11. General features- Group 1 Group 2 Types Steroids,iodothyronines, calcitriol ,retinoids Polypeptides,proteins, glycoproteins, catecholamines. Solubility Lipophilic Hydrophilic Transport protein Yes No Plasma half life Long (hours to days) Short(minutes) Receptor Intracellular Plasma membrane Mediators Receptor – hormone complex cAMP ,cGMP,Ca 2+, metabolites of complex phosphoinositols, kinase cascades.