This document provides information about endometriosis. It defines endometriosis as the presence of endometrial-like tissue outside the uterus, most often found in the ovaries and pelvis, which induces chronic inflammation. Some key points include:
- Endometriosis is most common in women of reproductive age.
- The exact etiology is unknown but theories include retrograde menstruation, coelomic metaplasia, lymphatic or hematogenous spread, and direct transplantation from tissue trauma or surgery.
- Risk factors include infertility, early menarche, shorter menstrual cycles, and nulliparity.
- Symptoms include pelvic pain, dysmenorrhea, dys
3. Endometriosis is a disease or better a syndromeEndometriosis is a disease or better a syndrome
that starts around the prepubertal age,that starts around the prepubertal age,
flourishing after menarche, with symptomsflourishing after menarche, with symptoms
progressing in intensity through the years.progressing in intensity through the years.
Predominantly found in women of reproductivePredominantly found in women of reproductive
ageage
Found in all the ethnic & social groupsFound in all the ethnic & social groups
4. DEFINITIONDEFINITION
EndometriosisEndometriosis (from(from endoendo, "inside", and, "inside", and metrametra, ", "wombwomb""
Presence of endometrial like tissue (glands/stroma)Presence of endometrial like tissue (glands/stroma)
outside the uterus which induces chronic inflammatoryoutside the uterus which induces chronic inflammatory
reaction.reaction.
Most frequent sites are pelvic viscera & peritoneum outMost frequent sites are pelvic viscera & peritoneum out
of which most common site is ovary (RCOG guidelineof which most common site is ovary (RCOG guideline
no. 24, 2006)no. 24, 2006)
Adenomyosis is ectopic endometrium inside theAdenomyosis is ectopic endometrium inside the
myometrium of uterus, previously known asmyometrium of uterus, previously known as
endometriosis interna.endometriosis interna.
5. INCIDENCEINCIDENCE
• Asymptomatic women undergoing tubal sterilizationAsymptomatic women undergoing tubal sterilization
i.e. women with proven fertility - 7%i.e. women with proven fertility - 7%
• Primary infertility (20-30%)Primary infertility (20-30%)
• Dysmenorrhoea (40-60%)Dysmenorrhoea (40-60%)
• Chronic pelvic pain(71-80%)Chronic pelvic pain(71-80%)
6. ETIOLOGYETIOLOGY
Exact etiology of endometriosis is unknown.Exact etiology of endometriosis is unknown.
Understanding of endometriosis is just a beginning.Understanding of endometriosis is just a beginning.
It is a estrogen dependent disease.It is a estrogen dependent disease.
8. • Most widely recognized & plausible theory on the genesisMost widely recognized & plausible theory on the genesis
of endometriosis.of endometriosis.
• Based on the assumption that endometriosis is causedBased on the assumption that endometriosis is caused
by the seeding or implantation of endometrial cell byby the seeding or implantation of endometrial cell by
trans tubal regurgitation during menstruation.trans tubal regurgitation during menstruation.
• Supported by – Blood can be found in peritoneal cavitySupported by – Blood can be found in peritoneal cavity
on laparoscopy during menstruation in 75-90%on laparoscopy during menstruation in 75-90%
- most often found in dependent portions- most often found in dependent portions
of the pelvis like ovaries, anterior & posterior cul-de-sac,of the pelvis like ovaries, anterior & posterior cul-de-sac,
the uterosacral ligaments, posterior uterus, posteriorthe uterosacral ligaments, posterior uterus, posterior
broad ligaments.broad ligaments.
More in women with stenosis of internal osMore in women with stenosis of internal os
Mullerian abnormalitiesMullerian abnormalities
9. 2.2. Coelomic Metaplasia/ MetaplasticCoelomic Metaplasia/ Metaplastic
Transformation/ Meyer’s theoryTransformation/ Meyer’s theory --
Both peritoneal and endometrial tissues share aBoth peritoneal and endometrial tissues share a
common embryologic precursor the coelomic cell.common embryologic precursor the coelomic cell.
