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Opioids

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Khalid

consider it as a source for you<br />complete summery from Barash Clinical Anesthesia TextBook<br />By Khalid Al-Jonaieh

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OPIOIDS Dr.Khalid Al-Jonaieh Demonstrator Anesthesia Department KKUH بسم الله الرحمن الرحيم
Terminology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Efficacy and Potency ,[object Object]
ENDOGENOUS OPIOIDS AND OPIOID RECEPTORS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Proenkephalin ,[object Object]
The dynorphin ,[object Object]
Pro-opiomelanocortin ,[object Object],[object Object],[object Object]
Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Selectivity ,[object Object],[object Object],[object Object],[object Object]
Cellular Level ,[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics & Pharmacodynamic ,[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object]
Pharmacodynamic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacodynamic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Morphine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia ,[object Object],[object Object],[object Object],[object Object]
At the spinal cord level ,[object Object],[object Object],[object Object],[object Object],[object Object]
At the Supraspinal level ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
At Peripheral Level ,[object Object],[object Object],[object Object],[object Object]
Pain Relief ,[object Object],[object Object],[object Object]
Effect on MAC of Volatile Anesthetics ,[object Object],[object Object],[object Object]
Other Central Nervous System Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hormonal Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object]
Cautions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cough Reflex ,[object Object],[object Object]
Muscle Rigidity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nausea and Vomiting ,[object Object],[object Object],[object Object],[object Object],[object Object]
The vomiting center ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antiemetic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Gastrointestinal Motility and Secretion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Biliary Tract ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genitourinary Effects ,[object Object],[object Object],[object Object]
Histamine Release ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiovascular Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Active Metabolites ,[object Object],[object Object]
Dosage and Administration of Morphine ,[object Object],[object Object],[object Object],[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object]
Meperidine ,[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia and Effect on MAC of Volatile Anesthetics ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiovascular Effects ,[object Object],[object Object],[object Object]
Shivering ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Active Metabolites ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration of Meperidine ,[object Object],[object Object],[object Object],[object Object],[object Object]
Methadone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia and Use in Anesthesia ,[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration of Methadone ,[object Object],[object Object],[object Object]
Fentanyl ,[object Object],[object Object],[object Object],[object Object]
Analgesia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
stress - free anesthesia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other CNS Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Airway Reflexes ,[object Object],[object Object]
Cardiovascular Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object]
Endocrine Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth Muscle and Gastrointestinal Effects ,[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration of Fentanyl ,[object Object],[object Object],[object Object],[object Object]
Intubation Time ,[object Object],[object Object],[object Object],[object Object]
cardiac surgery ,[object Object],[object Object],[object Object]
Sufentanil ,[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia ,[object Object],[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object]
Other CNS Effects ,[object Object],[object Object],[object Object],[object Object]
In patients with intracranial tumors ,[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object]
CVS Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
Endocrine Effects ,[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiac Anesthesia ,[object Object],[object Object]
Alfentanil ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia ,[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object],[object Object]
Other CNS Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
Neurosurgical patients ,[object Object],[object Object],[object Object],[object Object],[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiovascular Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Nausea and Vomiting ,[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Dosage and Administration ,[object Object],[object Object],[object Object],[object Object],[object Object]
Intubation ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
For Long Procedures ,[object Object],[object Object],[object Object],[object Object]
Cardiac Surgery ,[object Object],[object Object],[object Object]
Remifentanil ,[object Object],[object Object],[object Object],[object Object],[object Object]
Analgesia ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Use in Anesthesia ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TIVA ,[object Object],[object Object],[object Object],[object Object]
Cardiac Anesthesia ,[object Object],[object Object],[object Object],[object Object]
Monitored Anesthesia Care ,[object Object],[object Object],[object Object],[object Object],[object Object]
Other CNS Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
Motor - Evoked Potentials ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Respiratory Depression ,[object Object],[object Object],[object Object],[object Object],[object Object]
Recovery from Resp. Depression ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hemodynamic Effects ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Coronary Artery Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cardiac Surgery ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gastrointestinal Effects ,[object Object],[object Object],[object Object],[object Object]
Remifentanil ,[object Object],[object Object],[object Object]
Other Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disposition Kinetics ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosage and Administration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Induction Dosage, Intubation, LMA Placement ,[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object]
Maintenance of General Anesthesia ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Cardiac Surgery ,[object Object],[object Object]
A disadvantage of remifentanil ,[object Object],[object Object],[object Object],[object Object],[object Object]
Monitored Anesthesia Care ,[object Object],[object Object],[object Object]
ESWT ,[object Object]
Ophthalmologic Surgery ,[object Object],[object Object]
Regional Anesthesia ,[object Object],[object Object],[object Object]
Partial Agonists and Mixed Agonist–Antagonists ,[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object]
[object Object]
Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The major role for using them ,[object Object],[object Object],[object Object]
Nalbuphine ,[object Object],[object Object],[object Object],[object Object],[object Object]
Study ,[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object]
Comparison with fentanyl ,[object Object],[object Object],[object Object],[object Object]
Features ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Butorphanol ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Buprenorphine ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
Extra Info. ,[object Object],[object Object],[object Object],[object Object]
Opioid Antagonists ,[object Object],[object Object],[object Object],[object Object],[object Object]
Naloxone ,[object Object],[object Object],[object Object],[object Object]
Naltrexone ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Mechanism Pulm. Edema ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Using As Infusion ,[object Object],[object Object],[object Object]
Use of Opioids in Clinical Anesthesia ,[object Object],[object Object],[object Object],[object Object],[object Object]
For induction of anesthesia ,[object Object],[object Object]
During maintenance of general anesthesia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]
 
[object Object],[object Object]
Context - Sensitive Half - Time ,[object Object]
Explanation ,[object Object]
[object Object]
[object Object]
Context - sensitive half - times
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