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Processing Human Data – from the
Art of Medicine to the Science of Health

               Anette Asher
               October 2011
Art of Medicine to the Science of Health
            The Art of Medicine and Today’s Vision

            The Tipping Point … and it’s getting personal

            The Issues: Trusted Information and More Useful Information
            Moves us to the Sciences of Health

            The Pace of Health Information to Sciences of Health

            The Future That Will Get Us To Meaningful Use–
            Computational Individual Predictive Modeling

            The Optimal Outcome is Meaningful Use


 Anette Asher                                                             September 11
The Century Old
Medical Development Cycle

The complexity of modern
medicine exceeds the
inherent limitations of the
unaided human mind.
David M. Eddy (1990)




   Anette Asher               September 11
The Global Health Care Vision


Vision without execution is a day
dream —
Execution without Vision is a
nightmare…
Japanese proverb

Anette Asher                            September 11
Medicine as an Art
!   Medicine is limited by a shortage of artists
    and widespread profiteering
!   High quality medicine is limited by masters of
    the art
!   A person’s medical & Rx history is usually,
    inaccurate and incomplete
!   Accuracy of Dx is frequently false ±
!   The majority of health is managed at the
    organ level
!   Treatments are based upon the artist’s
    experiences & resources
!   Medical diagnostic & therapeutic resources
    are poorly distributed
!   The minority of the world’s people are
    provided the majority of proper health care
    Anette Asher                                     September 11
Health as a Science
                                          !   Knowledge of Medicine is widely available via
                                              telemedicine ATM global health network
                                          !   High quality and accurate medical care via
                                              ATM global health network
                                          !   A person’s medical & Rx history is accurate
                                              and complete @ PoC
                                          !   Dx is accurate via protein disease biomarker
                                              signatures
                                          !   Health, Dx & Rx are managed at the personal
                                              cellular & molecular level
                                          !   Treatments are based upon the ATM global
                                              health network resources @ PoC
                                          !   Medical diagnostic & therapeutic resources
Trusted ICT Convergence into Healthcare       are widely distributed
                                          !   The world’s majority are provided proper
                                              health care
     Anette Asher                                                             September 11
Moving Human Data to Wisdom



                               Data


                       Information

                        Knowledge

                           Wisdom

               From Data to Information to Knowledge to the
Anette Asher                  Wisdom of Life                  September 11
From the Art of Medicine to the
 Science of Health…

                           2010 the Tipping Point




Art of                                                          Science of
Medicine                                                            Health
                   2000                                  2020
at the                                                               at the
organ level                                                  molecular level
                                        2010



                   Data   Information     Knowledge   Wisdom


    Anette Asher                                               September 11
The Building Blocks of Life

                                                     ?.&%.1#8-.*#J&.&7##
                                                         #.0#K'60%3&50'7#.0##
                                                     !"#$%&'()#*+#$,$-./*'0$'1$2.1#3$
                                                         #    ##

               !"#$%&'(#)*&++,'$,#-'#.*,#/01.2$,'03-)#,%&#-1#&#)03/+,.,#
               )03/4.,%#%,/%,1,'.&50'#06#.*,#),++#&'(#.*,#0%$&'-137#8*-)*#
               8-++#,'&9+,#!"#$%&'(")'*+$,-./!(")#06#*-$*,%2+,:,+#
               )03/+,;-.<#06#),++4+&%#/%0),11,1#&'(#0%$&'-13#9,*&:-0%1#
               6%03#$,'03-)#-'60%3&50'=>##

                         Building Blocks of Life                            Wiring Diagrams of Life


                      Genetic                   Chemical                    Genetic      Chemical
                      Materials                 Materials                  Networks      Networks

                  ?04%),@#ABCC7#A<0.0#B')<)+0/,(-&#06#C,',1#&'(#C,'03,1#
                  *D/@EE888=$,'03,=F/EG,$$E##HIIH#
Anette Asher                                                                                          September 11
Knowledge of Disease
     from the Organ to the Cell

!      The Life Sciences Research Community
         !         Doubles its Data Every 3 Months
         !         Growing Data from Terabytes to Petabytes
         !         Developing Knowledge of Disease at the Cellular Level
         !         Advancing Knowledge of Disease to the Molecular Level
         !         Accelerating the Convergence with Visualization




    Anette Asher                  Disease from the Organ to the Cell       September 11
Trusted Healthcare ICT



       P&5,'.1Q#N,(-)&+#O,)0%(1#




     N,(-)&+#K'14%&'),#O,)0%(1#




     L,&+.*)&%,#M0334'-)&50'1#




 Anette Asher                                                            September 11
                              Healthinformatics and Trusting Health IT
The ICT Governance of Human
Data




                              September 11
A Reference Body

 LSIT References IT Standards & Best Practices




         http://www.himss.org/asp/topics_FocusDynamic.asp?faid=440   September 11
GIP Guidance
Institutional Ecosystem
GIP Encompasses
Regulated Institutional Governance

  GIP Guidance @ the Core




                                     September 11
Trusting Healthcare ICT

      !

