2. Lung Volumes and Capacities
PFT tracings have:
Four Lung volumes:
tidal volume, inspiratory
reserve volume,
expiratory reserve
volume, and residual
volume
Five capacities:,
inspiratory capacity,
expiratory capacity, vital
capacity, functional
residual capacity, and
total lung capacity
3. Lung Volumes
Tidal Volume (TV):
volume of air inhaled or
exhaled with each
breath during quiet
breathing (6-8 ml/kg)
Inspiratory Reserve
Volume (IRV):
maximum volume of air
inhaled from the end-
inspiratory tidal
position.(1900-3300ml)
Expiratory Reserve
Volume (ERV):
maximum volume of air
that can be exhaled
from resting end-
expiratory tidal
4. Lung Volumes
Residual Volume
(RV):
Volume of air
remaining in lungs
after maximium
exhalation (20-25
ml/kg) (1700-
2100ml)
Indirectly measured
(FRC-ERV)
It can not be
measured by
spirometry
5. Lung Capacities
Total Lung Capacity
(TLC): Sum of all volume
compartments or volume
of air in lungs after
maximum inspiration (4-6
L)
Vital Capacity (VC):
TLC minus RV or
maximum volume of air
exhaled from maximal
inspiratory level. (60-70
ml/kg) (3100-4800ml)
Inspiratory Capacity
(IC): Sum of IRV and TV
or the maximum volume
of air that can be inhaled
from the end-expiratory
tidal position. (2400-
3800ml).
Expiratory Capacity
(EC): TV+ ERV
6. Lung Capacities
Functional Residual
Capacity (FRC):
Sum of RV and ERV or
the volume of air in the
lungs at end-expiratory
tidal position.(30-35
ml/kg) (2300-3300ml).
It can not be measured
by spirometry)
7. VOLUMES, CAPACITIES AND
THEIR CLINICAL SIGNIFICANCE
1) TIDAL VOLUME (TV):
VOLUME OF AIR INHALED/EXHALED IN EACH BREATH
DURING QUIET RESPIRATION.
N – 6-8 ml/kg.
TV FALLS WITH DECREASE IN COMPLIANCE,
DECREASED VENTILATORY MUSCLE STRENGTH.
2) INSPIRATORY RESERVE VOLUME (IRV):
MAX. VOL. OF AIR WHICH CAN BE INSPIRED AFTER A
NORMAL TIDAL INSPIRATION i.e. FROM END
INSPIRATION PT.
N- 1900 ml- 3300 ml.
8. CONTINUED………
3) EXPIRATORY RESERVE VOLUME (ERV):
MAX. VOLUME OF AIR WHICH CAN BE EXPIRED
AFTER A NORMAL TIDAL EXPIRATION i.e. FROM
END EXPIRATION PT.
N- 700 ml – 1000 ml
4) INSPIRATORY CAPACITY (IC) :
MAX. VOL. OF AIR WHICH CAN BE INSPIRED
AFTER A NORMAL TIDAL EXPIRATION.
IC = IRV + TV
N-2400 ml – 3800 ml.
9. CONTINUED………..
4) VITAL CAPACITY:
MAX. VOL. OF AIR EXPIRED AFTER A MAX.
INSPIRATION .
MEASURED WITH VITALOGRAPH
VC= TV+ERV+IRV
N- 3.1-4.8L. OR 60-70 ml/kg
VC IS COSIDERED ABNORMAL IF ≤ 80% OF
PREDICTED VALUE
10. FACTORS INFLUENCING VC
PHYSIOLOGICAL :
physical dimensions- directly proportional to
ht.
SEX – more in males : large chest size, more
muscle power.
AGE – decreases with increasing age
STRENGTH OF RESPIRATORY MUSCLES
POSTURE – decreases in supine position
PREGNANCY- unchanged or increases by
10% ( increase in AP diameter In pregnancy)
15. VC CONTINUED…….
VC correlates with capability for deep
breathing and effective cough.
So in post operative period if VC falls below 3
times VC– artificial respiration is needed to
maintain airway clear of secretions.
