1. Natural Product for Skin Care+ Increases Migration,
Proliferation And Survival of Skin Cells
The naturally occuring skin treatment active ingredient supplied by the Helix Aspersa Müller has
come a long way in the last 30 years since 1981 undergoing 3 generations of collection method.
http://biocutis.com/ is leading the pack with its newest and also greatest improvement in the
procurement of this precious immune secretion.
Existing research concentration of PHYSICIAN Tomic-Canic is molecular and also cellular
systems of cut treatment and also its inhibition with the long-lasting aim to deliver bench-side
analysis back to patients at the bedside. Her study includes human and diabetic types of
laceration recovery, wound genomics studies, generating key cells from patients' injury biopsies,
local sustained gene delivery, cellular assays of laceration recovery, as well as histology as well
as immunohistochemistry of skin.
The "how" of cell growth control. Each cell that is growing binds seemingly insignificant amounts
of positive regulatory proteins called growth factors that promote cell division. The naturally
occuring serum, made from glyco biomolecules, that powers all http://biocutis.com/ skin
treatment creams nourishes as well as revitalizes the cells of the skin, and also has actually
been the object of intense study by researchers as well as skin specialists enrolled by a few of
the most prominent dermatology services on the planet, holds potential as mediator elements in
injury treatment and also stem cell regenerative medicine. Below is an extract from a terrific post
on the matter: Human skin stem cells (epithelial stem cells) located at the basal layer of the
epidermis (the upper layer of the skin) and within the hair follicles replenish & maintain the
natural balance of cells within the epidermis layer of the skin. They also regenerate tissue
damaged from injury or excess solar exposure. To do their feat properly stem cells need to
communicate with each other and there must also be good communication between their
internal organelles. This is the function of glyco (sugar) molecules, and the recognition of their
role by the sweet science of glycobiology has led to think of them as messenger molecules that
are able to bridge communication between cells and within cells. "Glycans control the societal
interactions of cells," noted Michael Tiemeyer, University of Georgia professor of biochemistry
and molecular biology. "They control how cells interact with each other and how they interact
with their environment." What has slowly become clear to biochemists is that these sugars play
as vital a role in making the cell work as do the proteins. They combine to form giant molecules
such as carbohydrates and cellulose; they are already known to regulate hormones, organize
embryonic development, direct the movement of cells and proteins throughout the body, and
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2. regulate the immune system. As of 2012, we are aware of only L'Oréal Research recognizing
the importance of the latest discoveries in glycobiology. Yves Saint Laurent launched Forever
Youth Liberator, a new facial skincare which contains synthetic versions of 3 glycans to
"stimulate the skin's youth-promoting functions".
This is after 24 years of discoveries in this new field of biology and chemistry. So if you have
been with us since we launched the first generation of skincare products made with snail serum,
more than 13 years ago, you may understand that the naturally occurring serum that powers our
skin care products should be looked upon as a benchmark by the cosmetic industry. The topical
application of the serum collected from live snails nourishes the fibroblasts in the basal layer of
the skin and they preserve the vitality and youthful appearance of skin. This results in newer,
stronger & longer lasting skin cells, more resistant to UV exposure & all around healthier.
The serum is the main active ingredient in all our creams and we also offer a highly
concentrated "skin serum" for intense treatment of damaged skin, BIOSKINREVITALIZER,
made with the organic secretions of snails and with a hydrating Seaweed extract and Hyaluronic
Acid base, a pioneering & must-have addition on the journey to younger looking skin. Glyco
Molecules Support the Immune System Our IMMUNE SYSTEM is a complex biological
subsystem made up of molecules, proteins, cells, and organs that function together to recognize
and defend against disease producing bacteria, viruses, fungi, and cells that have undergone
malignant transformation.
The aging process decreases tissue function and our regenerative capacity. This is associated
with a decline in the number of adult or somatic stem cells and their ability to divide and repair
within multiple tissues. This process is called senescence. Senescence is the biological slowing
down of cellular division as dictated by stem cells & genetic instruction. It is a sort of biological
clock & a natural component of aging. Stem cells are the natural architects of reparation. Found
in all multicellular organisms, they can self-replicate and differentiate into diverse specialized
cell types in order to propagate the growth of an existing cell type.
The potential therapeutic application of stem cells to reduce the burden of aging and stimulate
tissue regeneration after trauma is very promising. Regenerative medicine products are
beginning to change medical practice today. Human tissue engineered skin and tissue
engineered cartilage were amongst the first to be used for the treatment of chronic wounds and
burns, and joint degeneration and injury, respectively. Other regenerative techniques are being
developed to repair bone, the cornea, the bladder and several other common medical
conditions. An innovative technology that isolates, purifies and multiplies a patient's own
fibroblast cells (a type of skin cell that makes collagen) for injection has been developed and
can be used for acne scarring and other therapeutic skin treatments.
