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Intro to Physical Disabilities

  Kinesiotherapy Training Module
Disabilities

•    Cerebrovascular Accident             •  Diabetes Mellitus
•    Head Injury                          •  Amyotrophic Lateral
•    Spinal Cord Injury                      Sclerosis
•    Disorders of the Spine               •  Parkinson’s Disease
•    Multiple Sclerosis                   •  Huntington’s Disease
•    Guillain-Barre                       •  Alzheimer’s Disease
•    Myasthenia Gravis                    •  Lupus Erythematosis
•    Amputation                           •  Arthritis



                          Illness, Injuries, Diseases               2
Cerebrovascular Accident (CVA, Stroke)

•  Loss of brain functions due to oxygen deprivation
    •  Oxygen deprivation occurs as result of a blockage or hemorrhage
        •  Blockage (Ischemic type) – caused by a clot (thrombus or
           embolus) that occludes a blood vessel; accounts for 80% of all
           strokes
        •  Hemorrhage – blood vessel bursts, often from an aneurysm;
           accounts for 20% of all strokes

•  Second leading cause of death worldwide
•  Result in varying degrees of neurological impairment
    •  Ischemic strokes tend to result in greater neurologic loss, but also
       tend to have a higher survival rate



                              Illness, Injuries, Diseases                     3
Illness, Injuries, Diseases   4
CVA

•  Risk factors for stroke include:
    •  Advanced age
    •  Diabetes
    •  Elevated cholesterol levels
    •  Smoking
    •  Hypertension (the most modifiable risk factor)

•  Stroke Characteristics:
    •  Left brain lesion results in right side impairment
    •  Right brain lesion results in left side impairment
    •  Speech, memory, and vision are often impaired as well




                              Illness, Injuries, Diseases      5
CVA

•  Terminology
    •  Hemiparesis – partial paralysis on one side, often resulting in
       diminished motor skills
    •  Hemiplegia – paralysis in on one side, often resulting in loss of
       motor skill
    •  Aphasia – partial or total loss of the ability to express or understand
       verbal or written language
    •  Lability - uncontrollable emotional outbursts
    •  Apraxia – inability to perform purposeful movements, but not
       accompanied by a loss of sensory function or paralysis
    •  Ataxia - inability to coordinate voluntary muscle movements




                           Illness, Injuries, Diseases                       6
Head Injury

•  Closed Head Injury – an injury to the brain caused by an external source
   that imposes an acceleration, a deceleration, or rotational force

•  Open Head Injury – an injury to the brain caused by a penetrating wound

•  Symptoms depend upon the region of the brain that is injured

•  Impairment as a result of brain injury:
    •  Physical – motor weakness, imbalance, spasticity
    •  Cognitive – impaired short term memory, perceptual function, and
       decision making
    •  Behavioral – emotional outbursts, impulsivity




                              Illness, Injuries, Diseases                     7
Spinal Cord Injury

•  The spinal cord is an elongated cylindrical mass of nervous tissue that is
   enclosed in the spinal canal of the vertebral column
    •  Between 17 or 18 inches long in the average adult

•  Extends from the base of the brain to about the 1st or 2nd lumbar
   vertebra

•  Nerves descending below the ending of the spinal cord form the Cauda
   Equina, before exiting to periphery

•  Cervical and lumbar enlargements are noted, to accommodate the cell
   bodies (lower motor neurons) for upper and lower extremities




                              Illness, Injuries, Diseases                       8
Illness, Injuries, Diseases   9
Spinal Cord Injury

•  Spinal Cord Injury (SCI)
    •  Results from a lesion (injury) to the spinal cord, disrupting motor
       function and sensation below the level of the lesion

    •  Classified according to the spinal level of the lesion, (i.e. injury at the
       6th thoracic vertebra is classified as a T6 injury)

    •  Complete - injury that results in the complete loss of function below
       the point of injury

    •  Incomplete - injury in which some feeling or movement is still evident
       below the point of injury




                               Illness, Injuries, Diseases                       10
Spinal Cord Injury

•  Spinal Cord Injury
    •  Paralysis – inability to move a body part due to injury or disease of the
       nerves that supply the involved muscles
        •  Plegia - true paralysis
        •  Paresis - significant weakening of the affected muscle(s)

•  Causes:
    •  Trauma – the majority of SCI (gunshots, car/diving accident, etc)
    •  Infections – (viral, bacterial) polio, transverse myelitis, meningitis, etc
    •  Tumors – both benign and malignant
    •  Exposure to toxins




