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Prepared by: ANAM KHAN


Brain and spinal cord:

Receives and processes incoming

sensory information and responds by
sending out signals that initiate or modify
a process.
 Includes

all the neurons and ganglia found
outside the CNS-any nerve that enters
or leaves the CNS


The main function of the PNS is to connect the
CNS to the limbs and organs, essentially

serving as a communication
relay going back and forth between the brain
and the extremities.



It is subdivided into:


Efferent Division – the neurons of which carry
signals away from the brain and spinal cord to
peripheral tissues.


= Afferent division – the neurons of which bring
info from the periphery to the CNS.They provide
sensory input to modulate the function of efferent
division.
 Efferent

Somatic

Autonomic
 Somatic

efferent neurons are Involved in the

voluntary control of functions
Autonomic Efferent Regulates everyday

requirement of vital bodily functions without the
conscious participation of the mind.


Preganglionic neurons






Cell body is located
within the CNS

Postganglionic neurons

Cell body originating
in the ganglion
preganglionic





Either
unmyelinated or
myelinated

Emerge from
brainstem or spinal
cord and make
synaptic connection
in ganglia

postganglionic



Generally
Nonmyelinated



Terminates on
effector organs


These fibers
arise from the
cranium (from
cranial
nerves
III,VII,IX and
X) and from the
sacral
region(S2-4) of
spinal cord.
Efferent nerve fibers
originate from nerve
cells in the lateral
gray column of the
spinal cord between

first thoracic and
second lumbar
segments( thoracic
outflow)


Two types of acetylcholine receptors exists
 Acetylcholine

has the ability to bind
with both of these receptors.


In preganglionic neurons, both
parasympathetic and sympathetic, the
release of acetylcholine binds
predominantly with nicotinic

receptors
neurons

on the postganglionic
Sympathetic system:
•At the synapses within the ganglia, preganglionic
neurons release acetylcholine.
•In response to this stimulus postganglionic neurons with two important exceptions - release nor
epinephrine.
•Activates adrenergic receptors on the peripheral
target tissues.
The activation of
target tissue
receptors causes
the effects
associated with
the sympathetic
system.
The two exceptions mentioned above are:

•

postganglionic neurons of
sweat glands and
• chromaffin cells of the
adrenal medulla.
Parasympathetic system
 The parasympathetic nervous system uses
chiefly acetylcholine (ACh) as its
neurotransmitter.

 Most transmissions occur in two stages:
•When stimulated, the preganglionic nerve releases
ACh at the ganglion.

•which acts on nicotinic receptors of
postganglionic neurons.
•The postganglionic nerve then releases ACh to
stimulate the muscarinic receptors of the target
organ.


Both always present in the blood.



Nor epinephrine varies



Epinephrine is a constant


3rd division of ANS



Works independently of CNS
 Brain

of Gut ( as it

is the collection of
nerve fibers that
innervate the
gastrointestinal tract ,
pancreas and gall
bladder)


Modulated by both the parasympathetic and
sympathetic nervous system
 Exocrine/endocrine

secretions
 and microcirculation of
gastrointestinal tract


Continually active to some degree



Diffused distribution of postganglionic
Fibers.


The changes experienced by the body during
emergencies have been referred to as the “fight
or flight” response.
 Maintains



essential bodily functions

Generally dominant over sympathetic system in
“Rest

and Digest”

situations.


It usually acts to oppose or balance the
actions of sympathetic division.


Eye

P-constricts pupils ( III occulomotor)

S-dilates pupils


Heart muscles
P-decreases rate; slows and steadies
heart(bradycardia)
S-Increases rate and force of heartbeat


Blood vessels
P-vasoconstriction
S- vasodilation


Glands (nasal, lacrimal, salivary, gastric,
pancreas)

P-stimulates secretary activity
S-inhibits secretary activity


Lungs

P-constricts bronchioles
S-Dilates bronchioles and mildly constricts
blood vessels


Digestive Tract Organs:

P-increases motility and amount of
secretions by digestive organs' relaxes
sphincters and allow movement of food
along tract
S-decreases activity of glands and muscles of
digestive system and constricts sphincte r;
causes vasoconstriction
Sweat Glands
S-stimulates sweating




Arrector pili muscles attached to hair follicle
S-stimulates to contract—Goosebumps
Liver
S-Epinephrine stimulates liver to release glucose
to blood

Adrenal Medulla
S-Stimulates
medulla cells to
secrete
epinephrine and
noreponephrine
into bloodstream




Kidney
S- causes vasoconstriction; decreases urine
output


Gallbladder

P-stimulates activity; gallbladder contracts to expel bile
S-gallbladder relaxed



Bladder, Urethra

P-contraction smooth muscle of bladder wall
S-relaxation of smooth muscle of bladder wall
Summary

51

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Autonomic Nervous System

Hinweis der Redaktion

  1. Myelinatedwith the conscious participation of minddirect action ,no participation of pro or postganglionic neurons.
  2. Come from thoracic and lumbar regions of the spinal cord, and they synapse in two cord like chains of ganglia that run in parallel on each side of spinal cord.
  3. acetylcholine, a neurotransmitter that activates nicotinic acetylcholine receptors on postganglionic neurons. Has widespread action on body as the result of preganglionic fibers synapsing many postganglionic neurons.
  4. preganglionic fibers tend to be shorter because sympathetic ganglia are often closer to the spinal cord
  5. Postganglionic neurons of sweat glands release acetylcholine for the activation of muscarinic receptors
  6. :,
  7. Nor epinephrine varies according to the amount of stress present and will cause transient changes in heart rate and systemic arteries and veins. Epinephrine is a constant in regulating heart rate, vasoconstriction in systemic arteries and veins and vasodilation of muscles and liver.
  8. Motility also.
  9. Continually active ( in maintaining tone of vascular beds) This system with its diffused distribution of postganglionic fibers is involved in a wide array of physiologic activities but it is not essential for life.
  10. These reactions are triggered by both direct sympathetic activation of the effectors organs and by stimulation of adrenal medulla to release epinephrine and lesser amounts of nor epinephrine
  11. Maintains essential bodily functions, such as digestive process and elimination of wastes and is required for life.
  12. Increase blood flow to the skeletal muscles and the heart while diverting flow from the skin and internal organs
  13. S-inhibits secretary activity; causes vasoconstriction of blood vessels supplying glands
  14. P-contraction smooth muscle of bladder wall; relaxes urethral sphincter; promotes voiding S-relaxation of smooth muscle of bladder wall; constricts urethral sphincter; inhibits voiding