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3. An artists impression of cell multiplication via http://alexanderandturner.com
Because the cells originate from the patient rather than a foreign source, the chance of an
allergic reaction is extremely small, and results in patients have been shown to last for as many
as seven years, without the recurring return treatments required by conventional fillers. (As with
every invention there are risks involved and the procedure is very new so all of them may not
have been detected, thus be sure you do your due diligence before recurring to that procedure).
Small fibroblast samples are taken from behind the patient's ear and sent to the Fibrocell
Science lab. Over a period of approximately 90 days, hundreds of millions of fibroblasts are
cultured and then frozen until needed for treatment. The recommended course of laVív
administration is a series of three treatments, typically three to six weeks apart. Additional
information about laVív, including complete Prescribing Information, is available on
www.mylaviv.com Fibroblast Growth Factors (FGFs) and Their Receptors (FGFRs) Are Major
Players In Tissue Repair Much research is currently ongoing to identify the factors and
molecular mediators of stem cell self-renewal to reach these goals.
Over the last two decades, fibroblast growth factors (FGFs) and their receptors (FGFRs) have
stood up as major players in both embryonic development and tissue repair. Moreover, many
studies point to somatic stem cells as major targets of FGF signaling in both tissue homeostasis
and repair. FGFs appear to promote self-renewing proliferation and inhibit cellular senescence
in nearly all tissues tested to date. Roles of FGF signaling in stem cell self-renewal, senescence
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4. and aging Daniel L.Coutu 1 & Jacques Galipeau 2 1-Stem Cell Dynamics Research Unit,
Helmholtz Zentrum München, 85764 Munich (Germany) 2-Departments of Hematology &
Medical Oncology, and Pediatrics, Emory University, Winship Cancer Institute, Atlanta 30322,
GA (USA) The process of aging is a systemic degenerative process caused by intrinsic (genetic,
epigenetic) and extrinsic (environmental) factors. It affects multiple organs, mainly those with a
high metabolic demand or those actively dividing and replicating their chromosomes and those
requiring constant or frequent regeneration. As such, aging is associated with a decrease in the
regenerative properties of many tissues including bone, skin, muscle, brain and more. Adult
stem cells constantly provide replacement cells for tissue homeostasis and repair while at the
same time maintaining a pool of stem cells by the process of self-renewal, where after cell
division takes place at least one daughter cell is still a stem cell whereas the other is either a
stem cell (symmetric division) or a differentiated progeny (asymmetric division).
The stem cell pool only regresses when a symmetric division giving rise to two differentiated
progeny occurs, or when the stem cell undergoes cellular senescence (these two processes not
being exclusive). In recent years, a number of studies have identified fibroblast growth factors
(FGFs) and their receptors (FGFRs) as key regulators of both senescence and self-renewal in a
variety of stem cell types. The Fibroblast growth factors (FGFs) comprise a large family of
growth and differentiation factors with essential functions in development, metabolism, and
repair of various tissues and organs. Dysregulation of FGF signaling is associated with a wide
variety of human diseases, including several developmental/genetic diseases, metabolic
disorders, and malignancies.
FGFs (23 known members) and FGFRs (5 known members, expressed as multiple splice
variants) have long been known for their important roles in embryonic development. However,
the vast number of somewhat redundant ligands and receptor variants, as well as the
promiscuous ligand usage by the receptors has made it difficult to study the roles of
FGFs-FGFRs using genetic methods. Furthermore, FGF signaling is modulated by tissue
specific heparan-sulfate proteoglycans (HSPGs) that either inhibit or amplify FGFR activation.
The divergent effects of FGF signaling also appear to depend on the state of differentiation of
the cells, the repertoire of FGFRs they express, and the presence of other growth factors or
cytokines.
Nevertheless, as further tools and reagents are developed, a more comprehensive image is
starting to emerge. Since FGF signaling is so potent at inducing stem cell self-renewal and
inhibiting their senescence, therapeutic targeting of FGF signaling components by recombinant
proteins, gene therapy or small molecules could well be used to reverse some of the effects of
aging. In fact, various FGFs are currently being tested therapeutically for a number of
age-related disorders such as cardiovascular diseases, diabetes, osteoarthritis, chronic kidney
disease, Parkinson's disease and mood disorders (reviewed in Beenken A, Mohammadi M: The
FGF family: biology, pathophysiology and therapy. Nature Reviews Drug discovery 2009,
8:235-53. Also see http://clinicaltrials.gov).
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5. Natural Product for Skin Care+ Increases Migration, Proliferation And Survival of Skin Cells
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