                                Illness, Injuries, Diseases                      11
Illness, Injuries, Diseases   12
Spinal Cord Injury
•  Complications:
    •  Motor loss
    •  Sensory loss
    •  Incontinence
    •  Decubitus ulcers
    •  Spasticity
    •  Urinary tract infections
    •  Respiratory illness

•  Quadriplegia - lesion above T1 (1st thoracic vertebra)
    •  Involves any injury in the cervical spine
    •  Effects all four extremities, and trunk

•  Paraplegia – lesion at T1 or lower
    •  Involves any injury from the 1st thoracic vertebrae down to the coccyx
    •  Effects both lower extremities

                              Illness, Injuries, Diseases                   13
Spinal Cord Injury




  Illness, Injuries, Diseases   14
Spinal Cord Nerve Levels




     Illness, Injuries, Diseases   15
Spinal Cord Dermatomes




     Illness, Injuries, Diseases   16
Disorders of the Spine
•  Spinal Stenosis – progressive narrowing of the spaces in the spine, resulting
   in compression of nerve roots or spinal cord by bony spurs or soft tissue
   such as discs in the spinal canal
    •  Most often occurs in the lumbar spine, but can occur in the cervical
       region; less frequently in the thoracic region

    •  Can cause pain or numbness in legs, back, neck, shoulders or arms; limb
       weakness and
       incoordination; loss of sensation
       in extremities; problems
       with bladder or bowel function

    •  Commonly caused by age-related
       changes in the spine (osteo-
       arthritis, disk degeneration,
       thickened ligaments)
                                Illness, Injuries, Diseases                    17
Disorders of the Spine
•  Spondylolysis – a defect or fracture of the pars interarticularis (posterior
   part of the spine)
    •  Pars joins together the upper and lower joints of the vertebra

•  Spondyolisthesis - anterior or posterior displacement of one vertebra or
   vertebral segment in relation to the vertebra below
   •  Usually occurs because there is a spondylolysis in the vertebra on top
   •  Can occur anywhere in the spine, but is most common in the lower
       spine
   •  Displacement can cause pressure on spinal cord or nerve roots

•  Ankylosing spondylitis - inflammation of the facet joints between
   vertebrae; eventually causes the affected spinal bones to fuse
    •  Usually begins between the ages of 20 and 40; affects men more often
       than women

                                Illness, Injuries, Diseases                       18
Disorders of the Spine




    Illness, Injuries, Diseases   19
Disorders of the Spine

•  Herniated Disc - the inner disc material (nucleus), seeps through a crack in
   its outer shell (annulus)

•  Bulging Disc - a bulge in the annulus
    •  Occurs when the outer shell of a spinal disc weakens to the point where
       pressure causes it to bulge

•  Scoliosis - the sideways curvature of the spine

•  Kyphosis - rounding forward of the upper spine

•  Spina Bifida - incomplete closure of the bony spinal column; leaves a
   portion of the membranes or spinal cord exposed


                               Illness, Injuries, Diseases                   20
Disorders of the Spine

•  Radiculitis - inflammation of a nerve root, synonymous with radicular pain

•  Radicular Pain – pain which radiates along the dermatome (sensory
   distribution) of a nerve due to inflammation or other irritation of the nerve
   root from its connection to the spinal cord

•  Radiculopathy - chronic injury of spinal nerve roots caused by nerve
   compression or irritation
    •  Most common in lower back (lumbar radiculopathy) and neck (cervical
       radiculopathy)
    •  Numbness, tingling, weakness, loss of motor function, and radiating
       pain are some of the common symptoms
    •  Pain is often described as sharp and radiating; worsens with activity or
       change in position


                                Illness, Injuries, Diseases                    21
Multiple Sclerosis

•  Multiple Sclerosis (MS) – a progressive neurologic disease characterized
   by a loss of myelin (demyelinization)
    •  Myelin – the coating of nerve fibers




                              Illness, Injuries, Diseases                     22
Multiple Sclerosis

•  Often results in continual loss of physical functions with progressive
   weakness, spasticity, and impaired coordination; can also affect speech and
   vision
•  Often marked by periods of exacerbations and remissions
        •  Exacerbations – symptoms worsen
        •  Remission – symptoms diminish or stabilize

•  Excessive heat exacerbates negative symptoms

•  Therapeutic exercise cannot reverse or halt the disease progression;
   however exercise can help maintain musculoskeletal function so that the
   patient can more effectively maintain functional independence

