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Antenatal Care: Clinical Practice
Guideline
Walk-In Clinic – Client Pathway
ANC Clinic – Client Pathway
Initial Risk Assessment
 History:
Personal condition:
 current pregnancy information, previous obstetric risk,
medical & surgical history, current medication, family history
of risk factors.
any complains in the current pregnancy.
Examination:
Vital signs and the BMI results, Perform systematic
examination.
“Clients with more than ten (>10) weeks of gestational age
calculates BMI by using pre-pregnancy weight”.
Initial Risk Assessment
Review screening test results.
CBC: Hb, WBC, Platelets level.
Urine analysis (Routine & Microscpic) & urine culture.
Blood grouping/ Rh identification.
FBS or RBS
Screening for syphilis (RPR test).
Hepatitis B & C serology.
Rubella IgG.
HIV test.
Ultrasonography (U/S)
Management
• according to the findings from clinical assessment
and lab investigation results.
• Prescribe Routine Supplement. (folic acid)
• Issue Pregnancy Care notebook and document
information
Follow-UP
 No risk factor
Primigravida:
- 1st & 2nd trimester every 4 weeks
- 3rd trimester  every 2 weeks
Multigravida: follow at specific gestational ages up to 34
wk according to the following schedule:
 Booking (6-10 weeks),
 11-14 weeks gestation,
 22-24 weeks gestation,
 28 weeks gestation,
 30-32 weeks gestation
 34weeks gestation.
 High risk factor:
 Close follow up may needed based to client risk and according to
available management guideline.
Referral
 No risk: referred at 34 wks gestation to WH.
 High risk: early referral to WH
Regular Follow up
 Review risk & previous management.
 Review screening test result.
 Assess Gestational age (by week).
 Do general obstetric examination as per gestational age.
 Check Fetal heart sounds and movement (present or not).
 Assess position of the fetus (Longitudinal, oblique, transverse) and
presenting part; cephalic or breach (mainly in 3rd trimester).
 Risk grading and manage accordingly.
 Request for standard screening tests according to gestation age.
 Health counseling & education. In addition to give relevant educational
material.
 Prescribe routine Supplement: folic acid, iron & vitamin D tablet (after 12
weeks gestation).
 Maintain complete record (clinical form & notebook).
Late Enrolment
If pregnant women attend initial visit and she is ≥ 34 weeks:
-Determine the reason of late antenatal care.
- Assess the pregnancy risk factors, Ask about any complain.
- Request for ANC standard screening tests.
- Request for U/S & glucose 75 gm.
- Check vital signs & BMI results.
 Refer to ANC clinic by giving nearest appointment within 1 week to be
seen by a physician.
 At first ANC clinic: the physician should check the result, do obstetric
examination, check fetal heart, and document all information at antenatal
care clinical form & notebook then refer to nearest obstetric Hospital
either secondary or tertiary Hospital based on client risks .
Screening tests during antenatal care visit
screening tests during antenatal care visit
Case 1
24 year-old Aisha , G2 P1, at 15 weeks gestation
is found on routine prenatal CBC to have:
hemoglobin9.0, hematocrit 26.3, MCV 75, RDW
18..
What is your Management?
Anemia
HGB screening is requested at:
Booking visit & at 28 weeks.
If patient is on 2nd or 3rd trimester and she
cannot tolerate oral iron supplement and Hb
level is ≤ 8  refer urgently to obstetric
Hospital for IV ferosac and continue antenatal
care follow up at PHC Center.
Anemia
If Hb <11 g/dL, MCV, MCH are normal (normochromic,
normocytic anemia)
 Check Ferritin level:
 Ferritin level is <20 mcg/L treat as iron
deficiency anemia + manage according to above
guideline.
 Ferritin level is >20 mcg/L  refer to
hematologist & continue ANC at PHCC.
If Hb <11 g/dL, MCV, MCH are high (macrocytic,
hyperchromic anemia)
 Check B12 & folate.
Refers to hematology department and
continue ANC at primary health care center.
High Risk to B12 Deficiency anemia:
Patient With chronic illness.
Family history of B12 deficiency.
Previous history of blood transfusion.
K/C of anemia.
Vegetarians.
Counseling
 iron rich food and factors inhibiting and promoting Iron absorption.
 should be taken on an empty stomach, 1 hr before meals, with a
source of vitamin C (ascorbic acid) such as orange juice to maximize
absorption.
 Avoid taking it with some medication as it reduces iron absorption
for example: Antacids, PPI , bile acid sequestrates (cholestyramine
& colestipol).
 Most iron preparations inhibit the absorption of some medications
such as; tetracycline, sulphonamides
.