Metaplastic transformation of coelomic epitheliumMetaplastic transformation of coelomic epithelium
into endometrial tissue can occur.into endometrial tissue can occur.
Premenarchal girl who have never menstruatedPremenarchal girl who have never menstruated
Unusual sites( Extremities, brain, pleura)Unusual sites( Extremities, brain, pleura)
10. 33. Lymphatic or Hematogenous Spread Distant to. Lymphatic or Hematogenous Spread Distant to
pelvis/ Hallban’s theory –pelvis/ Hallban’s theory –
Explain the observation of endometriosis in unusualExplain the observation of endometriosis in unusual
sites such as brain & pleurasites such as brain & pleura
Extra pelvic endometriosis - vascular or lymphaticExtra pelvic endometriosis - vascular or lymphatic
dissemination of endometrial cellsdissemination of endometrial cells
Ovarian endometriotic lesion may arise directly fromOvarian endometriotic lesion may arise directly from
ovarian surface epithelium through a metaplasticovarian surface epithelium through a metaplastic
differentiation process induced by activation of andifferentiation process induced by activation of an
oncogenic K-ras allele.oncogenic K-ras allele.
Ovarian endometriosis - retrograde menstruation orOvarian endometriosis - retrograde menstruation or
lymphatic flow from the uterus.lymphatic flow from the uterus.
11. 4.4. Direct Transplantation from Tissue Trauma orDirect Transplantation from Tissue Trauma or
SurgerySurgery
Explain the finding of localized endometriosisExplain the finding of localized endometriosis
cesarean-section scar or episiotomy sites.cesarean-section scar or episiotomy sites.
• Biologically distinct tissue may directly attach to aBiologically distinct tissue may directly attach to a
site accompanied by initiation of localized oncogenic-site accompanied by initiation of localized oncogenic-
like cascades leading to implant survival.like cascades leading to implant survival.
• Decreased immunosurveillance which wouldDecreased immunosurveillance which would
normally clear the ectopic tissue--may also be therenormally clear the ectopic tissue--may also be there
12. 5.5. Induction theory –Induction theory –
An endogenous undefined biochemical factorAn endogenous undefined biochemical factor
can induce undifferentiated peritoneal cells tocan induce undifferentiated peritoneal cells to
develop into endometrial tissue.develop into endometrial tissue.
6.6. Stem cell may be a sourceStem cell may be a source
7.7. Activation of mullerian cell restActivation of mullerian cell rest
13. Factor with increase risk of endometriosisFactor with increase risk of endometriosis
In fertilityIn fertility – when 3 groups of patients were compared i.e.– when 3 groups of patients were compared i.e.
• Asymptomatic patients under going an unrelated procedureAsymptomatic patients under going an unrelated procedure
• Symptomatic patientsSymptomatic patients
• In fertile patientsIn fertile patients
• Highest prevalence rate are typically found in infertile patientsHighest prevalence rate are typically found in infertile patients
ranging from 5-50%.ranging from 5-50%.
Red hair colourRed hair colour – Direct correlation– Direct correlation
Early age at menarcheEarly age at menarche
Shorter menstrual cycleShorter menstrual cycle
Hypermenorrhoea / menorrhagiaHypermenorrhoea / menorrhagia
NulliparityNulliparity
14. Mullerian anomalies – obstructive and non obstructive –Mullerian anomalies – obstructive and non obstructive –
higher incidence in patients with septate or arcuate uterushigher incidence in patients with septate or arcuate uterus
High social classHigh social class
One of multiple fetal gestationOne of multiple fetal gestation – Due to higher estrogen– Due to higher estrogen
exposureexposure
DES exposure in uteroDES exposure in utero – DES alter estrogen receptor– DES alter estrogen receptor
expression and immune system.expression and immune system.