16. CONTINUED…….
6) TOTAL LUNG CAPACITY :
Maximum volume of air attained in lungs after
maximal inspiration.
N- 4-6 l or 80-100 ml/kg
TLC= VC + RV
7) RESIDUAL VOLUME (RV):
Volume of air remaining in the lungs after
maximal expiration.
N- 1570 – 2100 ml OR 20 – 25 ml/kg.
17. CONTINUED……
8) FUNCTIONAL RESIDUAL CAPACITY
(FRC):
Volume of air remaining in the lungs at
passive end expiration.
N- 2.3 -3.3 L OR 30-35 ml/kg.
FRC = RV + ERV
Decreases under anaesthesia
with spontaneous Respiration – decreases by
20%
With paralysis – decreases by 16%
18. FACTORS AFFECTING FRC
FRC INCREASES WITH
Increased height
Erect position (30% more than in supine)
Decreased lung recoil (e.g. emphysema)
FRC DECREASES WITH
Obesity
Muscle paralysis (especially in supine)
Supine position
Restrictive lung disease (e.g. fibrosis, Pregnancy)
Anaesthesia
FRC does NOT change with age.
19. Pulmonary Function Tests
The term encompasses a wide variety of
objective tests to assess lung function
Provide objective and standardized
measurements for assessing the presence and
severity of respiratory dysfunction.
20. GOALS
To predict the presence of pulmonary
dysfunction
To know the functional nature of disease
(obstructive or restrictive. )
To assess the severity of disease
To assess the progression of disease
To assess the response to treatment
To identify patients at increased risk of
morbidity and mortality, undergoing pulmonary
resection.
21. To wean patient from ventilator in icu.
Medicolegal- to assess lung impairment as a
result of occupational hazard.
Epidemiological surveys- to assess the
hazards to document incidence of disease
To identify patients at perioperative risk of
pulmonary complications
CONTINUED……..
22. INDICATIONS OF PFT IN PAC
GUIDELINES FOR PREOPERATIVE
SPIROMETRY
Age > 70 yrs.
Morbid obesity
Thoracic surgery
Upper abdominal surgery
Smoking history and cough
Any pulomonary disease
23. INDICATIONS FOR
PREOPERATIVE SPIROMETRY
ACP GUIDELINES FOR PREOPERATIVE
SPIROMETRY
Lung resection
H/o smoking, dyspnoea
Cardiac surgery
Upper abdominal surgery
Lower abdominal surgery
Uncharacterized pulmonary disease(defined as
history of pulmonary Disease or symptoms and no
PFT in last 60 days)
24. CONTRAINDICATIONS FOR PFT
1.Myocardial infarction within a month
2.Unstable angina
3.Recent thoraco abdominal surgery
4.Recent ophthalmic surgery
5.Thoracic or abdominal aneurysm
6.Pnemothorax
25. BED SIDE PFT
1) Sabrasez breath holding test:
• Ask the patient to take a full but not too deep breath & hold it as long
as possible.
>25 SEC.-NORMAL Cardiopulmonary Reserve (CPR)
15-25 SEC- LIMITED CPR
<15 SEC- VERY POOR CPR (Contraindication for elective
surgery)
25- 30 SEC - 3500 ml VC
20 – 25 SEC - 3000 ml VC
15 - 20 SEC - 2500 ml VC
10 - 15 SEC - 2000 ml VC
5 - 10 SEC - 1500 ml VC
26. BED SIDE PFT
2) Single breath count:
After deep breath, hold it and start counting till
the next breath.
N- 30-40 COUNT
Indicates vital capacity
27. BED SIDE PFT
3) SCHNEIDER’S MATCH BLOWING TEST:
MEASURES Maximum Breathing Capacity.