•  Persons are prone to early muscular fatigue, so exercise progression should
   avoid over-fatigue


                              Illness, Injuries, Diseases                    23
Guillain-Barre Syndrome

•  Guillain-Barre Syndrome – rare inflammatory disorder, causes symmetrical
   paralysis and loss of reflexes; usually begins in the lower extremities, then
   progresses upward
    •  An autoimmune disorder (the body’s immune system attacks itself)

    •  Results in destruction of the myelin sheath of the peripheral nerves

    •  Often occurs after a respiratory infection, or may be triggered by a
       vaccination

    •  Weakness and numbness begin in the distal extremities and
       progressively worsen as symptoms move toward the trunk




                                Illness, Injuries, Diseases                   24
 
                   Guillain-Barre Syndrome

•  Paralysis can progress to impair respiration

•  If early symptoms are severe, there is a significant increase in risk for
   serious long-term complications

•  Outcome usually very good when symptoms abate within 3 weeks of
   initial onset

•  Complete recovery noted in 70-80% of cases, but recovery can take
   weeks, months, or years; 20-30% have incomplete recovery

•  Up to 10 percent of people will experience a relapse



                           Illness, Injuries, Diseases                         25
Myasthenia Gravis

•  Myasthenia Gravis – a non-progressive disease of unknown origin
    •  Autoimmune neuromuscular disorder

    •  Onset can be sudden or gradual

    •  No known cure but treatment efforts are often favorable

    •  Often goes into remission for long periods

    •  Results in extreme fatigue and muscular exhaustion

    •  Muscular fatigue worsens as the day progresses
        •  Patterns of weakness usually begin in the face and spread to the other body
           parts
        •  An initial symptom is ptosis ( drooping eye lid) that exacerbates as the day
           progresses

                                  Illness, Injuries, Diseases                             26
Myasthenia Gravis

•  Muscular fatigue worsens as the day progresses (cont.)
   •  Other symptoms include double vision, speech impairments, and
      difficulty chewing
   •  As symptoms spread, the shoulders and thighs become weak and can
      eventually impair the muscles of respiration

•  Symptoms get worse with repeated use and improve with rest

•  Shortness of breath can lead to respiratory failure if proper treatment is not
   administered




                                Illness, Injuries, Diseases                     27
Amputation

•  Amputation – the cutting off of a limb or part of a limb

•  Major causes of amputation:
    •  Peripheral vascular disease – leading cause
        •  Particularly linked to smoking and diabetes
        •  Seen mostly in elderly

    •  Trauma – second leading cause
        •  Most related to motor vehicle accidents and gunshot wounds
        •  Young males represent the largest population group

•  Lower extremity amputation sites:
    •  Toe
    •  Ray - toe and part of the corresponding metatarsal
    •  Transmetatarsal – through the metatarsal
    •  Lisfranc - amputation of the foot at the tarsometatarsal joint
    •  Chopart - removes the forefoot and midfoot, saving talus and calcaneus
                               Illness, Injuries, Diseases                      28
Amputation

•  Lower extremity amputation sites:
    •  Ankle disarticulation (Symes) – through the ankle
    •  Transtibial (BK - below knee)
    •  Knee disarticulation – through the knee
    •  Transfemoral (AK - above knee)
    •  Hip disarticulation – through the hip
    •  Hemipelvectomy – partial pelvis removal
    •  Hemicorporectomy – both lower limbs and all of pelvis removed

•  Phantom Limb Sensation - any sensory phenomenon (except pain) which is
   felt below an amputation site

    •  Phantom Limb Pain - mild to extreme pain felt in the area below the
       amputation site; can be extremely agonizing

                             Illness, Injuries, Diseases                     29
Illness, Injuries, Diseases   30
Diabetes Mellitus

•  Diabetes Mellitus – A chronic disease in which the body either doesn’t
   produce enough insulin or can’t use its own insulin efficiently
    •  Insulin is a hormone produced in the pancreas, an organ near the
       stomach
    •  Insulin is needed to convert sugar and other food into energy
    •  This causes elevated blood glucose levels

•  Type 1 Diabetes – juvenile onset, insulin dependent
    •  Type 1 is irreversible

•  Type 2 Diabetes – Non-insulin dependent, primarily adult onset, but can
   affect children
    •  Type 2 can be reversed or minimized through diet, exercise, and weight
       control