Endometriosis in first degree relativeEndometriosis in first degree relative
16. Sites of EndometriosisSites of Endometriosis
Pelvis –Pelvis –
• OvariesOvaries
• Pouch of DouglasPouch of Douglas
• Uterosacral ligamentUterosacral ligament
• Broad ligament and round ligamentBroad ligament and round ligament
• Recto vaginal septumRecto vaginal septum
• Fallopian tubesFallopian tubes
• The back of the uterus and posterior cul-de-sacThe back of the uterus and posterior cul-de-sac
• The front of the uterus and the anterior cul-de-sacThe front of the uterus and the anterior cul-de-sac
• Pelvic and back wallPelvic and back wall
18. Extra genital / Extra pelvic –Extra genital / Extra pelvic –
• Most common sites of extra pelvic disease is gastro intestinal –Most common sites of extra pelvic disease is gastro intestinal –
rectosigmoid, appendix, small bowel, rectumrectosigmoid, appendix, small bowel, rectum
• Urinary tract – ratio of bladder : ureter : kidney is 40:5:1Urinary tract – ratio of bladder : ureter : kidney is 40:5:1
• Diaphragmatic or thoracicDiaphragmatic or thoracic
• LiverLiver
• The only site where extra genital endometriosis has not beenThe only site where extra genital endometriosis has not been
reported is spleenreported is spleen
Other rarer sites –Other rarer sites –
• Described in virtually every location that can be reached byDescribed in virtually every location that can be reached by
hematogenous, lymphatic or direct disseminationhematogenous, lymphatic or direct dissemination
• HepaticHepatic
• CutaneousCutaneous
• MusculoskeletalMusculoskeletal
• Nerve – commonly in sciatic nerveNerve – commonly in sciatic nerve
• Surgical scarsSurgical scars
• CervicalCervical
• BrainBrain
• EyesEyes
22. DIAGNOSIS OF ENDOMETRIOSISDIAGNOSIS OF ENDOMETRIOSIS
History Examination BBT
or
Benzamine sign
Investigation
Non invasive
Blood
investigations
or
Serum markers
Imaging
|
USG
MRI
TVS
TRUS
Invasive
Laparoscopy
+
Histology
Laparotomy
23. SYMPTOMATOLOGYSYMPTOMATOLOGY
Pelvic painPelvic pain
• Dysmenorrhea – Especially suggestive of endometriosisDysmenorrhea – Especially suggestive of endometriosis
if it occurs after years of pain free menstruation.if it occurs after years of pain free menstruation.
Start before onset of menstruation and continuesStart before onset of menstruation and continues
Usually bilateralUsually bilateral
• Deep dyspareuniaDeep dyspareunia
• Chronic pelvic painChronic pelvic pain
• Ovualtion painOvualtion pain
• Other types of pain – SciaticaOther types of pain – Sciatica
InfertilityInfertility
Symptoms of extra pelvic endometriosis- typically presentSymptoms of extra pelvic endometriosis- typically present
cyclicaly, correlated with menstruation so-calledcyclicaly, correlated with menstruation so-called catamenialcatamenial
symptomssymptoms which are considered pathognomonic. Later inwhich are considered pathognomonic. Later in
disease progression, symptoms become more continuous.disease progression, symptoms become more continuous.
26. EXAMINATIONEXAMINATION
INSPECTION:INSPECTION: Scar endometriosisScar endometriosis
PER SPECULUM EXAMINATION:PER SPECULUM EXAMINATION: Cervical endometriosisCervical endometriosis
BIMANUAL EXAMINATION:BIMANUAL EXAMINATION:
Focal tendernessFocal tenderness
Lateral cervical displacementLateral cervical displacement
Fixed retroverted uterusFixed retroverted uterus
Uterosacral / cul-de-sac nodularityUterosacral / cul-de-sac nodularity
Painful swelling of rectovaginal septumPainful swelling of rectovaginal septum
Unilateral cystic ovarian enlargementUnilateral cystic ovarian enlargement
↓↓ mobility of fallopian tubes / ovariesmobility of fallopian tubes / ovaries
““Deeply infiltrating nodules are most reliably detected whenDeeply infiltrating nodules are most reliably detected when
clinical examination is performed during menstruation”clinical examination is performed during menstruation”
(Evidence level III, RCOG Guideline No. 24, 2006).(Evidence level III, RCOG Guideline No. 24, 2006).