      !

      !

      !

      !

      !

      !
          Good Informatics Practice
                      !



      !

      !
          (G IP) C hapter 1 -
      !

      !
          E xecutive Summary        !
          A framewor k for trusted information systems
      !

          Ford Winslow, A nette Asher, Steven Fouskarinis, Gabor
          F ulop, Damian Gomez, Oscar G hopeh, A ndrew Jacobson,
          John K im, L inda Speake, M ar k V ilicich, Howard Asher




                                    F ebruary 2011
                  © H ealthcare I nformation and M anagement Systems !"#$%%&




http://www.himss.org/content/files/LSITOverviewCh1forwebsite270111.pdf         September 11
Global Health First…
Healthcare can achieve Global Equality


Unhealthy people do not remain isolated!




  Anette Asher                             September 11
Personalized Medicine D-Rx




•  Each Person is Different
•  Each Person with the Same Disease is Different
•  Each Person Responds to the Same Prescription (Rx)
   Medication Differently                                                                                  THE REIMBURSEMENT LANDSCAPE FOR



•  One Rx Does Not Fit ALL                                                                                 Novel Diagnostics
                                                                                                                      ! C U R R E N T L I M I TAT I O N S

•  By matching your Genotype/Phenotype & Biomarker                                                                    ! R E A L - W O R L D I M PA C T
                                                                                                                      ! PROPOSED SOLUTIONS

   with the Rx Most Compatible with Exact Disease &
   Genomic Type—Treat the illness, with little or no side
   effects.
•  Your Personal Genome will become a part of Your
   Medical Record and Pharmacokinetics @ PoC

     Anette Asher                                                                                                          September 11
                     http://www.bio.org/content/reimbursement-landscape-novel-diagnostics-current-limitations
The Nomic-Sciences of Medicines
 Personalized




Anette Asher   Disease from the Organ to YOUR Cell   September 11
Let’s get Personal Health Records




                ATM Health Link-for-Life™ Global PHR
 Anette Asher                                          September 11
Institutional Centric
Electronic Medical Record
                        Institutional Centric EMRs
                        ! Manage the institutional resources for
                          different patient medical needs.
                        ! Each institution must have EMRs
                          aligned to their specific clinical work
                          flows & resources to be useful.
                        ! Each patient’s needs are different and
                          the EMR needs to align to different
                          clinical, medical specialty, surgical,
                          laboratory, Rx, radiologic, and billing
                          needs for each specific patient.
                        ! EMRs must be institutional centric to
                          be successful.




  Anette Asher                                        September 11
Individual Centric
Personal Health Records

Individual Centric Private PHRs
! Manage the private and personal medical
  history and health records belonging to each
  individual for their specific medical needs.
! Each individual must have their PHRs
  aligned to their specific medical needs to be
  useful.
! Each patient’s needs are different and the
  PHR needs to align to different clinical,
  medical specialty, surgical, laboratory, Rx,
  radiologic, and billing needs for each specific
  individual.
! PHRs must be 24/7 available to the
  individual accurate, complete, health
  records, anywhere, anytime they need
                                                    Automatically Align to the Credential of Caregiver @ PoC.
  health care. At point-of-care PoC.
! PHRs must be individual centric to be
  successful.


  Anette Asher                                                                                 September 11
Institutional Electronic Medical Record
Individual Private & Personal Health Records




                               Mirrored
                               @ PoC




                                          True
                         EMR



    Anette Asher                                 September 11
ATM White Paper
Link-for-Life™— a Global Public Health Solutions
for we the people.


                                                )

                                                )

                                                )

                                                )

                                                )

                                                                                      !
                                                                                      !
                                                                                      !
                                                                                      !
                                                                                      !
                                                                                      !
                                                                                      !
                                                                                      !
                                                                                      !
                                                                                      !
                                                "#$!%&'!%!()&%*+'&!!
                                                ,*!%!()&%*+'!-.%/'!!
                                                0!"#$1&'!2,/34!5'&6!2,/37!

                                                !
                                                !
                                                          8,*39:#&98,:' ;%!<.#=%.!-$=.,/!>'%.)?!(#.$),#*2!
                                                                        ™



                                                                             :#&!!"#$%"#&"'&("@!!              !