                               Illness, Injuries, Diseases                  31
Amyotrophic Lateral Sclerosis

•  Amyotrophic Lateral Sclerosis (ALS) – also known as Lou Gehrig’s
   Disease
    •  Chronic, progressive, fatal disease characterized by degeneration of
       both upper and lower motor neurons in the spinal cord

    •  As motor neurons die, the ability of the brain to initiate and control
       muscle movement is lost, affecting voluntary muscle action
        •  Generally results in total paralysis during the latter stages of the
           disease

    •  Symptoms generally appear in the 4th or 5th decade of life

    •  Average life span is 8 years from the onset of the disease



                               Illness, Injuries, Diseases                        32
Parkinson's Disease

•  Parkinson’s Disease (paralysis agitans)- progressive movement disorder
   caused by degeneration in areas of the cerebrum resulting in a decreased
   production of dopamine

    •  Characterized by:
        •  Tremors
        •  Rigidity
        •  Slow voluntary movements (bradykinesia)
        •  Postural instability
        •  Muscle weakness

•  Occurs when cells in one of the movement-control centers of the brain begin
   to die for unknown reasons


                               Illness, Injuries, Diseases                    33
Illness, Injuries, Diseases   34
Huntington's Disease

•  Huntington’s Disease – inherited genetic disorder of the CNS,
   characterized by progressive mental and physical deterioration, eventually
   resulting in death
    •  Caused by a dominant gene, which when inherited the gene from one
       or both parents, causes a 50% likelihood of developing the disease
    •  HD is also known as Huntington’s Chorea

•  Chorea (dyskinesia) - a neurological disorder causing abnormal
   involuntary movements
    •  Chorea comes from the Greek word for dance
    •  Chorea – restless, wiggling, turning bodily movements
    •  Chorea movements - uncontrollable and irregular muscle movements,
       especially of the arms, legs, and face




                              Illness, Injuries, Diseases                   35
Huntington's Disease

•  Symptoms
    •  Can begin at any age from infancy to old age, but usually arise
       between 35 and 44 years of age

    •  Earliest symptoms are a general lack of coordination and unsteady gait

    •  As the disease advances, uncoordinated jerky body movements become
       more apparent, and behavioral and psychiatric problems increase

    •  Physical abilities are gradually impeded until coordinated movement
       becomes very difficult to impossible

    •  Mental abilities generally decline into dementia


                              Illness, Injuries, Diseases                    36
Alzheimer's Disease

•  Alzheimer’s Disease – disabling neurological disorder resulting in dementia,
   characterized by dysfunction and death of specific cerebral neurons
    •  Most serious form of dementia

    •  Results in widespread intellectual impairment and personality changes

    •  A significant pathological marker for the disease is the presence of
       neurofibrillary tangles in specific portions of the brain

    •  Most important known risk factor is age

    •  The number of people with AD doubles every 5 years beyond age 65

    •  Forgetfulness is an early sign, then short term memory loss, progressing
       to long term memory loss, and finally, total memory loss

                                Illness, Injuries, Diseases                    37
Illness, Injuries, Diseases   38
Lupus

•  Lupus – chronic inflammatory autoimmune disorder affecting the
   connective tissue

    •  Systemic lupus erythematosus (SLE) - can affect any part of the body,
       but most often harms the heart, joints, skin, lungs, blood vessels, liver,
       kidneys, and nervous system
         •  The course of the disease is unpredictable with periods of illness
            (called flares) alternating with remissions
         •  Common complaints include fever, malaise, muscle pain, fatigue,
            and temporary loss of cognitive abilities; joint pain especially in the
            wrists, small joints of the hands, elbows, knees, and ankles is also
            common

    •  Cutaneous (discoid) - version of the disease that is limited to the skin;
       characterized by a rash that appears on the face, neck, and scalp; does
       not affect internal organs
                                Illness, Injuries, Diseases                        39
Lupus
•  Characterized by sensitivity to direct sunlight; must avoid overheating
•  More common in women; can occur at any age, but is usually diagnosed
   between the ages of 15 and 40.