 S.E: Epigastric discomfort, nausea, diarrhea, or
constipation may appear with a daily dose of 60 mg or
more supplement should be taken with meals.
 Stools may turn black, which is not harmful
Treatment should continue.
 Maintenance dose:
If hemoglobin level becomes normal  maintenance
dose of iron which is 65 mg /day.
Refer to WH
Emergency
No Resolution
Obesity in pregnancy
(BMI) > = 30 kg/m2 at the first antenatal visit
using current weight if < 10 weeks gestation and
pre-pregnancy weight if > 10 weeks gestation
Recommended Weight Gain:
Management
Preconception Care:
 Counseling:
-Inform about risk of obesity during pregnancy and child
birth.
-Advice on weight loss and lifestyle modification before
getting pregnant.
- Consider healthy diet.
Supplement:
-o If BMI ≥30 kg/m² Give folate supplement 5 mg daily,
starting one month before conception and continue
during 1st trimester.
Management
Antenatal Care:
 Measure weight, height and BMI (using current weight if <
10 weeks gestation and pre-pregnancy weight If > 10 weeks
gestation) at booking visit.
 Counseling:
- Counsel about the recommended weight gain during pregnancy
based on her calculated BMI.
- Advice in healthy eating, appropriate exercise
- risk of obesity during pregnancy and child birth and
counsel about signs of thromboembolism.
- dietitian referrale
-risks of long term obesity, possible of developing HTN&
DM.
Prescription:
 BMI ≥30 kg/m²  Prescribe folic acid 5 mg once daily.
 If BMI ≥40 kg/m²; Prescribe oral aspirin (enteric
coated) 75-100 mg once daily.
 Maintenance dose of Vitamin D supplement 1,000 IU
orally on daily basis after 12 weeks of gestational age.
Referral:
 If BMI ≥40 kg/m²; regularly refer to obstetric Hospital
for antenatal follow-up, if client > 34 weeks of
gestational age refer urgently
Thyroid disease
 Hypothyroidism:
Subclinical Hypothyroidism
 Hyperthyroidism:
Gestational Hyperthyroidism & Hyperemesis
Gravidarum
Graves’ Disease
Screening
ONLY for high risk for thyroid dysfunction:
-Personal history of thyroid dysfunction and/or thyroid surgery.
-Family history
-Age > 30 years.
-BMI ≥ 40 kg/m2.
-Positive Thyroid Peroxidase Antibodies (TPO Ab).
- Clinical signs and symptoms or the presence of goiter.
- her autoimmune disease such as: DM1, vitiligo, adrenal
insufficiency, hypoparathyroidism, .
- History of miscarriage or preterm delivery.
- Case of infertility.
- Received radiation to the head or neck area as a cancer treatment.
- Use of amiodarone or lithium, or recent administration of iodinated
radiologic contrast.
- Residing in an area of known moderate to severe iodine insufficiency.
Hypothyroidism
K/C of Hypothyroidism (Overt Hypothyroidism)
Management:
 Preconception: adjust the dose to reach a TSH level not higher than
2.5 μU/L prior to pregnancy.
 Newly pregnant: increase the dose by 25% -30%.
 Postpartum: Preconception dose.
Follow-up:
 Antenatal: Check TFT every 4-6 weeks.
 Postnatal: Check TFT at 6-8 weeks postpartum.
Hypothyroidism
Newly diagnosed hypothyroidism during pregnancy:
Diagnosis:
 TSH1 (>2.5 μU/L) + low FT4 concentration.
 TSH >10.0 μU/L irrespective to FT4level.
Management:
 start with low dose & observe the response to treatment, if the patient
responding very well, continue with the same dose. If not, you can
gradually increase the medication dose.
 Start treatment to adjust TSH level not higher than the normal value
which is based on pregnancy trimester.
Follow up :
 Postnatal: Check TFT at 6-8 weeks postpartum.
Dose:
- TSH < 10 μU/L a 1 mcg/kg/day.
- TSH > 10 μU/L  1.6
mcg/kg/day.
Max f 200 mcg/day.
Subclinical Hypothyroidism:
Diagnosis:
 TSH (2.5- 10 mIU/L) with a normal FT4 level.
Management:
 Check thyroid peroxidase (TPO) antibodies:
 If Positive, start treatment to adjust TSH level not higher the normal
value based on trimester.
 If Negative: treatment based on physician/patient decision. If the
decision was for no treatment then continue monitor TFT level.
Follow up:
 Check TFTS in 4-6 wks.
Euthyroid with Thyroid Antibodies(Tab) Positive
Euthyroid woman with thyroid autoimmunity (not receiving L-thyroxin) who is
Tab positive is at risk for developing for hypothyroidism. Close monitoring of
TSH level is necessary.
