how bioflux can contribute to solve the antibiotic crisis

1. Bio-Strike
Rüdiger Trojok
ITAS, University Kalrsruhe
Technikfolgenabschätzungsbüro
beim Bundestag
Opentechsummit, Berlin
14.05.2015

2. Souce: center for disease control
Tragedy of the Commons:
Antibiotics crisis

3. overuse of antibiotics
spread of
antibiotics in
environment
development of
resistant bacteria
by mutation
Antibiotic crisis

4. overuse of antibiotics
spread of
antibiotics in
environment
development of
resistant bacteria
by mutation
spread of resistance
genes by Horizontal
Gene Transfer
resistance genes
render antibiotics
useless
Antibiotic crisis

5. Antibiotics Crisis
Market failure
1990
– 18 companies,
– 10 new antibiotics
2011
– 4 companies,
– 2 new antibiotics

6. Antibiotics Crisis
Drug/BillionUSDollar

7. Solutions
• Reduce antibiotic consumption
– Regulation
– Management
– Education
• Research new antibiotics
• Find entirely new cures…
 Citizen Science Initiative Biostrike !

8. Scenario I
Decentralized RESEARCH Centralized
Biostrike

9. http://synthesis.cc/
9

10. Bio-Language AGTC

11. Scenario I
Scenario II
Decentralized RESEARCH Centralized
Biostrike

12. Prof. Blaney, Broad Institute http://www.youtube.com/watch?v=66Oc8fLKXlE
12
Moore‘s law for Biolabs

13. Digital biology
Nanopore
Sequencing
Microfluidics
SynthesisAnalog Biology
Digital Biology
AGTC

14. Phage Therapy
• Well known since 100 years
• Programmable
• Highly specific
• Safe

15. Wetware
Software
Hardware 0
Bio-Commons
License
Biostrike
Citizens / NGOs / Academics
§§
Personalized
Phages

17. Ampicillin
(blocks D-Alanin-Transpeptidase )
Bakteria
With cell wall
(grampositiv)
Plasmid
With Ampicillin
Resistannce gene
beta-lactamase
(destorys Ampicillin)
Ampicillin Resistenz