                          Illness, Injuries, Diseases                   40
Arthritis

•  Arthritis - joint disorder characterized by arthralgia , swelling, stiffness,
   and redness
    •  Arthralgia – severe joint pain, extending along a nerve or group of
       nerves
    •  Involves breakdown of articular cartilage
         •  Cartilage - dense, elastic, fibrous connective tissue composed of
            collagen fibers and/or elastin fibers
         •  Cartilage is contained in various joint structures, the outer ear,
            larynx, and various other body structures

    •  Over 100 different types of arthritis exist; the most common types are:
    •  Osteoarthritis
    •  Rheumatoid Arthritis



                                 Illness, Injuries, Diseases                       41
Arthritis




Illness, Injuries, Diseases   42
Arthritis


•  Osteoarthritis (OA) is the most common type
    •  Chronic degenerative disorder primarily affecting the articular cartilage
       of synovial joints
    •  Eventually results in bone remodeling, with spurs and lipping
       overgrowth at the joint margins

•  Rheumatoid arthritis (RA) - an autoimmune, chronic, inflammatory,
   systemic disease; initially attacks the synovial membrane within a joint
    •  Systemic - relating to or affecting the entire body or an entire organism
    •  Inflammation of the synovial membrane leads to the destruction of the
       articular cartilage




                               Illness, Injuries, Diseases                     43
Arthritis




Illness, Injuries, Diseases   44

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Intro to Physical Disabilities Training Module