27. THE BENJAMIN SIGNTHE BENJAMIN SIGN::
When Basal BodyWhen Basal Body
Temperature (BBT) of anTemperature (BBT) of an
adolescent girl, with anadolescent girl, with an
endometriotic syndrome,endometriotic syndrome,
stays high during thestays high during the
menstrual flow or hasmenstrual flow or has upup
and downsand downs during theduring the
same and falls onlysame and falls only at theat the
end of it, we shouldend of it, we should
strongly suspectstrongly suspect
endometriosis and go forendometriosis and go for
a laparoscopy.a laparoscopy.
37,5
37,4
37,3
37,2
37,1
37
36.9
36,8
36,7
36,6
36,5
Menstruación
Atypical Benjamin
sign
28. Invasive procedures should not be used in adolescents withInvasive procedures should not be used in adolescents with
severe dysmenorrhea if their basal body temperature, thesevere dysmenorrhea if their basal body temperature, the
so called “so called “Benjamin signBenjamin sign”, has not been investigated.”, has not been investigated.
BBT is charted fromBBT is charted from
22 day of the cycle22 day of the cycle
to end of flow for atto end of flow for at
least 2cycle. Thereleast 2cycle. There
is a late decline ofis a late decline of
BBT after the onsetBBT after the onset
of menstruation inof menstruation in
34.5% of cases.34.5% of cases.
29. Markers for endometriosisMarkers for endometriosis No blood test is reliable for the diagnosis ofNo blood test is reliable for the diagnosis of
endometriosisendometriosis
Tumour markers and polypeptidesTumour markers and polypeptides
CA-125, CA-19-9CA-125, CA-19-9
Immunological markersImmunological markers
Cytokines: IL-6, TNFCytokines: IL-6, TNF
AutoantibodiesAutoantibodies
(1) Antiendometrial: Serum & Peritoneal fluid(1) Antiendometrial: Serum & Peritoneal fluid
(2) Autoantibodies to markers of oxidative stress(2) Autoantibodies to markers of oxidative stress
30. ULTRASONOGRAPHYULTRASONOGRAPHY
Limited utilityLimited utility
Lacks adequate resolution to identify superficialLacks adequate resolution to identify superficial
peritoneal implants,peritoneal implants, small (<2 cm) ovariansmall (<2 cm) ovarian
endometriomata and adhesionsendometriomata and adhesions
TVSTVS
Help in the diagnosis of endometriomas, bladder lesions,Help in the diagnosis of endometriomas, bladder lesions,
deep nodules e.g. on rectovaginal septumdeep nodules e.g. on rectovaginal septum
32. CT - ScanCT - Scan
• Endometriomas mayEndometriomas may
appear solid, cystic orappear solid, cystic or
mixedmixed
• Because of poorBecause of poor
specificity & highspecificity & high
radiation, CT has beenradiation, CT has been
replaced by MRIreplaced by MRI
33. MRIMRI
Use full in deep pelvic endometriosisUse full in deep pelvic endometriosis
Magnetic resonance imaging using fat saturation canMagnetic resonance imaging using fat saturation can
detect up to 50% of small, haemorrhagic lesionsdetect up to 50% of small, haemorrhagic lesions
measuring not more than 5 mm and allows thenmeasuring not more than 5 mm and allows then
diagnose of mild disease in 75% of cases.diagnose of mild disease in 75% of cases.
