2. What is It??
 Any malignant tumor of the breast
 Almost all tumors of the breast are
carcinomas, therefore breast cancer usually applies to a
malignancy of the breast ducts or glands.
 Sarcomas are rare; angiosarcoma being the most
common, and arises from radiation therapy.

4. Are there different kinds??
 Ductal Carcinoma
 1.) Arises from epithelium lining the breast ducts
 2.) Accounts for 75-80% of breast cancers
 Lobular Carcinoma
 1.) Epithelium of smallest ducts or milk glands themselves
 2.) Accounts for 10-15% of breast cancers

5. Microscopic Types and Frequencies
of Breast Cancer
Histologic Type % of all Breast Cancers
Carcinoma in situ 15-30%
Ductal 80%
Lobular 20%
Invasive 70-85%
Ductal 80%
Lobular 10%
Other 10%

6. Is it Lobular Carcinoma?
 Difficult to diagnose by mammography
 Often seen at multiple sites in the affected breast
 Tend to see cancer in both of the breasts occur (still in
question).

7. What about Ductal Carcinoma??
 Most common cancer of the breast. Also the most
aggressive when its invasive.
 Less likely to see another cancer in the opposite breast
(theory still in question)
 Cause growth of a very dense, scar like tissue

8. Can men get Breast Cancer
 YES
 Gynecomastia describes male breast cancer
 Usually bilateral
 Caused by high levels of estrogen
 Account for 1% of all breast cancers

9. Risk Factors
 Women are at 100x more of a risk then men
 Lobular Carcinoma
 Family History (BRAC-1, BRAC-2)
 Age
 Estrogen
 Obesity, alcoholism, and cigarette smoking

10. Prognosis
 5 year survival can vary from 10% to 100%
Important Risk Factors
 Carcinoma in situ v. Invasive Carcinoma
 Lymph node metastasis
 Tumor size
 Invasion of skin or chest wall

11. Prognosis Continued…
Less important prognostic factors
 Histological type of carcinoma
 Histological grade of the carcinoma
 Rate of tumor cell division and aneupodiy
 Presence or absence of receptors on tumor cells

12. Treatments
 Bilateral mastectomy
 Simple mastectomy
 Lumpectomy
 Chemotherapy
 Radiation

13. Prevention
 Maintain a healthy body weight
(BMI less than 25) throughout your life
 Minimize or avoid alcohol.
 Consume as many fruits and vegetables
as possible.
 Exercise regularly the rest of your life
 Do your fats right!
 Do your carbs right!
 Consume whole food soy products
regularly
 Minimize exposure to pharmacologic
estrogens and xeno-estrogens
 Take your supplements daily

14. Citations
 American Cancer Society. 2011. Cancer Facts and Figures 2011. p. 4. NW, Atlanta, GA
 Mayo Foundation for Medical Education and Research, 11/30/2011, Ductal carcinoma in situ
(DCIS), http://www.bing.com/health/article/mayo-MADS00983/Ductal-carcinoma-in-situ-
DCIS?q=ductal+carcinoma
 McConnell,Thomas H., 2007.The Nature of Disease, p. 571-577. Lippincott Williams &
Wilkins, Baltimore , MD 21201.
 Webmd, 11/27/2011, Lobular Carcinoma (Invasive and In Situ), http://www.webmd.com/breast-
cancer/lobular-carcinoma-invasive-and-in-situ, 02/08/2010
 Weninger, Jessica, 12/01/2011, BSGI: The Best for Your Bust, http://imaging-radiation-
oncology.advanceweb.com/Student-and-New-Grad-Center/Student-Papers/BSGI-The-Best-
for-Your-Bust.aspx, 11/02/2010
 Womens Health, 12/05/2011, Dr. Ann's 10-Steps to Prevent Breast
Cancer, http://womenshealth.about.com/od/cancerprevention/a/10stepsprevbcan.htm, Octob
er 30, 2009

15.  Breast 232,620 2,140 230,480 39,970 450 39,520