  • 1. Intro to Physical Disabilities Kinesiotherapy Training Module
  • 2. Disabilities •  Cerebrovascular Accident •  Diabetes Mellitus •  Head Injury •  Amyotrophic Lateral •  Spinal Cord Injury Sclerosis •  Disorders of the Spine •  Parkinson’s Disease •  Multiple Sclerosis •  Huntington’s Disease •  Guillain-Barre •  Alzheimer’s Disease •  Myasthenia Gravis •  Lupus Erythematosis •  Amputation •  Arthritis Illness, Injuries, Diseases 2
  • 3. Cerebrovascular Accident (CVA, Stroke) •  Loss of brain functions due to oxygen deprivation •  Oxygen deprivation occurs as result of a blockage or hemorrhage •  Blockage (Ischemic type) – caused by a clot (thrombus or embolus) that occludes a blood vessel; accounts for 80% of all strokes •  Hemorrhage – blood vessel bursts, often from an aneurysm; accounts for 20% of all strokes •  Second leading cause of death worldwide •  Result in varying degrees of neurological impairment •  Ischemic strokes tend to result in greater neurologic loss, but also tend to have a higher survival rate Illness, Injuries, Diseases 3
  • 5. CVA •  Risk factors for stroke include: •  Advanced age •  Diabetes •  Elevated cholesterol levels •  Smoking •  Hypertension (the most modifiable risk factor) •  Stroke Characteristics: •  Left brain lesion results in right side impairment •  Right brain lesion results in left side impairment •  Speech, memory, and vision are often impaired as well Illness, Injuries, Diseases 5
  • 6. CVA •  Terminology •  Hemiparesis – partial paralysis on one side, often resulting in diminished motor skills •  Hemiplegia – paralysis in on one side, often resulting in loss of motor skill •  Aphasia – partial or total loss of the ability to express or understand verbal or written language •  Lability - uncontrollable emotional outbursts •  Apraxia – inability to perform purposeful movements, but not accompanied by a loss of sensory function or paralysis •  Ataxia - inability to coordinate voluntary muscle movements Illness, Injuries, Diseases 6
  • 7. Head Injury •  Closed Head Injury – an injury to the brain caused by an external source that imposes an acceleration, a deceleration, or rotational force •  Open Head Injury – an injury to the brain caused by a penetrating wound •  Symptoms depend upon the region of the brain that is injured •  Impairment as a result of brain injury: •  Physical – motor weakness, imbalance, spasticity •  Cognitive – impaired short term memory, perceptual function, and decision making •  Behavioral – emotional outbursts, impulsivity Illness, Injuries, Diseases 7
  • 8. Spinal Cord Injury •  The spinal cord is an elongated cylindrical mass of nervous tissue that is enclosed in the spinal canal of the vertebral column •  Between 17 or 18 inches long in the average adult •  Extends from the base of the brain to about the 1st or 2nd lumbar vertebra •  Nerves descending below the ending of the spinal cord form the Cauda Equina, before exiting to periphery •  Cervical and lumbar enlargements are noted, to accommodate the cell bodies (lower motor neurons) for upper and lower extremities Illness, Injuries, Diseases 8
  • 10. Spinal Cord Injury •  Spinal Cord Injury (SCI) •  Results from a lesion (injury) to the spinal cord, disrupting motor function and sensation below the level of the lesion •  Classified according to the spinal level of the lesion, (i.e. injury at the 6th thoracic vertebra is classified as a T6 injury) •  Complete - injury that results in the complete loss of function below the point of injury •  Incomplete - injury in which some feeling or movement is still evident below the point of injury Illness, Injuries, Diseases 10
  • 11. Spinal Cord Injury •  Spinal Cord Injury •  Paralysis – inability to move a body part due to injury or disease of the nerves that supply the involved muscles •  Plegia - true paralysis •  Paresis - significant weakening of the affected muscle(s) •  Causes: •  Trauma – the majority of SCI (gunshots, car/diving accident, etc) •  Infections – (viral, bacterial) polio, transverse myelitis, meningitis, etc •  Tumors – both benign and malignant •  Exposure to toxins Illness, Injuries, Diseases 11
  • 13. Spinal Cord Injury •  Complications: •  Motor loss •  Sensory loss •  Incontinence •  Decubitus ulcers •  Spasticity •  Urinary tract infections •  Respiratory illness •  Quadriplegia - lesion above T1 (1st thoracic vertebra) •  Involves any injury in the cervical spine •  Effects all four extremities, and trunk •  Paraplegia – lesion at T1 or lower •  Involves any injury from the 1st thoracic vertebrae down to the coccyx •  Effects both lower extremities Illness, Injuries, Diseases 13
  • 14. Spinal Cord Injury Illness, Injuries, Diseases 14
  • 15. Spinal Cord Nerve Levels Illness, Injuries, Diseases 15
  • 16. Spinal Cord Dermatomes Illness, Injuries, Diseases 16
  • 17. Disorders of the Spine •  Spinal Stenosis – progressive narrowing of the spaces in the spine, resulting in compression of nerve roots or spinal cord by bony spurs or soft tissue such as discs in the spinal canal •  Most often occurs in the lumbar spine, but can occur in the cervical region; less frequently in the thoracic region •  Can cause pain or numbness in legs, back, neck, shoulders or arms; limb weakness and incoordination; loss of sensation in extremities; problems with bladder or bowel function •  Commonly caused by age-related changes in the spine (osteo- arthritis, disk degeneration, thickened ligaments) Illness, Injuries, Diseases 17
  • 18. Disorders of the Spine •  Spondylolysis – a defect or fracture of the pars interarticularis (posterior part of the spine) •  Pars joins together the upper and lower joints of the vertebra •  Spondyolisthesis - anterior or posterior displacement of one vertebra or vertebral segment in relation to the vertebra below •  Usually occurs because there is a spondylolysis in the vertebra on top •  Can occur anywhere in the spine, but is most common in the lower spine •  Displacement can cause pressure on spinal cord or nerve roots •  Ankylosing spondylitis - inflammation of the facet joints between vertebrae; eventually causes the affected spinal bones to fuse •  Usually begins between the ages of 20 and 40; affects men more often than women Illness, Injuries, Diseases 18