Follow up: Check TFT every 4-6 weeks.
Treatment:
o Therapy should be started once TSH level rise above trimester specific
status.
Counseling:
Medication should be taken in empty stomach. Ideally 30 minute to one
hour before breakfast.
Note: “Empty stomach means 3-4hrs after meal”.
Certain drugs e.g.: cholestyramine, ferrous sulfate, calcium carbonate &
antacid, may interfere with L-thyroxine absorption from the gut. L-thyroxine
Hyperthyroidism
Gestational Hyperthyroidism & Hyperemesis
Gravidarum:
Diagnosis:
 No prior history of thyroid disease or signs of Graves’s
disease.
 TFT: Low serum TSH and an elevated FT4.
 Limited to the first half of pregnancy
 Serum T4 return to normal by 14-18 wks gestation.
Treatment:
 Antithyroid Drugs (ATD) are not indicated.
Hyperthyroidism
Graves’ Disease:
Preconception:
 Counseling: reach euthyroid state before attempting pregnancy.
Antenatal care: medications are Not available at PHCC
If graves’ disease diagnosed during pregnancy:
 Diagnosed during 1st Trimester begin prophlthiouracil.
 Diagnosed during 2nd trimester  begin methimazol.
If graves’ disease diagnosed and treated prior to pregnancy:
 Currently on methimazole: switch to prophlthiouracil as soon as
pregnancy confirmed.
Medication dose:
 Mild hyperthyroidism start PTU 50 mg,
3times/day, or methamazole 5-10 mg/day.
 severe hyperthyrodisium  start PTU 100
mg, 3times/day, or methamazole 10-30
mg/day.
Referral:
Refer urgently to endocrine clinic at women’s
Hospital and continue ANC at women’s
Hospital.
Management and Referral
Considerations for Common Risk
Conditions during PregnancyActionRisk Condition
- Assess social, mental & health risk &
wellbeing.
- Provide standard antenatal care & follow-up
unless the client has Risk.
- Diet advice.
- Ensure family support.
Age < 15 years
- Do U/S at 11-14 wks. For nuchal translucency
& nasal bone.
- Counsel about amniocentesis to rule out
anomalies. If the client agreed refer to FMU
(Feto Maternal Unit) at women’ Hospital to do
the procedure.
- Do U/S at 20 wks. of gestational age for
checking detail anomalies.
Age ≥ 35 years
“advance maternal age”
ActionRisk Condition
Refere to WH.
- Need U/S at 10-12 wks. For nuchal translucency & nasal bone by
well trained staff.
- Detail anomaly scan in FMU (Feto Maternal Unit), if abnormality
discovered the client should be followed in tertiary care facility.
age ≥ 40 years
- Prescribe Aspirin 75-100 mg once daily.
- Prescribe folic acid 5 mg once daily.
- Regular Referral to the nearest obstetric Hospital (Secondary
Care).
Note:” If client > 34 wks of gestational age, urgently refer to the
nearest obstetric hospital
(BMI) ≥ 40 kg/m2
-Diet advice.
- Give iron + multivitamins supplement.
- Refer to dietitian at PHCC.
- Monitor fetal well-being by U/S routinely unless if abnormality
discovered its need more often or refer to hospital based on
abnormality result.
BMI < 18.5 kg/m2 or
weight (less than) < 45kg
ActionRisk Condition
Emergency referral to WHUnexpected Problem in Current
Pregnancy:
- Massive Polyhydramnious.
- Oligohydramnious.
- Vaginal Bleeding.
- Absent fetal heart or fetal
movement.
- Decrease fetal movement (from
24wks gestation).
- Signs of preterm labor.
Urgent Referral to FMU) depending on Trimester and type of
Hazard for detailed anomalies scans between 20 -22 weeks.
Exposed to hazardous medication or
radiation in current pregnancy
- Counsel the client about risk of abortion if keeping or
removing IUCD.
- Should not be removed in PHCC.
Note:” Would refer to emergency of the nearest obstetric
hospital (secondary care)”
Pregnancy with IUCD in situ
- Refer to WH
- Urgent Referral to WH if ≥ 20 wks gestation otherwise regular referral
is acceptable.
Note: “Multiple pregnancy ≥ 3 should be referred & followed in WH.”
Multiple Pregnancy
Emergency referral to WHPlatelet < 30,000
irrespective to gestational
age
- Request for U/S if available in your HC;
If normal, continue antenatal care at PHCC.
If abnormality is suspected, refer to emergency (WH)
- If U/S is not available; emergency refer to the WH.
-Suspected hydatidiform
mole.
- Previous Molar Pregnancy
-< 14wks Urgent referral to FMU at WH.
- > 14 weeks refer to emergency.
