts of the body relative to others.

Karnatak Registered Pharmacist Association (KRPA), Mysuru. 8
31/07/2020

31/07/2020

Controlled Drug Delivery Systems
• It consists of a combination of an effective
active pharmaceutical ingredient and a
tailored controlled release (CR) rate.

Modulated Drug Delivery Systems
• In modulated drug delivery systems drug release
controlled by physical, chemical or biochemical
process or facilitated by the energy supplied
externally.
• In this system drug delivery achieved by based
different physic chemical properties like
magnetically, osmotically, enzymatic and
activation of vapour pressure, nanoparticles etc.

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Oral Drug Delivery Systems
• Oral Drug Delivery. Oral drug
delivery (ODD) is the most preferred and
convenient route of drug administration due
to high patient compliance, cost-effectiveness,
least sterility constraints, flexibility in the
design of dosage form and ease of production.

Oral Drug Delivery Systems
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Pulmonary Drug Delivery
• Pulmonary drug delivery is
the inhalation of drug formulation through
mouth and the further deposition of inhaled
pharmacological agent in lower airways is the
main purpose of this drug delivery route.

Pulmonary Drug Delivery
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Injectable/Parenteral Drug
Delivery Systems
• Parenteral drug delivery systems are the
preparations that are given other than oral
route. (Para-outside, enteric– intestine).
• The Parenteral administration route is the
most common and efficient for delivery of
active drug substances with poor bio-
availability and the drugs with a narrow
therapeutic index.

Injectable Drug Delivery Systems

Infusion Drug Delivery
• Pre-Filled Infusion Therapy: with this latest
technology, a unit dose can be metered to the
location from a pre-filled container.

Ocular Drug Delivery
• Delivery of drugs to the targeted ocular tissues
is restricted by various precorneal, dynamic
and static ocular barriers.

Nasal Drug Delivery
• Nasal administration is a route
of administration in which drugs are in
sufflated through the nose.
• It can be a form of either
topical administration or
systemic administration, as the drugs thus
locally delivered can go on to have either
purely local or systemic effects.

Nasal Drug Delivery
31/07/2020

Topical Drug Deliver
• Many topical medications are epicutaneous,
meaning that they are applied directly to the
skin.

Implantable Drug Delivery
• Implantable drug-delivery systems are being
developed to release drugs to the bloodstream
continuously as well as free patients from
being hospitalized to receive intravenous
infusions or frequent injections.
• Implantable devices are called upon to serve a
variety of functions.

Implantable Drug Delivery
31/07/2020

Transmucosal Drug Delivery
• Oral transmucosal drug delivery (OTDD)
may be defined as the administration of
pharmaceutically active agents through the
oral mucosa to achieve systemic effects.
• Transmucosal refers to the route of
administration in which the drug is diffused
through the mucous membrane.
• This can refer to inhalation, nasal, sublingual,
vaginal, rectal, or ocular routes.

Transmucosal Drug Delivery
31/07/2020

Transdermal Drug Delivery Systems
• Transdermal Drug Delivery System (TDDS)
are defined as self contained, discrete dosage
forms which are also known as
“patches” when patches are applied to the
intact skin, deliver the drug through the skin
at a controlled rate to the systemic circulation.

Transdermal Drug Delivery Systems
31/07/2020

Vaccines
• A vaccine is a biological preparation that
provides active acquired immunity to a
particular disease.
• A vaccine typically contains an agent that
resembles a disease-causing microorganism
and is often made from weakened or killed
forms of the microbe, its toxins, or one of its
surface proteins.

Vaccines
31/07/2020

Biosimilars
• A biosimilar is a biologic medical product
(also known as biologic) highly similar to
another already approved biological medicine
(the 'reference medicine').
• Biosimilars are approved according to the
same standards of pharmaceutical quality,
safety and efficacy that apply to all biological
medicines.

Biosimilars
31/07/2020

Nanoparticles
• Nanoparticle are particles between 1 and 100
nanometres in size with a surrounding
interfacial layer.
• The interfacial layer is an integral part of
nanoscale matter, fundamentally affecting all
of its properties.
• The interfacial layer typically consists of ions,
inorganic and organic molecules.

Nanoparticles
31/07/2020

Liposomes
• A liposome is a spherical vesicle having at
least one lipid bilayer.
• The liposome can be used as a vehicle for
administration of nutrients and pharmaceutical
drugs.
• Liposomes can be prepared by disrupting
biological membranes (such as by sonication).