  • 19. Disorders of the Spine Illness, Injuries, Diseases 19
  • 20. Disorders of the Spine •  Herniated Disc - the inner disc material (nucleus), seeps through a crack in its outer shell (annulus) •  Bulging Disc - a bulge in the annulus •  Occurs when the outer shell of a spinal disc weakens to the point where pressure causes it to bulge •  Scoliosis - the sideways curvature of the spine •  Kyphosis - rounding forward of the upper spine •  Spina Bifida - incomplete closure of the bony spinal column; leaves a portion of the membranes or spinal cord exposed Illness, Injuries, Diseases 20
  • 21. Disorders of the Spine •  Radiculitis - inflammation of a nerve root, synonymous with radicular pain •  Radicular Pain – pain which radiates along the dermatome (sensory distribution) of a nerve due to inflammation or other irritation of the nerve root from its connection to the spinal cord •  Radiculopathy - chronic injury of spinal nerve roots caused by nerve compression or irritation •  Most common in lower back (lumbar radiculopathy) and neck (cervical radiculopathy) •  Numbness, tingling, weakness, loss of motor function, and radiating pain are some of the common symptoms •  Pain is often described as sharp and radiating; worsens with activity or change in position Illness, Injuries, Diseases 21
  • 22. Multiple Sclerosis •  Multiple Sclerosis (MS) – a progressive neurologic disease characterized by a loss of myelin (demyelinization) •  Myelin – the coating of nerve fibers Illness, Injuries, Diseases 22
  • 23. Multiple Sclerosis •  Often results in continual loss of physical functions with progressive weakness, spasticity, and impaired coordination; can also affect speech and vision •  Often marked by periods of exacerbations and remissions •  Exacerbations – symptoms worsen •  Remission – symptoms diminish or stabilize •  Excessive heat exacerbates negative symptoms •  Therapeutic exercise cannot reverse or halt the disease progression; however exercise can help maintain musculoskeletal function so that the patient can more effectively maintain functional independence •  Persons are prone to early muscular fatigue, so exercise progression should avoid over-fatigue Illness, Injuries, Diseases 23
  • 24. Guillain-Barre Syndrome •  Guillain-Barre Syndrome – rare inflammatory disorder, causes symmetrical paralysis and loss of reflexes; usually begins in the lower extremities, then progresses upward •  An autoimmune disorder (the body’s immune system attacks itself) •  Results in destruction of the myelin sheath of the peripheral nerves •  Often occurs after a respiratory infection, or may be triggered by a vaccination •  Weakness and numbness begin in the distal extremities and progressively worsen as symptoms move toward the trunk Illness, Injuries, Diseases 24
  • 25.   Guillain-Barre Syndrome •  Paralysis can progress to impair respiration •  If early symptoms are severe, there is a significant increase in risk for serious long-term complications •  Outcome usually very good when symptoms abate within 3 weeks of initial onset •  Complete recovery noted in 70-80% of cases, but recovery can take weeks, months, or years; 20-30% have incomplete recovery •  Up to 10 percent of people will experience a relapse Illness, Injuries, Diseases 25
  • 26. Myasthenia Gravis •  Myasthenia Gravis – a non-progressive disease of unknown origin •  Autoimmune neuromuscular disorder •  Onset can be sudden or gradual •  No known cure but treatment efforts are often favorable •  Often goes into remission for long periods •  Results in extreme fatigue and muscular exhaustion •  Muscular fatigue worsens as the day progresses •  Patterns of weakness usually begin in the face and spread to the other body parts •  An initial symptom is ptosis ( drooping eye lid) that exacerbates as the day progresses Illness, Injuries, Diseases 26
  • 27. Myasthenia Gravis •  Muscular fatigue worsens as the day progresses (cont.) •  Other symptoms include double vision, speech impairments, and difficulty chewing •  As symptoms spread, the shoulders and thighs become weak and can eventually impair the muscles of respiration •  Symptoms get worse with repeated use and improve with rest •  Shortness of breath can lead to respiratory failure if proper treatment is not administered Illness, Injuries, Diseases 27
  • 28. Amputation •  Amputation – the cutting off of a limb or part of a limb •  Major causes of amputation: •  Peripheral vascular disease – leading cause •  Particularly linked to smoking and diabetes •  Seen mostly in elderly •  Trauma – second leading cause •  Most related to motor vehicle accidents and gunshot wounds •  Young males represent the largest population group •  Lower extremity amputation sites: •  Toe •  Ray - toe and part of the corresponding metatarsal •  Transmetatarsal – through the metatarsal •  Lisfranc - amputation of the foot at the tarsometatarsal joint •  Chopart - removes the forefoot and midfoot, saving talus and calcaneus Illness, Injuries, Diseases 28
  • 29. Amputation •  Lower extremity amputation sites: •  Ankle disarticulation (Symes) – through the ankle •  Transtibial (BK - below knee) •  Knee disarticulation – through the knee •  Transfemoral (AK - above knee) •  Hip disarticulation – through the hip •  Hemipelvectomy – partial pelvis removal •  Hemicorporectomy – both lower limbs and all of pelvis removed •  Phantom Limb Sensation - any sensory phenomenon (except pain) which is felt below an amputation site •  Phantom Limb Pain - mild to extreme pain felt in the area below the amputation site; can be extremely agonizing Illness, Injuries, Diseases 29