Rh –ve with Positive Rh
antibodies in current
pregnancy
- Request for U/S
- Checks Beta-hCG level, Get at least 2-3 reading within 48hrs.
- If ectopic confirmed refer to emergency to nearest obstetric
Hospital.
Suspect Ectopic Pregnancy
ActionRisk
If chronic problem is stable:
- Regular Referral WH and continue antenatal care at the same
hospital.
K/C of Chronic Disease:
- Autoimmune/lupus.
- Congenital heart disease,
cardiomyopathy, Hx of MI.
-IBD.
-ITP.
- Kidney disease.
- Pulmonary hypertension.
- Thromboembolic
Urgent Referral to WH and continues antenatal care at the same
hospital.
- Cancer.
- Mental Disorder.
Urgent Referral to women’s Hospital (Tertiary care) and
continues antenatal care at the same hospital.
- Bleeding disorder (ex. Hemophilia)
Urgent referral to endocrine clinic and continue antenatal care at
the same Hospital.
Graves’s disease,Thyroid nodule &
previous Hx of thyroid cancer.
Urgent referral WH- Epileptic disease.
- Stop all antihypertensive medication.
- Prescribe aldoment drug; starting dose between 250 mg – 500
mg (depending on patient condition).
- Prescribe 75 -100 mg of aspirin daily and stop at 32 weeks of
gestational age.
- Give calcium supplement 1000 mg/ day.
- Refer urgently to WH.
K/C of Chronic Hypertension:
Women who have high BP ≥140/90
before or early pregnancy (before 20
weeks).
Action to be takenRisk Factors
- Confirmed: if two (2) reading of blood pressure ≥140/90
per week in a setting position.
- Prescribe aldoment drug; starting dose between 250 mg
– 500 mg
- Give Ca supplement 1000 mg/ day.
- Refer urgently to WH if pregnant ≥ 20wks of gestational
age
Pregnancy induced hypertension:
High BP≥140/90 that develops after 20
wks in without proteinuria and goes
away after delivery
Emergency Referral to WH by ambulanceBP ≥ 140 / 90 and with symptoms of pre-
eclampsia:
- Severe headache.
- Problems with vision, such as blurring
vision or flashing.
- Severe pain just below the ribs.
- Vomiting.
- Sudden swelling of the face, hands or
feet and sudden weight gain in short
period
Urgent referral WH
Previous Obstetric Problem:
- IUFD/still birth or neonatal death.
- Fetal anomaly, congenital or genetic
disease.
- Down syndrome.
.
Urgent referral to FMU. abnormal 
WH.normal HC
Previous History of RH isoimmunization
(+ ve combs test) or hydrops fetalies.
Urgent referra to WHPrevious Hx of mid trimester miscarriage
( >16 wks gestation)
Regular referral to WH≥ 2 previous subsequent abortions.
Prescribe aspirin 100 mg daily from 12 wks.
- Close monitoring the fetal wellbeing by U/S at
26 & 28 wks.
- Urgent referral to WH at 28wks.
Previous Hx of IUGR:
” Term baby with weight less than 2.5 kg”
Emergency WHIUGR in Current Pregnancy:
- IUGR with Reduce Fetal Movement
URGENT referral to WH
- Only IUGR
- If C/S done at governmental obstetric Hospital:
Regular Referral at 32 wks
- If C/S done outside governmental Hospital such as
in private or abroad Hospital:
Regular Referral at 28 wks.
- If C/S done at early gestational age “<37wks” refer
as early as possible
Previous Cesarean Section “C/S”
Contact:
Close contact with no previous Hx of infection, refer
to emergency and continue Antenatal care at PHC.
Active Lesion:
Assess the general condition of patient to rule out
pneumonia:
- Give antipyretic.
- Give calamine lotion.
- Avoid contact with others.
- Emergency referrale to WH.
Positive Infectious Disease:
- Chicken Pox
- 1ST attack start (Acyclovir) and Urgent referral WH
- 2nd and more attack with active lesion need
urgent referral to WH
- Genitalia Herpes
- Check all serology of hepatitis B.
- Check result of Hepatitis C.
- Urgent Referral to a specialist in
Gastroenterology within nearest secondary
care.
- Continue antenatal care at PHC.
- Hepatitis B
Give Treatment for client & partner with urgent
referral to nearest obstetric hospital (secondary
care) for further investigation.
- Syphilis
Emergency Referral to Women’s Hospital
Patients on Teratogenic Drugs

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Antenatal care

  • 1. Antenatal Care: Clinical Practice Guideline
  • 2. Walk-In Clinic – Client Pathway
  • 3.
  • 4. ANC Clinic – Client Pathway
  • 5.
