The Krebs cycle, also known as the citric acid cycle or tricarboxylic acid (TCA) cycle, is a series of chemical reactions in the mitochondria that produces energy through oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The cycle is made up of eight successive steps that begin with the addition of acetyl-CoA to oxaloacetate to form citrate and end with the regeneration of oxaloacetate. The cycle generates high-energy electron carriers NADH and FADH2 that fuel oxidative phosphorylation to produce ATP.

1. KREB’S CYCLE (TRICARBOXYLIC ACID (TCA)CYCLE/CITRIC ACID CYCLE) BIOCHEMISTRY LEC WEEK 3

8. The citric acid cycle enzymes are found in the matrix of the mitochondria

13. Kreb’s Cycle

14. 1. Citrate Synthase Reaction