1. Anxiety Linked to Shortened
Telomeres And Cell Division:
Puzzling Findings Relating to
Centromere Structure
Reconciled
Alejandra Henao Buitrago
Medical student

2. FOLDING

3. FOLDING

4. INTRODUCTION
Understanding
Telomeres are
centromeres is critical
considered markers of
because of the role
biological or cellular
they play in maintaining
aging.
genomic integrity.

5. Cell Division: Puzzling Findings Relating
To Centromere Structure Reconciled
Science Daily (July 19,
2012)

6. Cell Division: Puzzling Findings Relating
To Centromere Structure Reconciled
A nucleosome, a short coil
of DNA twisted around a
core of proteins forms at
each centromere. Within
the core is a protein, called
Cse4 in yeast. But the
overall architecture of that
nucleosome was unknown.
has used live cell imaging
to reveal constituents of the
centromeric protein core.

7. Cell Division: Puzzling Findings Relating
To Centromere Structure Reconciled
• Two methods were combined to probe yeast
cells engineered to express Cse4 hooked to a
green fluorescent protein (GFP) tag.
• The approach allowed them to track and then
count in a living cell the number of Cse4
molecules in a centromeric nucleosome.
• Yeast cells have 16 chromosomes, each with
one centromere. If each centromere contained
just one copy of Cse4, then the dot glowing in
each cell should be 16 times brighter than a
single GFP molecule.

8. Cell Division: Puzzling Findings Relating
To Centromere Structure Reconciled
 Was found that two evidence
molecules of Cse4 were
interacting at the centromere
in anaphase, but these
interactions were not present
during the rest of the cell
cycle.
 Is concluded that the timing of
structural changes differs in
yeast and human cells, But
that human and yeast
centromeres undergo similar
dynamic changes with the cell
cycle.

9. Comment
 know the functioning of the
centromere is important for
understanding the
segregation of chromosomes
and of the consequences of
errors in cell division.

10. Anxiety Linked to Shortened
Telomeres, Accelerated Aging
ScienceDaily (July 11, 2012)

11. Anxiety Linked to Shortened
Telomeres, Accelerated Aging

12. Anxiety Linked to Shortened
Telomeres, Accelerated Aging
A new study shows that a phobic
anxiety was associated with shorter
telomeres in middle aged and older
women.

13. Anxiety Linked to Shortened
Telomeres, Accelerated Aging
Shortened telomeres have been linked to
increased risk of cancers, heart disease,
dementia and mortality.
This study is notable for showing a
connection between a common form of
psychological stress, phobic anxiety, and
a plausible mechanism for premature
aging.

14. Comment
See the
relationship
between a
psychological
stress with
premature aging,
is important to give
appropriate
diagnostic, provide
timely treatment
using the

15. MEDICAL UTILITY

16. MEDICAL UTILITY
Most cells in the adult
exhibit only limited
telomerase activity,
meaning that as cells
divide and replicate their
DNA, the chromosomes’
telomeres become
shorter. This limits the
number of times a cell
can divide and
contributes to aging.

17. MEDICAL UTILITY
Longer telomeres
are hypothesized to
correlate with
improved longevity
and reduced disease
burden.

18. MEDICAL UTILITY
The study of
centromere helps
detect genetic
diseases when
there are errors in
cell division

19. BIBLIOGRAPHY
 MARTINEZ S, Lina María, Biología
molecular, 7 ed. Medellín: UPB. Fac de
Medicina , 2012. 69-70 p.
 WATSON, James, Biología molecular del
Gen, 5 ed. Buenos Aires, Madrid, ed
panamericana, 2006. 151-153 p.