  • 31. Diabetes Mellitus •  Diabetes Mellitus – A chronic disease in which the body either doesn’t produce enough insulin or can’t use its own insulin efficiently •  Insulin is a hormone produced in the pancreas, an organ near the stomach •  Insulin is needed to convert sugar and other food into energy •  This causes elevated blood glucose levels •  Type 1 Diabetes – juvenile onset, insulin dependent •  Type 1 is irreversible •  Type 2 Diabetes – Non-insulin dependent, primarily adult onset, but can affect children •  Type 2 can be reversed or minimized through diet, exercise, and weight control Illness, Injuries, Diseases 31
  • 32. Amyotrophic Lateral Sclerosis •  Amyotrophic Lateral Sclerosis (ALS) – also known as Lou Gehrig’s Disease •  Chronic, progressive, fatal disease characterized by degeneration of both upper and lower motor neurons in the spinal cord •  As motor neurons die, the ability of the brain to initiate and control muscle movement is lost, affecting voluntary muscle action •  Generally results in total paralysis during the latter stages of the disease •  Symptoms generally appear in the 4th or 5th decade of life •  Average life span is 8 years from the onset of the disease Illness, Injuries, Diseases 32
  • 33. Parkinson's Disease •  Parkinson’s Disease (paralysis agitans)- progressive movement disorder caused by degeneration in areas of the cerebrum resulting in a decreased production of dopamine •  Characterized by: •  Tremors •  Rigidity •  Slow voluntary movements (bradykinesia) •  Postural instability •  Muscle weakness •  Occurs when cells in one of the movement-control centers of the brain begin to die for unknown reasons Illness, Injuries, Diseases 33
  • 35. Huntington's Disease •  Huntington’s Disease – inherited genetic disorder of the CNS, characterized by progressive mental and physical deterioration, eventually resulting in death •  Caused by a dominant gene, which when inherited the gene from one or both parents, causes a 50% likelihood of developing the disease •  HD is also known as Huntington’s Chorea •  Chorea (dyskinesia) - a neurological disorder causing abnormal involuntary movements •  Chorea comes from the Greek word for dance •  Chorea – restless, wiggling, turning bodily movements •  Chorea movements - uncontrollable and irregular muscle movements, especially of the arms, legs, and face Illness, Injuries, Diseases 35
  • 36. Huntington's Disease •  Symptoms •  Can begin at any age from infancy to old age, but usually arise between 35 and 44 years of age •  Earliest symptoms are a general lack of coordination and unsteady gait •  As the disease advances, uncoordinated jerky body movements become more apparent, and behavioral and psychiatric problems increase •  Physical abilities are gradually impeded until coordinated movement becomes very difficult to impossible •  Mental abilities generally decline into dementia Illness, Injuries, Diseases 36
  • 37. Alzheimer's Disease •  Alzheimer’s Disease – disabling neurological disorder resulting in dementia, characterized by dysfunction and death of specific cerebral neurons •  Most serious form of dementia •  Results in widespread intellectual impairment and personality changes •  A significant pathological marker for the disease is the presence of neurofibrillary tangles in specific portions of the brain •  Most important known risk factor is age •  The number of people with AD doubles every 5 years beyond age 65 •  Forgetfulness is an early sign, then short term memory loss, progressing to long term memory loss, and finally, total memory loss Illness, Injuries, Diseases 37
  • 39. Lupus •  Lupus – chronic inflammatory autoimmune disorder affecting the connective tissue •  Systemic lupus erythematosus (SLE) - can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system •  The course of the disease is unpredictable with periods of illness (called flares) alternating with remissions •  Common complaints include fever, malaise, muscle pain, fatigue, and temporary loss of cognitive abilities; joint pain especially in the wrists, small joints of the hands, elbows, knees, and ankles is also common •  Cutaneous (discoid) - version of the disease that is limited to the skin; characterized by a rash that appears on the face, neck, and scalp; does not affect internal organs Illness, Injuries, Diseases 39
  • 40. Lupus •  Characterized by sensitivity to direct sunlight; must avoid overheating •  More common in women; can occur at any age, but is usually diagnosed between the ages of 15 and 40. Illness, Injuries, Diseases 40
  • 41. Arthritis •  Arthritis - joint disorder characterized by arthralgia , swelling, stiffness, and redness •  Arthralgia – severe joint pain, extending along a nerve or group of nerves •  Involves breakdown of articular cartilage •  Cartilage - dense, elastic, fibrous connective tissue composed of collagen fibers and/or elastin fibers •  Cartilage is contained in various joint structures, the outer ear, larynx, and various other body structures •  Over 100 different types of arthritis exist; the most common types are: •  Osteoarthritis •  Rheumatoid Arthritis Illness, Injuries, Diseases 41
  • 43. Arthritis •  Osteoarthritis (OA) is the most common type •  Chronic degenerative disorder primarily affecting the articular cartilage of synovial joints •  Eventually results in bone remodeling, with spurs and lipping overgrowth at the joint margins •  Rheumatoid arthritis (RA) - an autoimmune, chronic, inflammatory, systemic disease; initially attacks the synovial membrane within a joint •  Systemic - relating to or affecting the entire body or an entire organism •  Inflammation of the synovial membrane leads to the destruction of the articular cartilage Illness, Injuries, Diseases 43