1. Second annotated bibliography: Capasso R, Borrelli F, Aviello G, Romano B, Scalisi
C, Capasso F, Izzo AA. 2008. Cannabidiol, extracted from cannabis sativa, selectively
inhibits inflammatory hypermotility in mice. Br J Pharmacol 154(5):1001-8.
In this research paper, the matter of discussion is whether cannabidiol inhibits
inflammatory hypermotility in mice. In vivo experimenting and in vitro experimenting are
used to determine in which case the cannabidiol has a greater inhibition effect. To
produce intestinal inflammation, irritant croton oil was induced in the experimental
group. In the results, it is established that cannabidiol is active when there is an
inflammatory stimulus. Also, it is pointed out that by having a larger quantity of
cannabidiol, the inhibition percentage increases. After conducting experimentation on the
mice using irritant croton oil, it is concluded that the use of cannabidiol is, in fact, helpful
in normalizing intestinal motility. It may come to your attention that in my review paper
I’m not focusing on hypermotility, but this paper helps me to understand many concepts
about how the cannabidiol acts in the reduction of inflammation in inflammatory bowel
diseases. It explains how it reacts under different conditions, either by reducing
inflammation or having no effect at all.