Shock
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3rd Year MBBS By Dr. Yasir Shabbir Gujranwala Medical College Gujranwala
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Shock
- 1. SHOCK By DR. YASIR SHABBIR Pathology DePartment
- 2. SHOCK • Impaired Tissue Perfusion • Hypoxia
- 3. TYPES • Cardiogenic • Hypovolemic • Shock Associated with Inflamation
- 5. HYPOVLEMIC • Inadequate Blood • Plasma Volume
- 6. SHOCK ASSOCIATED WITH INFLAMMATION • Bacteial • Fungal • Truma • Burns • Pancreratitis
- 7. PATHOGENESIS • Activation of Cytokine • Peripheral Vasodilation • Pooling of Blood • Endothelial Injury • Leukocyte Damage • DIC
- 8. PATHOGENESIS OF SEPTIC SHOCK
- 10. ENDOTHELIAL INJURY • NO • C3a • C5a • PAF
- 11. INDUCTION OF PROCOAGULANT STATE • TFPI • Thrombomodulin • Protein C • Thrombin
- 12. METABOLIC ABNORMALITIES • Glucagon • Growth Hormone • Gluco Corticoides • TNF • IL-I • Hyperglycemia • Bactericidal Activity • Lactic Acidosis Oxidative Phosphorylation
- 13. WATER HOUSE FRIDERCERISEN SYNDROME • DIC • Adrenal Necrosis
- 14. ORGAN DYSFUNCTION • Hypoxia • Edema • ARDS • Kidney • Liver • Lung • Heart
- 15. STAGES OF SHOCK • Non Progressive Stage • Progressive Stage • Irreversible Stage
- 16. NON PROGRESSIVE STAGE Reflex Mechanism • Vasoconstriction
- 17. PROGRESSIVE STAGE • Metabolic Imbalance • Lactic Acidosis
- 18. IRREVERSIBLE STAGE • Intracellular Damage • Tissue Injury
- 19. MARPHOLOGY • Adrenal • Caracal Cell Lipid Depletion • Kidney • ATN • Diffuse Alveolar Damage • DIC
- 20. CLINICAL CONSEQUENCES • Hypotension • Weak Rapid Pulse • Tachypnea • Cool Clammy Cyanotic Skin • Septic Shock • Warm and flush skin • Metabolic Acidosis