7. Public microarray data led to
• Novel receptor in type 2 diabetes
• Mouse knockout model
• Human serum companion diagnostic
• Prototype drug for type 2 diabetes
Integrating publicly-available data yielded CD44 as a new targetable receptor for
type 2 diabetes
10. Share successful, failed, and so-so data
• Rituximab in ANCA-Associated Vasculitis (RAVE) trial of new approach to
the induction of remission
• But even though rituximab was found to be non-inferior than
cyclophosphamide, which drug is the right one to use?
11. The five lessons I’ve learned in the past 18 years
• Be careful asking for standard procedures, or you will risk over-fitting
those standard models
• Make data and computational methods publicly available, no exceptions
for clinical or clinical trials data
• Wisdom of the crowd approach: trust what you see in common across
experiments
• Outsource the problematic parts to experts or companies
• Failed, successful, and so-so studies should all be shared