1. January 3rd 2012 Science Daily January 9th 2012 Science Daily
Novel Compound to Spasticity Gene
Finding Provides Clues
Halt Virus to Causes of Nerve Cell
Introduction Degeneration
Replication Identified
Smallpox, vaccinia virus and the Monkeypox virus are Hereditary spastic paraplegia (HSP) is a disease
Cytogenetic studies chromosomes, their structure
Poxviruses that invade host cells in order to replicate caused by specific degeneration of axons. A team of
and heritability. It allows recognizing when a
and finally are the cause of the disease. Besides scientists discovered a cause for one of the forms of
chromosome is not normal, maybe as a result of a
smallpox was declared eradicated, the number of HSP and it is the deletion in the gene reticulon 2 on
deletion, investment or translocation. These
chromosome 19. Reticulon 2 has a key role in
chromosomal anomalies are exposed in the people being infected by Monkeypox is increasing
globally. That´s why a group of scientists looked for shaping the endoplasmic reticulum. The defects in
karyotype. The study of the chromosomes makes
compounds that could stop vaccinia from replicating how the endoplasmic reticulum is shaped and
easier the labor of discover where the beginnings of
inside human cells. They identified some of them and formed could underlie axon degeneration. If there is
a disease are.
then they discovered that the virus can enter the cell a deletion on reticulon, the axons degenerate and
in its presence, but once the virus was inside, the nervous signals can´t pass through neuronsbreaking
with the communication within the central nervous
compound inactivates an essential piece of virus
machinery system.
Vaccinia virus
OBSERVATIONS
Cytogenetic has a huge importance as a method to
determinate the chromosome abnormalities as
OBSERVATIONS
Viruses have RNA as genetic material instead of DNA deletions.If this science techniques identify the
and that’s the reason why they codify reverse specific point in a chromosome where is the defect,
transcriptase. This enzyme catalyzes DNA synthesis scientists can discover the beginnings of a disease
from RNA mold. If science want to stop viruses and interfere in the development of it. If in this case
replication, has to find the best way to enter inside the the point where the deletion is clear, they can find
The central dogma of the molecular biology defines virus and inhibit reverse transcriptase maybe using the incidence of the disease in a population accord
the sequence of the protein synthesis. It is based on competition for the hotspot where the enzyme works. the heritage and make a solution to the
how RNA can be an intermediate and make the If the method to do that is clear, viruses won´t be able degeneration of the axons and maybe anticipate to
synthesis go to cytoplasm, transferring at the same to do the synthesis of DNA from RNA, and the the developed physical defects as paraplegia.
time genetic information from DNA to ribosomes. replication will stop.

2. Bibliography MOLECULAR BIOLOGY
Medical utility
 MARTINEZ S, Lina María. Biología Molecular. 6
Novel Compound to Halt
Nowadays, technology makes easier to medicine to ed. Medellín: UPB. Fac de Medicina. Virus replication Identified
know the chromosomal constitution of a person. If
science can be able to study the genes and its
AND Spasticity Gene
 Novel Compound to Halt Virus Replication
structure, medicine has a great chance to intervene. Identified. Science Daily (January 3, 2012). Finding Provides Clues to
Knowing the specific point in a chromosome where
Causes of Nerve Cell
the problem is, helps the studies to determinate the
incidence of a disease based on the heritage and Degeneration
 Spasticity Gene Finding Provides Clues to
with this knowledge, medicine can anticipate to the Causes of Nerve Cell Degeneration. Science
development of a disease and its degeneration Daily (January 9, 2012).
results.
The central dogma is the base of a lot of
pharmaceutical products. Let’s take Monoclonal
antibodies as an example, these are proteins
produced in laboratories using cellular replication
models in controlled conditions, which ability is, to
specifically bind to any molecule with antigenic
character, signaling to the immune system where
work to be done is.
Ana María Arango Rivas
III semester
Medicine student
Universidad Pontificia
Bolivariana
February 6, 2012
Medellín Colombia