1. 13-4 Applications of
genetic engineering
Goal: modify cells to correct a defect
or produce a desired product.

2. 13-4 applications of genetic
engineering
• Transgenic engineering:
• Transgenic bacterium
• Transgenic animals: mice,
transgenic livestock
• Transgenic plants: with natural
insecticide, producing human
antibodies

3. • Eg: transgenic plants
produce natural pesticide
to resist to pest

4. Transgenic plants
• Genetically modified (GM) food

5. Engineered Plants
（转基因植物）
• Cotton plants that display
resistance to herbicide

6. Engineered Plants
（转基因植物）
• Tobacco plants that produce
human proteins

7. Engineered Plants
（转基因植物）
• Mustard plant ( 芥菜 ) cells that
produce biodegradable plastic

8. Engineered Mammals
（转基因动物）
Hi~~~ I’m ANDi,
the world’s first
genetically
modified non-
human primate

9. A monkey named
ANDi, for "inserted
DNA", in a picture
released in January
2001. ANDi was born
in October 2000 at the
Oregon Health
Science University
after receiving an
extra bit of genetic
material to become
the world's first
genetically modified
non-human primate

10. Cloning Dolly
• Sheep A: donate body cell nucleus
• Sheep B: donate an egg cell without nucleus
• Sheep C: surrogate mother
A B C Dolly
Who’s its
mother?

11. Cloning Dolly
1997 - A sheep cloned from an adult
cell
• Nucleus from body cell was inserted
into an empty egg
• Embryo implanted into surrogate
mother
• Sheep is genetic replica of animal
from which body cell was taken

12. Ethical Issues
• Who decides what should be
“corrected” through genetic
engineering?
• Should animals be modified to provide
organs for human transplants?
• Should humans be cloned?