                                                !"#$%&$'()**)                         )                        *)




                                    http://dl.dropbox.com/u/2204007/Link-for-Life%20Whitepaper.pdf


                                                                                                             September 11
Trusted Health Clouds

                                   !



                                   !""#$%&'"()*+,-.$/(*-+,-0.1$
                                   2!%/3$!4,#*&-0$54.,&0..$
                                   6"#07$$
                                   890&$:"4(-0$;<,+0$/*90($
                                   =">*(#$?@$A.<0($"$
                                   !

                                   !

                                   #$%!&'()*%((!+,)-%,(!./!0*!.1%*!(.',2%!3,'(3%+!4*/.,503).*!#%2$*.6.78!
                                   9.-%,*0*2%!:)3$)*!0!2.55.*!,%/%,%*2%!/,05%:.,;!/.,!3$%!76.&06!
                                   <%063$!=0,%>!?)/%!@2)%*2%(!0*+!A'&6)2!<%063$!=.55'*)3)%(B!
                                   !
                                   !




                                                                                                      !
                                   "!:::BC76(B2.5D2%.B1$1!!




                                   !




                        http://www.himss.org/ASP/ContentRedirector.asp?ContentID=76169
                                                                                         September 11
The Role of Healthinformatics
in Health Sciences & Patient Outcomes

        Healthonomics drives Health Care Informatics

                       Improved Patient Care & Clinical Outcomes

        Patient’s                        Health Services Approvals & Reimbursements
       Genetic, Dx,
       Medical & Rx                              Healthinformatics
        Records                                        Clinical, Urgent, Emergency, Surgical, Critical, Recovery,
                                    Clinical
                                     Labs            Optimal Clinical Management
                                                       Rehabilitation, Follow-up, Referral Services, Outpatient Care
       Personalized                                       Personalized                  Disease &
         Optimal                    Clinical            Medicines Dx – Rx               Disorder               Medical Devices,
                                                        Biomarkers PD –                Regression             Supplies & Services
         Clinical                  Imaging                  PK & PV                    Progression
         Protocol
                                   Telediagnostic • Telemedicine • Telesurgical • Teleimaging • Remote Care


   PD: Pharmacodynamics (what the drug does to the body)
   PK: Pharmacokinetics (what the body does to the drug)                                                            Healthonomics
   PV: Pharmacovigilance (is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects)
   Anette Asher                                                                                                          September 11
The Sciences of Health

X-informatics Modeling
  ! Computational Predictive Modeling of Disease
    Prevention, Intervention & Elimination
  ! Genetic Remodeling to Optimize Health
  ! Managing Epidemic & Preventing Pandemic
  ! Cloud ATM Computing Medical & Health Records
  ! Translational Evidence-based Health Sciences
  ! Modeling the Gene/Phenotype of Disease
  ! Modeling Rx Intervention of Disease
                                          From Data to Information to Knowledge to the
                                                                        Wisdom of Life

   Anette Asher                                                         September 11
The Global Business of Life

Art of Medicine to the Science of Health
              Anette Asher
         AnetteAsher@me.com

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Anette Asher:Trend in Medical Informatics