  • 6. Initial Risk Assessment  History: Personal condition:  current pregnancy information, previous obstetric risk, medical & surgical history, current medication, family history of risk factors. any complains in the current pregnancy. Examination: Vital signs and the BMI results, Perform systematic examination. “Clients with more than ten (>10) weeks of gestational age calculates BMI by using pre-pregnancy weight”.
  • 7. Initial Risk Assessment Review screening test results. CBC: Hb, WBC, Platelets level. Urine analysis (Routine & Microscpic) & urine culture. Blood grouping/ Rh identification. FBS or RBS Screening for syphilis (RPR test). Hepatitis B & C serology. Rubella IgG. HIV test. Ultrasonography (U/S)
  • 8. Management • according to the findings from clinical assessment and lab investigation results. • Prescribe Routine Supplement. (folic acid) • Issue Pregnancy Care notebook and document information
  • 9. Follow-UP  No risk factor Primigravida: - 1st & 2nd trimester every 4 weeks - 3rd trimester  every 2 weeks Multigravida: follow at specific gestational ages up to 34 wk according to the following schedule:  Booking (6-10 weeks),  11-14 weeks gestation,  22-24 weeks gestation,  28 weeks gestation,  30-32 weeks gestation  34weeks gestation.  High risk factor:  Close follow up may needed based to client risk and according to available management guideline.
  • 10. Referral  No risk: referred at 34 wks gestation to WH.  High risk: early referral to WH
  • 11. Regular Follow up  Review risk & previous management.  Review screening test result.  Assess Gestational age (by week).  Do general obstetric examination as per gestational age.  Check Fetal heart sounds and movement (present or not).  Assess position of the fetus (Longitudinal, oblique, transverse) and presenting part; cephalic or breach (mainly in 3rd trimester).  Risk grading and manage accordingly.  Request for standard screening tests according to gestation age.  Health counseling & education. In addition to give relevant educational material.  Prescribe routine Supplement: folic acid, iron & vitamin D tablet (after 12 weeks gestation).  Maintain complete record (clinical form & notebook).
  • 12. Late Enrolment If pregnant women attend initial visit and she is ≥ 34 weeks: -Determine the reason of late antenatal care. - Assess the pregnancy risk factors, Ask about any complain. - Request for ANC standard screening tests. - Request for U/S & glucose 75 gm. - Check vital signs & BMI results.  Refer to ANC clinic by giving nearest appointment within 1 week to be seen by a physician.  At first ANC clinic: the physician should check the result, do obstetric examination, check fetal heart, and document all information at antenatal care clinical form & notebook then refer to nearest obstetric Hospital either secondary or tertiary Hospital based on client risks .
  • 13. Screening tests during antenatal care visit
  • 14. screening tests during antenatal care visit
  • 15. Case 1 24 year-old Aisha , G2 P1, at 15 weeks gestation is found on routine prenatal CBC to have: hemoglobin9.0, hematocrit 26.3, MCV 75, RDW 18.. What is your Management?
  • 16. Anemia HGB screening is requested at: Booking visit & at 28 weeks. If patient is on 2nd or 3rd trimester and she cannot tolerate oral iron supplement and Hb level is ≤ 8  refer urgently to obstetric Hospital for IV ferosac and continue antenatal care follow up at PHC Center.
  • 18.
  • 19.
  • 20. If Hb <11 g/dL, MCV, MCH are normal (normochromic, normocytic anemia)  Check Ferritin level:  Ferritin level is <20 mcg/L treat as iron deficiency anemia + manage according to above guideline.  Ferritin level is >20 mcg/L  refer to hematologist & continue ANC at PHCC.
  • 21. If Hb <11 g/dL, MCV, MCH are high (macrocytic, hyperchromic anemia)  Check B12 & folate. Refers to hematology department and continue ANC at primary health care center. High Risk to B12 Deficiency anemia: Patient With chronic illness. Family history of B12 deficiency. Previous history of blood transfusion. K/C of anemia. Vegetarians.
  • 22. Counseling  iron rich food and factors inhibiting and promoting Iron absorption.  should be taken on an empty stomach, 1 hr before meals, with a source of vitamin C (ascorbic acid) such as orange juice to maximize absorption.  Avoid taking it with some medication as it reduces iron absorption for example: Antacids, PPI , bile acid sequestrates (cholestyramine & colestipol).  Most iron preparations inhibit the absorption of some medications such as; tetracycline, sulphonamides .
  • 23.  S.E: Epigastric discomfort, nausea, diarrhea, or constipation may appear with a daily dose of 60 mg or more supplement should be taken with meals.  Stools may turn black, which is not harmful Treatment should continue.  Maintenance dose: If hemoglobin level becomes normal  maintenance dose of iron which is 65 mg /day.