Ask to blow a match stick from a distance of 6”
(15 cms) with-
Mouth wide open
Chin rested/supported
No purse lipping
No head movement
No air movement in the room
Mouth and match at the same level
28. BED SIDE PFT
Can not blow out a match
MBC < 60 L/min
FEV1 < 1.6L
Able to blow out a match
MBC > 60 L/min
FEV1 > 1.6L
MODIFIED MATCH TEST:
DISTANCE MBC
9” >150 L/MIN.
6” >60 L/MIN.
3” > 40 L/MIN.
29. BED SIDE TEST
4) COUGH TEST: DEEP BREATH F/BY
COUGH
ABILITY TO COUGH
STRENGTH
EFFECTIVENESS
INADEQUATE COUGH IF: FVC<20 ML/KG
FEV1 < 15 ML/KG
PEFR < 200 L/MIN.
VC ~ 3 TIMES TV FOR EFFECTIVE COUGH.
A wet productive cough / self propagated
paraoxysms of coughing – patient susceptible
for pulmonary Complication.
30. Tracheal auscultation/ Forced
expiratory time
After deep breath, exhale maximally and
forcefully & keep stethoscope over trachea &
listen.
N FET – 3-5 SECS.
OBS.LUNG DIS. - > 6 SEC
RES. LUNG DIS.- < 3 SEC
31. DEBONO WHISTLE
BLOWING TEST
MEASURES PEFR.
Patient blows down a wide bore tube at the
end of which is a whistle, on the side is a hole
with adjustable knob.
As subject blows → whistle blows, leak hole
is gradually increased till the intensity of
whistle disappears.
At the last position at which the whistle can
be blown , the PEFR can be read off the scale.
32.
33. PEFR(peak expiratory flow rate)
Simple and cheap test.
Patient ask to take full inspiration to TLC and
then blow out forcefully into peak flow meter.
Lips must be placed tightly around the
mouthpiece.
Best three test is recorded.
Not a good measure of airflow limitation.
Best used to monitor progression of disease
and Rx.
Coughing is ineffective if peak flow is
34. SPIROMETRY
SPIROMETRY : CORNERSTONE OF ALL
PFTs.
John hutchinson – invented spirometer.
“Spirometry is a medical test that measures
the volume of air an individual inhales or
exhales as a function of time.”
Measures VC, FVC, FEV1, PEFR.
CAN’T MEASURE – FRC, RV, TLC.
35. PREPERATION
Prior explanation to the patient
Not to smoke /inhale bronchodilators 6 hrs
prior or oral bronchodilators 12hrs prior.
Remove any tight clothings/ waist belt/
dentures
Pt. Seated comfortably
If obese, child < 12 yrs- standing
36. Nose clip to close nostrils.
Exp. Effort shld last ≥ 4 secs.
Should not be interfered by coughing, glottic
closure, mechanical obstruction.
3 acceptable tracings taken & largest value is
used.
39. Measurements Obtained from the
FVC Curve
FEV1---the volume exhaled during the first
second of the FVC maneuver
FEF 25-75%---the mean expiratory flow
during the middle half of the FVC maneuver;
reflects flow through the small (<2 mm in
diameter) airways
FEV1/FVC---the ratio of FEV1 to FVC X 100
(expressed as a percent); an important value
because a reduction of this ratio from
expected values is specific for obstructive
rather than restrictive diseases
40. Spirometry Interpretation:
Obstructive vs. Restrictive Defect
Obstructive Disorders
Characterized by a
limitation of expiratory
airflow so that airways
cannot empty as rapidly
compared to normal (such
as through narrowed
airways from
bronchospasm,
inflammation, etc.)
Examples:
Asthma
Emphysema
Cystic Fibrosis
Restrictive Disorders
Characterized by reduced
lung volumes/decreased
lung compliance
Examples:
Interstitial Fibrosis
Scoliosis
Obesity
Lung Resection
Neuromuscular diseases
Cystic Fibrosis
42. Spirometry Interpretation
FVC
Interpretation of %
predicted:
80-120% Normal
70-79% Mild reduction
50%-69% Moderate
reduction
<50% Severe reduction
FEV1
Interpretation of %
predicted:
>75% Normal
60%-75% Mild obstruction
50-59% Moderate
obstruction
<49% Severe obstruction
<25 y.o. add 5% and >60
y.o. subtract 5
43. Spirometry Interpretation
FEF 25-75%
Interpretation of %
predicted:
>79% Normal
60-79%Mild
obstruction
40-59%Moderate
obstruction
<40% Severe
obstruction
FEV1/FVC
Interpretation of
absolute value:
80 or higher
Normal
79 or lower
Abnormal
44. FLOW VOLUME LOOPS
Measured in respiratory function department.