35. LAPAROSCOPYLAPAROSCOPY
For definitive diagnosis of endometriosis visualFor definitive diagnosis of endometriosis visual
inspection of the pelvis at laparoscopy is goldinspection of the pelvis at laparoscopy is gold
standard, unless disease is visible in vagina orstandard, unless disease is visible in vagina or
elsewhereelsewhere
Should not be performed during or within 3Should not be performed during or within 3
months of hormonal treatment to avoid undermonths of hormonal treatment to avoid under
diagnosisdiagnosis
36. Types of lesionTypes of lesion
Three primary types of endometriosis areThree primary types of endometriosis are
• Superficial peritoneal lesion,Superficial peritoneal lesion,
• Ovarian endometriomaOvarian endometrioma
• Deep infiltrating endometriosisDeep infiltrating endometriosis
37. Superficial peritoneal lesionSuperficial peritoneal lesion
Typically located on pelvic organ or pelvicTypically located on pelvic organ or pelvic
peritoneumperitoneum
Classical lesion are ‘Classical lesion are ‘powder burn or gun shotpowder burn or gun shot
lesionlesion.’ These are black, dark brown or bluish.’ These are black, dark brown or bluish
nodules or small cyst containing old hemorrhage.nodules or small cyst containing old hemorrhage.
May be associated with hemosiderin depositMay be associated with hemosiderin deposit
Non classical lesion are subtle lesions – RedNon classical lesion are subtle lesions – Red
implantsimplants
(Petechial/vasicular/polypoidal/hemorrhage/ red(Petechial/vasicular/polypoidal/hemorrhage/ red
flame like.flame like.
Serous or clear vesiclesSerous or clear vesicles
White plaquesScaringWhite plaquesScaring
Yellow-brown discoloration of the peritoneumYellow-brown discoloration of the peritoneum
Sub ovarian adhesionSub ovarian adhesion
39. Endometrioma (Chocolate cyst)Endometrioma (Chocolate cyst)
Usually located onUsually located on
anterior surface of theanterior surface of the
ovaryovary
Diameter <Diameter < 12cm12cm
Associated with retractionAssociated with retraction
pigmentation andpigmentation and
adhesion to posterioradhesion to posterior
peritoneumperitoneum
40. Endometrioma(Chocolate cyst)Endometrioma(Chocolate cyst)
Contain tarry,thickContain tarry,thick
chocolate coloured fluidchocolate coloured fluid
composed of hemosiderincomposed of hemosiderin
derived from previousderived from previous
intraovarian hemorrhageintraovarian hemorrhage
Marker of more extensiveMarker of more extensive
pelvic and intestinalpelvic and intestinal
diseasedisease
Histological conformationHistological conformation
is necessaryis necessary
41. CLASSIFICATIONCLASSIFICATION
Current classification is by “American society ofCurrent classification is by “American society of
Reproductive Medicine”Reproductive Medicine”, former “American, former “American
Fertility Society”(AFS) systemFertility Society”(AFS) system
Based on morphology, size and depth ofBased on morphology, size and depth of
peritoneal implantperitoneal implant
Morphology-Morphology-
Red ( Red, Red-pink & clear lesions)Red ( Red, Red-pink & clear lesions)
White (White, yellow-brown & peritoneal defects)White (White, yellow-brown & peritoneal defects)
Black (Black & blue lesions)Black (Black & blue lesions)
Presence extent and type of peritonealPresence extent and type of peritoneal
adhesionsadhesions
Degree of cul-de-sac obliterationDegree of cul-de-sac obliteration
42. Staging
– American society of Reproductive
Medicine, 1996
Stage I – Minimal
Isolated superficial implants,
No adhesions
Stage II – Mild
More superficial implants (<5cm),
No significant adhesions
43. Stage III – Moderate
Multiple superficial & invasive implants,
Peritubal & Periovarian adhesions may be
present
Stage IV – Severe
Multiple implants,
Ovarian endometriomas,
Many dense adhesions
44. TREATMENTTREATMENT
Must be individualizedMust be individualized
Highly dependent on the wishes of the patient -Highly dependent on the wishes of the patient -
fertility or contraceptionfertility or contraception
Symptom and severity of the diseaseSymptom and severity of the disease
Location of the diseaseLocation of the disease
45. MEDICAL TREATMENTMEDICAL TREATMENT
Four chief medical approaches-Four chief medical approaches-
1- Analgesia1- Analgesia
2- Suppresion of ovulatory function2- Suppresion of ovulatory function
3- Direct action of endometrial implant3- Direct action of endometrial implant
4- Modulation of immune system4- Modulation of immune system
46. Non Hormonal MedicationsNon Hormonal Medications
NSAIDs :NSAIDs : NaproxenNaproxen
• Mechanism:Mechanism: Local anti-nocioceptive effectLocal anti-nocioceptive effect
↓↓ central sensitizationcentral sensitization
Anti-inflammatory effectsAnti-inflammatory effects
• Side effects:Side effects: Gastric ulcerationsGastric ulcerations
Inhibition of ovulationInhibition of ovulation
““Inconclusive evidence regarding their effectivenessInconclusive evidence regarding their effectiveness
(especially Naproxen)”(especially Naproxen)” ((ESHRE, 2007 updateESHRE, 2007 update))
48. Table 1. Medical treatment options in women with symptomatic endometriosis who are not
seeking pregnancy.