  • 26.
  • 27. Obesity in pregnancy (BMI) > = 30 kg/m2 at the first antenatal visit using current weight if < 10 weeks gestation and pre-pregnancy weight if > 10 weeks gestation
  • 29. Management Preconception Care:  Counseling: -Inform about risk of obesity during pregnancy and child birth. -Advice on weight loss and lifestyle modification before getting pregnant. - Consider healthy diet. Supplement: -o If BMI ≥30 kg/m² Give folate supplement 5 mg daily, starting one month before conception and continue during 1st trimester.
  • 30. Management Antenatal Care:  Measure weight, height and BMI (using current weight if < 10 weeks gestation and pre-pregnancy weight If > 10 weeks gestation) at booking visit.  Counseling: - Counsel about the recommended weight gain during pregnancy based on her calculated BMI. - Advice in healthy eating, appropriate exercise - risk of obesity during pregnancy and child birth and counsel about signs of thromboembolism. - dietitian referrale -risks of long term obesity, possible of developing HTN& DM.
  • 31. Prescription:  BMI ≥30 kg/m²  Prescribe folic acid 5 mg once daily.  If BMI ≥40 kg/m²; Prescribe oral aspirin (enteric coated) 75-100 mg once daily.  Maintenance dose of Vitamin D supplement 1,000 IU orally on daily basis after 12 weeks of gestational age. Referral:  If BMI ≥40 kg/m²; regularly refer to obstetric Hospital for antenatal follow-up, if client > 34 weeks of gestational age refer urgently
  • 32. Thyroid disease  Hypothyroidism: Subclinical Hypothyroidism  Hyperthyroidism: Gestational Hyperthyroidism & Hyperemesis Gravidarum Graves’ Disease
  • 33. Screening ONLY for high risk for thyroid dysfunction: -Personal history of thyroid dysfunction and/or thyroid surgery. -Family history -Age > 30 years. -BMI ≥ 40 kg/m2. -Positive Thyroid Peroxidase Antibodies (TPO Ab). - Clinical signs and symptoms or the presence of goiter. - her autoimmune disease such as: DM1, vitiligo, adrenal insufficiency, hypoparathyroidism, . - History of miscarriage or preterm delivery. - Case of infertility. - Received radiation to the head or neck area as a cancer treatment. - Use of amiodarone or lithium, or recent administration of iodinated radiologic contrast. - Residing in an area of known moderate to severe iodine insufficiency.
  • 34. Hypothyroidism K/C of Hypothyroidism (Overt Hypothyroidism) Management:  Preconception: adjust the dose to reach a TSH level not higher than 2.5 μU/L prior to pregnancy.  Newly pregnant: increase the dose by 25% -30%.  Postpartum: Preconception dose. Follow-up:  Antenatal: Check TFT every 4-6 weeks.  Postnatal: Check TFT at 6-8 weeks postpartum.
  • 35. Hypothyroidism Newly diagnosed hypothyroidism during pregnancy: Diagnosis:  TSH1 (>2.5 μU/L) + low FT4 concentration.  TSH >10.0 μU/L irrespective to FT4level. Management:  start with low dose & observe the response to treatment, if the patient responding very well, continue with the same dose. If not, you can gradually increase the medication dose.  Start treatment to adjust TSH level not higher than the normal value which is based on pregnancy trimester. Follow up :  Postnatal: Check TFT at 6-8 weeks postpartum. Dose: - TSH < 10 μU/L a 1 mcg/kg/day. - TSH > 10 μU/L  1.6 mcg/kg/day. Max f 200 mcg/day.
  • 36. Subclinical Hypothyroidism: Diagnosis:  TSH (2.5- 10 mIU/L) with a normal FT4 level. Management:  Check thyroid peroxidase (TPO) antibodies:  If Positive, start treatment to adjust TSH level not higher the normal value based on trimester.  If Negative: treatment based on physician/patient decision. If the decision was for no treatment then continue monitor TFT level. Follow up:  Check TFTS in 4-6 wks.
  • 37. Euthyroid with Thyroid Antibodies(Tab) Positive Euthyroid woman with thyroid autoimmunity (not receiving L-thyroxin) who is Tab positive is at risk for developing for hypothyroidism. Close monitoring of TSH level is necessary. Follow up: Check TFT every 4-6 weeks. Treatment: o Therapy should be started once TSH level rise above trimester specific status. Counseling: Medication should be taken in empty stomach. Ideally 30 minute to one hour before breakfast. Note: “Empty stomach means 3-4hrs after meal”. Certain drugs e.g.: cholestyramine, ferrous sulfate, calcium carbonate & antacid, may interfere with L-thyroxine absorption from the gut. L-thyroxine
  • 38. Hyperthyroidism Gestational Hyperthyroidism & Hyperemesis Gravidarum: Diagnosis:  No prior history of thyroid disease or signs of Graves’s disease.  TFT: Low serum TSH and an elevated FT4.  Limited to the first half of pregnancy  Serum T4 return to normal by 14-18 wks gestation. Treatment:  Antithyroid Drugs (ATD) are not indicated.