Peak flow at different lung vol are recorded.
Although more complex to interpret, provide
more accurate regarding ventilatory function.
Provide useful data abt severity of obstructive
& respiratory disease.
47. Methacholine challenge test
Also known as bronchial challenge test.
Primarily used to diagnose bronchial hyper-
reactivity.
Methacholine is an agent that, when inhaled,
causes the airways to spasm and narrow if
asthma is present.
During this test, patient inhale increasing
amounts of methacholine aerosol mist before
and after spirometry.
48. CONTD….
Considered positive, meaning asthma is
present, if the lung function drops by at least
20%.
A bronchodilator is always given at the end of
the test to reverse the effects of the
methacholine.
Therapeutic uses are limited by its adverse
cardiovascular effects, such as bradycardia
and hypotension.
49. SINGLE BREATH TEST USING
CO
Pt inspires a dilute mixture of CO and hold the
breath for 10 secs.
CO taken up is determined by infrared
analysis:
DlCO = CO ml/min/mmhg
PACO – PcCO
N range 17- 25 ml/min./mmhg.
DLO2 = DLCO x 1.23
51. CONTINUED………..
2) HELIUM DILUTION METHOD:
Patient breathes in and out of a spirometer filled with 10%
helium and 90% o2, till conc. In spirometer and lung becomes
same (equilibirium).
As no helium is lost; (as he is insoluble in blood)
C1 X V1 = C2 ( V1 + V2)
V2 = V1 ( C1 – C2)
C2
V1= VOL. OF SPIROMETER
V2= FRC
C1= Conc.of He in the spirometer before equilibrium
C2 = Conc, of He in the spirometer after equilibrium
53. CONTINUED…….
1) STAIR CLIMBING TEST:
If able to climb 3 flights of stairs without stopping/dypnoea at his/her
own pace- ↓ed morbidity & mortality
If not able to climb 2 flights – high risk
2) 6 MINUTE WALK TEST:
- Gold standard
- C.P. reserve is measured by estimating max. O2 uptake during
exercise
- Modified if pt. can’t walk – bicycle exercises
- If pt. is able to walk for >2000 feet during 6 min pd,
- VO2 max > 15 ml/kg/min
- If 1080 feet in 1 min : VO2 of 12ml/kg/min
- Simultaneously oximetry is done & if Spo2 falls >4%- high risk
Ic decresed in the presence of extrathoracic airway obstuction
Cough test has its impotance in recovery period
The whistle shows when the rate of airflow through the whistle exceeds a certain value
ReceNt research suggests that FEF25-75% or FEF25-50% may be a more sensitive parameter than FEV1 in the detection of obstructive small airway disease. A Tiffeneau index (FEV1/FVC x 100)
A normal Flow-Volume loop begins on the X-axis (Volume axis): at the start of the test both flow and volume are equal to zero. After the starting point the curve rapidly mounts to a peak: Peak (Expiratory) Flow. After the PEF the curve descends (=the flow diminishes) as more air is expired. A normal, non-pathological F/V loop will descend in a straight or a convex line from top (PEF) to bottom (FVC).
Helpful in evaluation of air flow limitation on inspiration and expiration Fixed obstruction: constant airflow limitation on inspiration and expiration—such as in tumor, tracheal stenosis Variable extrathoracic obstruction: limitation of inspiratory flow, flattened inspiratory loop—such as in vocal cord dysfunction
Measure the diffusion of co into the lungs, using single breath of gas containg 0.3% co and 10% helium held for 20 sec. r