  • 1. Processing Human Data – from the Art of Medicine to the Science of Health Anette Asher October 2011
  • 2. Art of Medicine to the Science of Health The Art of Medicine and Today’s Vision The Tipping Point … and it’s getting personal The Issues: Trusted Information and More Useful Information Moves us to the Sciences of Health The Pace of Health Information to Sciences of Health The Future That Will Get Us To Meaningful Use– Computational Individual Predictive Modeling The Optimal Outcome is Meaningful Use Anette Asher September 11
  • 3. The Century Old Medical Development Cycle The complexity of modern medicine exceeds the inherent limitations of the unaided human mind. David M. Eddy (1990) Anette Asher September 11
  • 4. The Global Health Care Vision Vision without execution is a day dream — Execution without Vision is a nightmare… Japanese proverb Anette Asher September 11
  • 5. Medicine as an Art ! Medicine is limited by a shortage of artists and widespread profiteering ! High quality medicine is limited by masters of the art ! A person’s medical & Rx history is usually, inaccurate and incomplete ! Accuracy of Dx is frequently false ± ! The majority of health is managed at the organ level ! Treatments are based upon the artist’s experiences & resources ! Medical diagnostic & therapeutic resources are poorly distributed ! The minority of the world’s people are provided the majority of proper health care Anette Asher September 11
  • 6. Health as a Science ! Knowledge of Medicine is widely available via telemedicine ATM global health network ! High quality and accurate medical care via ATM global health network ! A person’s medical & Rx history is accurate and complete @ PoC ! Dx is accurate via protein disease biomarker signatures ! Health, Dx & Rx are managed at the personal cellular & molecular level ! Treatments are based upon the ATM global health network resources @ PoC ! Medical diagnostic & therapeutic resources Trusted ICT Convergence into Healthcare are widely distributed ! The world’s majority are provided proper health care Anette Asher September 11
  • 7. Moving Human Data to Wisdom Data Information Knowledge Wisdom From Data to Information to Knowledge to the Anette Asher Wisdom of Life September 11
  • 8. From the Art of Medicine to the Science of Health… 2010 the Tipping Point Art of Science of Medicine Health 2000 2020 at the at the organ level molecular level 2010 Data Information Knowledge Wisdom Anette Asher September 11
  • 9. The Building Blocks of Life ?.&%.1#8-.*#J&.&7## #.0#K'60%3&50'7#.0## !"#$%&'()#*+#$,$-./*'0$'1$2.1#3$ # ## !"#$%&'(#)*&++,'$,#-'#.*,#/01.2$,'03-)#,%&#-1#&#)03/+,.,# )03/4.,%#%,/%,1,'.&50'#06#.*,#),++#&'(#.*,#0%$&'-137#8*-)*# 8-++#,'&9+,#!"#$%&'(")'*+$,-./!(")#06#*-$*,%2+,:,+# )03/+,;-.<#06#),++4+&%#/%0),11,1#&'(#0%$&'-13#9,*&:-0%1# 6%03#$,'03-)#-'60%3&50'=>## Building Blocks of Life Wiring Diagrams of Life Genetic Chemical Genetic Chemical Materials Materials Networks Networks ?04%),@#ABCC7#A<0.0#B')<)+0/,(-&#06#C,',1#&'(#C,'03,1# *D/@EE888=$,'03,=F/EG,$$E##HIIH# Anette Asher September 11
  • 10. Knowledge of Disease from the Organ to the Cell ! The Life Sciences Research Community ! Doubles its Data Every 3 Months ! Growing Data from Terabytes to Petabytes ! Developing Knowledge of Disease at the Cellular Level ! Advancing Knowledge of Disease to the Molecular Level ! Accelerating the Convergence with Visualization Anette Asher Disease from the Organ to the Cell September 11
  • 11. Trusted Healthcare ICT P&5,'.1Q#N,(-)&+#O,)0%(1# N,(-)&+#K'14%&'),#O,)0%(1# L,&+.*)&%,#M0334'-)&50'1# Anette Asher September 11 Healthinformatics and Trusting Health IT
  • 12. The ICT Governance of Human Data September 11
  • 13. A Reference Body LSIT References IT Standards & Best Practices http://www.himss.org/asp/topics_FocusDynamic.asp?faid=440 September 11
  • 14. GIP Guidance Institutional Ecosystem GIP Encompasses Regulated Institutional Governance GIP Guidance @ the Core September 11
  • 15. Trusting Healthcare ICT ! ! ! ! ! ! ! Good Informatics Practice ! ! ! (G IP) C hapter 1 - ! ! E xecutive Summary ! A framewor k for trusted information systems ! Ford Winslow, A nette Asher, Steven Fouskarinis, Gabor F ulop, Damian Gomez, Oscar G hopeh, A ndrew Jacobson, John K im, L inda Speake, M ar k V ilicich, Howard Asher F ebruary 2011 © H ealthcare I nformation and M anagement Systems !"#$%%& http://www.himss.org/content/files/LSITOverviewCh1forwebsite270111.pdf September 11
  • 16. Global Health First… Healthcare can achieve Global Equality Unhealthy people do not remain isolated! Anette Asher September 11