  • 39. Hyperthyroidism Graves’ Disease: Preconception:  Counseling: reach euthyroid state before attempting pregnancy. Antenatal care: medications are Not available at PHCC If graves’ disease diagnosed during pregnancy:  Diagnosed during 1st Trimester begin prophlthiouracil.  Diagnosed during 2nd trimester  begin methimazol. If graves’ disease diagnosed and treated prior to pregnancy:  Currently on methimazole: switch to prophlthiouracil as soon as pregnancy confirmed.
  • 40. Medication dose:  Mild hyperthyroidism start PTU 50 mg, 3times/day, or methamazole 5-10 mg/day.  severe hyperthyrodisium  start PTU 100 mg, 3times/day, or methamazole 10-30 mg/day. Referral: Refer urgently to endocrine clinic at women’s Hospital and continue ANC at women’s Hospital.
  • 41. Management and Referral Considerations for Common Risk Conditions during PregnancyActionRisk Condition - Assess social, mental & health risk & wellbeing. - Provide standard antenatal care & follow-up unless the client has Risk. - Diet advice. - Ensure family support. Age < 15 years - Do U/S at 11-14 wks. For nuchal translucency & nasal bone. - Counsel about amniocentesis to rule out anomalies. If the client agreed refer to FMU (Feto Maternal Unit) at women’ Hospital to do the procedure. - Do U/S at 20 wks. of gestational age for checking detail anomalies. Age ≥ 35 years “advance maternal age”
  • 42. ActionRisk Condition Refere to WH. - Need U/S at 10-12 wks. For nuchal translucency & nasal bone by well trained staff. - Detail anomaly scan in FMU (Feto Maternal Unit), if abnormality discovered the client should be followed in tertiary care facility. age ≥ 40 years - Prescribe Aspirin 75-100 mg once daily. - Prescribe folic acid 5 mg once daily. - Regular Referral to the nearest obstetric Hospital (Secondary Care). Note:” If client > 34 wks of gestational age, urgently refer to the nearest obstetric hospital (BMI) ≥ 40 kg/m2 -Diet advice. - Give iron + multivitamins supplement. - Refer to dietitian at PHCC. - Monitor fetal well-being by U/S routinely unless if abnormality discovered its need more often or refer to hospital based on abnormality result. BMI < 18.5 kg/m2 or weight (less than) < 45kg
  • 43. ActionRisk Condition Emergency referral to WHUnexpected Problem in Current Pregnancy: - Massive Polyhydramnious. - Oligohydramnious. - Vaginal Bleeding. - Absent fetal heart or fetal movement. - Decrease fetal movement (from 24wks gestation). - Signs of preterm labor. Urgent Referral to FMU) depending on Trimester and type of Hazard for detailed anomalies scans between 20 -22 weeks. Exposed to hazardous medication or radiation in current pregnancy - Counsel the client about risk of abortion if keeping or removing IUCD. - Should not be removed in PHCC. Note:” Would refer to emergency of the nearest obstetric hospital (secondary care)” Pregnancy with IUCD in situ
  • 44. - Refer to WH - Urgent Referral to WH if ≥ 20 wks gestation otherwise regular referral is acceptable. Note: “Multiple pregnancy ≥ 3 should be referred & followed in WH.” Multiple Pregnancy Emergency referral to WHPlatelet < 30,000 irrespective to gestational age - Request for U/S if available in your HC; If normal, continue antenatal care at PHCC. If abnormality is suspected, refer to emergency (WH) - If U/S is not available; emergency refer to the WH. -Suspected hydatidiform mole. - Previous Molar Pregnancy -< 14wks Urgent referral to FMU at WH. - > 14 weeks refer to emergency. Rh –ve with Positive Rh antibodies in current pregnancy - Request for U/S - Checks Beta-hCG level, Get at least 2-3 reading within 48hrs. - If ectopic confirmed refer to emergency to nearest obstetric Hospital. Suspect Ectopic Pregnancy
  • 45. ActionRisk If chronic problem is stable: - Regular Referral WH and continue antenatal care at the same hospital. K/C of Chronic Disease: - Autoimmune/lupus. - Congenital heart disease, cardiomyopathy, Hx of MI. -IBD. -ITP. - Kidney disease. - Pulmonary hypertension. - Thromboembolic Urgent Referral to WH and continues antenatal care at the same hospital. - Cancer. - Mental Disorder. Urgent Referral to women’s Hospital (Tertiary care) and continues antenatal care at the same hospital. - Bleeding disorder (ex. Hemophilia) Urgent referral to endocrine clinic and continue antenatal care at the same Hospital. Graves’s disease,Thyroid nodule & previous Hx of thyroid cancer. Urgent referral WH- Epileptic disease. - Stop all antihypertensive medication. - Prescribe aldoment drug; starting dose between 250 mg – 500 mg (depending on patient condition). - Prescribe 75 -100 mg of aspirin daily and stop at 32 weeks of gestational age. - Give calcium supplement 1000 mg/ day. - Refer urgently to WH. K/C of Chronic Hypertension: Women who have high BP ≥140/90 before or early pregnancy (before 20 weeks).