Liposomes
31/07/2020

Microspheres
• Microspheres are small spherical particles,
with diameters in the micrometer range
(typically 1 μm to 1000 μm (1 mm)).
• Microspheres are sometimes referred to as
spherical microparticles.
• In general microspheres are solid or hollow
and do not have a fluid inside, as opposed to
microcapsules.

Microspheres
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Monoclonal antibodies
• Monoclonal antibodies (mAb or moAb)
are antibodies that are made by identical
immune cells that are all clones of a unique
parent cell.
• Monoclonal antibodies can have monovalent
affinity, in that they bind to the same epitope
(the part of an antigen that is recognized by
the antibody).

Monoclonal antibodies
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Pre-Formulation & Formulation Aspects
• Pre-Formulation & Formulation Aspects.
Pharmaceutics is the study of relationships
between preformulation,
pharmaceutical formulation, delivery,
disposition and clinical response.

Nanoparticulate Drug Delivery Systems
• The modern form of a drug delivery
system should minimize side-effects and
reduce both dosage and dosage frequency.

Smart Drug Delivery Systems
• Smart drug delivery system (SDDS) is a
recently emerging therapeutic approach, now
turning into a conventional model to
deliver drug to specific sites or target.
• Drug targeted (DT) delivery systems maintain
the concentration of the drugs at desirable
doses in the body and avoid the need for
repeated doses.

Smart Drug Delivery Systems
31/07/2020

Medical Devices for Drug Delivery
• Drug delivery devices are specialized tools
for the delivery of a drug or therapeutic agent
via a specific route of administration.
• Such devices are used as part of one or
more medical treatments.

Medical Devices for Drug Delivery
31/07/2020

2D & 3D Printing in Drug Delivery
• This allows controlling the properties of the
printed substances.
• It opens up new avenues for tailoring
physicochemical properties of organic
substances.
• With the FDA approval of the first 3D printed
tablet, Spritam®, there is now precedence set
for the utilization of 3D printing for the
preparation of drug delivery systems.

31/07/2020

• Fused deposition
• Modeling
• Inkjet powder bed printing
• Particle printing
• Personalized dosage forms
• Oro dispersible dosage forms
• Selective laser sintering
• Stereo lithography
• Computer-aided tissue engineering
• 3D plotting bio printing

Global Drug Delivery Policy
• In the developing world especially, approximately half
the population has no access to public health services.
• It is obvious then that other sources of care will be
used.
• However, the wide range, types and formulations of
over-the-counter (OTC) drugs available in these retail
outlets constitute a major health hazard.
• Yet, both users and proprietors of retail outlets know
little or nothing about the drugs and thus use or sell
them inappropriately.

Embolization of Particles
• The Contour PVA Embolization particles are
small and irregular flakes of polyvinyl alcohol,
which are used for permanent occlusion within
a blood vessel.
• The Contour PVA Embolization
Particles have been proven to be safe and
effective in many clinical scenarios for
decades.

Embolization of Particles
31/07/2020

Liquid Embolics
• The polymerization process that occurs when it
contacts blood results in an exothermic
reaction that causes vessel wall injury and
coagulative occlusion of the vessel.

Selective Internal Radiation Therapy
• Selective Internal Radiation Therapy (SIRT)
is a treatment for liver cancers or tumours that
delivers millions of tiny radioactive
microspheres or beads called SIR-Spheres®
directly to the liver tumours. ... SIR-Spheres®
are approved for the treatment of liver
tumours that cannot be removed by surgery.

Selective Internal Radiation Therapy
31/07/2020

Holmium-based Microspheres
• The radioactive HoPO4-MS that have a
high holmium content (52 wt%) are very
stable in human serum (holmium release less
than 0.1%).
• It is concluded that these HoPO4-MS are
attractive microspheres for application in the
SIRT technology for liver malignancies and for
intratumoral treatment of solid tumors.

Holmium-based Microspheres
31/07/2020

Nanoparticles
• Nanoparticle are particles between 1 and 100
nanometres in size with a surrounding
interfacial layer.
• The interfacial layer is an integral part of
nanoscale matter, fundamentally affecting all
of its properties.
• The interfacial layer typically consists of ions,
inorganic and organic molecules.

Nanoparticles Nanosuspension
31/07/2020

Global Market

Key Players
• Abbott Laboratories
• AstraZeneca PLC
• Bayer Healthcare Pharmaceuticals
• GlaxoSmithKline PLC
• Johnson & Johnson
• Merck & Co.
• Novartis AG
• Pfizer Inc.
• Roche
• Sanofi S.A.

THANK YOUe-mail: nanjwadebk@gmail.com
31/07/2020

Novel drug delivery system

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