Measures of Central Tendency: Mean, Median and Mode
Presentation13 nanotech vela
1. SCBC- Bio-Link Conference
Emerging Technologies Panel
Nanotechnology
Opportunities
and
Challenges
Adriana Vela
NanoTecNexus
Founder & CEO
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2. Innovation
“There is nothing more difficult to
plan, more doubtful of success,
more dangerous to manage than
the creation of a new system”
– Machiavelli (1469-1527)
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3. Where does
Nanotechnology fit in the
innovation game?
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5. Nano Dreams….
A vision of what
could be possible
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6. Nanotechnology Definition
Nanotechnology is defined by the US
Government as involving:
1) research and development at the
atomic, molecular and sub-molecular
levels in the scale of 1-100 nm in scale
2) creating or using structures, devices
and systems with novel properties and
functions,
3) that are controlled or manipulated at
the atomic scale.
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7. But nanoengineering is much
more!
An Entirely New Toolbox Of Engineering Capabilities Has Been Opened Up For Us
To Explore, Invent With, Imagine With, And EDUCATE About.
8. Nanotechnology: potentially ubiquitous
Medicine Information Energy Materials Food, Water Instruments
and Technology Production Science and the
Health / Storage Environment
Drug delivery GMR Hard Hydrogen Lightweight Remediation Tunneling
Disk Fuel Cells and strong methods microscopy
• to serve citizens and satisfy their needs
• to support industrial competitiveness
• to exploit science and technology advances
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SOURCE: European Commission
9. Examples of
Nanotechnology
in Medicine
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10. Evolution of
Humankind & Disease
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13. Applications - Bioanalysis
High Throughput (HTP) screens, sensors & diagnostic platforms:
• Multiplexed assays in solution: dots, bars, beads
• Arrays by deposition: beads, particles, wires
• Nanopore transport (sequencing, ion channels)
• Microfluidics to nanofluidics
NanoInk
• Detection and separation: molecular tags (nanoink)
NanoSphere
H. Criaghead, Cornell
Nanoplex
Quantum Dot
Novel detection leads to enhanced sensitivity NanoSys
Higher throughput is nice, but multiplexed format is key
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14. Applications - Medical Devices
Medical imaging:
– Contrast agents
– Shielding agents
– Tissue-specific image
Retinal cortex
enhancement
Implantable sensors:
– Retinal processing BioPhan: MRI
compatible coatings
– Neural interconnects
– Stents with drug delivery
and active monitoring
Nanoscale Surgery:
– Tissue-directed light/heat
ablation
– Cell-specific gene therapy
Atherosclerotic Coronary Disease
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15. Applications - Therapeutics
Drugs & drug delivery platforms:
Drugs with enhanced bioavailability & specificity
– Improve drugs with poor solubility
– Traverse membranes, possibly blood-brain barrier
– Delivery of nanostructured silicon for bone structure APP’s Abraxane
Drug delivery systems
– Delivery via skin, lungs, GI tract
– Encapsulation for “stealth-mode” release
– Encapsulation for scavenging/removal
– Devices for long-term in vivo delivery
Tissue-specific payload deposition
– High local dose NanoMed
– Lower toxicity & side effects
Nanopore drug delivery
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17. Top 10 Therapeutic
Areas in Drug Development
R&D Directions Magazine (October 2009 issue) published its 9th annual
report profiles for the top 10 areas of research. These areas have the
greatest competition for investigator recruiting.
# ILS
# of Drugs
Investigators
Oncology 717 1125
CNS 323 1681
Infectious Disease 233 798
Cardio Vascular 182 1386
Diabetes 152 881
Respiratory 142 807
Pain/Inflammation 132 1234
GI 105 1099
Blood 86 834
Dermatology 68 502
Total 2,140 10,347
Source: Investigator Location Services
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19. Nanotechnology is an
Enabler of New Solutions for Cancer
Focus Areas:
• Molecular imaging and
early detection
• In vivo imaging
• Reporters of efficacy
• Multifunctional
therapeutics
• Prevention and control
• Research enablers
Early detection Imaging Therapy
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20. Nanotechnology is
changing the fight
against cancer
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21. What it takes to make it happen
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26. Mission
• To catalyze collaboration and knowledge
exchange in the nanotech field by connecting
people, technology, investment, and industry.
The goal is to promote safe
and market accepted
advances in
nanosciences
maximizing societal
benefits from new
product and applications
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27. NanoTecNexus Brings It All Together
Industry - Academia -
Innovative Leading-edge
Companies Research
•Industry Events
NTN •Grant Support
•Education Programs
•Consulting Services
•Partnership
•Collaboration
•Collaboration
•Outreach
Philanthropy -
Next Generation
Students
Business-Education Ecosystem
30. Educational Opportunities
A key challenge for nanotechnology
development is the education and training of
a new generation of skilled workers in the
multidisciplinary perspectives necessary
for rapid progress of the new technology
Source: Mihail C Roco, Senior Advisor for Nanotechnology at the
National Science Foundation
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31. Nanotech Job Projections
• It is estimated that about 2 million nanotechnology
workers will be needed worldwide by 2015.
• …an approximate distribution of nanotechnology
workers needed in various areas by 2015 would be:
0.8-0.9 million in the US, 0.5-0.6 million in Japan,
0.3-0.4 million in Europe, about 0.2 million in the
Asia-Pacific region excluding Japan and 0.1 million
in other regions.
• …nanotechnology has the potential to create 5
million additional related jobs overall by 2015 in the
global market.
Source: Mihail C Roco, Senior Advisor for Nanotechnology at the
National Science Foundation
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32. Talent Crisis Looming
for Global Companies
Unemployment remains high, yet
senior execs doubt they can find
enough talent to drive growth
and successfully pursue global
business strategies, according to
PwC’s annual survey of global
CEOs.
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38. "The question is not whether nanotechnology is
going to happen but when. … “
Thank You
Contact me:
adriana@nanotecnexus.org
858-774-8283
www.nanotecnexus.org
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