First-line treatments
Peritoneal disease and endometriotic cysts 3 cm
Oestrogeneprogestin combinations used cyclically or continuously* (oral,
intravaginal or transdermic use)
Rectovaginal lesions-
Noretistherone acetate, 2.5 mg/day per os used continuously*
Second-line treatments
Depot GnRH analogues plus add-back therapy (e.g. tibolone 2.5 mg/day per os)
Alternative progestins (e.g. medroxyprogesterone acetate, desogestrel,
cyproterone acetate)
Third-line treatments
Low-dose danazol (e.g. 200 mg/day, oral or intravaginal use)
Gestrinone, 2.5 mg twice weekly per os
Specific conditions
Parous women with dysmenorrhoea as main symptom
Levonorgestrel-releasing intra-uterine device
Hysterectomized women with residual disease
Depot medroxyprogesterone acetate (150 mg intramuscularly every 3e6 months)
GnRH, gonadotrophin-releasing hormone.
* A 7-day interruption is suggested in case of breakthrough bleeding during
49. SURGICAL TREATMENTSURGICAL TREATMENT
GoalGoal
To excise all visible lesions and associated adhesionsTo excise all visible lesions and associated adhesions
To restore normal anatomyTo restore normal anatomy
Laparoscopy is betterLaparoscopy is better
Laparotomy – reserve forLaparotomy – reserve for
• Advanced stage diseaseAdvanced stage disease
• Who cannot go laparoscopyWho cannot go laparoscopy
• Fertility is not desiredFertility is not desired
52. LAPAROTOMYLAPAROTOMY
Total abdominal hysterectomy + bilateral salpingo-Total abdominal hysterectomy + bilateral salpingo-
oophrectomyoophrectomy
Hysterectomy alone is not effectiveHysterectomy alone is not effective
• Reserve for severe situationReserve for severe situation
• HRT is recommended in young women afterHRT is recommended in young women after
bilateral oophorectomy (bilateral oophorectomy (ROCG guideline 24, 2006).ROCG guideline 24, 2006).
• Estrogen should be withheld until 3 month afterEstrogen should be withheld until 3 month after
surgerysurgery
53. Empirical treatment of pain symptomsEmpirical treatment of pain symptoms
without a definitive Diagnosiswithout a definitive Diagnosis
CounsellingCounselling
Adequate analgesiaAdequate analgesia
Nutritional therapyNutritional therapy
ProgestagensProgestagens
Combined oral contraceptive (COC)Combined oral contraceptive (COC)
54. Treatment of endometriosis-associatedTreatment of endometriosis-associated
pain in confirmed diseasepain in confirmed disease
Non-steroidal anti-inflammatory drugsNon-steroidal anti-inflammatory drugs
Hormonal treatmentHormonal treatment
Surgical treatmentSurgical treatment