  • 46. Action to be takenRisk Factors - Confirmed: if two (2) reading of blood pressure ≥140/90 per week in a setting position. - Prescribe aldoment drug; starting dose between 250 mg – 500 mg - Give Ca supplement 1000 mg/ day. - Refer urgently to WH if pregnant ≥ 20wks of gestational age Pregnancy induced hypertension: High BP≥140/90 that develops after 20 wks in without proteinuria and goes away after delivery Emergency Referral to WH by ambulanceBP ≥ 140 / 90 and with symptoms of pre- eclampsia: - Severe headache. - Problems with vision, such as blurring vision or flashing. - Severe pain just below the ribs. - Vomiting. - Sudden swelling of the face, hands or feet and sudden weight gain in short period Urgent referral WH Previous Obstetric Problem: - IUFD/still birth or neonatal death. - Fetal anomaly, congenital or genetic disease. - Down syndrome.
  • 47. . Urgent referral to FMU. abnormal  WH.normal HC Previous History of RH isoimmunization (+ ve combs test) or hydrops fetalies. Urgent referra to WHPrevious Hx of mid trimester miscarriage ( >16 wks gestation) Regular referral to WH≥ 2 previous subsequent abortions. Prescribe aspirin 100 mg daily from 12 wks. - Close monitoring the fetal wellbeing by U/S at 26 & 28 wks. - Urgent referral to WH at 28wks. Previous Hx of IUGR: ” Term baby with weight less than 2.5 kg” Emergency WHIUGR in Current Pregnancy: - IUGR with Reduce Fetal Movement URGENT referral to WH - Only IUGR
  • 48. - If C/S done at governmental obstetric Hospital: Regular Referral at 32 wks - If C/S done outside governmental Hospital such as in private or abroad Hospital: Regular Referral at 28 wks. - If C/S done at early gestational age “<37wks” refer as early as possible Previous Cesarean Section “C/S” Contact: Close contact with no previous Hx of infection, refer to emergency and continue Antenatal care at PHC. Active Lesion: Assess the general condition of patient to rule out pneumonia: - Give antipyretic. - Give calamine lotion. - Avoid contact with others. - Emergency referrale to WH. Positive Infectious Disease: - Chicken Pox - 1ST attack start (Acyclovir) and Urgent referral WH - 2nd and more attack with active lesion need urgent referral to WH - Genitalia Herpes
  • 49. - Check all serology of hepatitis B. - Check result of Hepatitis C. - Urgent Referral to a specialist in Gastroenterology within nearest secondary care. - Continue antenatal care at PHC. - Hepatitis B Give Treatment for client & partner with urgent referral to nearest obstetric hospital (secondary care) for further investigation. - Syphilis Emergency Referral to Women’s Hospital Patients on Teratogenic Drugs

Hinweis der Redaktion

  1. It should be carried out as soon as a woman is diagnosed to be pregnant. The assign physician should document by using the Antenatal care booking form.
  2. Dietary Advice: o Meats.Fish, Seeds ,Spinach, silver beet, Pumpkin, Dried fruits, Oatmeal cereal
  3. THS
  4. Note: “the physician should maintain the TSH level within normal range value based on trimester”
  5. start L-Thyroxine at 1 mcg/kg/day. start L-Thyroxine at 1.6 mcg/kg/day.
  6. thyroid peroxidase (TPO) antibodies: Note: “Endocrine section at HMC advice to treat pregnant women with subclinical hypothyroidism regardless to TPO antibody status”
  7. Remove slide
  8. What is the definition
  9. Consideration during lactation: methimazole in dose up to 20-30 mg/day is safe for lactating mothers and their infants. Prophlthiouracil at dose up to 300 mg /day is a second line agent due to concerns about severe hepatotoxicity. Anti thyroid drugs should be administered following a feeding & in divided dose”
  10. No NEED this siled