  • 17. Personalized Medicine D-Rx •  Each Person is Different •  Each Person with the Same Disease is Different •  Each Person Responds to the Same Prescription (Rx) Medication Differently THE REIMBURSEMENT LANDSCAPE FOR •  One Rx Does Not Fit ALL Novel Diagnostics ! C U R R E N T L I M I TAT I O N S •  By matching your Genotype/Phenotype & Biomarker ! R E A L - W O R L D I M PA C T ! PROPOSED SOLUTIONS with the Rx Most Compatible with Exact Disease & Genomic Type—Treat the illness, with little or no side effects. •  Your Personal Genome will become a part of Your Medical Record and Pharmacokinetics @ PoC Anette Asher September 11 http://www.bio.org/content/reimbursement-landscape-novel-diagnostics-current-limitations
  • 18. The Nomic-Sciences of Medicines Personalized Anette Asher Disease from the Organ to YOUR Cell September 11
  • 19. Let’s get Personal Health Records ATM Health Link-for-Life™ Global PHR Anette Asher September 11
  • 20. Institutional Centric Electronic Medical Record Institutional Centric EMRs ! Manage the institutional resources for different patient medical needs. ! Each institution must have EMRs aligned to their specific clinical work flows & resources to be useful. ! Each patient’s needs are different and the EMR needs to align to different clinical, medical specialty, surgical, laboratory, Rx, radiologic, and billing needs for each specific patient. ! EMRs must be institutional centric to be successful. Anette Asher September 11
  • 21. Individual Centric Personal Health Records Individual Centric Private PHRs ! Manage the private and personal medical history and health records belonging to each individual for their specific medical needs. ! Each individual must have their PHRs aligned to their specific medical needs to be useful. ! Each patient’s needs are different and the PHR needs to align to different clinical, medical specialty, surgical, laboratory, Rx, radiologic, and billing needs for each specific individual. ! PHRs must be 24/7 available to the individual accurate, complete, health records, anywhere, anytime they need Automatically Align to the Credential of Caregiver @ PoC. health care. At point-of-care PoC. ! PHRs must be individual centric to be successful. Anette Asher September 11
  • 22. Institutional Electronic Medical Record Individual Private & Personal Health Records Mirrored @ PoC True EMR Anette Asher September 11
  • 23. ATM White Paper Link-for-Life™— a Global Public Health Solutions for we the people. ) ) ) ) ) ! ! ! ! ! ! ! ! ! ! "#$!%&'!%!()&%*+'&!! ,*!%!()&%*+'!-.%/'!! 0!"#$1&'!2,/34!5'&6!2,/37! ! ! 8,*39:#&98,:' ;%!<.#=%.!-$=.,/!>'%.)?!(#.$),#*2! ™ :#&!!"#$%"#&"'&("@!! ! !"#$%&$'()**) ) *) http://dl.dropbox.com/u/2204007/Link-for-Life%20Whitepaper.pdf September 11
  • 24. Trusted Health Clouds ! !""#$%&'"()*+,-.$/(*-+,-0.1$ 2!%/3$!4,#*&-0$54.,&0..$ 6"#07$$ 890&$:"4(-0$;<,+0$/*90($ =">*(#$?@$A.<0($"$ ! ! #$%!&'()*%((!+,)-%,(!./!0*!.1%*!(.',2%!3,'(3%+!4*/.,503).*!#%2$*.6.78! 9.-%,*0*2%!:)3$)*!0!2.55.*!,%/%,%*2%!/,05%:.,;!/.,!3$%!76.&06! <%063$!=0,%>!?)/%!@2)%*2%(!0*+!A'&6)2!<%063$!=.55'*)3)%(B! ! ! ! "!:::BC76(B2.5D2%.B1$1!! ! http://www.himss.org/ASP/ContentRedirector.asp?ContentID=76169 September 11
  • 25. The Role of Healthinformatics in Health Sciences & Patient Outcomes Healthonomics drives Health Care Informatics Improved Patient Care & Clinical Outcomes Patient’s Health Services Approvals & Reimbursements Genetic, Dx, Medical & Rx Healthinformatics Records Clinical, Urgent, Emergency, Surgical, Critical, Recovery, Clinical Labs Optimal Clinical Management Rehabilitation, Follow-up, Referral Services, Outpatient Care Personalized Personalized Disease & Optimal Clinical Medicines Dx – Rx Disorder Medical Devices, Biomarkers PD – Regression Supplies & Services Clinical Imaging PK & PV Progression Protocol Telediagnostic • Telemedicine • Telesurgical • Teleimaging • Remote Care PD: Pharmacodynamics (what the drug does to the body) PK: Pharmacokinetics (what the body does to the drug) Healthonomics PV: Pharmacovigilance (is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects) Anette Asher September 11
  • 26. The Sciences of Health X-informatics Modeling ! Computational Predictive Modeling of Disease Prevention, Intervention & Elimination ! Genetic Remodeling to Optimize Health ! Managing Epidemic & Preventing Pandemic ! Cloud ATM Computing Medical & Health Records ! Translational Evidence-based Health Sciences ! Modeling the Gene/Phenotype of Disease ! Modeling Rx Intervention of Disease From Data to Information to Knowledge to the Wisdom of Life Anette Asher September 11
  • 27. The Global Business of Life Art of Medicine to the Science of Health Anette Asher AnetteAsher@me.com